Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Naprt | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of NAPRT mRNA] | CTD | PMID:31150632 | Naprt | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Naprt (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of NAPRT mRNA | CTD | PMID:36331819 | Naprt | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Naprt (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NAPRT mRNA | CTD | PMID:22206623 | Naprt | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Naprt (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of NAPRT mRNA | CTD | PMID:22206623 | Naprt | Rat | 1-chloro-2,4-dinitrobenzene | affects binding | ISO | NAPRT (Homo sapiens) | 6480464 | Dinitrochlorobenzene binds to NAPRT protein | CTD | PMID:32991956 | Naprt | Rat | 17beta-estradiol | multiple interactions | ISO | NAPRT (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of NAPRT mRNA | CTD | PMID:30165855 | Naprt | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NAPRT mRNA | CTD | PMID:21215274 | Naprt | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NAPRT mRNA | CTD | PMID:33387578 | Naprt | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Naprt (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NAPRT mRNA | CTD | PMID:18796159 and PMID:19933214 | Naprt | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Naprt (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of NAPRT mRNA | CTD | PMID:21570461 | Naprt | Rat | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of NAPRT mRNA | CTD | PMID:21346803 | Naprt | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of NAPRT mRNA | CTD | PMID:21346803 | Naprt | Rat | 3-chloropropane-1,2-diol | decreases expression | EXP | | 6480464 | alpha-Chlorohydrin results in decreased expression of NAPRT protein | CTD | PMID:34915118 | Naprt | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Naprt (Mus musculus) | 6480464 | bisphenol S affects the methylation of NAPRT gene | CTD | PMID:31683443 | Naprt | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of NAPRT1 mRNA | CTD | PMID:30047161 | Naprt | Rat | acrylamide | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of NAPRT mRNA | CTD | PMID:32763439 | Naprt | Rat | aflatoxin B1 | affects expression | ISO | NAPRT (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of NAPRT protein | CTD | PMID:20106945 | Naprt | Rat | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of NAPRT mRNA and Amitrole results in increased expression of NAPRT1 mRNA | CTD | PMID:30047161 and PMID:38685447 | Naprt | Rat | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of NAPRT mRNA | CTD | PMID:30779732 | Naprt | Rat | Aroclor 1254 | increases expression | ISO | Naprt (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of NAPRT mRNA | CTD | PMID:23650126 | Naprt | Rat | benzo[a]pyrene | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of NAPRT mRNA | CTD | PMID:20106945 | Naprt | Rat | benzo[a]pyrene | decreases methylation | ISO | NAPRT (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of NAPRT exon and Benzo(a)pyrene results in decreased methylation of NAPRT promoter | CTD | PMID:27901495 | Naprt | Rat | benzo[e]pyrene | decreases methylation | ISO | NAPRT (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of NAPRT polyA tail | CTD | PMID:30157460 | Naprt | Rat | beta-lapachone | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of NAPRT mRNA | CTD | PMID:38218311 | Naprt | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of NAPRT mRNA | CTD | PMID:25181051 and PMID:30816183 | Naprt | Rat | bisphenol A | increases expression | ISO | NAPRT (Homo sapiens) | 6480464 | bisphenol A results in increased expression of NAPRT protein | CTD | PMID:34186270 | Naprt | Rat | bisphenol A | increases expression | ISO | Naprt (Mus musculus) | 6480464 | bisphenol A results in increased expression of NAPRT mRNA | CTD | PMID:33221593 | Naprt | Rat | bisphenol A | decreases expression | ISO | Naprt (Mus musculus) | 6480464 | bisphenol A results in decreased expression of NAPRT mRNA | CTD | PMID:26063408 | Naprt | Rat | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of NAPRT mRNA | CTD | PMID:33453195 | Naprt | Rat | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of NAPRT mRNA | CTD | PMID:24386269 | Naprt | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of NAPRT mRNA | CTD | PMID:27523638 | Naprt | Rat | cyclosporin A | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of NAPRT mRNA | CTD | PMID:20106945 and PMID:27989131 | Naprt | Rat | cyclosporin A | decreases expression | ISO | Naprt (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of NAPRT mRNA | CTD | PMID:19770486 | Naprt | Rat | cyproconazole | decreases expression | ISO | Naprt (Mus musculus) | 6480464 | cyproconazole results in decreased expression of NAPRT mRNA | CTD | PMID:22334560 | Naprt | Rat | dibenzofurans | increases expression | ISO | Naprt (Mus musculus) | 6480464 | Dibenzofurans results in increased expression of NAPRT mRNA | CTD | PMID:34254344 | Naprt | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of NAPRT mRNA | CTD | PMID:21266533 | Naprt | Rat | dibutyl phthalate | decreases expression | ISO | Naprt (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of NAPRT mRNA | CTD | PMID:21266533 | Naprt | Rat | doxorubicin | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of NAPRT mRNA | CTD | PMID:29803840 | Naprt | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of NAPRT mRNA | CTD | PMID:29391264 | Naprt | Rat | epoxiconazole | decreases expression | ISO | Naprt (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of NAPRT mRNA | CTD | PMID:22334560 and PMID:35436446 | Naprt | Rat | fenthion | decreases expression | ISO | Naprt (Mus musculus) | 6480464 | Fenthion results in decreased expression of NAPRT mRNA | CTD | PMID:34813904 | Naprt | Rat | folic acid | multiple interactions | ISO | Naprt (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NAPRT mRNA | CTD | PMID:22206623 | Naprt | Rat | FR900359 | decreases phosphorylation | ISO | NAPRT (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of NAPRT protein | CTD | PMID:37730182 | Naprt | Rat | ivermectin | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of NAPRT protein | CTD | PMID:32959892 | Naprt | Rat | lead diacetate | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | lead acetate results in decreased expression of NAPRT mRNA | CTD | PMID:38568856 | Naprt | Rat | methapyrilene | decreases methylation | ISO | NAPRT (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of NAPRT polyA tail | CTD | PMID:30157460 | Naprt | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of NAPRT1 mRNA | CTD | PMID:30047161 | Naprt | Rat | ochratoxin A | decreases expression | EXP | | 6480464 | ochratoxin A results in decreased expression of NAPRT mRNA | CTD | PMID:23358140 | Naprt | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of NAPRT mRNA | CTD | PMID:25729387 | Naprt | Rat | paracetamol | affects expression | ISO | Naprt (Mus musculus) | 6480464 | Acetaminophen affects the expression of NAPRT mRNA | CTD | PMID:17562736 | Naprt | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of NAPRT mRNA | CTD | PMID:33387578 | Naprt | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Naprt (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of NAPRT mRNA | CTD | PMID:36331819 | Naprt | Rat | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of NAPRT1 mRNA | CTD | PMID:30047161 | Naprt | Rat | propiconazole | decreases expression | ISO | Naprt (Mus musculus) | 6480464 | propiconazole results in decreased expression of NAPRT mRNA | CTD | PMID:22334560 | Naprt | Rat | Propiverine | affects binding | EXP | | 6480464 | propiverine binds to NAPRT protein | CTD | PMID:29273565 | Naprt | Rat | sodium arsenite | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of NAPRT mRNA | CTD | PMID:38568856 | Naprt | Rat | sodium arsenite | decreases expression | ISO | Naprt (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of NAPRT mRNA | CTD | PMID:37682722 | Naprt | Rat | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of NAPRT mRNA | CTD | PMID:19281266 | Naprt | Rat | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of NAPRT1 mRNA | CTD | PMID:30047161 | Naprt | Rat | sunitinib | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of NAPRT mRNA | CTD | PMID:31533062 | Naprt | Rat | tetrachloromethane | decreases expression | ISO | Naprt (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of NAPRT mRNA | CTD | PMID:27339419 | Naprt | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of NAPRT mRNA | CTD | PMID:30723492 and PMID:31150632 | Naprt | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of NAPRT mRNA] | CTD | PMID:31150632 | Naprt | Rat | thimerosal | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of NAPRT mRNA | CTD | PMID:27188386 | Naprt | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of NAPRT mRNA | CTD | PMID:23411599 and PMID:34492290 | Naprt | Rat | thiram | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | Thiram results in decreased expression of NAPRT mRNA | CTD | PMID:38568856 | Naprt | Rat | titanium dioxide | increases expression | ISO | Naprt (Mus musculus) | 6480464 | titanium dioxide results in increased expression of NAPRT mRNA | CTD | PMID:23557971 | Naprt | Rat | titanium dioxide | decreases methylation | ISO | Naprt (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of NAPRT1 enhancer and titanium dioxide results in decreased methylation of NAPRT1 gene | CTD | PMID:35295148 | Naprt | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of NAPRT mRNA | CTD | PMID:25729387 | Naprt | Rat | triazines | multiple interactions | ISO | Naprt (Mus musculus) | 6480464 | Triazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of NAPRT mRNA] | CTD | PMID:27469509 | Naprt | Rat | triphenyl phosphate | affects expression | ISO | NAPRT (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of NAPRT mRNA | CTD | PMID:37042841 | Naprt | Rat | triptonide | increases expression | ISO | Naprt (Mus musculus) | 6480464 | triptonide results in increased expression of NAPRT mRNA | CTD | PMID:33045310 | Naprt | Rat | trovafloxacin | increases expression | ISO | Naprt (Mus musculus) | 6480464 | trovafloxacin results in increased expression of NAPRT mRNA | CTD | PMID:35537566 | Naprt | Rat | valproic acid | decreases expression | ISO | NAPRT (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of NAPRT mRNA | CTD | PMID:23179753 and PMID:29154799 | Naprt | Rat | valproic acid | increases methylation | ISO | NAPRT (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of NAPRT gene | CTD | PMID:29154799 | Naprt | Rat | valproic acid | affects expression | ISO | NAPRT (Homo sapiens) | 6480464 | Valproic Acid affects the expression of NAPRT mRNA | CTD | PMID:25979313 | |