| 1308438 | Usp5 | ubiquitin specific peptidase 5 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); ubiquitin binding (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); negative regulation of T cell mediated immune r esponse to tumor cell (ortholog); negative regulation of ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene | 4 | 159305927 | 159321345 | Rat | 150 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1318206 | USP5 | ubiquitin specific peptidase 5 | Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquit in chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010] | 12 | 6852150 | 6866632 | Human | 155 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1550992 | Usp5 | ubiquitin specific peptidase 5 (isopeptidase T) | Predicted to enable cysteine-type deubiquitinase activity and ubiquitin binding activity. Involved in regulation protein catabolic process at presynapse. Predicted to be located in presynapse. Predicted to be active in cytosol and nucleus. Orthologous to human USP5 an> (ubiquitin specific peptidase 5). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 124791982 | 124806404 | Mouse | 158 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8976692 | Usp5 | ubiquitin specific peptidase 5 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); ubiquitin binding (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); negative regulation of T cell mediated immune r esponse to tumor cell (ortholog); negative regulation of ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (ortholog) | NW_004955413 | 4451530 | 4466832 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11966293 | USP5 | ubiquitin specific peptidase 5 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (inferred); negative regulation of T cell mediated immune response to tumor cell (inferred); negative regulation of ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic stress granule (inferred); nucleus (inferred) | 12 | 6983941 | 6998469 | Bonobo | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12221896 | USP5 | ubiquitin specific peptidase 5 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (inferred); negative regulation of T cell me diated immune response to tumor cell (inferred); negative regulation of ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic stress granule (inferred); nucleus (inferred) | 27 | 38158850 | 38172689 | Dog | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12693689 | Usp5 | ubiquitin specific peptidase 5 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (inferred); negative regulation of T cell me diated immune response to tumor cell (inferred); negative regulation of ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic stress granule (inferred); nucleus (inferred) | NW_004936709 | 952225 | 966429 | Squirrel | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13917216 | USP5 | ubiquitin specific peptidase 5 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); deubiquitinase activity (inferred); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (inferred); negative regulation of T cell me diated immune response to tumor cell (inferred); negative regulation of ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic stress granule (inferred); nucleus (inferred) | | | | Pig | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14389112 | Usp5 | | | | | | Fly | | symbol | gene, null |
| 18730956 | USP5 | ubiquitin specific peptidase 5 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (inferred); negative regulation of T cell mediated immune response to tumor cell (inferred); negative regulation of ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic stress granule (inferred); nucleus (inferred) | | | | Green Monkey | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907153 | Usp5 | ubiquitin specific peptidase 5 | ENCODES a protein that exhibits deubiquitinase activity (ortholog); ubiquitin binding (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); negative regulation of T cell mediated immune response to tumor cell (ortholog); negative regulat ion of ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257390 | usp5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626146789 | Usp5 | ubiquitin specific peptidase 5 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); deubiquitinase activity (ortholog); ubiquitin binding (ortholog); INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); negative regulation of T cell mediated immune r esponse to tumor cell (ortholog); negative regulation of ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257468 | usp5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239605 | usp5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16565930 | AL137190.1 | ubiquitin specific peptidase 5 (isopeptidase T) (USP5) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1343119 | USP50 | ubiquitin specific peptidase 50 | Enables cysteine-type deubiquitinase activity. Involved in regulation of cell cycle G2/M phase transition. Acts upstream of or within several processes, including nuclear speck organization; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of interleukin-1 beta pro duction. Located in centrosome; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 15 | 50493025 | 50546666 | Human | 45 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1558505 | Usp50 | ubiquitin specific peptidase 50 | Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within positive regulation of NLRP3 inflammasome complex assembly; positive regulation of interleukin-1 beta production; and positive regulation of interleukin-18 production. Predicted to be located in centrosome; cytopla sm; and nucleus. Predicted to be active in cytosol; midbody; and postsynaptic density. Orthologous to human USP50 (ubiquitin specific peptidase 50). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 126602970 | 126625380 | Mouse | 67 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564751 | Usp50 | ubiquitin specific peptidase 50 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); ubiquitin-like protein peptidase activity (ortholog); INVOLVED IN nuclear speck organization (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of interleukin-18 production (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH bisphenol A; paracetamol; trichloroethene | 3 | 134465469 | 134488859 | Rat | 55 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9050708 | Usp50 | ubiquitin specific peptidase 50 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); ubiquitin-like protein peptidase activity (ortholog); INVOLVED IN nuclear speck organization (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of interleukin-18 production (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); nucleus (ortholog) | NW_004955409 | 3788723 | 3838077 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11983217 | USP50 | ubiquitin specific peptidase 50 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN nuclear speck organization (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of int erleukin-18 production (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); nucleus (inferred) | 15 | 29450804 | 29500515 | Bonobo | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12383897 | USP50 | ubiquitin specific peptidase 50 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); ubiquitin-like protein peptidase activity (inferred); INVOLVED IN nuclear speck organization (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulati on of interleukin-18 production (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); nucleus (inferred) | 30 | 16409293 | 16453788 | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12729518 | Usp50 | ubiquitin specific peptidase 50 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN nuclear speck organization (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of int erleukin-18 production (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); nucleus (inferred) | NW_004936471 | 12522361 | 12552611 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14149575 | USP50 | ubiquitin specific peptidase 50 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); ubiquitin-like protein peptidase activity (inferred); INVOLVED IN nuclear speck organization (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulati on of interleukin-18 production (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Pig | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18644169 | USP50 | ubiquitin specific peptidase 50 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); ubiquitin-like protein peptidase activity (ortholog); INVOLVED IN nuclear speck organization (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of interleukin-18 production (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); nucleus (ortholog) | | | | Green Monkey | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866722 | USP50 | ubiquitin specific peptidase 50 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein deubiquitination (inferred); regulation of cell cycle G2/M phase transition (inferred); FOUND IN centrosome (inferred); cy toplasm (inferred); nucleus (inferred) | | | | Green Monkey | 11 | symbol | gene, protein-coding |
| 626114679 | Usp50 | ubiquitin specific peptidase 50 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); ubiquitin-like protein peptidase activity (ortholog); INVOLVED IN nuclear speck organization (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of interleukin-18 production (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1562211 | Usp51 | ubiquitin specific peptidase 51 | ENCODES a protein that exhibits chromatin binding (ortholog); cysteine-type deubiquitinase activity (ortholog); histone binding (ortholog); INVOLVED IN DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); regulation of cell cycle process (ortholog); ASSOCIATED WITH D warfism (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | X | 21750630 | 21757163 | Rat | 61 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1603172 | USP51 | ubiquitin specific peptidase 51 | Enables chromatin binding activity; deubiquitinase activity; and histone binding activity. Involved in DNA repair-dependent chromatin remodeling; regulation of cell cycle process; and regulation of double-strand break repair. Predicted to be located in chromosome. [provided by Alliance of Genome Res ources, Jul 2025] | X | 55484616 | 55489848 | Human | 67 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1618708 | Usp51 | ubiquitin specific protease 51 | Predicted to enable chromatin binding activity; deubiquitinase activity; and histone binding activity. Predicted to be involved in DNA repair-dependent chromatin remodeling; regulation of cell cycle process; and regulation of double-strand break repair. Predicted to be located in chromosome. Ortholo gous to human USP51 (ubiquitin specific peptidase 51). [provided by Alliance of Genome Resources, Jul 2025] | X | 151789433 | 151794360 | Mouse | 78 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 11912298 | USP51 | ubiquitin specific peptidase 51 | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); INVOLVED IN DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); regulation of cell cycle process (ortholog); ASSOCIATED WITH Dwarfism (ortholog) | X | 47747547 | 47753119 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12180760 | USP51 | ubiquitin specific peptidase 51 | ENCODES a protein that exhibits chromatin binding (ortholog); cysteine-type deubiquitinase activity (ortholog); histone binding (ortholog); INVOLVED IN DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); regulation of cell cycle process (ortholog); ASSOCIATED WITH D warfism (ortholog) | X | 47055226 | 47059552 | Dog | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12599026 | Usp51 | ubiquitin specific peptidase 51 | ENCODES a protein that exhibits chromatin binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN DNA damage response (inferred); DNA repair-dependent chromatin remodeling (inferred); protein deubiquitination (inferred); ASSOCIAT ED WITH Dwarfism (ortholog) | NW_004936819 | 1115524 | 1119083 | Squirrel | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13878791 | USP51 | ubiquitin specific peptidase 51 | ENCODES a protein that exhibits chromatin binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN DNA damage response (inferred); DNA repair-dependent chromatin remodeling (inferred); protein deubiquitination (inferred); ASSOCIAT ED WITH Dwarfism (ortholog) | | | | Pig | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18417829 | USP51 | ubiquitin specific peptidase 51 | ENCODES a protein that exhibits chromatin binding (inferred); cysteine-type deubiquitinase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN DNA damage response (inferred); DNA repair-dependent chromatin remodeling (inferred); protein deubiquitination (inferred); ASSOCIAT ED WITH Dwarfism (ortholog) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626148461 | Usp51 | ubiquitin specific peptidase 51 | ENCODES a protein that exhibits chromatin binding (ortholog); cysteine-type deubiquitinase activity (ortholog); histone binding (ortholog); INVOLVED IN DNA damage response (ortholog); DNA repair-dependent chromatin remodeling (ortholog); regulation of cell cycle process (ortholog); ASSOCIATED WITH D warfism (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1306615 | Usp53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (orthol og); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (ortholog); cell-cell junction (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acrylamide | 2 | 213744106 | 213805619 | Rat | 112 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315332 | USP53 | ubiquitin specific peptidase 53 | Enables K63-linked deubiquitinase activity. Predicted to be involved in response to auditory stimulus and sensory perception of sound. Predicted to act upstream of or within action potential; epithelial cell apoptotic process; and outer hair cell apoptotic process. Located in bicellular tight juncti on. Implicated in progressive familial intrahepatic cholestasis. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 119212601 | 119295518 | Human | 161 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1550534 | Usp53 | ubiquitin specific peptidase 53 | Predicted to enable K63-linked deubiquitinase activity. Acts upstream of or within several processes, including outer hair cell apoptotic process; response to auditory stimulus; and sensory perception of sound. Located in cell-cell junction. Is expressed in olfactory epithelium; submandibular gland primordium; and tooth. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human USP53 (ubiquitin specific peptidase 53). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 122725142 | 122778184 | Mouse | 142 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9068207 | Usp53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (orthol og); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (ortholog); cell-cell junction (ortholog) | NW_004955428 | 20957807 | 21023380 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11694234 | USP53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred) | 4 | 111407037 | 111483541 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12224684 | USP53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred) | 32 | 38148120 | 38213370 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12665718 | Usp53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred) | NW_004936869 | 169118 | 226495 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14094288 | USP53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred) | | | | Pig | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18373014 | USP53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256238 | usp53 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625873532 | Usp53 | ubiquitin specific peptidase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); neuron apoptotic process (ortholog); ASSOCIATED WITH cholestasis (ortholog); genetic disease (orthol og); primary ovarian insufficiency (ortholog); FOUND IN bicellular tight junction (ortholog); cell-cell junction (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1303206 | Usp54 | ubiquitin specific peptidase 54 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); INTERACTS WITH 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil | 15 | 3706013 | 3806935 | Rat | 75 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1343407 | USP54 | ubiquitin specific peptidase 54 | Enables K63-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. [provided by Alliance of Genome Resources, Jul 2025] | 10 | 73497538 | 73625981 | Human | 78 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1618263 | Usp54 | ubiquitin specific peptidase 54 | Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. Orthologous to human USP54 (ubiquitin specific peptidase 54). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 20598980 | 20694559 | Mouse | 96 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8716851 | Usp54 | ubiquitin specific peptidase 54 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog) | NW_004955437 | 18240303 | 18322197 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11736968 | USP54 | ubiquitin specific peptidase 54 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); K63-linked deubiquitinase activity (inferred); INVOLVED IN protein deubiquitination (inferred) | 10 | 70044872 | 70173486 | Bonobo | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12319268 | USP54 | ubiquitin specific peptidase 54 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); K63-linked deubiquitinase activity (inferred); INVOLVED IN protein deubiquitination (inferred) | 4 | 24029926 | 24151871 | Dog | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12554925 | Usp54 | ubiquitin specific peptidase 54 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); K63-linked deubiquitinase activity (inferred); INVOLVED IN protein deubiquitination (inferred) | NW_004936521 | 5432420 | 5559698 | Squirrel | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14019955 | USP54 | ubiquitin specific peptidase 54 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); K63-linked deubiquitinase activity (inferred); INVOLVED IN protein deubiquitination (inferred); proteolysis (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18571267 | USP54 | ubiquitin specific peptidase 54 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); K63-linked deubiquitinase activity (inferred); INVOLVED IN protein deubiquitination (inferred) | | | | Green Monkey | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18916070 | Usp54 | ubiquitin specific peptidase 54 | ENCODES a protein that exhibits K63-linked deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (inferred) | | | | Naked Mole-Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234074 | usp54 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625999341 | Usp54 | ubiquitin specific peptidase 54 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256239 | usp53.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256842 | usp53.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251829 | usp54.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856359 | usp54.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859381 | usp54.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859997 | usp54.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860120 | usp54.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626177521 | usp54.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626177676 | usp54.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626188995 | usp54.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38616286 | USP53-DT | USP53 divergent transcript | | 4 | 119192773 | 119212644 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 18930475 | LOC101723513 | inactive ubiquitin carboxyl-terminal hydrolase 53 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); INVOLVED IN response to auditory stimulus (inferred); sensory perception of sound (inferred); FOUND IN cell-cell junction (inferred) | | | | Naked Mole-Rat | 5 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1303301 | Pan2 | poly(A) specific ribonuclease subunit PAN2 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN P-body (ortholog); PAN complex (ortholog); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; cadmium atom | 7 | 1313654 | 1332252 | Rat | 127 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1348496 | PAN2 | poly(A) specific ribonuclease subunit PAN2 | This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] | 12 | 56316936 | 56334000 | Human | 121 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1553696 | Pan2 | PAN2 poly(A) specific ribonuclease subunit | Predicted to enable 3'-5'-RNA exonuclease activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process. Located in P-body. I s expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; primary oocyte; and secondary oocyte. Orthologous to human PAN2 (poly(A) specific ribonuclease subunit PAN2). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 128135106 | 128157227 | Mouse | 128 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12274827 | PAN2 | poly(A) specific ribonuclease subunit PAN2 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN mRNA processing (inferred); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (inferred); nuclear-transcribed mRNA poly(A) ta il shortening (inferred); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred) | 10 | 621286 | 636899 | Dog | 35 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8662489 | PPP3CB-AS1 | PPP3CB antisense RNA 1 | INTERACTS WITH sodium arsenite; thiram | 10 | 73495752 | 73507309 | Human | 2 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 16565003 | AC073389.1 | novel transcript, antisense to USP54 | | | | | Human | | name | gene, lncrna |