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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ada
Name: adenosine deaminase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adadecreases expressionISOAda (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ADA mRNAPMID:21569818
Adaincreases activityISOAda (Mus musculus)6480464CTDBenzo(a)pyrene results in increased activity of ADA proteinPMID:18057710 PMID:36193556
Adaincreases expressionISOADA (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ADA mRNAPMID:20106945 PMID:21632981 PMID:22316170
Adamultiple interactionsISOAda (Mus musculus)6480464CTDQuercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of ADA protein]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in increased activity of ADA protein]PMID:18057710 PMID:36193556
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