ZNF703 (zinc finger protein 703) - Rat Genome Database

Name: ZNF703
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: ZNF703 (zinc finger protein 703) Homo sapiens

Analyze

Symbol:

ZNF703

Name:

zinc finger protein 703

RGD ID:

1602208

HGNC Page

HGNC:25883

Description:

Predicted to enable DNA-binding transcription factor binding activity and metal ion binding activity. Involved in several processes, including cellular response to estradiol stimulus; mammary gland epithelial cell differentiation; and positive regulation of mammary gland epithelial cell proliferation. Located in cytoplasm and nuclear matrix. Part of protein-containing complex.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

FLJ14299; NLZ1; ZEPPO1; zinc finger elbow-related proline domain protein 1; ZNF503L; ZPO1

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Zfp703 (zinc finger protein 703)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Zfp703 (zinc finger protein 703)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Znf703 (zinc finger protein 703)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	ZNF703 (zinc finger protein 703)	NCBI	Ortholog
Canis lupus familiaris (dog):	ZNF703 (zinc finger protein 703)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Znf703 (zinc finger protein 703)	NCBI	Ortholog
Sus scrofa (pig):	ZNF703 (zinc finger protein 703)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	ZNF703 (zinc finger protein 703)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Znf703 (zinc finger protein 703)	NCBI	Ortholog
Other homologs ²
Rattus norvegicus (Norway rat):	Zfp503 (zinc finger protein 503)	HGNC	OrthoDB
Mus musculus (house mouse):	Zfp503 (zinc finger protein 503)	HGNC	OrthoDB
Canis lupus familiaris (dog):	ZNF503 (zinc finger protein 503)	HGNC	OrthoDB
Sus scrofa (pig):	ZNF503 (zinc finger protein 503)	HGNC	OrthoDB
Rattus norvegicus (Norway rat):	Hnf4g (hepatocyte nuclear factor 4, gamma)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Zfp703 (zinc finger protein 703)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Zfp703 (zinc finger protein 703)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	znf703 (zinc finger protein 703)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	tlp-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Drosophila melanogaster (fruit fly):	elB	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	noc	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	znf703.L	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	znf703	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	znf703.S	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	37,695,782 - 37,700,019 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	8	37,695,782 - 37,700,019 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	37,553,300 - 37,557,537 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	37,672,459 - 37,675,554 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	36,506,270 - 36,509,365 (+)	NCBI		Celera
Cytogenetic Map	8	p11.23	NCBI
HuRef	8	36,088,055 - 36,091,097 (+)	NCBI		HuRef
CHM1_1	8	37,754,737 - 37,757,832 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	37,972,157 - 37,976,394 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2-hydroxypropanoic acid (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

acrylamide (ISO)

afimoxifene (EXP)

all-trans-retinoic acid (EXP,ISO)

amiodarone (EXP)

amphetamine (ISO)

antirheumatic drug (EXP)

aristolochic acid A (EXP)

atrazine (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

C60 fullerene (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP)

CGP 52608 (EXP)

chlorpyrifos (ISO)

cisplatin (EXP)

clofibrate (ISO)

coumestrol (EXP)

diazinon (EXP)

dicrotophos (EXP)

dorsomorphin (EXP)

doxorubicin (EXP)

Enterolactone (EXP)

enzyme inhibitor (EXP)

epoxiconazole (ISO)

Ethylenethiourea (ISO)

fenarimol (ISO)

flusilazole (ISO)

genistein (EXP)

gentamycin (ISO)

leflunomide (EXP)

Licochalcone B (EXP)

manganese(II) chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

p-toluidine (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (EXP)

propiconazole (ISO)

prothioconazole (EXP)

rac-lactic acid (EXP)

resveratrol (EXP)

SB 431542 (EXP)

silicon dioxide (ISO)

sodium arsenite (EXP)

Soman (ISO)

sunitinib (EXP)

thioacetamide (ISO)

triadimefon (ISO)

trichostatin A (EXP)

triptonide (ISO)

troglitazone (ISO)

tungsten (ISO)

urethane (EXP)

valproic acid (EXP)

vorinostat (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adherens junction assembly (IEA,ISS)

cellular response to estradiol stimulus (IDA)

mammary gland epithelial cell differentiation (IDA)

negative regulation of DNA-templated transcription (IBA,IEA,IMP)

negative regulation of homotypic cell-cell adhesion (IEA,ISS)

positive regulation of cell migration (IEA,ISS)

positive regulation of cell population proliferation (IDA)

positive regulation of epithelial to mesenchymal transition (IEA,ISS)

positive regulation of mammary gland epithelial cell proliferation (IDA,IEA)

regulation of canonical Wnt signaling pathway (IEA,ISS)

regulation of cell cycle (IDA)

regulation of DNA-templated transcription (IDA)

regulation of transforming growth factor beta receptor signaling pathway (IDA,IEA)

