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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ada
Name: adenosine deaminase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adaaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of ADA mRNAPMID:34747641
Adaincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ADA mRNAPMID:33387578
Adaaffects expressionISOAda (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ADA mRNAPMID:21570461
Adadecreases activityISOAda (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased activity of ADA proteinPMID:7853360
Adadecreases expressionISOADA (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ADA mRNAPMID:19901195
Adaincreases expressionISOAda (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ADA mRNAPMID:19933214
Adamultiple interactionsISOAda (Mus musculus)6480464CTD[Quercetin co-treated with Tetrachlorodibenzodioxin] results in decreased activity of ADA protein; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADA mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of ADA mRNA; Tetrachlorodibenzodioxin inhibits the reaction [Genistein results in decreased activity of ADA protein]; Tetrachlorodibenzodioxin inhibits the reaction [Neomycin results in decreased activity of ADA protein]; Tetrachlorodibenzodioxin inhibits the reaction [Quercetin results in decreased activity of ADA protein]PMID:17942748 PMID:25975270 PMID:7853360
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