| 1317471 | Sync | syncoilin | Acts upstream of or within intermediate filament-based process. Located in several cellular components, including Z disc; neuromuscular junction; and sarcolemma. Is expressed in tibialis anterior. Orthologous to human SYNC (sync pan>oilin, intermediate filament protein). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 129181066 | 129203175 | Mouse | 87 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1313848 | Cadm2 | cell adhesion molecule 2 | Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in axon. Predicted to be active in neuronal cell body membrane. Is expressed in bone; central nervous system; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 66452302 | 67417825 | Mouse | 83 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1315992 | Cadm3 | cell adhesion molecule 3 | Enables protein homodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within protein localization. Located in cell-cell junction. Is active in paralle l fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in several structures, including intestine; liver; nervous system; neural retina; and olfactory epithelium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease. Orthologous to human CADM3 (cell adhesion molecule 3). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 173161825 | 173195214 | Mouse | 92 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1557624 | Syncrip | synaptotagmin binding, cytoplasmic RNA interacting protein | Enables poly(A) binding activity. Predicted to be involved in several processes, including cellular response to type II interferon; negative regulation of mRNA metabolic process; and regulation of translation. Located in cytoplasm. Part of histone pre-mRNA 3'end processing complex. Is expressed in s everal structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 88331417 | 88364645 | Mouse | 235 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1615713 | Syna | syncytin a | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a mouse endogenous retrovirus provirus on chromosome 5 that has inactivating mutations in th e gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015] | 5 | 134586108 | 134605891 | Mouse | 46 | old_gene_name , name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 30309386 | Synb | syncytin b | Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015] | 14 | 69527827 | 69549857 | Mouse | 70 | old_gene_name , name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312332 | Cadm4 | cell adhesion molecule 4 | Enables enzyme binding activity and vascular endothelial growth factor receptor binding activity. Involved in several processes, including negative regulation of cellular response to growth factor stimulus; negative regulation of protein phosphorylation; and regulation of Rac protein signal transduc tion. Predicted to be located in cell leading edge. Predicted to be active in cell-cell contact zone. Is expressed in dentate gyrus subgranular zone; dorsal root ganglion; spinal cord; spinal cord gray matter; and spinal cord white matter. Orthologous to human CADM4 (cell adhesion molecule 4). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 24181448 | 24203958 | Mouse | 118 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733709 | Sycn | syncollin | Predicted to be involved in exocytosis. Predicted to be located in zymogen granule membrane. Orthologous to human SYCN (syncollin). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 28240310 | 28241635 | Mouse | 39 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1322221 | Cadm1 | cell adhesion molecule 1 | Enables PDZ domain binding activity; protein homodimerization activity; and signaling receptor binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and synapse organization. Acts upstream of or within bone development; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; and unidimensional cell growth. Located in several cellular components, including basolateral plasma membrane; dendrite; and synaptic vesicle. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including central nervous system; metanephros; peripheral nervous system; sensory organ; and tooth. Human ortholog(s) of this gene implicated in breast carcinoma and prostate cancer. Orthologous to human CADM1 (cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 47441468 | 47773578 | Mouse | 315 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1614143 | Gm27174 | predicted gene 27174 | INTERACTS WITH bisphenol A (ortholog); trichloroethene (ortholog) | 14 | 69760100 | 69792776 | Mouse | 2 | old_gene_name | gene, ncrna, VALIDATED [RefSeq] |
| 39129649 | Gm27179 | predicted gene 27179 | INTERACTS WITH 2-hydroxypropanoic acid (ortholog); amphetamine (ortholog); ethylparaben (ortholog) | 14 | 69745042 | 69753064 | Mouse | 7 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1550521 | Ace2 | angiotensin converting enzyme 2 | Enables metallocarboxypeptidase activity. Involved in angiotensin maturation; positive regulation of cardiac muscle contraction; and tryptophan transport. Located in brush border membrane and cytoplasm. Is active in extracellular region. Is expressed in several structures, including blastocyst; brai n; early embryo; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Jul 2025] | X | 162922338 | 162971414 | Mouse | 564 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 735831 | Ccng1 | cyclin G1 | Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; mitotic G2 DNA damage checkpoint signaling; and syncytium formation. Predicte d to be located in dendrite; neuronal cell body; and perinuclear region of cytoplasm. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); localized osteosarcoma; ovarian cancer (multiple); and sarcoma. Orthologous to human CCNG1 (cyclin G1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 40639379 | 40646044 | Mouse | 375 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 731701 | Cd81 | CD81 antigen | Predicted to enable cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of receptor clustering; and syncytium formati on by plasma membrane fusion. Acts upstream of or within regulation of cell motility. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 142606487 | 142621667 | Mouse | 299 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 62144 | Gcm1 | glial cells missing homolog 1 | Enables DNA binding activity and zinc ion binding activity. Acts upstream of or within several processes, including astrocyte fate commitment; embryonic placenta development; and positive regulation of syncytium formation by plasma membrane fusion. Located in nu cleus. Is expressed in several structures, including extraembryonic component; metanephros; pancreas; placenta; and thymus. Orthologous to human GCM1 (glial cells missing transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 77959240 | 77972906 | Mouse | 135 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1620109 | Il9 | interleukin 9 | Enables cytokine activity. Involved in positive regulation of interleukin-5 production. Acts upstream of or within several processes, including B cell activation; regulation of peptidyl-tyrosine phosphorylation; and regulation of receptor signaling pathway via JAK-STAT. Located in extracellular spac e. Is expressed in gut; liver; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma and respiratory syncytial virus infectious disease. Orthologous to human IL9 (interleukin 9). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 56627090 | 56630070 | Mouse | 136 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1619105 | Izumo1 | izumo sperm-egg fusion 1 | Enables protein binding activity involved in heterotypic cell-cell adhesion; protein homodimerization activity; and receptor ligand activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization and syncytium formation by plasma me mbrane fusion. Acts upstream of or within sperm-egg recognition. Located in acrosomal membrane and endoplasmic reticulum membrane. Part of protein complex involved in cell-cell adhesion. Is active in plasma membrane. Orthologous to human IZUMO1 (izumo sperm-oocyte fusion 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 45270251 | 45276653 | Mouse | 73 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1557123 | Rsad2 | radical S-adenosyl methionine domain containing 2 | Predicted to enable 4 iron, 4 sulfur cluster binding activity. Involved in several processes, including CD4-positive, alpha-beta T cell differentiation; negative regulation of viral genome replication; and positive regulation of immune response. Located in endoplasmic reticulum and lipid droplet. Is expressed in liver. Human ortholog(s) of this gene implicated in respiratory syncytial virus infectious disease. Orthologous to human RSAD2 (radical S-adenosyl methionine domain containing 2). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 26492742 | 26506451 | Mouse | 276 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1552674 | Sftpa1 | surfactant associated protein A1 | Predicted to enable carbohydrate binding activity and metal ion binding activity. Predicted to be involved in positive regulation of phagocytosis. Located in collagen-containing extracellular matrix. Is expressed in extraembryonic component; lung; lung surfactant; and placenta. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to several human genes including SFTPA2 (surfactant protein A2). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 40853745 | 40858330 | Mouse | 200 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737198 | Sftpb | surfactant associated protein B | Predicted to be involved in respiratory gaseous exchange by respiratory system and sphingolipid metabolic process. Located in cytoplasm. Is expressed in lung surfactant and respiratory system. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory sync 700;'>syncytial virus infectious disease; and toxic shock syndrome. Orthologous to human SFTPB (surfactant protein B). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 72281594 | 72291354 | Mouse | 272 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 733829 | Sftpc | surfactant associated protein C | Predicted to enable identical protein binding activity. Predicted to be involved in respiratory gaseous exchange by respiratory system. Located in cytoplasm and extracellular region. Is expressed in several structures, including lung; lung surfactant; and main bronchus epithelium. Used to study desq uamative interstitial pneumonia. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); and respiratory syncytial virus infectious disease. Orthologous to human SFTPC (surfactant protein C). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 70758381 | 70761521 | Mouse | 230 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11287 | Sftpd | surfactant associated protein D | Enables identical protein binding activity. Predicted to be involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Located in cytoplasm. Is expressed in epidermis spinous layer; lung; lung surfactant; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 40894169 | 40907155 | Mouse | 259 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 736945 | Syt1 | synaptotagmin I | Enables several functions, including calcium ion sensor activity; calcium-dependent phospholipid binding activity; and syntaxin-1 binding activity. Involved in modulation of chemical synaptic transmission; regulation of dopamine secretion; and synaptic vesicle exocytosis. Acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter; spontaneous neurotransmitter secretion; and synchronous neurotransmitter secretion. Located in several cellular components, including Golgi apparatus; presynaptic membrane; and secretory vesicle. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 108333511 | 108846852 | Mouse | 399 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737014 | Tlr4 | toll-like receptor 4 | This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracel lular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015] | 4 | 66745788 | 66765338 | Mouse | 1600 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1618984 | Vash2 | vasohibin 2 | Enables actin binding activity and metallocarboxypeptidase activity. Involved in proteolysis. Acts upstream of or within labyrinthine layer blood vessel development; positive regulation of angiogenesis; and syncytium formation by plasma membrane fusion. Predicte d to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in brain; cerebral cortex intermediate zone; cerebral cortex ventricular layer; cortical plate; and hippocampus. Orthologous to human VASH2 (vasohibin 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 190679843 | 190711500 | Mouse | 127 | description | gene, protein-coding, VALIDATED [RefSeq] |
