Trp53bp2 (transformation related protein 53 binding protein 2) - Rat Genome Database

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Gene: Trp53bp2 (transformation related protein 53 binding protein 2) Mus musculus
Analyze
Symbol: Trp53bp2
Name: transformation related protein 53 binding protein 2
RGD ID: 1313501
MGI Page MGI
Description: Predicted to enable NF-kappaB binding activity; p53 binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including embryo development; heart development; and response to ionizing radiation. Predicted to be located in cell junction and cytosol. Predicted to be active in nucleus. Predicted to colocalize with perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Used to study chromosome 1q41-q42 deletion syndrome. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 53BP; 53BP2; A; AI746547; apoptosis-stimulating of p53 protein 2; ASPP2; expressed sequence AI746547; p53-binding protein 2; p53BP2; PPP1R13A; Tp53bp2; tumor protein p53 binding protein, 2; tumor suppressor p53-binding protein 2; X98550
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,236,737 - 182,289,997 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,236,737 - 182,289,997 (+)EnsemblGRCm39 Ensembl
GRCm381182,409,167 - 182,462,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,409,172 - 182,462,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv371184,339,298 - 184,392,567 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,265,679 - 184,299,107 (+)NCBIMGSCv36mm8
Celera1189,451,621 - 189,504,880 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map184.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Trp53bp2Mousegastrointestinal stromal tumor  ISOTP53BP2 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Trp53bp2Mouseparathyroid carcinoma  ISOTP53BP2 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Trp53bp2Mousebreast lobular carcinoma  ISOTP53BP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28650484
Trp53bp2MouseBreast Neoplasms  ISOTP53BP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28650484
Trp53bp2MouseNeoplasm Invasiveness  ISOTP53BP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28650484
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
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Original Reference(s)
Trp53bp2Mousechromosome 1q41-q42 deletion syndrome  IAGP 13592920OMIM:612530MouseDO 

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Object Symbol
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Reference
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Original Reference(s)
Trp53bp2Mouse(S)-naringenin multiple interactionsISOTP53BP2 (Homo sapiens)6480464[naringenin metabolite co-treated with bisphenol A] results in increased expression of TP53BP2 mRNACTDPMID:36235125
Trp53bp2Mouse1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOTp53bp2 (Rattus norvegicus)6480464o and p'-DDT results in increased expression of TP53BP2 mRNACTDPMID:22937105
Trp53bp2Mouse1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionISOTp53bp2 (Rattus norvegicus)6480464o and p'-DDT analog results in decreased expression of TP53BP2 mRNACTDPMID:22937105
Trp53bp2Mouse1,1-dichloroethene decreases expressionEXP 6480464vinylidene chloride results in decreased expression of TRP53BP2 mRNACTDPMID:26682919
Trp53bp2Mouse1,2-dimethylhydrazine increases expressionEXP 64804641 and 2-Dimethylhydrazine results in increased expression of TRP53BP2 mRNACTDPMID:22206623
Trp53bp2Mouse17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of TRP53BP2 mRNACTDPMID:17555576
Trp53bp2Mouse17beta-estradiol increases expressionISOTP53BP2 (Homo sapiens)6480464Estradiol results in increased expression of TP53BP2 mRNACTDPMID:20106945
Trp53bp2Mouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of TRP53BP2 mRNACTDPMID:39298647
Trp53bp2Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of TRP53BP2 mRNACTDPMID:21570461
Trp53bp2Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTp53bp2 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of TP53BP2 mRNACTDPMID:33387578
Trp53bp2Mouse2,4-dinitrotoluene affects expressionISOTp53bp2 (Rattus norvegicus)64804642 and 4-dinitrotoluene affects the expression of TRP53BP2 mRNACTDPMID:21346803
Trp53bp2Mouse2,6-dinitrotoluene affects expressionISOTp53bp2 (Rattus norvegicus)64804642 and 6-dinitrotoluene affects the expression of TRP53BP2 mRNACTDPMID:21346803
Trp53bp2Mouse2-methylcholine affects expressionISOTP53BP2 (Homo sapiens)6480464beta-methylcholine affects the expression of TP53BP2 mRNACTDPMID:21179406
Trp53bp2Mouse3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of TRP53BP2 mRNACTDPMID:26251327
Trp53bp2Mouse3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOTP53BP2 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of TP53BP2 mRNACTDPMID:28628672
Trp53bp2Mouse3-methyladenine multiple interactionsEXP 6480464TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of GPT protein] more ...CTDPMID:31513885
Trp53bp2Mouse4,4'-sulfonyldiphenol multiple interactionsISOTP53BP2 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of TP53BP2 mRNACTDPMID:28628672
Trp53bp2Mouse4,4'-sulfonyldiphenol decreases methylationISOTP53BP2 (Homo sapiens)6480464bisphenol S results in decreased methylation of TP53BP2 geneCTDPMID:31601247
Trp53bp2Mouse4,4'-sulfonyldiphenol increases expressionISOTP53BP2 (Homo sapiens)6480464bisphenol S results in increased expression of TP53BP2 mRNACTDPMID:33312107
Trp53bp2Mouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of TRP53BP2 mRNACTDPMID:39298647

