ULK1 (unc-51 like autophagy activating kinase 1) - Rat Genome Database

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Gene: ULK1 (unc-51 like autophagy activating kinase 1) Chlorocebus sabaeus
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Symbol: ULK1
Name: unc-51 like autophagy activating kinase 1
RGD ID: 18445241
Description: ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); axonogenesis (ortholog); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH metabolic dysfunction-associated steatohepatitis (ortholog); mucositis (ortholog); Osteoarthritis, Experimental (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytoplasmic vesicle membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase ULK1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111127,276,172 - 127,304,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11127,276,210 - 127,304,497 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037117,654,277 - 117,669,065 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagosome assembly  (IEA)
autophagy  (IEA)
autophagy of mitochondrion  (IEA)
axon extension  (IEA,ISO)
axon guidance  (ISO)
axonogenesis  (IEA,ISO)
cellular response to amino acid starvation  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to stress  (IEA)
cerebellar granule cell differentiation  (ISO)
chromatin remodeling  (IEA)
collateral sprouting  (ISO)
establishment of localization in cell  (ISO)
macroautophagy  (IEA,ISO)
mitophagy  (ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of collateral sprouting  (IEA,ISO)
negative regulation of protein-containing complex assembly  (IEA)
neuron migration  (ISO)
neuron projection development  (IEA,ISO)
neuron projection regeneration  (ISO)
peptidyl-serine phosphorylation  (ISO)
piecemeal microautophagy of the nucleus  (IEA)
positive regulation of autophagosome assembly  (ISO)
positive regulation of autophagy  (IEA)
protein autophosphorylation  (ISO)
protein localization  (IEA,ISO)
radial glia guided migration of cerebellar granule cell  (ISO)
Ras protein signal transduction  (ISO)
receptor internalization  (ISO)
regulation of autophagy  (IEA)
regulation of gene expression  (ISO)
regulation of macroautophagy  (IEA)
regulation of neurotrophin TRK receptor signaling pathway  (ISO)
regulation of protein lipidation  (IEA)
response to mitochondrial depolarisation  (ISO)
response to starvation  (IEA)
reticulophagy  (IEA)
signal transduction  (IEA)
somatic sensory system development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:28890335   PMID:30032202  


Genomics

Comparative Map Data
ULK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111127,276,172 - 127,304,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11127,276,210 - 127,304,497 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037117,654,277 - 117,669,065 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ULK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812131,894,622 - 131,923,150 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12131,894,622 - 131,923,150 (+)EnsemblGRCh38hg38GRCh38
GRCh3712132,379,167 - 132,407,695 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612130,945,232 - 130,973,649 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412131,045,508 - 131,073,926NCBI
Celera12132,008,428 - 132,026,099 (+)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12129,276,372 - 129,293,381 (+)NCBIHuRef
CHM1_112132,200,212 - 132,228,619 (+)NCBICHM1_1
T2T-CHM13v2.012131,939,343 - 131,971,098 (+)NCBIT2T-CHM13v2.0
Ulk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,932,355 - 110,957,991 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,932,354 - 110,957,963 (-)EnsemblGRCm39 Ensembl
GRCm385110,784,489 - 110,810,120 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,784,488 - 110,810,097 (-)EnsemblGRCm38mm10GRCm38
MGSCv375111,213,508 - 111,239,100 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365111,024,791 - 111,050,383 (-)NCBIMGSCv36mm8
Celera5107,916,517 - 107,942,075 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.7NCBI
Ulk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,511,492 - 51,537,746 (+)NCBIGRCr8
mRatBN7.21245,851,710 - 45,877,966 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,851,710 - 45,877,966 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,027,176 - 47,053,431 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,632,609 - 47,658,852 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,693,137 - 46,719,380 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,908,105 - 51,934,704 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,908,448 - 51,934,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01253,646,513 - 53,673,055 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,996,251 - 46,022,505 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1247,411,122 - 47,437,376 (+)NCBICelera
Cytogenetic Map12q16NCBI
Ulk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955482761,811 - 777,133 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955482760,200 - 777,133 (-)NCBIChiLan1.0ChiLan1.0
ULK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210139,987,482 - 140,016,926 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112139,984,001 - 140,013,443 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012129,549,399 - 129,579,087 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112133,980,316 - 134,007,687 (+)NCBIpanpan1.1PanPan1.1panPan2
ULK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126968,714 - 982,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26970,138 - 982,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,012,410 - 1,033,785 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,030,431 - 1,051,812 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,030,432 - 1,051,789 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.126967,560 - 988,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0261,064,168 - 1,085,536 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.026987,330 - 1,008,708 (-)NCBIUU_Cfam_GSD_1.0
Ulk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118122,532,232 - 122,560,686 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366602,163,844 - 2,187,080 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366602,160,394 - 2,188,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ULK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1423,423,698 - 23,448,136 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11423,423,693 - 23,448,130 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21424,875,257 - 24,913,433 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ulk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474727,681,033 - 27,695,966 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474727,680,994 - 27,697,342 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000016646   ⟹   ENSCSAP00000016148
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl11127,276,210 - 127,304,497 (+)Ensembl
RefSeq Acc Id: XM_037987283   ⟹   XP_037843211
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037117,654,277 - 117,669,065 (-)NCBI
RefSeq Acc Id: XM_037987287   ⟹   XP_037843215
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037117,654,277 - 117,669,065 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037843211 (Get FASTA)   NCBI Sequence Viewer  
  XP_037843215 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016148.1
Ensembl Acc Id: ENSCSAP00000016148   ⟸   ENSCSAT00000016646
RefSeq Acc Id: XP_037843215   ⟸   XM_037987287
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S5K9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037843211   ⟸   XM_037987283
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S5K9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001882 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016646.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Atg1-like UniProtKB/TrEMBL
  ATG1-like_MIT2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kin_STPK_Ulk-1/2 UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser/Thr_kinase_C UniProtKB/TrEMBL
NCBI Gene ULK1 ENTREZGENE
PANTHER PTHR24348 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE ULK1 UniProtKB/TrEMBL
Pfam ATG1-like_MIT2 UniProtKB/TrEMBL
  DUF3543 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PIRSF Ser/Thr_PK_STPK_ULK-1/2 UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9S5K9 ENTREZGENE, UniProtKB/TrEMBL