| 1344835 | ULK1 | unc-51 like autophagy activating kinase 1 | Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; protein phosphorylation; and regulation of autophagy. Located in bounding membrane of organelle; cytosol; and phag ophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 131894622 | 131923150 | Human | 389 | symbol , old_gene_name , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1557076 | Ulk1 | unc-51 like kinase 1 | Enables Hsp90 protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; macroautophagy; and response to mitochondrial depolarisation. Acts upstream of or within several processes, including Ras protein signal transduction; generation of neurons; and radial glia guided migration of cerebellar granule cell. Located in several cellular components, including cytoplasmic vesicle membrane; neuronal cell body; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; retina; and tibialis anterior. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 110932355 | 110957991 | Mouse | 403 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1589743 | Ulk1 | unc-51 like autophagy activating kinase 1 | ENCODES a protein that exhibits GTPase binding (ortholog); Hsp90 protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN neuron projection development; neuron projection regeneration; positive regulation of autophagosome assembly; PARTICIPATES IN autophagy pathway; mitochondria l autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH metabolic dysfunction-associated steatohepatitis; mucositis; Osteoarthritis, Experimental; FOUND IN axon; Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,4'-trichlorobiphenyl | 12 | 51511492 | 51537746 | Rat | 390 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8958808 | Ulk1 | unc-51 like autophagy activating kinase 1 | ENCODES a protein that exhibits GTPase binding (ortholog); Hsp90 protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); autophagy (ortholog); axon extension (ortholog); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH metabolic dysfunction-associated steatohepatitis (ortholog); mucositis (ortholog); Osteoarthritis, Experimental (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog); autophagosome membrane (ortholog) | NW_004955482 | 760200 | 777133 | Chinchilla | 119 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 12009483 | ULK1 | unc-51 like autophagy activating kinase 1 | ENCODES a protein that exhibits GTPase binding (ortholog); Hsp90 protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); axonogenesis (ortholog); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; mTOR signal ing pathway; ASSOCIATED WITH metabolic dysfunction-associated steatohepatitis (ortholog); mucositis (ortholog); Osteoarthritis, Experimental (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); autophagosome membrane (ortholog); axon (ortholog) | 12 | 129549399 | 129579087 | Bonobo | 127 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 12418171 | ULK1 | unc-51 like autophagy activating kinase 1 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); axonogenesis (ortholog); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH m etabolic dysfunction-associated steatohepatitis (ortholog); mucositis (ortholog); Osteoarthritis, Experimental (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytoplasmic vesicle membrane (ortholog) | 26 | 968714 | 982244 | Dog | 135 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12452434 | Ulk1 | unc-51 like autophagy activating kinase 1 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); axonogenesis (ortholog); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH m etabolic dysfunction-associated steatohepatitis (ortholog); mucositis (ortholog); Osteoarthritis, Experimental (ortholog); FOUND IN axon (ortholog); cytoplasmic vesicle membrane (ortholog); neuron projection (ortholog) | NW_004936660 | 2160394 | 2188848 | Squirrel | 124 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14238970 | ULK1 | unc-51 like autophagy activating kinase 1 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); axonogenesis (ortholog); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH m etabolic dysfunction-associated steatohepatitis (ortholog); mucositis (ortholog); Osteoarthritis, Experimental (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytoplasmic vesicle membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 137 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18445241 | ULK1 | unc-51 like autophagy activating kinase 1 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein kinase binding (ortholog); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); axonogenesis (ortholog); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH m etabolic dysfunction-associated steatohepatitis (ortholog); mucositis (ortholog); Osteoarthritis, Experimental (ortholog); FOUND IN axon (ortholog); cytoplasmic vesicle membrane (ortholog); neuron projection (ortholog) | | | | Green Monkey | 131 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18935938 | Ulk1 | unc-51 like autophagy activating kinase 1 | ENCODES a protein that exhibits GTPase binding (ortholog); Hsp90 protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); axonogenesis (ortholog); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; mTOR signal ing pathway; ASSOCIATED WITH metabolic dysfunction-associated steatohepatitis (ortholog); mucositis (ortholog); Osteoarthritis, Experimental (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); autophagosome membrane (ortholog); axon (ortholog) | | | | Naked Mole-Rat | 130 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 155235691 | ulk1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625881419 | Ulk1 | unc-51 like autophagy activating kinase 1 | ENCODES a protein that exhibits GTPase binding (ortholog); Hsp90 protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); autophagy (ortholog); axon extension (ortholog); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH metabolic dysfunction-associated steatohepatitis (ortholog); mucositis (ortholog); Osteoarthritis, Experimental (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog); autophagosome membrane (ortholog) | | | | Black Rat | 119 | symbol , old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 155238559 | ulk1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257756 | ulk1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12710411 | LOC101955668 | serine/threonine-protein kinase ULK1-like | | NW_004938973 | 5713 | 7973 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 1602213 | ATG101 | autophagy related 101 | Enables identical protein binding activity. Involved in autophagosome assembly and negative regulation of cell population proliferation. Located in phagophore assembly site. Part of Atg1/ULK1 kinase complex. Biomarker of cholangiocarcinoma; colon cancer; and hep atocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 52065300 | 52077495 | Human | 82 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11784781 | ATG101 | autophagy related 101 | ENCODES a protein that exhibits identical protein binding (inferred); protein kinase binding (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of protein lipidation (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); colon cancer (ortholog); hepatocellular carc inoma (ortholog); FOUND IN Atg1/ULK1 kinase complex (inferred); phagophore assembly site (inferred) | 12 | 36685897 | 36693613 | Bonobo | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 12499090 | Atg101 | autophagy related 101 | ENCODES a protein that exhibits identical protein binding (inferred); protein kinase binding (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of protein lipidation (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); colon cancer (ortholog); hepatocellular carc inoma (ortholog); FOUND IN Atg1/ULK1 kinase complex (inferred); phagophore assembly site (inferred) | NW_004936512 | 9518128 | 9525986 | Squirrel | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 18521645 | ATG101 | autophagy related 101 | ENCODES a protein that exhibits identical protein binding (inferred); protein kinase binding (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of protein lipidation (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); colon cancer (ortholog); hepatocellular carc inoma (ortholog); FOUND IN Atg1/ULK1 kinase complex (inferred); phagophore assembly site (inferred) | | | | Green Monkey | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 18916102 | Atg101 | autophagy related 101 | ENCODES a protein that exhibits identical protein binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN negative regulation of cell population proliferation (ortholog); positive regulation of autophagy (ortholog); regulation of protein lipidation (ortholog); ASSOCIATED WITH cholangiocarcinoma (ortholog); colon cancer (ortholog); hepatocellular carcinoma (ortholog); FOUND IN Atg1/ULK1 kinase complex (inferred); phagophore assembly site (inferred) | | | | Naked Mole-Rat | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 1310685 | Atg13 | autophagy related 13 | ENCODES a protein that exhibits kinase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); mitophagy (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPATES IN autophagy pathway; mTOR signaling pathway; AS SOCIATED WITH Liver Reperfusion Injury (ortholog); prostate cancer (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); cytosol (ortholog); mitochondrion (ortholog); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; cadmium atom | 3 | 98102831 | 98136741 | Rat | 124 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1332180 | Atg13 | autophagy related 13 | Predicted to enable protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in several processes, including macroautophagy; positive regulation of autophagy; and response to mitochondrial depolarisation. Located in cytosol and phagophore assembly site. Part o f Atg1/ULK1 kinase complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human ATG13 (autophagy related 13). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 91504957 | 91540947 | Mouse | 130 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8849641 | Atg13 | autophagy related 13 | ENCODES a protein that exhibits kinase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); mitophagy (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPATES IN autophagy pathway; mTOR signaling pathway; AS SOCIATED WITH Liver Reperfusion Injury (ortholog); prostate cancer (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); cytosol (ortholog); mitochondrion (ortholog) | NW_004955422 | 1398646 | 1432440 | Chinchilla | 48 | description | gene, protein-coding, MODEL [RefSeq] |
| 12033307 | ATG13 | autophagy related 13 | ENCODES a protein that exhibits kinase activator activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagosome assembly (ortholog); obsolete positive regulation of protein targeting to mitochondrion (ortholog); regulation of protein lipidation (ortholog); PARTICIPATES IN autophag y pathway; mTOR signaling pathway; ASSOCIATED WITH Liver Reperfusion Injury (ortholog); prostate cancer (ortholog); FOUND IN Atg1/ULK1 kinase complex (inferred); cytosol (inferred); mitochondrion (inferred) | 11 | 46567728 | 46623609 | Bonobo | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 12229154 | ATG13 | autophagy related 13 | ENCODES a protein that exhibits kinase activator activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagosome assembly (ortholog); obsolete positive regulation of protein targeting to mitochondrion (ortholog); regulation of protein lipidation (ortholog); PARTICIPATES IN autophag y pathway; mTOR signaling pathway; ASSOCIATED WITH Liver Reperfusion Injury (ortholog); prostate cancer (ortholog); FOUND IN Atg1/ULK1 kinase complex (inferred); cytosol (inferred); mitochondrion (inferred) | 18 | 42834538 | 42886873 | Dog | 57 | description | gene, protein-coding, MODEL [RefSeq] |
| 12711516 | Atg13 | autophagy related 13 | ENCODES a protein that exhibits kinase activator activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagosome assembly (ortholog); obsolete positive regulation of protein targeting to mitochondrion (ortholog); regulation of protein lipidation (ortholog); PARTICIPATES IN autophag y pathway; mTOR signaling pathway; ASSOCIATED WITH Liver Reperfusion Injury (ortholog); prostate cancer (ortholog); FOUND IN Atg1/ULK1 kinase complex (inferred); cytosol (inferred); mitochondrion (inferred) | NW_004936562 | 2424398 | 2473103 | Squirrel | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 14210471 | ATG13 | autophagy related 13 | ENCODES a protein that exhibits kinase activator activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagosome assembly (ortholog); obsolete positive regulation of protein targeting to mitochondrion (ortholog); regulation of protein lipidation (ortholog); PARTICIPATES IN autophag y pathway; mTOR signaling pathway; ASSOCIATED WITH Liver Reperfusion Injury (ortholog); prostate cancer (ortholog); FOUND IN Atg1/ULK1 kinase complex (inferred); cytosol (inferred); mitochondrion (inferred) | | | | Pig | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 18479870 | ATG13 | autophagy related 13 | ENCODES a protein that exhibits kinase activator activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagosome assembly (ortholog); obsolete positive regulation of protein targeting to mitochondrion (ortholog); regulation of protein lipidation (ortholog); PARTICIPATES IN autophag y pathway; mTOR signaling pathway; ASSOCIATED WITH Liver Reperfusion Injury (ortholog); prostate cancer (ortholog); FOUND IN Atg1/ULK1 kinase complex (inferred); cytosol (inferred); mitochondrion (inferred) | | | | Green Monkey | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 625871288 | Atg13 | autophagy related 13 | ENCODES a protein that exhibits kinase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); mitophagy (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPATES IN autophagy pathway; mTOR signaling pathway; AS SOCIATED WITH Liver Reperfusion Injury (ortholog); prostate cancer (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); cytosol (ortholog); mitochondrion (ortholog) | | | | Black Rat | 47 | description | gene, protein-coding, MODEL [RefSeq] |
| 8893185 | C9orf72 | C9orf72-SMCR8 complex subunit | ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); autophagy (ortholog); axon extension (ortholog); ASSOCIATED WITH amyotrophic lateral scl erosis (ortholog); autism spectrum disorder (ortholog); autoimmune disease (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog); axonal growth cone (ortholog) | NW_004955472 | 7299092 | 7337591 | Chinchilla | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 18931913 | C9orf72 | C9orf72-SMCR8 complex subunit | ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); negative regulation of protein phosphorylation (ortholog); positive regulation of macroautophagy (ortholog); ASSOCIATED W ITH amyotrophic lateral sclerosis (ortholog); autism spectrum disorder (ortholog); autoimmune disease (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); axonal growth cone (ortholog); cytoplasmic stress granule (ortholog) | | | | Naked Mole-Rat | 65 | description | gene, protein-coding, MODEL [RefSeq] |
| 625920169 | C9orf72 | C9orf72-SMCR8 complex subunit | ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); autophagy (ortholog); axon extension (ortholog); ASSOCIATED WITH amyotrophic lateral scl erosis (ortholog); autism spectrum disorder (ortholog); autoimmune disease (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog); axonal growth cone (ortholog) | | | | Black Rat | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 18909489 | LOC101713718 | autophagy-related protein 13-like | INVOLVED IN autophagosome assembly (inferred); autophagy (inferred); mitophagy (inferred); FOUND IN Atg1/ULK1 kinase complex (inferred); cytosol (inferred); phagophore assembly site (inferred) | | | | Naked Mole-Rat | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 18900600 | LOC101721047 | RB1-inducible coiled-coil protein 1-like | ENCODES a protein that exhibits molecular adaptor activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagosome assembly (inferred); autophagy (inferred); autophagy of mitochondrion (inferred); FOUND IN Atg1/ULK1 kinase complex (inferred); cy tosol (inferred); lysosome (inferred) | | | | Naked Mole-Rat | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 1309346 | Rb1cc1 | RB1-inducible coiled-coil 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN autophagosome assembly (ortholog); autophagy (ortholog); defense response to virus (ortholog); PARTICIPATES IN autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH breas t adenocarcinoma (ortholog); breast cancer (ortholog); Breast Cancer, Familial (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); autophagosome membrane (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 5 | 17948522 | 18012434 | Rat | 183 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319645 | Rb1cc1 | RB1-inducible coiled-coil 1 | Enables protein kinase binding activity. Involved in autophagosome assembly; negative regulation of cell population proliferation; and positive regulation of autophagy. Acts upstream of or within several processes, including defense response to other organism; positive regulation of cell size; and r egulation of signal transduction. Located in autophagosome membrane; nucleus; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including cerebral cortex; ganglia; musculoskeletal system; oocyte; and trunk paraxial mesenchyme. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RB1CC1 (RB1 inducible coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 6284858 | 6346599 | Mouse | 255 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8898763 | Rb1cc1 | RB1 inducible coiled-coil 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN autophagosome assembly (ortholog); autophagy (ortholog); defense response to virus (ortholog); PARTICIPATES IN autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH breas t adenocarcinoma (ortholog); breast cancer (ortholog); Breast Cancer, Familial (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); autophagosome membrane (ortholog); cytosol (ortholog) | NW_004955454 | 12201566 | 12257383 | Chinchilla | 63 | description | gene, protein-coding, MODEL [RefSeq] |
| 625910022 | Rb1cc1 | RB1 inducible coiled-coil 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN autophagosome assembly (ortholog); autophagy (ortholog); defense response to virus (ortholog); PARTICIPATES IN autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH breas t adenocarcinoma (ortholog); breast cancer (ortholog); Breast Cancer, Familial (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); autophagosome membrane (ortholog); cytosol (ortholog) | | | | Black Rat | 63 | description | gene, protein-coding, MODEL [RefSeq] |
| 1359108 | RGD1359108 | similar to RIKEN cDNA 3110043O21 | ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); autophagy (ortholog); axon extension (ortholog); ASSOCIATED WITH amyotrophic lateral scl erosis (ortholog); autism spectrum disorder (ortholog); autoimmune disease (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog); axonal growth cone (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride | 5 | 54562570 | 54587649 | Rat | 230 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1566319 | Sesn2 | sestrin 2 | ENCODES a protein that exhibits GDP-dissociation inhibitor activity (ortholog); L-leucine binding (ortholog); peroxidase activity (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); cellular oxidant detoxification (ortholog); cellular response to amino acid starvation (ortholog ); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); Hepatomegaly (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); cytoplasm (ortholog); GATOR2 complex (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 149986304 | 150005255 | Rat | 411 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8849954 | Sesn2 | sestrin 2 | ENCODES a protein that exhibits GDP-dissociation inhibitor activity (ortholog); L-leucine binding (ortholog); peroxidase activity (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); cellular oxidant detoxification (ortholog); cellular response to amino acid starvation (ortholog ); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); Hepatomegaly (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); cytoplasm (ortholog); GATOR2 complex (ortholog) | NW_004955452 | 7392644 | 7417204 | Chinchilla | 78 | description | gene, protein-coding, MODEL [RefSeq] |
| 18918126 | Sesn2 | sestrin 2 | ENCODES a protein that exhibits GDP-dissociation inhibitor activity (ortholog); peroxidase activity (ortholog); PH domain binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); cellular oxidant detoxification (ortholog); cellular response to amino acid starvation (ortholog ); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); Hepatomegaly (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); GATOR2 complex (ortholog); lysosomal membrane (ortholog) | | | | Naked Mole-Rat | 79 | description | gene, protein-coding, MODEL [RefSeq] |
| 625986736 | Sesn2 | sestrin 2 | ENCODES a protein that exhibits GDP-dissociation inhibitor activity (ortholog); L-leucine binding (ortholog); peroxidase activity (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); cellular oxidant detoxification (ortholog); cellular response to amino acid starvation (ortholog ); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); Hepatomegaly (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); cytoplasm (ortholog); GATOR2 complex (ortholog) | | | | Black Rat | 78 | description | gene, protein-coding, MODEL [RefSeq] |
| 1345463 | SMCR8 | SMCR8-C9orf72 complex subunit | Enables GTPase activator activity; protein kinase binding activity; and protein kinase inhibitor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in negative regulation of gene expression; regulation of TOR signaling; and regulation of macroautophagy. Located in Atg1/... (more) an style='font-weight:700;'>ULK1 kinase complex; chromatin; and nucleoplasm. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 18315293 | 18328056 | Human | 106 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564621 | Smcr8 | SMCR8-C9orf72 complex subunit | ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN negative regulation of autophagosome assembly (ortholog); negative regulation of gene expression (ortholog); negative regulation of macroautophagy (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); chromatin (ortholog); cytoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide | 10 | 45957146 | 45968388 | Rat | 112 | description | gene, protein-coding, INFERRED [RefSeq] |
| 8962845 | Smcr8 | SMCR8-C9orf72 complex subunit | ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN negative regulation of autophagosome assembly (ortholog); negative regulation of gene expression (ortholog); negative regulation of macroautophagy (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); chromatin (ortholog); cytoplasm (ortholog) | NW_004955478 | 11002174 | 11015123 | Chinchilla | 30 | description | gene, protein-coding, MODEL [RefSeq] |
| 11682652 | SMCR8 | SMCR8-C9orf72 complex subunit | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagy (inferred); negative regulation of autophagosome assembly (inferred); negative regulation of gene expression (inferred ); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog) | 17 | 32858205 | 32871132 | Bonobo | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12560774 | Smcr8 | SMCR8-C9orf72 complex subunit | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagy (inferred); negative regulation of autophagosome assembly (inferred); negative regulation of gene expression (inferred ); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog) | NW_004936741 | 1838974 | 1848742 | Squirrel | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 14163356 | SMCR8 | SMCR8-C9orf72 complex subunit | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagy (inferred); negative regulation of autophagosome assembly (inferred); negative regulation of gene expression (inferred ); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog) | | | | Pig | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 18770203 | SMCR8 | SMCR8-C9orf72 complex subunit | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagy (inferred); negative regulation of autophagosome assembly (inferred); negative regulation of gene expression (inferred ); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog) | | | | Green Monkey | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 18933017 | Smcr8 | SMCR8-C9orf72 complex subunit | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); protein kinase binding (ortholog); protein kinase inhibitor activity (ortholog); INVOLVED IN negative regulation of autophagosome assembly (ortholog); negative regulation of gene expression (ortholog); negative re gulation of macroautophagy (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); chromatin (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 40908626 | SMCR8 | SMCR8-C9orf72 complex subunit | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); protein kinase binding (inferred); INVOLVED IN autophagy (inferred); negative regulation of autophagosome assembly (inferred); negative regulation of gene expression (inferred ); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog) | | | | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 1321047 | TBC1D5 | TBC1 domain family member 5 | Enables AP-2 adaptor complex binding activity and retromer complex binding activity. Involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Located in several cellular components, including Atg1/ULK1 le='font-weight:700;'>ULK1 kinase complex; autophagosome; and cytoplasmic vesicle membrane. Part of retromer complex. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 17157162 | 17742631 | Human | 125 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1321048 | Tbc1d5 | TBC1 domain family, member 5 | Predicted to enable AP-2 adaptor complex binding activity; GTPase activator activity; and retromer complex binding activity. Predicted to be involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Predicte d to be located in autophagosome. Predicted to be part of AP-2 adaptor complex; Atg1/ULK1 kinase complex; and retromer complex. Predicted to be active in Golgi apparatus and endosome membrane. Orthologous to human TBC1D5 (TBC1 domain family member 5). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 51040155 | 51488228 | Mouse | 130 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1561626 | Tbc1d5 | TBC1 domain family, member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); protein-containing complex binding (ortholog); retromer complex binding (ortholog); INVOLVED IN autophagy (ortholog); macroautophagy (ortholog); positive regulation of receptor internalization (ortholog); PARTICIPATES IN retrom er-mediated pathway; FOUND IN AP-2 adaptor complex (ortholog); Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,5-hexanedione | 9 | 3740032 | 4256971 | Rat | 111 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9002078 | Tbc1d5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); protein-containing complex binding (ortholog); retromer complex binding (ortholog); INVOLVED IN autophagy (ortholog); macroautophagy (ortholog); positive regulation of receptor internalization (ortholog); PARTICIPATES IN retrom er-mediated pathway; FOUND IN AP-2 adaptor complex (ortholog); Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog) | NW_004955430 | 9411865 | 9966710 | Chinchilla | 30 | description | gene, protein-coding, MODEL [RefSeq] |
| 11967335 | TBC1D5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); GTPase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of cilium assembly (ortholog); PARTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (inferred); Atg 1/ULK1 kinase complex (inferred); autophagosome (inferred) | 3 | 17080589 | 17664776 | Bonobo | 39 | description | gene, protein-coding, MODEL [RefSeq] |
| 12335146 | TBC1D5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); GTPase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of cilium assembly (ortholog); PARTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (inferred); Atg 1/ULK1 kinase complex (inferred); autophagosome (inferred) | 23 | 25206825 | 25758026 | Dog | 43 | description | gene, protein-coding, MODEL [RefSeq] |
| 12476465 | Tbc1d5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); GTPase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of cilium assembly (ortholog); PARTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (inferred); Atg 1/ULK1 kinase complex (inferred); autophagosome (inferred) | NW_004936473 | 9868657 | 10294554 | Squirrel | 39 | description | gene, protein-coding, MODEL [RefSeq] |
| 14091805 | TBC1D5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); GTPase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of cilium assembly (ortholog); PARTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (inferred); Atg 1/ULK1 kinase complex (inferred); autophagosome (inferred) | | | | Pig | 43 | description | gene, protein-coding, MODEL [RefSeq] |
| 18713302 | TBC1D5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); GTPase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN regulation of cilium assembly (ortholog); PARTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (inferred); Atg 1/ULK1 kinase complex (inferred); autophagosome (inferred) | | | | Green Monkey | 39 | description | gene, protein-coding, MODEL [RefSeq] |
| 18916740 | Tbc1d5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); protein-containing complex binding (ortholog); retromer complex binding (ortholog); INVOLVED IN macroautophagy (ortholog); positive regulation of receptor internalization (ortholog); regulation of cilium assembly (ortholog); PA RTICIPATES IN retromer-mediated pathway; FOUND IN AP-2 adaptor complex (ortholog); Atg1/ULK1 kinase complex (ortholog); retromer complex (ortholog) | | | | Naked Mole-Rat | 35 | description | gene, protein-coding, MODEL [RefSeq] |
| 625948650 | Tbc1d5 | TBC1 domain family member 5 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); protein-containing complex binding (ortholog); retromer complex binding (ortholog); INVOLVED IN autophagy (ortholog); macroautophagy (ortholog); positive regulation of receptor internalization (ortholog); PARTICIPATES IN retrom er-mediated pathway; FOUND IN AP-2 adaptor complex (ortholog); Atg1/ULK1 kinase complex (ortholog); autophagosome (ortholog) | | | | Black Rat | 30 | description | gene, protein-coding, MODEL [RefSeq] |