Irak4 (interleukin-1 receptor-associated kinase 4) - Rat Genome Database

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Gene: Irak4 (interleukin-1 receptor-associated kinase 4) Rattus norvegicus
Analyze
Symbol: Irak4
Name: interleukin-1 receptor-associated kinase 4
RGD ID: 1305303
Description: Predicted to enable interleukin-1 receptor binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in JNK cascade; cytokine-mediated signaling pathway; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC300177
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87127,561,777 - 127,588,762 (+)NCBIGRCr8
mRatBN7.27125,682,502 - 125,708,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7125,682,488 - 125,717,837 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7127,467,774 - 127,493,636 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07129,693,680 - 129,719,540 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07129,594,914 - 129,620,776 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07135,803,723 - 135,831,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7135,803,698 - 135,832,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07135,461,296 - 135,487,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47133,055,185 - 133,081,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17133,131,009 - 133,157,870 (+)NCBI
Celera7122,072,276 - 122,098,055 (+)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling. Chandrasekar B, etal., J Biol Chem. 2005 Jul 15;280(28):26263-77. Epub 2005 May 11.
2. Protective effect of diallyl trisulfide on liver in rats with sepsis and the mechanism. Chen H, etal., J Huazhong Univ Sci Technolog Med Sci. 2012 Oct;32(5):657-62. doi: 10.1007/s11596-012-1013-7.
3. Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain. Felderhoff-Mueser U, etal., Ann Neurol. 2005 Jan;57(1):50-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Picard C, etal., Science. 2003 Mar 28;299(5615):2076-9. Epub 2003 Mar 13.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
16. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
17. Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. Yang YF, etal., Neuroscience. 2011 Nov 24;196:25-34. doi: 10.1016/j.neuroscience.2011.08.059. Epub 2011 Sep 10.
Additional References at PubMed
PMID:11960013   PMID:15292196   PMID:19167362   PMID:19351492   PMID:19663824   PMID:21911118   PMID:22158417   PMID:22771449   PMID:25918710   PMID:26310493   PMID:34958862  