Cellular Component

cytoplasm (IDA,IEA,ISS)

nuclear matrix (IDA)

nucleus (IBA,IDA,IEA)

protein-containing complex (IDA)

Molecular Function

DNA-binding transcription factor binding (IEA)

metal ion binding (IEA)

protein binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14702039	PMID:15489334	PMID:15897872	PMID:16341674	PMID:16344560	PMID:19330026	PMID:20811636	PMID:21317240	PMID:21328542	PMID:21337521	PMID:21873635
PMID:22747683	PMID:22886885	PMID:23991038	PMID:24156016	PMID:24481460	PMID:25017610	PMID:25281560	PMID:25659891	PMID:25742952	PMID:26063961	PMID:26186194	PMID:26912792
PMID:26972000	PMID:27453415	PMID:27650486	PMID:27705803	PMID:27764785	PMID:27880917	PMID:28514442	PMID:29395067	PMID:29676528	PMID:30361900	PMID:30362321	PMID:30415952
PMID:31091453	PMID:31574205	PMID:32269215	PMID:32271436	PMID:32994395	PMID:33080218	PMID:33246486	PMID:33277362	PMID:33389351	PMID:33961781	PMID:35140242	PMID:35198878
PMID:35271311	PMID:35819319	PMID:35987950	PMID:36232890

Genomics

Comparative Map Data

ZNF703
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	37,695,782 - 37,700,019 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	8	37,695,782 - 37,700,019 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	37,553,300 - 37,557,537 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	37,672,459 - 37,675,554 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	36,506,270 - 36,509,365 (+)	NCBI		Celera
Cytogenetic Map	8	p11.23	NCBI
HuRef	8	36,088,055 - 36,091,097 (+)	NCBI		HuRef
CHM1_1	8	37,754,737 - 37,757,832 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	37,972,157 - 37,976,394 (+)	NCBI		T2T-CHM13v2.0

Zfp703
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	27,467,364 - 27,471,490 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	27,467,353 - 27,471,489 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	26,977,336 - 26,981,462 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	26,977,325 - 26,981,461 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	28,087,808 - 28,091,934 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	28,441,489 - 28,447,402 (+)	NCBI		MGSCv36	mm8
Celera	8	28,466,249 - 28,470,375 (+)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI

Zfp703
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	65,076,507 - 65,080,677 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	65,076,507 - 65,080,677 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	70,359,975 - 70,364,169 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	16	73,766,303 - 73,770,497 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	16	69,011,894 - 69,016,064 (-)	NCBI	Rnor_WKY
Rnor_6.0	16	69,237,857 - 69,242,028 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	69,237,857 - 69,242,028 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	68,911,230 - 68,915,401 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	69,405,004 - 69,409,137 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	16	62,995,876 - 63,000,045 (-)	NCBI		Celera
Cytogenetic Map	16	q12.3	NCBI

Znf703
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955463	13,407,491 - 13,411,562 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955463	13,407,491 - 13,411,562 (+)	NCBI	ChiLan1.0	ChiLan1.0

ZNF703
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	8	31,971,881 - 31,976,120 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	36,994,222 - 36,998,462 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	34,172,354 - 34,185,140 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

ZNF703
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	27,669,506 - 27,673,732 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	27,670,897 - 27,673,803 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	28,186,221 - 28,190,501 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	29,568,710 - 29,572,990 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	29,568,721 - 29,588,889 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	27,790,090 - 27,794,370 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	28,367,780 - 28,372,070 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	28,406,977 - 28,411,257 (-)	NCBI		UU_Cfam_GSD_1.0

Znf703
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	50,302,241 - 50,306,207 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936710	1,155,006 - 1,158,974 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936710	1,155,007 - 1,158,972 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZNF703
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	48,692,320 - 48,696,644 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	48,692,316 - 48,696,639 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	55,809,369 - 55,813,713 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZNF703
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	35,730,678 - 35,735,015 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	35,730,736 - 35,737,788 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	6,270,025 - 6,274,311 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Znf703
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624780	5,895,998 - 5,900,367 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624780	5,896,424 - 5,900,425 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ZNF703
22 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3	copy number gain	See cases [RCV000050294]	Chr8:12609975..42085703 [GRCh38] Chr8:12467484..41943221 [GRCh37] Chr8:12511855..42062378 [NCBI36] Chr8:8p23.1-11.21	pathogenic
GRCh38/hg38 8p21.2-q11.21(chr8:25832130-48521849)x3	copy number gain	See cases [RCV000050904]	Chr8:25832130..48521849 [GRCh38] Chr8:25689646..49434409 [GRCh37] Chr8:25745563..49596962 [NCBI36] Chr8:8p21.2-q11.21	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3	copy number gain	See cases [RCV000050912]	Chr8:12728904..43673207 [GRCh38] Chr8:12586413..43528350 [GRCh37] Chr8:12630784..43647507 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p12-11.21(chr8:34312250-43158901)x1	copy number loss	See cases [RCV000050745]	Chr8:34312250..43158901 [GRCh38] Chr8:34169768..43014044 [GRCh37] Chr8:34289310..43133201 [NCBI36] Chr8:8p12-11.21	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3	copy number gain	See cases [RCV000051206]	Chr8:241530..145049449 [GRCh38] Chr8:191530..146274835 [GRCh37] Chr8:181530..146245639 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-41928741)x3	copy number gain	See cases [RCV000051110]	Chr8:12728904..41928741 [GRCh38] Chr8:12586413..41786259 [GRCh37] Chr8:12630784..41905416 [NCBI36] Chr8:8p23.1-11.21	pathogenic
GRCh38/hg38 8p12-q11.21(chr8:29719897-48521849)x3	copy number gain	See cases [RCV000050995]	Chr8:29719897..48521849 [GRCh38] Chr8:29577413..49434409 [GRCh37] Chr8:29633332..49596962 [NCBI36] Chr8:8p12-q11.21	pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:12609975-37892000)x3	copy number gain	See cases [RCV000053629]	Chr8:12609975..37892000 [GRCh38] Chr8:12467484..37749518 [GRCh37] Chr8:12511855..37868676 [NCBI36] Chr8:8p23.1-11.23	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3	copy number gain	See cases [RCV000053630]	Chr8:12609975..43336172 [GRCh38] Chr8:12467484..43191315 [GRCh37] Chr8:12511855..43310472 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]\|See cases [RCV000053631]	Chr8:12609975..43255410 [GRCh38] Chr8:12467484..43110553 [GRCh37] Chr8:12511855..43229710 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3	copy number gain	See cases [RCV000053632]	Chr8:12750796..43532444 [GRCh38] Chr8:12608305..43387587 [GRCh37] Chr8:12652676..43506744 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3	copy number gain	See cases [RCV000053635]	Chr8:14940110..47929925 [GRCh38] Chr8:14797619..48842485 [GRCh37] Chr8:14841990..49005038 [NCBI36] Chr8:8p22-q11.21	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3	copy number gain	See cases [RCV000053602]	Chr8:241530..145054634 [GRCh38] Chr8:191530..146280020 [GRCh37] Chr8:181530..146250824 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]\|See cases [RCV000053604]	Chr8:244417..145054775 [GRCh38] Chr8:194417..146280161 [GRCh37] Chr8:184417..146250965 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3	copy number gain	See cases [RCV000135786]	Chr8:12609975..43673207 [GRCh38] Chr8:12467484..43528350 [GRCh37] Chr8:12511855..43647507 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3	copy number gain	See cases [RCV000135566]	Chr8:12383584..43673207 [GRCh38] Chr8:12241093..43528350 [GRCh37] Chr8:12285464..43647507 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-40169194)x3	copy number gain	See cases [RCV000136516]	Chr8:12728904..40169194 [GRCh38] Chr8:12586413..40026713 [GRCh37] Chr8:12630784..40145870 [NCBI36] Chr8:8p23.1-11.21	pathogenic
GRCh38/hg38 8p12-11.21(chr8:29362097-40231708)x1	copy number loss	See cases [RCV000136878]	Chr8:29362097..40231708 [GRCh38] Chr8:29219614..40089227 [GRCh37] Chr8:29275533..40208384 [NCBI36] Chr8:8p12-11.21	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3	copy number gain	See cases [RCV000137249]	Chr8:12182421..43673207 [GRCh38] Chr8:12039930..43528350 [GRCh37] Chr8:12077339..43647507 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.3-11.23(chr8:226452-38021728)x3	copy number gain	See cases [RCV000137807]	Chr8:226452..38021728 [GRCh38] Chr8:176452..37879246 [GRCh37] Chr8:166452..37998403 [NCBI36] Chr8:8p23.3-11.23	pathogenic\|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3	copy number gain	See cases [RCV000138643]	Chr8:241605..145054781 [GRCh38] Chr8:191605..146280167 [GRCh37] Chr8:181605..146250971 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:7141697-38695546)x3	copy number gain	See cases [RCV000139891]	Chr8:7141697..38695546 [GRCh38] Chr8:6999219..38553064 [GRCh37] Chr8:6986629..38672221 [NCBI36] Chr8:8p23.1-11.22	pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:12729023-39235934)x3	copy number gain	See cases [RCV000139770]	Chr8:12729023..39235934 [GRCh38] Chr8:12586532..39093453 [GRCh37] Chr8:12630903..39212610 [NCBI36] Chr8:8p23.1-11.22	pathogenic
GRCh38/hg38 8p12-q12.1(chr8:36580103-59618998)x3	copy number gain	See cases [RCV000139582]	Chr8:36580103..59618998 [GRCh38] Chr8:36437621..60531557 [GRCh37] Chr8:36556779..60694111 [NCBI36] Chr8:8p12-q12.1	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3	copy number gain	See cases [RCV000139796]	Chr8:12646123..43686843 [GRCh38] Chr8:12503632..43541986 [GRCh37] Chr8:12548003..43661143 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3	copy number gain	See cases [RCV000141808]	Chr8:208048..145070385 [GRCh38] Chr8:158048..146295771 [GRCh37] Chr8:148048..146266575 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3	copy number gain	See cases [RCV000142021]	Chr8:21291522..145070385 [GRCh38] Chr8:21149033..146295771 [GRCh37] Chr8:21193313..146266575 [NCBI36] Chr8:8p21.3-q24.3	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3	copy number gain	See cases [RCV000142858]	Chr8:226452..145068712 [GRCh38] Chr8:176452..146294098 [GRCh37] Chr8:166452..146264902 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3	copy number gain	See cases [RCV000148092]	Chr8:241530..145054634 [GRCh38] Chr8:191530..146280020 [GRCh37] Chr8:181530..146250824 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12633490-40685533)x3	copy number gain	See cases [RCV000143508]	Chr8:12633490..40685533 [GRCh38] Chr8:12490999..40543052 [GRCh37] Chr8:12535370..40662209 [NCBI36] Chr8:8p23.1-11.21	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3	copy number gain	See cases [RCV000148237]	Chr8:12728904..43673207 [GRCh38] Chr8:12586413..43528350 [GRCh37] Chr8:12630784..43647507 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3	copy number gain	See cases [RCV000148249]	Chr8:12609975..42085703 [GRCh38] Chr8:12467484..41943221 [GRCh37] Chr8:12511855..42062378 [NCBI36] Chr8:8p23.1-11.21	pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12528482-39593802)x3	copy number gain	See cases [RCV000511325]	Chr8:12528482..39593802 [GRCh37] Chr8:8p23.1-11.22	pathogenic
GRCh37/hg19 8p11.23-11.22(chr8:37555526-38600788)x3	copy number gain	See cases [RCV000240444]	Chr8:37555526..38600788 [GRCh37] Chr8:8p11.23-11.22	uncertain significance
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3	copy number gain	not provided [RCV000848192]	Chr8:31936551..146295771 [GRCh37] Chr8:8p12-q24.3	pathogenic
GRCh37/hg19 8p21.2-q12.1(chr8:24772064-24813176)x3	copy number gain	See cases [RCV000446588]	Chr8:24772064..24813176 [GRCh37] Chr8:8p21.2-q12.1	uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3	copy number gain	See cases [RCV000447507]	Chr8:158991..146280828 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3	copy number gain	See cases [RCV000447909]	Chr8:158048..43786723 [GRCh37] Chr8:8p23.3-11.1	pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3	copy number gain	See cases [RCV000447913]	Chr8:12580132..43388233 [GRCh37] Chr8:8p23.1-11.1	pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)	copy number gain	See cases [RCV000510234]	Chr8:158049..146295771 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3	copy number gain	See cases [RCV000511028]	Chr8:11935023..43824035 [GRCh37] Chr8:8p23.1-11.1	pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3	copy number gain	See cases [RCV000511095]	Chr8:158049..146295771 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3	copy number gain	See cases [RCV000512169]	Chr8:12490999..146295771 [GRCh37] Chr8:8p23.1-q24.3	pathogenic
GRCh37/hg19 8p12-11.21(chr8:31352498-41481295)x3	copy number gain	not provided [RCV000683035]	Chr8:31352498..41481295 [GRCh37] Chr8:8p12-11.21	pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3	copy number gain	not provided [RCV000747248]	Chr8:10213..146293414 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3	copy number gain	not provided [RCV000747254]	Chr8:164984..146293414 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p12-11.23(chr8:36486830-37992515)x1	copy number loss	See cases [RCV000790586]	Chr8:36486830..37992515 [GRCh37] Chr8:8p12-11.23	uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)	copy number gain	Polydactyly [RCV002280629]	Chr8:158048..146295771 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3	copy number gain	not provided [RCV000848478]	Chr8:158048..146295771 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p12-11.1(chr8:36094421-43822214)x3	copy number gain	not provided [RCV000848822]	Chr8:36094421..43822214 [GRCh37] Chr8:8p12-11.1	uncertain significance
