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Gene: FLT3 (fms related receptor tyrosine kinase 3) Homo sapiens
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Symbol: FLT3
Name: fms related receptor tyrosine kinase 3
Description: Exhibits protein self-association. Involved in hemopoiesis. Localizes to the endoplasmic reticulum. Implicated in acute myeloid leukemia; precursor lymphoblastic lymphoma/leukemia; and prostate cancer. Biomarker of acute myeloid leukemia and myelofibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD135; CD135 antigen; fetal liver kinase 2; fetal liver kinase-2; FL cytokine receptor; FLK-2; FLK2; FLT-3; FLT3 receptor tyrosine kinase; fms related tyrosine kinase 3; fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; receptor-type tyrosine-protein kinase FLT3; stem cell tyrosine kinase 1; STK-1; STK1; tyrosine-protein kinase receptor FLT3
Orthologs:
Mus musculus (house mouse) : Flt3 (FMS-like tyrosine kinase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Flt3 (Fms related receptor tyrosine kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt3 (fms related receptor tyrosine kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT3 (fms related receptor tyrosine kinase 3)
Canis lupus familiaris (dog) : FLT3 (fms related receptor tyrosine kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt3 (fms related receptor tyrosine kinase 3)
Sus scrofa (pig) : FLT3 (fms related receptor tyrosine kinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1328,003,274 - 28,100,592 (-)Ensembl
GRCh381328,003,274 - 28,100,587 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371328,577,411 - 28,682,904 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,475,411 - 27,572,729 (-)NCBINCBI36hg18NCBI36
Build 341327,475,752 - 27,572,703NCBI
Celera139,652,471 - 9,749,817 (-)NCBI
Cytogenetic Map13q12.2NCBI
HuRef139,398,611 - 9,496,033 (-)NCBIHuRef
CHM1_11328,546,018 - 28,643,312 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on FLT3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321714
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.