Genomics

Comparative Map Data
Irak4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87127,561,777 - 127,588,762 (+)NCBIGRCr8
mRatBN7.27125,682,502 - 125,708,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7125,682,488 - 125,717,837 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7127,467,774 - 127,493,636 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07129,693,680 - 129,719,540 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07129,594,914 - 129,620,776 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07135,803,723 - 135,831,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7135,803,698 - 135,832,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07135,461,296 - 135,487,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47133,055,185 - 133,081,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17133,131,009 - 133,157,870 (+)NCBI
Celera7122,072,276 - 122,098,055 (+)NCBICelera
Cytogenetic Map7q35NCBI
IRAK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381243,758,951 - 43,789,541 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1243,758,944 - 43,798,307 (+)EnsemblGRCh38hg38GRCh38
GRCh371244,152,754 - 44,183,344 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361242,439,047 - 42,468,166 (+)NCBINCBI36Build 36hg18NCBI36
Build 341242,439,046 - 42,468,164NCBI
Celera1242,955,135 - 42,985,734 (+)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1241,181,921 - 41,210,557 (+)NCBIHuRef
CHM1_11244,117,733 - 44,148,328 (+)NCBICHM1_1
T2T-CHM13v2.01243,717,649 - 43,748,266 (+)NCBIT2T-CHM13v2.0
Irak4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391594,441,495 - 94,466,198 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1594,441,524 - 94,479,696 (+)EnsemblGRCm39 Ensembl
GRCm381594,543,613 - 94,568,317 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1594,543,643 - 94,581,815 (+)EnsemblGRCm38mm10GRCm38
MGSCv371594,374,091 - 94,398,748 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361594,371,900 - 94,396,212 (+)NCBIMGSCv36mm8
Celera1596,687,848 - 96,713,099 (+)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1548.55NCBI
Irak4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555003,010,505 - 3,051,986 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555003,010,505 - 3,039,090 (+)NCBIChiLan1.0ChiLan1.0
IRAK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21050,383,896 - 50,414,571 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11250,380,653 - 50,411,344 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01244,941,862 - 44,972,520 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11245,810,917 - 45,841,492 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1245,810,917 - 45,841,492 (-)Ensemblpanpan1.1panPan2
IRAK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12710,313,782 - 10,340,652 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2710,314,187 - 10,340,682 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2735,967,589 - 35,995,188 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02710,502,276 - 10,529,893 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2710,502,248 - 10,529,935 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12710,313,739 - 10,341,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02710,348,090 - 10,375,692 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02736,209,066 - 36,236,651 (+)NCBIUU_Cfam_GSD_1.0
Irak4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494570,892,828 - 70,916,756 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365122,248,146 - 2,272,002 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365122,248,116 - 2,272,002 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRAK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl574,834,600 - 74,859,344 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1574,842,184 - 74,858,125 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2577,646,762 - 77,672,328 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRAK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11139,967,738 - 39,999,969 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1139,977,636 - 39,999,847 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037206,510,824 - 206,545,598 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irak4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248168,778,299 - 8,802,883 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248168,783,075 - 8,808,734 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irak4
470 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:88
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000007932
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000007932   ⟹   ENSRNOP00000007932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7125,682,488 - 125,717,837 (+)Ensembl
Rnor_6.0 Ensembl7135,803,698 - 135,832,652 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104284   ⟹   ENSRNOP00000078243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7125,682,509 - 125,709,485 (+)Ensembl
RefSeq Acc Id: NM_001106791   ⟹   NP_001100261
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87127,561,777 - 127,587,569 (+)NCBI
mRatBN7.27125,682,502 - 125,708,294 (+)NCBI
Rnor_6.07135,803,723 - 135,831,006 (+)NCBI
Rnor_5.07135,461,296 - 135,487,468 (+)NCBI
RGSC_v3.47133,055,185 - 133,081,614 (+)RGD
Celera7122,072,276 - 122,098,055 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242193   ⟹   XP_006242255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87127,562,031 - 127,588,762 (+)NCBI
mRatBN7.27125,682,756 - 125,708,207 (+)NCBI
Rnor_6.07135,804,032 - 135,830,919 (+)NCBI
Rnor_5.07135,461,296 - 135,487,468 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078908   ⟹   XP_038934836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87127,574,594 - 127,588,762 (+)NCBI
mRatBN7.27125,695,480 - 125,708,207 (+)NCBI
RefSeq Acc Id: NP_001100261   ⟸   NM_001106791
- UniProtKB: D4A7K4 (UniProtKB/TrEMBL),   A0A8I6G1H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242255   ⟸   XM_006242193
- Peptide Label: isoform X1
- UniProtKB: D4A7K4 (UniProtKB/TrEMBL),   A0A8I6G1H3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007932   ⟸   ENSRNOT00000007932
RefSeq Acc Id: XP_038934836   ⟸   XM_039078908
- Peptide Label: isoform X2
- UniProtKB: A6K7U9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078243   ⟸   ENSRNOT00000104284
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7K4-F1-model_v2 AlphaFold D4A7K4 1-461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695603
Promoter ID:EPDNEW_R6128
Type:initiation region
Name:Irak4_1
Description:interleukin-1 receptor-associated kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07135,803,728 - 135,803,788EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305303 AgrOrtholog
BioCyc Gene G2FUF-32301 BioCyc
Ensembl Genes ENSRNOG00000005965 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007932.6 UniProtKB/TrEMBL
  ENSRNOT00000104284.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro DEATH-like UniProtKB/TrEMBL
  Immune_PlantDef_Kinases UniProtKB/TrEMBL
  Interleukin-1_rcpt-assoc_kin4 UniProtKB/TrEMBL
  IRAK4_Death UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report rno:300177 UniProtKB/TrEMBL
NCBI Gene 300177 ENTREZGENE
PANTHER OS01G0750732 PROTEIN UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE PBL28-RELATED UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Irak4 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
  IRAK4 UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005965 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A0A8I6G1H3 ENTREZGENE, UniProtKB/TrEMBL
  A6K7U9 ENTREZGENE, UniProtKB/TrEMBL
  D4A7K4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Irak4  interleukin-1 receptor-associated kinase 4   Irak4_predicted  interleukin-1 receptor-associated kinase 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Irak4_predicted  interleukin-1 receptor-associated kinase 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED