Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1) - Rat Genome Database

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Gene: Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1) Rattus norvegicus
Analyze
Symbol: Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
RGD ID: 1307379
Description: Predicted to enable GTPase activator activity and phospholipid binding activity. Predicted to be involved in several processes, including positive regulation of membrane tubulation; protein localization to cilium; and regulation of postsynapse organization. Predicted to act upstream of or within negative regulation of dendritic spine development. Predicted to be located in Golgi membrane; dendritic spine; and trans-Golgi network membrane. Predicted to be active in glutamatergic synapse and podosome. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1); PARTICIPATES IN Arf family mediated signaling pathway; endocytosis pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Ddef1; DEF-1; development and differentiation enhancing; development and differentiation enhancing factor 1; development and differentiation-enhancing factor 1; differentiation-enhancing factor 1; LOC314961; PIP2-dependent ARF1 GAP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8797,675,354 - 97,982,523 (-)NCBIGRCr8
mRatBN7.2795,786,130 - 96,093,111 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl795,787,818 - 96,092,754 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx797,559,806 - 97,822,370 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0799,761,470 - 100,024,009 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0799,683,352 - 99,953,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07104,670,076 - 104,951,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7104,669,672 - 104,801,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0791,673,052 - 91,955,738 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,303,973 - 101,575,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17101,337,297 - 101,575,548 (-)NCBI
Celera792,385,527 - 92,648,016 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP,ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
isoprenaline  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
MeIQx  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
phenol red  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
testosterone undecanoate  (ISO)
theophylline  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centriolar satellite  (IEA,ISO)
cytoplasm  (IEA)
dendritic spine  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
Golgi apparatus  (ISO)
Golgi membrane  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO)
podosome  (IBA,IEA,ISO)
synapse  (IEA)
trans-Golgi network membrane  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. Kruljac-Letunic A, etal., J Biol Chem. 2003 Aug 8;278(32):29560-70. Epub 2003 May 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9819391   PMID:10734117   PMID:16431365   PMID:17893324   PMID:20154719   PMID:20393563   PMID:21352810   PMID:23050017   PMID:25468996  


Genomics

Comparative Map Data
Asap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8797,675,354 - 97,982,523 (-)NCBIGRCr8
mRatBN7.2795,786,130 - 96,093,111 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl795,787,818 - 96,092,754 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx797,559,806 - 97,822,370 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0799,761,470 - 100,024,009 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0799,683,352 - 99,953,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07104,670,076 - 104,951,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7104,669,672 - 104,801,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0791,673,052 - 91,955,738 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47101,303,973 - 101,575,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17101,337,297 - 101,575,548 (-)NCBI
Celera792,385,527 - 92,648,016 (-)NCBICelera
Cytogenetic Map7q33NCBI
ASAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388130,052,104 - 130,443,674 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8130,052,104 - 130,443,674 (-)EnsemblGRCh38hg38GRCh38
GRCh378131,064,350 - 131,455,920 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368131,133,535 - 131,483,399 (-)NCBINCBI36Build 36hg18NCBI36
Build 348131,133,534 - 131,483,399NCBI
Celera8127,244,326 - 127,594,327 (-)NCBICelera
Cytogenetic Map8q24.21-q24.22NCBI
HuRef8126,384,999 - 126,734,847 (-)NCBIHuRef
CHM1_18131,103,607 - 131,496,464 (-)NCBICHM1_1
T2T-CHM13v2.08131,178,779 - 131,571,038 (-)NCBIT2T-CHM13v2.0
Asap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391563,958,704 - 64,254,922 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1563,958,706 - 64,254,768 (-)EnsemblGRCm39 Ensembl
GRCm381564,086,840 - 64,382,941 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1564,086,857 - 64,382,919 (-)EnsemblGRCm38mm10GRCm38
MGSCv371563,920,101 - 64,214,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361563,918,212 - 64,212,592 (-)NCBIMGSCv36mm8
Celera1565,591,405 - 65,885,771 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1528.55NCBI
Asap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554614,811,069 - 5,133,257 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554614,813,228 - 5,083,548 (-)NCBIChiLan1.0ChiLan1.0
ASAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27147,421,012 - 147,815,414 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18122,937,455 - 123,329,737 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08126,688,608 - 127,080,662 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18129,420,586 - 130,028,270 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8129,418,796 - 130,021,261 (-)Ensemblpanpan1.1panPan2
ASAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11327,111,785 - 27,468,476 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1327,113,994 - 27,430,758 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1327,078,250 - 27,434,794 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01327,456,229 - 27,813,403 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1327,456,243 - 27,813,396 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11327,172,486 - 27,529,425 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01327,291,577 - 27,648,950 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01327,593,113 - 27,950,475 (-)NCBIUU_Cfam_GSD_1.0
Asap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530310,913,682 - 11,214,295 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647018,339,616 - 18,640,624 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647018,340,120 - 18,640,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl410,179,758 - 10,451,929 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1410,103,860 - 10,451,928 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2410,385,433 - 10,423,543 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18124,515,274 - 124,912,076 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8124,514,210 - 124,869,668 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603915,203,778 - 15,599,896 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473525,409,902 - 25,732,967 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473525,410,002 - 25,732,847 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Asap1
1623 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:55
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000031906, ENSRNOT00000068192
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)789867376101773158Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D7Rat14  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8797,979,284 - 97,979,453 (+)Marker Load Pipeline
mRatBN7.2796,090,077 - 96,090,246 (+)MAPPERmRatBN7.2
Rnor_6.07104,982,653 - 104,982,821NCBIRnor6.0
Rnor_5.0791,988,027 - 91,988,195UniSTSRnor5.0
RGSC_v3.47101,619,417 - 101,619,586RGDRGSC3.4
RGSC_v3.47101,619,418 - 101,619,586UniSTSRGSC3.4
RGSC_v3.17101,653,648 - 101,653,816RGD
Celera792,679,755 - 92,679,923UniSTS
RH 3.4 Map7663.3UniSTS
RH 3.4 Map7663.3RGD
RH 2.0 Map7525.0RGD
SHRSP x BN Map757.9199RGD
Cytogenetic Map7q33UniSTS
D7Rat218  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8797,774,973 - 97,775,221 (+)Marker Load Pipeline
mRatBN7.2795,885,756 - 95,886,004 (+)MAPPERmRatBN7.2
Rnor_6.07104,767,076 - 104,767,323NCBIRnor6.0
Rnor_5.0791,770,089 - 91,770,336UniSTSRnor5.0
RGSC_v3.47101,402,079 - 101,402,326UniSTSRGSC3.4
RGSC_v3.47101,402,078 - 101,402,326RGDRGSC3.4
RGSC_v3.17101,436,308 - 101,436,556RGD
Celera792,482,546 - 92,482,793UniSTS
FHH x ACI Map746.7UniSTS
FHH x ACI Map746.7RGD
Cytogenetic Map7q33UniSTS
RH131168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2795,787,900 - 95,788,093 (+)MAPPERmRatBN7.2
Rnor_6.07104,669,256 - 104,669,448NCBIRnor6.0
Rnor_5.0791,672,232 - 91,672,424UniSTSRnor5.0
RGSC_v3.47101,303,153 - 101,303,345UniSTSRGSC3.4
Celera792,384,707 - 92,384,899UniSTS
RH 3.4 Map7658.2UniSTS
Cytogenetic Map7q33UniSTS
BF406006  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2795,879,516 - 95,879,721 (+)MAPPERmRatBN7.2
Rnor_6.07104,760,836 - 104,761,040NCBIRnor6.0
Rnor_5.0791,763,849 - 91,764,053UniSTSRnor5.0
RGSC_v3.47101,395,839 - 101,396,043UniSTSRGSC3.4
Celera792,476,306 - 92,476,510UniSTS
RH 3.4 Map7659.0UniSTS
Cytogenetic Map7q33UniSTS
AU047703  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2796,027,924 - 96,028,001 (+)MAPPERmRatBN7.2
Rnor_6.07104,920,167 - 104,920,244NCBIRnor6.0
Rnor_6.07104,920,081 - 104,920,244NCBIRnor6.0
Rnor_5.0791,924,037 - 91,924,200UniSTSRnor5.0
Rnor_5.0791,924,123 - 91,924,200UniSTSRnor5.0
RGSC_v3.47101,545,072 - 101,545,153UniSTSRGSC3.4
RGSC_v3.47101,544,986 - 101,545,153UniSTSRGSC3.4
Cytogenetic Map7q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001044245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ238622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ238623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ238624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000079524   ⟹   ENSRNOP00000070164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,836 - 96,092,754 (-)Ensembl
Rnor_6.0 Ensembl7104,670,076 - 104,801,045 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079981   ⟹   ENSRNOP00000072909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,836 - 96,092,691 (-)Ensembl
Rnor_6.0 Ensembl7104,669,672 - 104,749,552 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085650   ⟹   ENSRNOP00000071134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,818 - 96,020,812 (-)Ensembl
Rnor_6.0 Ensembl7104,670,076 - 104,800,536 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094033   ⟹   ENSRNOP00000077111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,836 - 96,020,950 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107914   ⟹   ENSRNOP00000084328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,836 - 95,920,279 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108328   ⟹   ENSRNOP00000087244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,818 - 96,020,812 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112210   ⟹   ENSRNOP00000080846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,787,836 - 96,092,754 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117838   ⟹   ENSRNOP00000096504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl795,789,860 - 96,058,369 (-)Ensembl
RefSeq Acc Id: NM_001044245   ⟹   NP_001037710
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,981,950 (-)NCBI
mRatBN7.2795,786,130 - 96,092,743 (-)NCBI
Rnor_6.07104,670,076 - 104,951,090 (-)NCBI
Rnor_5.0791,673,052 - 91,955,738 (-)NCBI
RGSC_v3.47101,303,973 - 101,575,856 (-)RGD
Celera792,385,527 - 92,648,016 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079174   ⟹   XP_038935102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,982,523 (-)NCBI
mRatBN7.2795,786,130 - 96,092,935 (-)NCBI
RefSeq Acc Id: XM_039079177   ⟹   XP_038935105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,982,523 (-)NCBI
mRatBN7.2795,786,130 - 96,092,939 (-)NCBI
RefSeq Acc Id: XM_039079178   ⟹   XP_038935106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,910,381 (-)NCBI
mRatBN7.2795,786,130 - 96,021,050 (-)NCBI
RefSeq Acc Id: XM_039079180   ⟹   XP_038935108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,982,523 (-)NCBI
mRatBN7.2795,786,130 - 96,092,937 (-)NCBI
RefSeq Acc Id: XM_063263529   ⟹   XP_063119599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,981,632 (-)NCBI
RefSeq Acc Id: XM_063263530   ⟹   XP_063119600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,910,381 (-)NCBI
RefSeq Acc Id: XM_063263531   ⟹   XP_063119601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,947,569 (-)NCBI
RefSeq Acc Id: XM_063263533   ⟹   XP_063119603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,910,380 (-)NCBI
RefSeq Acc Id: XM_063263534   ⟹   XP_063119604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,771,189 (-)NCBI
RefSeq Acc Id: XM_063263535   ⟹   XP_063119605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,675,354 - 97,883,200 (-)NCBI
RefSeq Acc Id: XM_063263536   ⟹   XP_063119606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,757,201 - 97,982,523 (-)NCBI
RefSeq Acc Id: XR_005486633
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8797,762,161 - 97,982,523 (-)NCBI
mRatBN7.2795,872,940 - 96,093,079 (-)NCBI
RefSeq Acc Id: NP_001037710   ⟸   NM_001044245
- UniProtKB: Q1AAU6 (UniProtKB/Swiss-Prot),   Q1AAU5 (UniProtKB/Swiss-Prot),   Q1AAU4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070164   ⟸   ENSRNOT00000079524
Ensembl Acc Id: ENSRNOP00000071134   ⟸   ENSRNOT00000085650
Ensembl Acc Id: ENSRNOP00000072909   ⟸   ENSRNOT00000079981
RefSeq Acc Id: XP_038935105   ⟸   XM_039079177
- Peptide Label: isoform X4
- UniProtKB: Q1AAU6 (UniProtKB/Swiss-Prot),   Q1AAU5 (UniProtKB/Swiss-Prot),   Q1AAU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038935108   ⟸   XM_039079180
- Peptide Label: isoform X7
- UniProtKB: Q1AAU6 (UniProtKB/Swiss-Prot),   Q1AAU5 (UniProtKB/Swiss-Prot),   Q1AAU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038935102   ⟸   XM_039079174
- Peptide Label: isoform X2
- UniProtKB: Q1AAU6 (UniProtKB/Swiss-Prot),   Q1AAU5 (UniProtKB/Swiss-Prot),   Q1AAU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038935106   ⟸   XM_039079178
- Peptide Label: isoform X5
- UniProtKB: Q1AAU6 (UniProtKB/Swiss-Prot),   Q1AAU5 (UniProtKB/Swiss-Prot),   Q1AAU4 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000080846   ⟸   ENSRNOT00000112210
Ensembl Acc Id: ENSRNOP00000084328   ⟸   ENSRNOT00000107914
Ensembl Acc Id: ENSRNOP00000096504   ⟸   ENSRNOT00000117838
Ensembl Acc Id: ENSRNOP00000087244   ⟸   ENSRNOT00000108328
Ensembl Acc Id: ENSRNOP00000077111   ⟸   ENSRNOT00000094033
RefSeq Acc Id: XP_063119599   ⟸   XM_063263529
- Peptide Label: isoform X1
- UniProtKB: Q1AAU6 (UniProtKB/Swiss-Prot),   Q1AAU5 (UniProtKB/Swiss-Prot),   Q1AAU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063119601   ⟸   XM_063263531
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZYZ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119600   ⟸   XM_063263530
- Peptide Label: isoform X3
- UniProtKB: Q1AAU6 (UniProtKB/Swiss-Prot),   Q1AAU5 (UniProtKB/Swiss-Prot),   Q1AAU4 (UniProtKB/Swiss-Prot),   A0A8I6GFT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119603   ⟸   XM_063263533
- Peptide Label: isoform X8
- UniProtKB: Q1AAU6 (UniProtKB/Swiss-Prot),   Q1AAU5 (UniProtKB/Swiss-Prot),   Q1AAU4 (UniProtKB/Swiss-Prot),   A0A0G2JZQ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119605   ⟸   XM_063263535
- Peptide Label: isoform X10
- UniProtKB: A0A0G2JX76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119604   ⟸   XM_063263534
- Peptide Label: isoform X9
- UniProtKB: A0A0G2JX76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119606   ⟸   XM_063263536
- Peptide Label: isoform X11
Protein Domains
Arf-GAP   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q1AAU6-F1-model_v2 AlphaFold Q1AAU6 1-1144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307379 AgrOrtholog
BioCyc Gene G2FUF-33141 BioCyc
Ensembl Genes ENSRNOG00000058733 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079524.2 UniProtKB/TrEMBL
  ENSRNOT00000079981.2 UniProtKB/TrEMBL
  ENSRNOT00000085650.2 UniProtKB/TrEMBL
  ENSRNOT00000094033.1 UniProtKB/TrEMBL
  ENSRNOT00000107914.1 UniProtKB/TrEMBL
  ENSRNOT00000108328.1 UniProtKB/TrEMBL
  ENSRNOT00000112210.1 UniProtKB/TrEMBL
  ENSRNOT00000117838.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARFGAP/RecO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASAP1_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASAP1_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_ASAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:314961 UniProtKB/Swiss-Prot
NCBI Gene 314961 ENTREZGENE
PANTHER ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Asap1 PhenoGen
PRINTS P67PHOX UniProtKB/TrEMBL
  REVINTRACTNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARFGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058733 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57863 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JX76 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JZQ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K451_RAT UniProtKB/TrEMBL
  A0A8I5YC67_RAT UniProtKB/TrEMBL
  A0A8I5ZQS2_RAT UniProtKB/TrEMBL
  A0A8I5ZYZ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APE3_RAT UniProtKB/TrEMBL
  A0A8I6GFT7 ENTREZGENE, UniProtKB/TrEMBL
  ASAP1_RAT UniProtKB/Swiss-Prot
  Q1AAU4 ENTREZGENE
  Q1AAU5 ENTREZGENE
  Q1AAU6 ENTREZGENE
UniProt Secondary Q1AAU4 UniProtKB/Swiss-Prot
  Q1AAU5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-15 Asap1  ArfGAP with SH3 domain, ankyrin repeat and PH domain 1  Ddef1  development and differentiation enhancing factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ddef1  development and differentiation enhancing factor 1  Ddef1  development and differentiation enhancing   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ddef1  development and differentiation enhancing   Ddef1_predicted  development and differentiation enhancing (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ddef1_predicted  development and differentiation enhancing (predicted)      Symbol and Name status set to approved 70820 APPROVED