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Gene: Hnf4g (hepatocyte nuclear factor 4, gamma) Rattus norvegicus

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Symbol:

Hnf4g

Name:

hepatocyte nuclear factor 4, gamma

RGD ID:

1310102

Description:

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. Orthologous to human HNF4G (hepatocyte nuclear factor 4 gamma); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 4,4'-diaminodiphenylmethane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hepatocyte nuclear factor 4-gamma; LOC365744

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HNF4G (hepatocyte nuclear factor 4 gamma)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Hnf4g (hepatocyte nuclear factor 4, gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hnf4g (hepatocyte nuclear factor 4 gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HNF4G (hepatocyte nuclear factor 4 gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HNF4G (hepatocyte nuclear factor 4 gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hnf4g (hepatocyte nuclear factor 4 gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HNF4G (hepatocyte nuclear factor 4 gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HNF4G (hepatocyte nuclear factor 4 gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hnf4g (hepatocyte nuclear factor 4 gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZNF703 (zinc finger protein 703)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	HNF4G (hepatocyte nuclear factor 4 gamma)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hnf4g (hepatocyte nuclear factor 4, gamma)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hnf4g (hepatocyte nuclear factor 4, gamma)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Hnf4	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nhr-49	Alliance	DIOPT (OMA\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	nhr-64	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nhr-69	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	hnf4g	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	99,792,942 - 99,943,811 (-)	NCBI		GRCr8
mRatBN7.2	2	97,885,773 - 98,036,650 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	97,887,432 - 98,036,592 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	104,468,305 - 104,616,180 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	102,589,371 - 102,737,257 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	97,617,327 - 97,765,461 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	100,225,880 - 100,372,710 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	100,225,888 - 100,372,252 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	119,961,786 - 120,108,045 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	100,367,290 - 100,518,496 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	100,312,845 - 100,331,225 (-)	NCBI
Celera	2	93,381,225 - 93,528,222 (-)	NCBI		Celera
Cytogenetic Map	2	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (EXP)

7,9-dihydro-1H-purine-2,6,8(3H)-trione (ISO)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

amiodarone (ISO)

aristolochic acid A (ISO)

atrazine (EXP)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

dibenzofurans (ISO)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

indole-3-methanol (EXP)

lead diacetate (ISO)

methyl methanesulfonate (ISO)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

ochratoxin A (EXP)

paracetamol (EXP,ISO)

PCB138 (ISO)

pirinixic acid (ISO)

quercetin (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IBA)

intracellular receptor signaling pathway (IEA)

positive regulation of DNA-templated transcription (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

cytosol (ISO)

intercellular bridge (ISO)

mitotic spindle (ISO)

nucleoplasm (ISO)

nucleus (IEA)

Molecular Function

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

nuclear receptor activity (IBA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

maturity-onset diabetes of the young pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10786614	PMID:12220531	PMID:23896584

Genomics

Comparative Map Data

Hnf4g
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	99,792,942 - 99,943,811 (-)	NCBI		GRCr8
mRatBN7.2	2	97,885,773 - 98,036,650 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	97,887,432 - 98,036,592 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	104,468,305 - 104,616,180 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	102,589,371 - 102,737,257 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	97,617,327 - 97,765,461 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	100,225,880 - 100,372,710 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	100,225,888 - 100,372,252 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	119,961,786 - 120,108,045 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	100,367,290 - 100,518,496 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	100,312,845 - 100,331,225 (-)	NCBI
Celera	2	93,381,225 - 93,528,222 (-)	NCBI		Celera
Cytogenetic Map	2	q23	NCBI

HNF4G
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	75,407,649 - 75,566,834 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	75,407,914 - 75,566,834 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	76,319,884 - 76,479,069 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	76,614,758 - 76,641,624 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	76,614,757 - 76,641,623	NCBI
Celera	8	72,447,027 - 72,473,891 (+)	NCBI		Celera
Cytogenetic Map	8	q21.13	NCBI
HuRef	8	71,939,833 - 71,966,703 (+)	NCBI		HuRef
CHM1_1	8	76,503,705 - 76,530,572 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	75,837,130 - 75,996,323 (+)	NCBI		T2T-CHM13v2.0

Hnf4g
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	3,573,090 - 3,724,863 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	3,573,084 - 3,724,860 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	3,508,030 - 3,659,800 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	3,508,030 - 3,658,052 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	3,508,030 - 3,659,800 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	3,493,753 - 3,643,025 (+)	NCBI		MGSCv36	mm8
Celera	3	3,597,238 - 3,748,931 (+)	NCBI		Celera
Cytogenetic Map	3	A1	NCBI
cM Map	3	1.82	NCBI

Hnf4g
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955444	5,080,954 - 5,107,542 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955444	5,081,013 - 5,157,988 (-)	NCBI	ChiLan1.0	ChiLan1.0

HNF4G
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	91,157,513 - 91,312,414 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	66,785,277 - 66,940,105 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	71,947,924 - 72,102,934 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	73,666,576 - 73,743,437 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	73,716,604 - 73,743,865 (+)	Ensembl	panpan1.1		panPan2

HNF4G
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	23,683,380 - 23,801,799 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	23,732,339 - 23,801,519 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	23,943,412 - 24,064,667 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	23,789,896 - 23,912,012 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	23,841,379 - 23,910,074 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	23,850,614 - 23,972,215 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	23,884,966 - 24,006,588 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	24,237,724 - 24,359,110 (+)	NCBI		UU_Cfam_GSD_1.0

Hnf4g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	55,478,667 - 55,609,805 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936648	3,943,626 - 3,968,622 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936648	3,943,632 - 3,968,550 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HNF4G
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	60,505,385 - 60,595,789 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	60,505,388 - 60,641,052 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

HNF4G
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	70,971,287 - 71,133,212 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	71,106,434 - 71,133,206 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	70,236,683 - 70,393,483 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hnf4g
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	15,648,466 - 15,683,973 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624744	15,648,463 - 15,797,403 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hnf4g
917 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	302
Count of miRNA genes:	194
Interacting mature miRNAs:	225
Transcripts:	ENSRNOT00000011890
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	59846005	104846005	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	81018907	126018907	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	82345893	130923501	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
2293676	Bmd19	Bone mineral density QTL 19	10.7	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	43162366	111362592	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
2293682	Bmd24	Bone mineral density QTL 24	8.9	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	43162366	111362592	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	38573329	122609194	Rat
1598862	Glom9	Glomerulus QTL 9	3.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	2	92337601	137337601	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	76539322	150540526	Rat
1598863	Cm65	Cardiac mass QTL 65	2.3		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	92337601	137337601	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	76539322	102785628	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	40067944	102785628	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
2300165	Bmd49	Bone mineral density QTL 49	4.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	2	88862519	133862519	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	59324377	103795077	Rat
2300170	Bmd45	Bone mineral density QTL 45	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
7411551	Bw131	Body weight QTL 131	29.6	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	67942638	112942638	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	78665616	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
2300185	Bmd46	Bone mineral density QTL 46	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	59324719	102755241	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	80270434	125270434	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	59324377	103795077	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	72532993	157142209	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
7207808	Bmd89	Bone mineral density QTL 89	4.1		femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	2	88862519	133862519	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	64366971	109366971	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	28484589	169504100	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	28484589	169504100	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat

Markers in Region

D2Got57

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	97,929,885 - 97,930,056 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	100,268,599 - 100,268,769	NCBI	Rnor6.0
Rnor_5.0	2	120,004,339 - 120,004,509	UniSTS	Rnor5.0
RGSC_v3.4	2	100,411,472 - 100,411,643	RGD	RGSC3.4
RGSC_v3.4	2	100,411,473 - 100,411,643	UniSTS	RGSC3.4
RGSC_v3.1	2	100,356,435 - 100,356,605	RGD
Celera	2	93,423,432 - 93,423,603	UniSTS
RH 3.4 Map	2	621.0	RGD
RH 3.4 Map	2	621.0	UniSTS
Cytogenetic Map	2	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	4	6	89	90	89	59	18	59	6	161	45	69	45	47	30

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001415087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001415088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011890 ⟹ ENSRNOP00000011890

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	97,887,432 - 98,036,592 (-)	Ensembl
Rnor_6.0 Ensembl	2	100,226,328 - 100,372,252 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000086760 ⟹ ENSRNOP00000070293

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	97,887,432 - 97,911,210 (-)	Ensembl
Rnor_6.0 Ensembl	2	100,225,888 - 100,249,811 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119478 ⟹ ENSRNOP00000082188

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	97,894,111 - 97,908,860 (-)	Ensembl

RefSeq Acc Id:

NM_001415087 ⟹ NP_001402016

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	99,792,942 - 99,943,811 (-)	NCBI
mRatBN7.2	2	97,885,773 - 98,036,650 (-)	NCBI

RefSeq Acc Id:

NM_001415088 ⟹ NP_001402017

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	99,792,942 - 99,818,385 (-)	NCBI
mRatBN7.2	2	97,885,773 - 97,911,218 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001402016	(Get FASTA)	NCBI Sequence Viewer
	NP_001402017	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM01044	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011890.6
	ENSRNOP00000070293.1
	ENSRNOP00000082188.1

Ensembl Acc Id:

ENSRNOP00000011890 ⟸ ENSRNOT00000011890

Ensembl Acc Id:

ENSRNOP00000070293 ⟸ ENSRNOT00000086760

Ensembl Acc Id:

ENSRNOP00000082188 ⟸ ENSRNOT00000119478

RefSeq Acc Id:	NP_001402016 ⟸ NM_001415087
- Peptide Label:	isoform 2

RefSeq Acc Id:	NP_001402017 ⟸ NM_001415088
- Peptide Label:	isoform 1
- UniProtKB:	A0A0G2JXJ1 (UniProtKB/TrEMBL)

Protein Domains

NR LBD Nuclear receptor

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JXJ1-F1-model_v2	AlphaFold	A0A0G2JXJ1	1-462	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691249

Promoter ID:

EPDNEW_R1772

Type:

initiation region

Name:

Hnf4g_1

Description:

hepatocyte nuclear factor 4, gamma

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R1773

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	100,249,623 - 100,249,683	EPDNEW

RGD ID:

13691248

Promoter ID:

EPDNEW_R1773

Type:

initiation region

Name:

Hnf4g_2

Description:

hepatocyte nuclear factor 4, gamma

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R1772

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	100,372,291 - 100,372,351	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310102	AgrOrtholog
BioCyc Gene	G2FUF-53661	BioCyc
Ensembl Genes	ENSRNOG00000008971	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011890.7	UniProtKB/TrEMBL
	ENSRNOT00000086760.2	UniProtKB/TrEMBL
	ENSRNOT00000119478.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.565.10	UniProtKB/TrEMBL
	3.30.50.10	UniProtKB/TrEMBL
InterPro	HNF4-like_DBD	UniProtKB/TrEMBL
	HNF4_LBD	UniProtKB/TrEMBL
	NHR_like_domain	UniProtKB/TrEMBL
	Nucl_hrmn_rcpt_lig-bd_core	UniProtKB/TrEMBL
	Nuclear_hormone_rcpt_NR2	UniProtKB/TrEMBL
	Str_hrmn_rcpt	UniProtKB/TrEMBL
	Znf_hrmn_rcpt	UniProtKB/TrEMBL
	Znf_NHR/GATA	UniProtKB/TrEMBL
NCBI Gene	365744	ENTREZGENE
PANTHER	HEPATOCYTE NUCLEAR FACTOR 4-GAMMA	UniProtKB/TrEMBL
	NUCLEAR HORMONE RECEPTOR	UniProtKB/TrEMBL
Pfam	Hormone_recep	UniProtKB/TrEMBL
	zf-C4	UniProtKB/TrEMBL
PhenoGen	Hnf4g	PhenoGen
PRINTS	COUPTNFACTOR	UniProtKB/TrEMBL
	STRDHORMONER	UniProtKB/TrEMBL
	STROIDFINGER	UniProtKB/TrEMBL
PROSITE	NR_LBD	UniProtKB/TrEMBL
	NUCLEAR_REC_DBD_1	UniProtKB/TrEMBL
	NUCLEAR_REC_DBD_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008971	RatGTEx
SMART	HOLI	UniProtKB/TrEMBL
	ZnF_C4	UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/TrEMBL
	Str_ncl_receptor	UniProtKB/TrEMBL
UniProt	A0A0G2JXJ1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G943_RAT	UniProtKB/TrEMBL
	A6IH96_RAT	UniProtKB/TrEMBL
	F1M342_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Hnf4g	hepatocyte nuclear factor 4, gamma	Hnf4g_predicted	hepatocyte nuclear factor 4, gamma (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Hnf4g_predicted	hepatocyte nuclear factor 4, gamma (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)