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Biological Process
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Cellular Component
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Object Symbol
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Reference
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Source
Original Reference(s)
Trp53bp2Mousecell junction located_inISOUniProtKB:Q136252290270 GO_CentralGO_REF:0000119
Trp53bp2Mousecytoplasm located_inISOUniProtKB:Q136252290270 GO_CentralGO_REF:0000119
Trp53bp2Mousecytoplasm located_inISSUniProtKB:Q136252290270 UniProtGO_REF:0000024
Trp53bp2Mousecytosol located_inISOUniProtKB:Q136252290270 GO_CentralGO_REF:0000119
Trp53bp2Mousenucleus located_inISOUniProtKB:Q136252290270 GO_CentralGO_REF:0000119
Trp53bp2Mousenucleus is_active_inIBAPANTHER:PTN001538228 more ...2290270 GO_CentralGO_REF:0000033
Trp53bp2Mousenucleus located_inISSUniProtKB:Q136252290270 UniProtGO_REF:0000024
Trp53bp2Mouseperinuclear region of cytoplasm located_inIEAUniProtKB-SubCell:SL-01982290270 UniProtGO_REF:0000044
Trp53bp2Mouseperinuclear region of cytoplasm located_inISOUniProtKB:Q136252290270 GO_CentralGO_REF:0000119
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Molecular Function
1 to 20 of 35 rows

  
Object Symbol
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Reference
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Original Reference(s)
Trp53bp2Mouseidentical protein binding enablesISOUniProtKB:Q136252290270 GO_CentralGO_REF:0000119
Trp53bp2MouseNF-kappaB binding enablesISOUniProtKB:Q136252290270 GO_CentralGO_REF:0000119
Trp53bp2Mousep53 binding enablesIBAPANTHER:PTN001538228 more ...2290270 GO_CentralGO_REF:0000033
Trp53bp2Mousep53 binding enablesIEAInterPro:IPR0471632290270 InterProGO_REF:0000002
Trp53bp2Mousep53 binding enablesISOUniProtKB:Q136252290270 GO_CentralGO_REF:0000119
Trp53bp2Mouseprotein binding enablesISOUniProtKB:A0MZ66-4 more ...9068941 PMID:32296183IntActPMID:32296183
Trp53bp2Mouseprotein binding enablesISOUniProtKB:P27958-PRO_00000375669068941 PMID:14985081AgBasePMID:14985081
Trp53bp2Mouseprotein binding enablesISOUniProtKB:P04637 and UniProtKB:P27958-PRO_00000375669068941 PMID:14985081IntActPMID:14985081
Trp53bp2Mouseprotein binding enablesISOUniProtKB:Q8NCE29068941 PMID:25910212IntActPMID:25910212
Trp53bp2Mouseprotein binding enablesISOUniProtKB:A2RUH7 more ...9068941 PMID:32814053IntActPMID:32814053
Trp53bp2Mouseprotein binding enablesISOUniProtKB:O14777 more ...9068941 PMID:25416956IntActPMID:25416956
Trp53bp2Mouseprotein binding enablesISOUniProtKB:Q042069068941 PMID:10498867IntActPMID:10498867
Trp53bp2Mouseprotein binding enablesISOUniProtKB:P35569 and UniProtKB:P355709068941 PMID:17965023IntActPMID:17965023
Trp53bp2Mouseprotein binding enablesISOUniProtKB:P368739068941 PMID:21988832IntActPMID:21988832
Trp53bp2Mouseprotein binding enablesISOUniProtKB:O15350 more ...9068941 PMID:18275817IntActPMID:18275817
Trp53bp2Mouseprotein binding enablesISOUniProtKB:P046379068941 PMID:11684014 more ...IntActPMID:11684014 more ...
Trp53bp2Mouseprotein binding enablesISOUniProtKB:O15350 and UniProtKB:Q9H3D49068941 PMID:14729977UniProtPMID:14729977
Trp53bp2Mouseprotein binding enablesISOUniProtKB:A0A0S2Z4M1 more ...9068941 PMID:26871637IntActPMID:26871637
Trp53bp2Mouseprotein binding enablesISOUniProtKB:P46936 and UniProtKB:P469379068941 PMID:11278422IntActPMID:11278422
Trp53bp2Mouseprotein binding enablesISOUniProtKB:P04637 and UniProtKB:Q094729068941 PMID:21513714IntActPMID:21513714
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RGD Manual Annotations


  
Object Symbol
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Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Trp53bp2Mousep53 signaling pathway   ISOTP53BP2 (Homo sapiens)8662965 RGD 
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Object Symbol
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Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Trp53bp2Mouseabnormal brain morphology  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal cell cycle checkpoint function  IAGP 5509061 MGIPMID:19251665
Trp53bp2Mouseabnormal cerebral cortex morphology  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal choroid plexus morphology  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal cortical plate morphology  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal cortical ventricular zone morphology  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal dorsal root ganglion morphology  IAGP 5509061 MGIPMID:27447114
Trp53bp2Mouseabnormal embryonic neuroepithelial cell proliferation  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal embryonic neuroepithelium morphology  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal embryonic neuroepithelium morphology  IAGP 5509061 MGIPMID:27447114
Trp53bp2Mouseabnormal embryonic/fetal subventricular zone morphology  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal gait  IAGP 5509061 MGIPMID:27447114
Trp53bp2Mouseabnormal heart position or orientation  IAGP 5509061 MGIPMID:27447114
Trp53bp2Mouseabnormal kidney physiology  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal lateral ventricle morphology  IAGP 5509061 MGIPMID:27447114
Trp53bp2Mouseabnormal neural tube morphology  IAGP 5509061 MGIPMID:27447114
Trp53bp2Mouseabnormal neuron differentiation  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal neuronal migration  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal neuronal precursor proliferation  IAGP 5509061 MGIPMID:20619750
Trp53bp2Mouseabnormal olfactory bulb morphology  IAGP 5509061 MGIPMID:27447114
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#
Reference Title
Reference Citation
1. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:8889548   PMID:9021147   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16702401   PMID:17211478   PMID:17965023   PMID:18793611   PMID:18799693   PMID:19251665   PMID:19657229   PMID:20619648   PMID:20619750   PMID:20798689  
PMID:21247419   PMID:21873635   PMID:22212482   PMID:22847423   PMID:23365256   PMID:23644657   PMID:24127607   PMID:24194600   PMID:24728844   PMID:24958857   PMID:25256142   PMID:25344754  
PMID:25360797   PMID:27437940   PMID:27447114   PMID:27625111   PMID:27939881   PMID:28671696   PMID:28706196   PMID:30560875   PMID:30675758   PMID:31015291   PMID:32060147   PMID:33378226  
PMID:33558702   PMID:34321999   PMID:35177595   PMID:35436632   PMID:35504951   PMID:36466835   PMID:37142655   PMID:38355793   PMID:38840923  



Trp53bp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,236,737 - 182,289,997 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,236,737 - 182,289,997 (+)EnsemblGRCm39 Ensembl
GRCm381182,409,167 - 182,462,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,409,172 - 182,462,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv371184,339,298 - 184,392,567 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,265,679 - 184,299,107 (+)NCBIMGSCv36mm8
Celera1189,451,621 - 189,504,880 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map184.93NCBI
TP53BP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381223,779,893 - 223,845,947 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1223,779,893 - 223,845,954 (-)EnsemblGRCh38hg38GRCh38
GRCh371223,967,595 - 224,033,649 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361222,034,218 - 222,100,297 (-)NCBINCBI36Build 36hg18NCBI36
Build 341220,274,525 - 220,340,354NCBI
Celera1197,123,518 - 197,189,585 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1194,580,009 - 194,645,609 (-)NCBIHuRef
CHM1_11225,239,932 - 225,305,937 (-)NCBICHM1_1
T2T-CHM13v2.01222,969,626 - 223,035,675 (-)NCBIT2T-CHM13v2.0
Tp53bp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81396,620,429 - 96,677,090 (+)NCBIGRCr8
mRatBN7.21394,088,769 - 94,145,436 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,088,709 - 94,145,432 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.013100,817,206 - 100,873,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13100,817,359 - 100,873,890 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013105,753,296 - 105,809,937 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41398,432,144 - 98,468,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11398,637,078 - 98,657,218 (+)NCBI
Celera1393,622,140 - 93,678,598 (+)NCBICelera
Cytogenetic Map13q26NCBI
Tp53bp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,257,216 - 1,285,322 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,254,853 - 1,285,118 (+)NCBIChiLan1.0ChiLan1.0
TP53BP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2125,522,290 - 25,587,973 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1125,478,188 - 25,543,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01199,403,194 - 199,469,079 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11204,414,218 - 204,455,684 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1204,414,218 - 204,457,739 (-)Ensemblpanpan1.1panPan2
TP53BP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1740,296,278 - 40,329,818 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl740,252,697 - 40,329,828 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha739,756,134 - 39,812,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0740,106,096 - 40,162,517 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl740,106,090 - 40,162,517 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1739,948,627 - 40,004,493 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0739,956,926 - 40,012,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0740,225,931 - 40,281,873 (+)NCBIUU_Cfam_GSD_1.0
Tp53bp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934453,747,260 - 53,810,316 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936526936,359 - 1,000,076 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936526936,981 - 1,000,070 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP53BP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,823,936 - 19,889,869 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,823,932 - 19,889,883 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21024,461,166 - 24,527,522 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TP53BP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1255,774,037 - 5,841,620 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl255,774,063 - 5,841,709 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660555,987,406 - 6,055,398 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp53bp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248355,744,543 - 5,790,603 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248355,744,973 - 5,790,840 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Trp53bp2
2948 total Variants

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:183
Interacting mature miRNAs:198
Transcripts:ENSMUST00000117245
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171632048189303617Mouse

1 to 10 of 83 rows
D1Mit360  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,422,914 - 182,423,027UniSTSGRCm38
MGSCv371184,353,045 - 184,353,158UniSTSGRCm37
Celera1189,465,371 - 189,465,484UniSTS
Cytogenetic Map1H5UniSTS
cM Map1101.2UniSTS
Whitehead Genetic1102.7UniSTS
Whitehead/MRC_RH12280.06UniSTS
RH125309  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,448,820 - 182,448,925UniSTSGRCm38
MGSCv371184,378,951 - 184,379,056UniSTSGRCm37
Celera1189,491,243 - 189,491,348UniSTS
Cytogenetic Map1H5UniSTS
cM Map195.0UniSTS
Trp53bp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H5UniSTS
cM Map195.0UniSTS
AI746547  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,461,954 - 182,462,047UniSTSGRCm38
MGSCv371184,392,085 - 184,392,178UniSTSGRCm37
Celera1189,504,398 - 189,504,491UniSTS
Cytogenetic Map1H5UniSTS
cM Map195.0UniSTS
Whitehead/MRC_RH12280.06UniSTS
Tp53bp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H5UniSTS
cM Map195.0UniSTS
cM Map1 UniSTS
Trp53bp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H5UniSTS







Ensembl Acc Id: ENSMUST00000117245   ⟹   ENSMUSP00000112508
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1182,236,737 - 182,289,997 (+)Ensembl
GRCm38.p6 Ensembl1182,409,172 - 182,462,432 (+)Ensembl
Ensembl Acc Id: ENSMUST00000191626   ⟹   ENSMUSP00000141889
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1182,272,337 - 182,276,080 (+)Ensembl
GRCm38.p6 Ensembl1182,444,772 - 182,448,515 (+)Ensembl
Ensembl Acc Id: ENSMUST00000191804
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1182,269,641 - 182,289,347 (+)Ensembl
GRCm38.p6 Ensembl1182,442,076 - 182,461,782 (+)Ensembl
RefSeq Acc Id: NM_173378   ⟹   NP_775554
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391182,236,737 - 182,289,997 (+)NCBI
GRCm381182,409,167 - 182,462,436 (+)ENTREZGENE
MGSCv371184,339,298 - 184,392,567 (+)RGD
Celera1189,451,621 - 189,504,880 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Protein RefSeqs NP_775554 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE21932 (Get FASTA)   NCBI Sequence Viewer  
  BAE22185 (Get FASTA)   NCBI Sequence Viewer  
  EDL13107 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000112508
GenBank Protein Q8CG79 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_775554   ⟸   NM_173378
- UniProtKB: Q8K2L5 (UniProtKB/Swiss-Prot),   Q8CG79 (UniProtKB/Swiss-Prot),   Q3UYM7 (UniProtKB/Swiss-Prot),   E9QJU8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000141889   ⟸   ENSMUST00000191626
Ensembl Acc Id: ENSMUSP00000112508   ⟸   ENSMUST00000117245
SH3

Name Modeler Protein Id AA Range Protein Structure
AF-Q8CG79-F1-model_v2 AlphaFold Q8CG79 1-1128 view protein structure

RGD ID:6875970
Promoter ID:EPDNEW_M1436
Type:multiple initiation site
Name:Trp53bp2_1
Description:Mus musculus transformation related protein 53 binding protein2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381182,409,172 - 182,409,232EPDNEW
RGD ID:6818653
Promoter ID:MM_KWN:3186
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK138310_GM10517,   NM_173378
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361184,338,989 - 184,339,489 (+)MPROMDB
RGD ID:6818650
Promoter ID:MM_KWN:3187
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:UC007DYD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361184,371,806 - 184,372,306 (+)MPROMDB
RGD ID:6846668
Promoter ID:MM_ACW:3519
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:TRP53BP2.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361184,388,756 - 184,389,256 (+)MPROMDB


1 to 38 of 38 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000026510 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000117245 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  ASPP1/2 UniProtKB/Swiss-Prot
  ASPP2-like_RA UniProtKB/Swiss-Prot
  RA_ASPP2 UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report mmu:209456 UniProtKB/Swiss-Prot
MGD MGI:2138319 ENTREZGENE
NCBI Gene Trp53bp2 ENTREZGENE
PANTHER APOPTOSIS-STIMULATING OF P53 PROTEIN UniProtKB/Swiss-Prot
  APOPTOSIS-STIMULATING OF P53 PROTEIN 2 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  ASPP2-like_RA UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Trp53bp2 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt A0A0A6YX89_MOUSE UniProtKB/TrEMBL
  ASPP2_MOUSE UniProtKB/Swiss-Prot
  E9QJU8 ENTREZGENE, UniProtKB/TrEMBL
  Q3UYM7 ENTREZGENE
  Q3UZC5_MOUSE UniProtKB/TrEMBL
  Q8CG79 ENTREZGENE
  Q8K2L5 ENTREZGENE
UniProt Secondary Q3UYM7 UniProtKB/Swiss-Prot
  Q8K2L5 UniProtKB/Swiss-Prot
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Trp53bp2  transformation related protein 53 binding protein 2  Tp53bp2  tumor protein p53 binding protein, 2  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Tp53bp2  tumor protein p53 binding protein, 2  Trp53bp2  transformation related protein 53 binding protein 2  Symbol and/or name change 5135510 APPROVED