| 1615067 | Ano9 | anoctamin 9 | Enables calcium channel activity and phospholipid scramblase activity. Involved in sensory perception of smell. Acts upstream of or within calcium activated phospholipid scrambling and establishment of localization in cell. Located in endoplasmic reticulum and plasma membrane. Is expressed in epithe lium; genital tubercle mesenchyme; rib cartilage condensation; and skin. Orthologous to human ANO9 (anoctamin 9). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 140681125 | 140697719 | Mouse | 69 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 11440 | Trp53 | transformation related protein 53 | This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] | 11 | 69471174 | 69482699 | Mouse | 5901 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1615099 | Trp53inp2 | transformation related protein 53 inducible nuclear protein 2 | Enables ubiquitin binding activity. Acts upstream of or within several processes, including osteoblast differentiation; tissue homeostasis; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in autophagosome and nucleus. Is expressed in seve ral structures, including 1st branchial arch; facial prominence; limb mesenchyme; nervous system; and otocyst. Orthologous to human TP53INP2 (tumor protein p53 inducible nuclear protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 155223742 | 155231767 | Mouse | 198 | description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1321114 | Perp | PERP, TP53 apoptosis effector | Involved in mammary gland duct morphogenesis; positive regulation of T cell apoptotic process; and tissue homeostasis. Acts upstream of or within several processes, including amelogenesis; desmosome organization; and intrinsic apoptotic signaling pathway by p53 class mediator. Located in several cel lular components, including Golgi apparatus; desmosome; and mitochondrion. Is expressed in several structures, including alimentary system; brain ventricle and choroid plexus; limb primordium; sensory organ; and skin. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to human PERP (p53 apoptosis effector related to PMP22). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 18720819 | 18732821 | Mouse | 173 | name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1623190 | Triap1 | TP53 regulated inhibitor of apoptosis 1 | Predicted to enable p53 binding activity. Predicted to contribute to phosphatidic acid transfer activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of apoptotic signaling pathway; and positive regulati on of phospholipid transport. Located in mitochondrion. Is expressed in inner ear. Orthologous to human TRIAP1 (TP53 regulated inhibitor of apoptosis 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 115479290 | 115481612 | Mouse | 130 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557502 | Rrm2b | ribonucleotide reductase M2 B (TP53 inducible) | Enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in mitochondrial DNA replication and positive regulation of G0 to G1 transition. Acts upstream of or within several processes, including DNA repair; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoside-diphosphate reductase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 37924196 | 37961562 | Mouse | 309 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1622309 | Rprm | reprimo, TP53 dependent G2 arrest mediator candidate | Acts upstream of or within regulation of mitotic cell cycle. Located in cytoplasm. Is expressed in several structures, including autopod; central nervous system; glans of male genital tubercle; metanephros; and sensory organ. Orthologous to human RPRM (reprimo, TP53 pan> dependent G2 arrest mediator homolog). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 53974105 | 53975564 | Mouse | 115 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1317578 | Trp53bp1 | transformation related protein 53 binding protein 1 | Enables damaged DNA binding activity; methylated histone binding activity; and telomeric DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and positive regulation of isotype swit ching. Acts upstream of or within DNA repair. Located in chromosome and nuclear body. Part of DNA repair complex. Is expressed in several structures, including ileum; liver; lung; nervous system; and sensory organ. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 121025316 | 121126830 | Mouse | 264 | old_gene_name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1619687 | Trp53rka | transformation related protein 53 regulating kinase A | Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Is expressed in embryo. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 165332032 | 165335244 | Mouse | 83 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1312622 | Trp53rkb | transformation related protein 53 regulating kinase B | Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; forelimb bud; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 166634379 | 166641412 | Mouse | 36 | old_gene_name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1558239 | Wrap53 | WD repeat containing, antisense to Trp53 | Enables RNA folding chaperone. Predicted to be involved in several processes, including RNA localization to Cajal body; positive regulation of double-strand break repair; and telomere organization. Predicted to be located in cytosol; nuclear body; and site of double-strand break. Predicted to be par t of telomerase holoenzyme complex. Predicted to be active in Cajal body. Is expressed in palatal shelf. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 69452580 | 69471076 | Mouse | 178 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1317527 | Tigar | Trp53 induced glycolysis regulatory phosphatase | Enables fructose-2,6-bisphosphate 2-phosphatase activity. Involved in positive regulation of pentose-phosphate shunt and response to ischemia. Acts upstream of or within several processes, including fructose 2,6-bisphosphate metabolic process; negative regulation of catabolic process; and positive r egulation of cardiac muscle cell apoptotic process. Located in mitochondrion. Is expressed in several structures, including brain; heart; immune system; and liver. Orthologous to human TIGAR (TP53 induced glycolysis regulatory phosphatase). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 127062079 | 127086564 | Mouse | 211 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1619720 | Trp53i11 | transformation related protein 53 inducible protein 11 | Predicted to be located in membrane. Is expressed in nervous system and neural retina. Orthologous to human TP53I11 (tumor protein p53 inducible protein 11). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 93017694 | 93032102 | Mouse | 126 | description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1312215 | Ppp1r13b | protein phosphatase 1, regulatory subunit 13B | Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in nucleus. Is expres sed in several structures, including blood; brain; cardiovascular system; embryo mesenchyme; and yolk sac. Orthologous to human PPP1R13B (protein phosphatase 1 regulatory subunit 13B). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 111794892 | 111874549 | Mouse | 111 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313200 | Topors | topoisomerase I binding, arginine/serine-rich | Predicted to enable several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of DNA -templated transcription; and regulation of cell population proliferation. Located in ciliary basal body; nucleus; and photoreceptor connecting cilium. Is expressed in skin. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 40259606 | 40269841 | Mouse | 189 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1313501 | Trp53bp2 | transformation related protein 53 binding protein 2 | Predicted to enable NF-kappaB binding activity; p53 binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including embryo development; heart development; and response to ionizing radiation. Predicted to be located in cell junction and cytosol. Predic ted to be active in nucleus. Predicted to colocalize with perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Used to study chromosome 1q41-q42 deletion syndrome. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 182236737 | 182289997 | Mouse | 231 | description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1614955 | Trp53i13 | transformation related protein 53 inducible protein 13 | Predicted to be involved in negative regulation of cell cycle. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Orthologous to human TP53I13 (tumor protein p53 inducible protein 13). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 77398925 | 77404214 | Mouse | 55 | description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1332277 | Trp53inp1 | transformation related protein 53 inducible nuclear protein 1 | Enables antioxidant activity. Involved in several processes, including negative regulation of fibroblast proliferation; negative regulation of myofibroblast differentiation; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to ethanol; cellu lar response to hydroperoxide; and cellular response to methyl methanesulfonate. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study abdominal obesity-metabolic syndrome 1. Orthologous to human TP53INP1 (tumor protein p53 inducible nuclear protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 11156441 | 11174379 | Mouse | 303 | description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1617493 | Trp53tg5 | transformation related protein 53 target 5 | Predicted to be located in chromosome and nucleolus. Orthologous to human TP53TG5 (TP53 target 5). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 164308303 | 164315787 | Mouse | 15 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1320312 | Tprkb | Tp53rk binding protein | Predicted to enable protein kinase binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 5. Orthologous to human TPRKB (TP53RK binding protein). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 85888842 | 85907266 | Mouse | 100 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 15567483 | CT025683.1 | tumor protein p53 inducible protein 3 (TP53I3), pseudogene | | | | | Mouse | | name | gene, unitary_pseudogene |
| 5145762 | Trp53cor1 | tumor protein p53 pathway corepressor 1 | Acts upstream of or within negative regulation of gene expression. Part of ribonucleoprotein complex. Is expressed in brain. Orthologous to human TP53COR1 (tumor protein p53 pathway corepressor 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 29276448 | 29298100 | Mouse | 13 | description | gene, ncrna, VALIDATED [RefSeq] |