GRCh37/hg19 8p23.3-11.1(chr8:176814-43396776)	copy number gain	Abnormal fetal cardiovascular morphology [RCV001291977]	Chr8:176814..43396776 [GRCh37] Chr8:8p23.3-11.1	pathogenic
GRCh37/hg19 8p11.23(chr8:37544476-37818465)x3	copy number gain	not provided [RCV001829089]	Chr8:37544476..37818465 [GRCh37] Chr8:8p11.23	uncertain significance
Single allele	complex	See cases [RCV002292428]	Chr8:6999114..11935023 [GRCh37] Chr8:8p23.3-11.21	pathogenic
Single allele	complex	8p inverted duplication/deletion syndrome [RCV002280753]	Chr8:158048..43019304 [GRCh37] Chr8:8p23.3-11.21	pathogenic
GRCh37/hg19 8p21.2-11.22(chr8:26808969-38346383)x1	copy number loss	not provided [RCV002472596]	Chr8:26808969..38346383 [GRCh37] Chr8:8p21.2-11.22	pathogenic
NM_025069.3(ZNF703):c.877G>C (p.Val293Leu)	single nucleotide variant	Inborn genetic diseases [RCV002817261]	Chr8:37697778 [GRCh38] Chr8:37555296 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1259G>A (p.Gly420Glu)	single nucleotide variant	Inborn genetic diseases [RCV002793463]	Chr8:37698160 [GRCh38] Chr8:37555678 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.610C>T (p.Pro204Ser)	single nucleotide variant	Inborn genetic diseases [RCV002774628]	Chr8:37697511 [GRCh38] Chr8:37555029 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.56G>A (p.Gly19Asp)	single nucleotide variant	Inborn genetic diseases [RCV002778271]	Chr8:37696035 [GRCh38] Chr8:37553553 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1045G>T (p.Gly349Cys)	single nucleotide variant	Inborn genetic diseases [RCV002738583]	Chr8:37697946 [GRCh38] Chr8:37555464 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1263C>A (p.His421Gln)	single nucleotide variant	Inborn genetic diseases [RCV002661389]	Chr8:37698164 [GRCh38] Chr8:37555682 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.796C>T (p.Pro266Ser)	single nucleotide variant	Inborn genetic diseases [RCV002661390]	Chr8:37697697 [GRCh38] Chr8:37555215 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1588G>A (p.Gly530Arg)	single nucleotide variant	Inborn genetic diseases [RCV002980052]	Chr8:37698489 [GRCh38] Chr8:37556007 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.32G>A (p.Arg11Lys)	single nucleotide variant	Inborn genetic diseases [RCV002802853]	Chr8:37696011 [GRCh38] Chr8:37553529 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.497C>T (p.Ser166Phe)	single nucleotide variant	Inborn genetic diseases [RCV002916003]	Chr8:37697398 [GRCh38] Chr8:37554916 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1286C>T (p.Ser429Leu)	single nucleotide variant	Inborn genetic diseases [RCV002803307]	Chr8:37698187 [GRCh38] Chr8:37555705 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.901C>A (p.Pro301Thr)	single nucleotide variant	Inborn genetic diseases [RCV002897313]	Chr8:37697802 [GRCh38] Chr8:37555320 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1390A>G (p.Ser464Gly)	single nucleotide variant	Inborn genetic diseases [RCV002896174]	Chr8:37698291 [GRCh38] Chr8:37555809 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.899A>G (p.Lys300Arg)	single nucleotide variant	Inborn genetic diseases [RCV002989228]	Chr8:37697800 [GRCh38] Chr8:37555318 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1744G>A (p.Ala582Thr)	single nucleotide variant	Inborn genetic diseases [RCV002989181]	Chr8:37698645 [GRCh38] Chr8:37556163 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.377C>G (p.Pro126Arg)	single nucleotide variant	Inborn genetic diseases [RCV003209393]	Chr8:37697278 [GRCh38] Chr8:37554796 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.665G>A (p.Arg222His)	single nucleotide variant	Inborn genetic diseases [RCV003202551]	Chr8:37697566 [GRCh38] Chr8:37555084 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1069C>T (p.Pro357Ser)	single nucleotide variant	Inborn genetic diseases [RCV003174240]	Chr8:37697970 [GRCh38] Chr8:37555488 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1723G>A (p.Ala575Thr)	single nucleotide variant	Inborn genetic diseases [RCV003188981]	Chr8:37698624 [GRCh38] Chr8:37556142 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1051G>T (p.Gly351Cys)	single nucleotide variant	Inborn genetic diseases [RCV003199746]	Chr8:37697952 [GRCh38] Chr8:37555470 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1030G>A (p.Gly344Ser)	single nucleotide variant	Inborn genetic diseases [RCV003184369]	Chr8:37697931 [GRCh38] Chr8:37555449 [GRCh37] Chr8:8p11.23	uncertain significance
NM_025069.3(ZNF703):c.1667C>T (p.Ala556Val)	single nucleotide variant	Inborn genetic diseases [RCV003204122]	Chr8:37698568 [GRCh38] Chr8:37556086 [GRCh37] Chr8:8p11.23	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	755
Count of miRNA genes:	471
Interacting mature miRNAs:	505
Transcripts:	ENST00000331569
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

WI-11883

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	8	37,557,403 - 37,557,529	UniSTS	GRCh37
Build 36	8	37,676,561 - 37,676,687	RGD	NCBI36
Celera	8	36,510,372 - 36,510,498	RGD
Cytogenetic Map	8	p11.23	UniSTS
HuRef	8	36,092,104 - 36,092,230	UniSTS
GeneMap99-GB4 RH Map	8	143.18	UniSTS
Whitehead-RH Map	8	189.5	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

2284

1867

1106

217

520

4179

1958

2868

160

1090

1462

171

1201

2787

Low

153

980

616

406

940

405

178

235

865

256

369

147

Below cutoff

140

414

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_025069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA527152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC137579	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK024361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC032534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC084581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BM770319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY996877	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA936465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000331569 ⟹ ENSP00000332325

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	8	37,695,782 - 37,700,019 (+)	Ensembl

RefSeq Acc Id:

NM_025069 ⟹ NP_079345

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	8	37,695,782 - 37,700,019 (+)	NCBI
GRCh37	8	37,553,301 - 37,556,396 (+)	RGD
Build 36	8	37,672,459 - 37,675,554 (+)	NCBI Archive
Celera	8	36,506,270 - 36,509,365 (+)	RGD
HuRef	8	36,088,055 - 36,091,097 (+)	ENTREZGENE
CHM1_1	8	37,754,705 - 37,758,975 (+)	NCBI
T2T-CHM13v2.0	8	37,972,157 - 37,976,394 (+)	NCBI

Sequence:

show sequence

GGTTTTTGTGTTGCTAGCCGGGGCCAGCGGCGGTGGCGGCGGCGGCGGAGGCGTCGGTGGAGGA
GGGGAGGCGGCGAGGAGGCGCAGCTCCCGCTGCACCGCGATCGACGCTGCGGAGCGAGCCCACC
CGCCCCGGGAGCTCGCCTCCCCGGTGCTCCCCCGCCCTCCCCGCCCCCCCAGCGGCGCTGCCTC
CTCCAAATGAGCGATTCGCCCGCTGGATCTAACCCAAGGACACCCGAAAGCAGCGGCAGCGGCA
GCGGCGGCGGCGGGAAGAGGCCGGCGGTGCCGGCAGCGGTGTCCCTCTTGCCACCGGCGGACCC
CCTGCGCCAGGCGAACCGGCTCCCGATCAGGGTCCTGAAGATGCTGAGCGCTCACACCGGTCAC
CTCCTGCACCCGGAGTACCTGCAGCCGCTGTCCTCCACTCCCGTCAGCCCCATTGAGCTGGACG
CCAAGAAGAGCCCCTTGGCGCTGCTGGCTCAGACCTGCTCGCAGATCGGCAAGCCGGACCCGCC
GCCCTCCTCCAAACTCAACTCGGTGGCGGCGGCGGCCAACGGGCTGGGAGCGGAGAAGGACCCC
GGCCGCTCAGCCCCGGGCGCCGCCTCCGCAGCCGCGGCCCTGAAGCAGCTGGGGGACTCACCGG
CCGAGGACAAGTCCAGCTTCAAGCCCTACTCCAAGGGCTCCGGCGGCGGCGACTCCCGCAAAGA
CAGCGGCTCCTCCTCGGTGTCTTCCACCTCCTCCTCGTCCTCCTCGTCCCCGGGAGACAAGGCG
GGCTTCAGGGTCCCCAGCGCCGCCTGCCCGCCCTTTCCCCCGCATGGAGCGCCGGTCTCCGCAT
CCTCGTCCTCGTCGTCGCCCGGCGGCTCCCGCGGCGGCTCCCCGCACCACTCTGACTGCAAGAA
CGGCGGCGGGGTTGGCGGCGGGGAGCTGGACAAGAAAGACCAGGAGCCCAAGCCCAGCCCGGAG
CCGGCAGCCGTGAGCCGCGGCGGCGGTGGGGAGCCCGGGGCGCACGGTGGCGCCGAGTCCGGGG
CCTCCGGGCGCAAGTCCGAGCCGCCCTCGGCGCTGGTGGGGGCCGGCCACGTGGCGCCGGTGTC
TCCCTACAAGCCGGGCCACTCGGTGTTCCCGCTGCCGCCCTCCAGCATTGGCTACCACGGCTCC
ATCGTGGGCGCCTACGCCGGCTACCCGTCTCAGTTCGTGCCTGGCCTGGATCCTAGCAAGTCCG
GCCTCGTGGGAGGCCAGCTGTCTGGGGGCCTGGGCCTGCCGCCGGGCAAGCCCCCCAGCTCCAG
CCCGCTCACCGGGGCCTCCCCGCCCTCCTTCCTGCAGGGATTATGCCGCGACCCCTATTGCTTG
GGAGGTTACCACGGCGCCTCGCACCTCGGCGGCTCCAGCTGCTCCACCTGCAGCGCGCACGACC
CTGCCGGGCCCAGCCTGAAGGCGGGGGGCTACCCGCTGGTGTACCCCGGGCACCCGCTGCAGCC
CGCCGCGCTCTCGTCCAGCGCCGCCCAGGCCGCGCTCCCCGGCCACCCGCTCTACACCTACGGC
TTCATGCTGCAGAACGAACCGCTGCCGCACAGCTGCAACTGGGTGGCAGCCAGTGGGCCGTGCG
ACAAGCGCTTCGCCACCTCGGAGGAGCTGCTCAGCCACCTACGGACCCACACGGCCCTGCCGGG
AGCCGAGAAACTTCTGGCCGCCTACCCCGGGGCCTCGGGCCTGGGCAGCGCCGCCGCCGCCGCC
GCCGCCGCCGCCTCCTGCCATCTGCACCTCCCCCCGCCCGCCGCCCCCGGCAGCCCCGGGTCGC
TGTCCTTGCGGAATCCACACACTTTGGGCCTAAGCCGGTACCACCCCTATGGCAAGAGCCACTT
ATCCACAGCGGGGGGCCTGGCCGTGCCGTCCCTCCCCACAGCCGGACCCTACTATTCGCCATAC
GCGCTGTATGGACAGAGACTAGCTTCAGCCTCGGCGCTGGGATACCAGTAACTACAGCTCTTCC
TCCACCCCAGCCCCCTCACCCTCCTCCCTCTCCCTCCTCCTCCCTCCCCACCTGCCGTCGCCGC
TGCAACCTCCACTACTGCTTGACCCTGCCGGGATTCCCCACCCAGCCCTTCCCCACCGGACTGT
GTATTTATTTACTATAATGTTAGCTTACAAGCTGGGAATATAAGTGCATTAACGGCCCACATGA
GTCAATGGTATGCAAAAAGTCTGTGTTCTCCCAAATAATAATATTAATCCCACAAATAACGACA
TGATCCCCGCCCCTGTTCCTTTCTGTTATTTTTTCTTAGATATAAGTTTTACATTTTTTATTCC
TTTTCCTCTTTTTTTGGTTTTGATTGGTTTGGTTTGAGGGAGAGTTGGGGTCTTTGGGTTCTTC
TAGACGTTTTGTTTTCCCTTCCTGGGGAGTTTCTTGCATGAGTCTTAACTTAAAACTACGTTTC
CGCCTTCTCTTTTTCCCTCTTCCCCCTTCATTCCCTCTTGTTTCCTTCCATTTGCGGTTCTGTT
TTTGTTTTTTGTTTTGTTTTGTTTTGTTTTTTCCTTTGTTGTACAAGTAACAGAGAGGAGGTTT
TTTTTGTAACTCATTTTGGGGGTGGAGGGGGCCACCTGGGTGGCAGGGGCCCTGGAGCTCTATT
GACCTGGTACACTGCTCCGGGACTCCTCCCCCGCCACCCTCCGCGCATAGGGTCCTTGGTCTGG
ACCCTGCCCCCCAAAAGTAGGGCCTTGCTCCTCTACCTTGCTCTGAGCACGGAGAGCCCTGACC
CCACCAGTAGGCTCGCCCCCAGAAGGGCCCAAGTGGCCGTCTACCGTCACCTTCCAGACTCCCG
CCCCTAACACCCAGTGGCTACAGTGCGCCTGTCGGGGCACCTGGAGCGCTCACCTGGTTGAATT
CAAAGTCCCAGAAGGCCCCGCTGGCGTGAAGCCGGCCCCTTACATTTTGCGAAGTGCATTATAG
TCCTTGTTTTTCTCTCCCTCGTGGGGGCAACGACCCCTCCCCTGGCAGTAGGGGTGGGGTAGGT
GACTCTCGCTAGATCCCTCCAAAGCAGACCGGTGGCGATGTCAGCGGATGTCACGAGCTCGTTA
GCTGCGTTCGGGGAAGGTTGGGGCGTCAGGGAGCTCTCGGATCACAGCAGCCCCCGCCCTCTCC
TAGGCCTGGCCCGGCAGAGCCCCCAGAGTGGACCCCCCAGCGACTGGGGTCTTCTCCCCACTCC
TCCCTCCTTCTGGTCTGATGCGGCAGCGCGGGGGCTGCGGGGCCTGTTTGGGACGAACAGAGCT
CTCCCTTGGTAAGACTTATTTTGTTAATAAATGGAATACTTGGCTATATTCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_079345	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH32534	(Get FASTA)	NCBI Sequence Viewer
	AAH84581	(Get FASTA)	NCBI Sequence Viewer
	BAB14897	(Get FASTA)	NCBI Sequence Viewer
	EAW63370	(Get FASTA)	NCBI Sequence Viewer
	Q9H7S9	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_079345 ⟸ NM_025069

- UniProtKB:

Q5XG76 (UniProtKB/Swiss-Prot), Q9H7S9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSDSPAGSNPRTPESSGSGSGGGGKRPAVPAAVSLLPPADPLRQANRLPIRVLKMLSAHTGHLL
HPEYLQPLSSTPVSPIELDAKKSPLALLAQTCSQIGKPDPPPSSKLNSVAAAANGLGAEKDPGR
SAPGAASAAAALKQLGDSPAEDKSSFKPYSKGSGGGDSRKDSGSSSVSSTSSSSSSSPGDKAGF
RVPSAACPPFPPHGAPVSASSSSSSPGGSRGGSPHHSDCKNGGGVGGGELDKKDQEPKPSPEPA
AVSRGGGGEPGAHGGAESGASGRKSEPPSALVGAGHVAPVSPYKPGHSVFPLPPSSIGYHGSIV
GAYAGYPSQFVPGLDPSKSGLVGGQLSGGLGLPPGKPPSSSPLTGASPPSFLQGLCRDPYCLGG
YHGASHLGGSSCSTCSAHDPAGPSLKAGGYPLVYPGHPLQPAALSSSAAQAALPGHPLYTYGFM
LQNEPLPHSCNWVAASGPCDKRFATSEELLSHLRTHTALPGAEKLLAAYPGASGLGSAAAAAAA
AASCHLHLPPPAAPGSPGSLSLRNPHTLGLSRYHPYGKSHLSTAGGLAVPSLPTAGPYYSPYAL
YGQRLASASALGYQ

hide sequence

RefSeq Acc Id:

ENSP00000332325 ⟸ ENST00000331569

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9H7S9-F1-model_v2	AlphaFold	Q9H7S9	1-590	view protein structure

Promoters

RGD ID:

6807193

Promoter ID:

HG_KWN:61113

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, HeLa_S3, Lymphoblastoid, NB4

Transcripts:

ENST00000397235, NM_025069

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	8	37,671,851 - 37,672,482 (+)	MPROMDB

RGD ID:

7213087

Promoter ID:

EPDNEW_H12289

Type:

initiation region

Name:

ZNF703_1

Description:

zinc finger protein 703

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	8	37,695,783 - 37,695,843	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:25883	AgrOrtholog
COSMIC	ZNF703	COSMIC
Ensembl Genes	ENSG00000183779	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSP00000332325	ENTREZGENE
	ENSP00000332325.4	UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000331569	ENTREZGENE
	ENST00000331569.6	UniProtKB/Swiss-Prot
Gene3D-CATH	Classic Zinc Finger	UniProtKB/Swiss-Prot
GTEx	ENSG00000183779	GTEx
HGNC ID	HGNC:25883	ENTREZGENE
Human Proteome Map	ZNF703	Human Proteome Map
InterPro	Tscrpt_rep_NocA-like	UniProtKB/Swiss-Prot
	Znf_C2H2_type	UniProtKB/Swiss-Prot
KEGG Report	hsa:80139	UniProtKB/Swiss-Prot
NCBI Gene	80139	ENTREZGENE
OMIM	617045	OMIM
PANTHER	ZINC FINGER PROTEIN 703	UniProtKB/Swiss-Prot
	ZINC-FINGER PROTEIN NOLZ1-RELATED	UniProtKB/Swiss-Prot
Pfam	nlz1	UniProtKB/Swiss-Prot
PharmGKB	PA142670500	PharmGKB
PROSITE	ZINC_FINGER_C2H2_2	UniProtKB/Swiss-Prot
UniProt	Q5XG76	ENTREZGENE
	Q9H7S9	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q5XG76	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar