Mdm4 (MDM4 regulator of p53) - Rat Genome Database

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Gene: Mdm4 (MDM4 regulator of p53) Rattus norvegicus
Analyze
Symbol: Mdm4
Name: MDM4 regulator of p53
RGD ID: 1309306
Description: Predicted to enable enzyme binding activity and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of macromolecule metabolic process; and protein stabilization. Predicted to act upstream of or within heart development; positive regulation of cell population proliferation; and regulation of heart rate. Predicted to be located in nucleoplasm. Predicted to be part of transcription repressor complex. Orthologous to human MDM4 (MDM4 regulator of p53); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: double minute 4 homolog; double minute 4 protein; LOC304798; mdm2-like p53-binding protein; Mdm4 p53 binding protein homolog; Mdm4 p53 binding protein homolog (mouse); MDM4, p53 regulator; p53-binding protein Mdm4; protein Mdmx; transformed mouse 3T3 cell double minute 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81346,922,236 - 47,068,241 (-)NCBIGRCr8
mRatBN7.21344,432,596 - 44,516,165 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,406,213 - 44,474,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,045,798 - 47,081,175 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01348,333,906 - 48,369,277 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,594,488 - 45,629,855 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01349,786,776 - 49,828,780 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,792,794 - 49,828,720 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01354,857,103 - 54,899,109 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41345,895,832 - 45,931,421 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11345,909,875 - 45,945,464 (-)NCBI
Celera1344,772,868 - 44,808,247 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daunorubicin  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
dorsomorphin  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formononetin  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
maneb  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
ruthenium atom  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Cell cycle checkpoint abnormalities during dementia: A plausible association with the loss of protection against oxidative stress in Alzheimer's disease . Katsel P, etal., PLoS One. 2013 Jul 5;8(7):e68361. doi: 10.1371/journal.pone.0068361. Print 2013.
4. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
5. The complexity of p53 stabilization and activation. Lavin MF and Gueven N, Cell Death Differ. 2006 Jun;13(6):941-50.
6. Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy. Li Q and Lozano G, Clin Cancer Res. 2013 Jan 1;19(1):34-41. doi: 10.1158/1078-0432.CCR-12-0053. Epub 2012 Dec 21.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9226370   PMID:10608892   PMID:12101245   PMID:12477932   PMID:14660608   PMID:14712235   PMID:19838211   PMID:20810912   PMID:22821713  


Genomics

Comparative Map Data
Mdm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81346,922,236 - 47,068,241 (-)NCBIGRCr8
mRatBN7.21344,432,596 - 44,516,165 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,406,213 - 44,474,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,045,798 - 47,081,175 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01348,333,906 - 48,369,277 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,594,488 - 45,629,855 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01349,786,776 - 49,828,780 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,792,794 - 49,828,720 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01354,857,103 - 54,899,109 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41345,895,832 - 45,931,421 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11345,909,875 - 45,945,464 (-)NCBI
Celera1344,772,868 - 44,808,247 (-)NCBICelera
Cytogenetic Map13q13NCBI
MDM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381204,516,406 - 204,558,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1204,516,379 - 204,558,120 (+)EnsemblGRCh38hg38GRCh38
GRCh371204,485,534 - 204,527,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,752,134 - 202,786,349 (+)NCBINCBI36Build 36hg18NCBI36
Build 341201,217,222 - 201,409,318NCBI
Celera1177,620,715 - 177,662,398 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1175,650,570 - 175,692,491 (+)NCBIHuRef
CHM1_11205,908,863 - 205,950,615 (+)NCBICHM1_1
T2T-CHM13v2.01203,780,802 - 203,822,528 (+)NCBIT2T-CHM13v2.0
Mdm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,913,843 - 132,958,325 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,887,222 - 132,958,299 (-)EnsemblGRCm39 Ensembl
GRCm381132,986,105 - 133,030,587 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,959,484 - 133,030,561 (-)EnsemblGRCm38mm10GRCm38
MGSCv371134,886,422 - 134,921,925 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,817,391 - 134,852,894 (-)NCBIMGSCv36mm8
Celera1135,598,842 - 135,634,680 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.75NCBI
Mdm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,346,588 - 40,387,977 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,346,617 - 40,387,977 (+)NCBIChiLan1.0ChiLan1.0
MDM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2144,819,760 - 44,863,970 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1144,784,970 - 44,829,166 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01180,117,364 - 180,151,144 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11184,406,124 - 184,439,344 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,406,124 - 184,439,344 (+)Ensemblpanpan1.1panPan2
MDM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1381,055,978 - 1,122,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl381,056,109 - 1,107,166 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha381,150,709 - 1,216,877 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0381,051,218 - 1,117,506 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl381,051,234 - 1,100,650 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1381,047,689 - 1,103,345 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,439,250 - 1,505,212 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0381,639,529 - 1,705,937 (+)NCBIUU_Cfam_GSD_1.0
Mdm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934471,034,877 - 71,064,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936567268,151 - 299,494 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936567268,151 - 299,494 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl965,175,377 - 65,219,742 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1965,175,488 - 65,219,747 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,509,117 - 71,547,900 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MDM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12524,797,238 - 24,843,034 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2524,797,278 - 24,833,485 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605525,553,750 - 25,603,137 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mdm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248076,486,333 - 6,522,801 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248076,480,785 - 6,522,149 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mdm4
369 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:36
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000012984
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
BE116762  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21344,471,057 - 44,471,207 (+)MAPPERmRatBN7.2
Rnor_6.01349,825,569 - 49,825,718NCBIRnor6.0
Rnor_5.01354,895,896 - 54,896,045UniSTSRnor5.0
RGSC_v3.41345,928,270 - 45,928,419UniSTSRGSC3.4
Celera1344,805,097 - 44,805,246UniSTS
RH 3.4 Map13114.4UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_595426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012984   ⟹   ENSRNOP00000012984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1344,438,617 - 44,474,226 (-)Ensembl
Rnor_6.0 Ensembl1349,792,794 - 49,828,720 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112527   ⟹   ENSRNOP00000084671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1344,438,617 - 44,474,226 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116113   ⟹   ENSRNOP00000076729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1344,406,213 - 44,474,226 (-)Ensembl
RefSeq Acc Id: NM_001012026   ⟹   NP_001012026
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,990,699 - 47,026,287 (-)NCBI
mRatBN7.21344,438,615 - 44,474,209 (-)NCBI
Rnor_6.01349,792,793 - 49,828,720 (-)NCBI
Rnor_5.01354,857,103 - 54,899,109 (-)NCBI
RGSC_v3.41345,895,832 - 45,931,421 (-)RGD
Celera1344,772,868 - 44,808,247 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249777   ⟹   XP_006249839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,984,681 - 47,026,367 (-)NCBI
mRatBN7.21344,432,596 - 44,474,285 (-)NCBI
Rnor_6.01349,786,776 - 49,828,779 (-)NCBI
Rnor_5.01354,857,103 - 54,899,109 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249778   ⟹   XP_006249840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,984,681 - 47,026,367 (-)NCBI
mRatBN7.21344,432,596 - 44,474,285 (-)NCBI
Rnor_6.01349,786,776 - 49,828,780 (-)NCBI
Rnor_5.01354,857,103 - 54,899,109 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249779   ⟹   XP_006249841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,984,681 - 47,026,367 (-)NCBI
mRatBN7.21344,432,596 - 44,474,285 (-)NCBI
Rnor_6.01349,786,776 - 49,828,780 (-)NCBI
Rnor_5.01354,857,103 - 54,899,109 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090700   ⟹   XP_038946628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,984,681 - 47,068,238 (-)NCBI
mRatBN7.21344,432,596 - 44,516,164 (-)NCBI
RefSeq Acc Id: XM_039090702   ⟹   XP_038946630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,984,681 - 47,068,241 (-)NCBI
mRatBN7.21344,432,596 - 44,516,165 (-)NCBI
RefSeq Acc Id: XM_039090703   ⟹   XP_038946631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,984,681 - 47,026,367 (-)NCBI
mRatBN7.21344,432,596 - 44,474,285 (-)NCBI
RefSeq Acc Id: XM_039090705   ⟹   XP_038946633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,984,681 - 47,026,367 (-)NCBI
mRatBN7.21344,432,596 - 44,474,285 (-)NCBI
RefSeq Acc Id: XM_039090706   ⟹   XP_038946634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,984,681 - 47,009,274 (-)NCBI
mRatBN7.21344,432,596 - 44,454,280 (-)NCBI
RefSeq Acc Id: XM_039090708   ⟹   XP_038946636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,990,699 - 47,026,367 (-)NCBI
mRatBN7.21344,432,596 - 44,474,285 (-)NCBI
RefSeq Acc Id: XM_063272288   ⟹   XP_063128358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,984,681 - 47,026,367 (-)NCBI
RefSeq Acc Id: XM_063272289   ⟹   XP_063128359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,984,681 - 47,026,367 (-)NCBI
RefSeq Acc Id: XM_063272291   ⟹   XP_063128361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,922,236 - 47,026,367 (-)NCBI
RefSeq Acc Id: XM_063272292   ⟹   XP_063128362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,996,729 - 47,026,367 (-)NCBI
RefSeq Acc Id: XM_063272293   ⟹   XP_063128363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81347,001,794 - 47,026,367 (-)NCBI
RefSeq Acc Id: NP_001012026   ⟸   NM_001012026
- UniProtKB: Q5XIN1 (UniProtKB/Swiss-Prot),   A6IC66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249841   ⟸   XM_006249779
- Peptide Label: isoform X4
- UniProtKB: A6IC66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249839   ⟸   XM_006249777
- Peptide Label: isoform X2
- UniProtKB: A6IC66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249840   ⟸   XM_006249778
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A2G0 (UniProtKB/TrEMBL),   A6IC66 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012984   ⟸   ENSRNOT00000012984
RefSeq Acc Id: XP_038946630   ⟸   XM_039090702
- Peptide Label: isoform X2
- UniProtKB: A6IC66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946628   ⟸   XM_039090700
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q5T6 (UniProtKB/TrEMBL),   A6IC66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946636   ⟸   XM_039090708
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038946631   ⟸   XM_039090703
- Peptide Label: isoform X5
- UniProtKB: A6IC66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946633   ⟸   XM_039090705
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZK52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946634   ⟸   XM_039090706
- Peptide Label: isoform X9
Ensembl Acc Id: ENSRNOP00000084671   ⟸   ENSRNOT00000112527
Ensembl Acc Id: ENSRNOP00000076729   ⟸   ENSRNOT00000116113
RefSeq Acc Id: XP_063128361   ⟸   XM_063272291
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063128358   ⟸   XM_063272288
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063128359   ⟸   XM_063272289
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063128362   ⟸   XM_063272292
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063128363   ⟸   XM_063272293
- Peptide Label: isoform X13
Protein Domains
DM2   RanBP2-type   RING-type   SWIB/MDM2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIN1-F1-model_v2 AlphaFold Q5XIN1 1-490 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698818
Promoter ID:EPDNEW_R9342
Type:initiation region
Name:Mdm4_1
Description:MDM4, p53 regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01349,828,737 - 49,828,797EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309306 AgrOrtholog
BioCyc Gene G2FUF-18297 BioCyc
Ensembl Genes ENSRNOG00000009696 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012984.6 UniProtKB/TrEMBL
  ENSRNOT00000112527.1 UniProtKB/TrEMBL
  ENSRNOT00000116113.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.245.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn-finger domain of Sec23/24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135053 IMAGE-MGC_LOAD
InterPro MDM2_MDM4_MUL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MDM4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53_neg-reg_MDM_2/4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SWIB_MDM2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SWIB_MDM2_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304798 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94476 IMAGE-MGC_LOAD
NCBI Gene 304798 ENTREZGENE
PANTHER MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN MDM4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SWIB UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-RanBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mdm4 PhenoGen
PIRSF MDM4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53_MDM_2/4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SWIB_MDM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009696 RatGTEx
Superfamily-SCOP SSF47592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90209 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZK52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A2G0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q5T6 ENTREZGENE, UniProtKB/TrEMBL
  A6IC66 ENTREZGENE, UniProtKB/TrEMBL
  MDM4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Mdm4  MDM4 regulator of p53  Mdm4  MDM4, p53 regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-07 Mdm4  MDM4, p53 regulator  Mdm4  Mdm4 p53 binding protein homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Mdm4  Mdm4 p53 binding protein homolog (mouse)  Mdm4  transformed mouse 3T3 cell double minute 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Mdm4  transformed mouse 3T3 cell double minute 4  Mdm4_predicted  transformed mouse 3T3 cell double minute 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mdm4_predicted  transformed mouse 3T3 cell double minute 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED