Usp51 (ubiquitin specific protease 51) - Rat Genome Database

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Gene: Usp51 (ubiquitin specific protease 51) Mus musculus
Analyze
Symbol: Usp51
Name: ubiquitin specific protease 51
RGD ID: 1618708
MGI Page MGI
Description: Predicted to enable chromatin binding activity; deubiquitinase activity; and histone binding activity. Predicted to be involved in DNA repair-dependent chromatin remodeling; regulation of cell cycle process; and regulation of double-strand break repair. Predicted to act upstream of or within DNA repair and proteolysis. Predicted to be located in chromosome. Orthologous to human USP51 (ubiquitin specific peptidase 51).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AV136873; deubiquitinating enzyme 51; ubiquitin carboxyl-terminal hydrolase 51; ubiquitin specific peptidase 51
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,789,433 - 151,794,360 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,789,465 - 151,792,412 (+)EnsemblGRCm39 Ensembl
GRCm38X153,006,469 - 153,011,364 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,006,469 - 153,009,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X149,441,012 - 149,444,004 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X148,349,229 - 148,350,113 (+)NCBIMGSCv36mm8
CeleraX136,241,129 - 136,244,306 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21267068  


Genomics

Comparative Map Data
Usp51
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,789,433 - 151,794,360 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,789,465 - 151,792,412 (+)EnsemblGRCm39 Ensembl
GRCm38X153,006,469 - 153,011,364 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,006,469 - 153,009,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X149,441,012 - 149,444,004 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X148,349,229 - 148,350,113 (+)NCBIMGSCv36mm8
CeleraX136,241,129 - 136,244,306 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
USP51
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X55,484,616 - 55,489,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX55,484,616 - 55,489,848 (-)EnsemblGRCh38hg38GRCh38
GRCh37X55,511,049 - 55,516,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X55,529,687 - 55,532,356 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX59,350,733 - 59,355,315 (-)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX52,562,965 - 52,563,571 (-)NCBIHuRef
CHM1_1X55,501,196 - 55,505,789 (-)NCBICHM1_1
T2T-CHM13v2.0X54,776,519 - 54,781,751 (+)NCBIT2T-CHM13v2.0
Usp51
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X21,750,630 - 21,757,163 (-)NCBIGRCr8
mRatBN7.2X18,374,940 - 18,381,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX18,376,930 - 18,379,888 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX15,779,131 - 15,782,177 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X24,342,778 - 24,345,824 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X18,838,203 - 18,841,250 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X19,268,352 - 19,273,753 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX19,270,181 - 19,273,139 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X20,034,328 - 20,039,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X38,541,807 - 38,544,854 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX18,650,454 - 18,653,501 (-)NCBICelera
Cytogenetic MapXq12NCBI
USP51
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X56,913,201 - 56,918,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X56,916,807 - 56,922,382 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X47,747,547 - 47,753,119 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
USP51
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X47,055,226 - 47,059,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX38,292,359 - 38,295,093 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X47,362,810 - 47,365,543 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X46,666,562 - 46,669,293 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X47,287,285 - 47,289,981 (+)NCBIUNSW_CanFamBas_1.0
Usp51
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X39,915,334 - 39,919,137 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368191,116,447 - 1,118,558 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368191,115,524 - 1,119,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP51
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX48,048,223 - 48,050,355 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X48,047,658 - 48,051,941 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X54,046,247 - 54,050,090 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103232044
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X51,539,955 - 51,545,552 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX51,542,091 - 51,544,223 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236667123,047 - 8,957 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Usp51
103 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:34
Interacting mature miRNAs:34
Transcripts:ENSMUST00000095755
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
12738421Lfibq17_mliver fibrosis QTL 17 (mouse)X148148453164945064Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000095755   ⟹   ENSMUSP00000093427
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX151,789,465 - 151,792,412 (+)Ensembl
GRCm38.p6 EnsemblX153,006,469 - 153,009,416 (+)Ensembl
RefSeq Acc Id: NM_001137547   ⟹   NP_001131019
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,789,465 - 151,792,457 (+)NCBI
GRCm38X153,006,469 - 153,009,461 (+)NCBI
MGSCv37X149,441,012 - 149,444,004 (+)RGD
CeleraX136,241,129 - 136,244,306 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017318594   ⟹   XP_017174083
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,789,433 - 151,794,360 (+)NCBI
GRCm38X153,007,390 - 153,011,364 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162072   ⟹   XP_036017965
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,789,442 - 151,794,360 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001131019 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174083 (Get FASTA)   NCBI Sequence Viewer  
  XP_036017965 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein B1AY15 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000093427
  ENSMUSP00000093427.4
Reference Protein Sequences
RefSeq Acc Id: NP_001131019   ⟸   NM_001137547
- UniProtKB: B1AY15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017174083   ⟸   XM_017318594
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000093427   ⟸   ENSMUST00000095755
RefSeq Acc Id: XP_036017965   ⟸   XM_036162072
- Peptide Label: isoform X2
Protein Domains
USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1AY15-F1-model_v2 AlphaFold B1AY15 1-661 view protein structure

Promoters
RGD ID:6846495
Promoter ID:MM_KWN:62420
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   Lung
Transcripts:ENSMUST00000087199
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X149,441,401 - 149,443,252 (+)MPROMDB
RGD ID:13681666
Promoter ID:EPDNEW_M24982
Type:initiation region
Name:Usp51_1
Description:Mus musculus ubiquitin specific protease 51 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X153,006,482 - 153,006,542EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3588217 AgrOrtholog
Ensembl Genes ENSMUSG00000067215 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000095755 ENTREZGENE
  ENSMUST00000095755.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
  Cysteine proteinases UniProtKB/Swiss-Prot
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Peptidase_C19_UCH UniProtKB/Swiss-Prot
  USP_CS UniProtKB/Swiss-Prot
  USP_dom UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_UBP UniProtKB/Swiss-Prot
KEGG Report mmu:635253 UniProtKB/Swiss-Prot
MGD MGI:3588217 ENTREZGENE
NCBI Gene 635253 ENTREZGENE
PANTHER PTHR21646:SF38 UniProtKB/Swiss-Prot
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot
Pfam UCH UniProtKB/Swiss-Prot
  zf-UBP UniProtKB/Swiss-Prot
PhenoGen Usp51 PhenoGen
PROSITE USP_1 UniProtKB/Swiss-Prot
  USP_2 UniProtKB/Swiss-Prot
  USP_3 UniProtKB/Swiss-Prot
  ZF_UBP UniProtKB/Swiss-Prot
Superfamily-SCOP Formin homology 2 domain (FH2 domain) UniProtKB/Swiss-Prot
  RING/U-box UniProtKB/Swiss-Prot
  SSF54001 UniProtKB/Swiss-Prot
UniProt B1AY15 ENTREZGENE, UniProtKB/Swiss-Prot