Ulk1 (unc-51 like kinase 1) - Rat Genome Database

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Gene: Ulk1 (unc-51 like kinase 1) Mus musculus
Analyze
Symbol: Ulk1
Name: unc-51 like kinase 1
RGD ID: 1557076
MGI Page MGI
Description: Enables Hsp90 protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; macroautophagy; and protein phosphorylation. Acts upstream of or within several processes, including negative regulation of collateral sprouting; nervous system development; and regulation of neurotrophin TRK receptor signaling pathway. Located in several cellular components, including cytoplasmic vesicle membrane; neuronal cell body; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU041434; mKIAA0722; serine/threonine-protein kinase ULK1; serine/threonine-protein kinase Unc51.1; unc-51-like kinase 1; Unc51.; Unc51.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,932,355 - 110,957,991 (-)NCBIGRCm39mm39
GRCm39 Ensembl5110,932,354 - 110,957,963 (-)Ensembl
GRCm385110,784,489 - 110,810,120 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,784,488 - 110,810,097 (-)EnsemblGRCm38mm10GRCm38
MGSCv375111,213,508 - 111,239,100 (-)NCBIGRCm37mm9NCBIm37
MGSCv365111,024,791 - 111,050,383 (-)NCBImm8
Celera5107,916,517 - 107,942,075 (-)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (ISO)
4-hydroxynon-2-enal  (EXP)
acadesine  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (EXP)
amphetamine  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
artesunate  (ISO)
bafilomycin A1  (ISO)
Benoxacor  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
bleomycin A2  (EXP)
buspirone  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (EXP,ISO)
Cannabidivarin  (EXP)
carbon disulfide  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cucurbitacin E  (ISO)
Curcumol  (ISO)
cyanocob(III)alamin  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dinitrogen  (ISO)
diosgenin  (ISO)
disulfiram  (ISO)
dorsomorphin  (EXP,ISO)
econazole  (EXP)
endosulfan  (ISO)
ethanol  (EXP,ISO)
folic acid  (EXP)
fulvestrant  (ISO)
fumonisin B1  (EXP)
gentamycin  (ISO)
glucose  (ISO)
glycine betaine  (EXP)
L-methionine  (EXP)
maslinic acid  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methylazoxymethanol  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
myxothiazol  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
Nonidet P-40  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP)
promethazine  (ISO)
propiconazole  (EXP)
quercetin  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
tebuconazole  (EXP)
Temsirolimus  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
torin 1  (ISO)
trans-piceid  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagosome assembly  (IBA,IDA,IMP,ISO)
autophagy  (IMP,ISO)
autophagy of mitochondrion  (IBA)
axon extension  (IBA,IMP)
axonogenesis  (IDA)
cellular response to amino acid starvation  (IGI)
cellular response to nutrient levels  (IDA)
cerebellar granule cell differentiation  (IMP)
collateral sprouting  (IMP)
establishment of localization in cell  (IMP)
late nucleophagy  (IBA)
macroautophagy  (IGI,IMP,ISO)
mitophagy  (IMP)
negative regulation of cell population proliferation  (IDA,ISO)
negative regulation of collateral sprouting  (IBA,IMP)
negative regulation of protein-containing complex assembly  (ISO)
neuron migration  (IMP)
neuron projection development  (IMP,ISO)
neuron projection regeneration  (ISO)
peptidyl-serine phosphorylation  (IBA,IDA,ISO)
peptidyl-threonine phosphorylation  (ISO)
phosphorylation  (IEA)
piecemeal microautophagy of the nucleus  (IBA)
positive regulation of autophagosome assembly  (ISO)
positive regulation of autophagy  (IBA,IDA,IMP,ISO)
protein autophosphorylation  (IDA,ISO)
protein localization  (ISO)
protein phosphorylation  (IDA,ISO)
radial glia guided migration of cerebellar granule cell  (IMP)
Ras protein signal transduction  (IDA)
receptor internalization  (IMP)
regulation of cell death  (IGI)
regulation of gene expression  (IGI)
regulation of macroautophagy  (ISO)
regulation of neurotrophin TRK receptor signaling pathway  (IMP)
regulation of protein lipidation  (IDA,ISO)
response to mitochondrial depolarisation  (IMP)
response to starvation  (IBA,IDA)
reticulophagy  (IBA)
signal transduction  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Assessment of the effect of laser irradiations at different wavelengths (660, 810, 980, and 1064 nm) on autophagy in a rat model of mucositis. Bostanciklioglu M, etal., Lasers Med Sci. 2015 May;30(4):1289-95. doi: 10.1007/s10103-015-1727-4. Epub 2015 Mar 3.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. Tougu Xiaotong capsule inhibits the tidemark replication and cartilage degradation of papain-induced osteoarthritis by the regulation of chondrocyte autophagy. Li X, etal., Int J Mol Med. 2013 Jun;31(6):1349-56. doi: 10.3892/ijmm.2013.1341. Epub 2013 Apr 9.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Early and sustained activation of autophagy in degenerating axons after spinal cord injury. Ribas VT, etal., Brain Pathol. 2015 Mar;25(2):157-70. doi: 10.1111/bpa.12170. Epub 2014 Sep 12.
13. LC3 conjugation system in mammalian autophagy. Tanida I, etal., Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18.
14. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
15. Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Yan J, etal., Biochem Biophys Res Commun 1998 May 8;246(1):222-7.
16. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10624947   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11423996   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273  
PMID:15014045   PMID:15226823   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17389358   PMID:17595159   PMID:17855365   PMID:17967808   PMID:18443221  
PMID:18539900   PMID:18799693   PMID:18936157   PMID:18981720   PMID:19211835   PMID:19225151   PMID:19258318   PMID:19597335   PMID:19807128   PMID:20498061   PMID:21205641   PMID:21220506  
PMID:21258367   PMID:21267068   PMID:21368103   PMID:21383122   PMID:21460634   PMID:21460635   PMID:21677750   PMID:21690395   PMID:21795849   PMID:21855797   PMID:21873635   PMID:21969579  
PMID:22275429   PMID:22452982   PMID:22493260   PMID:22539723   PMID:22613832   PMID:22932492   PMID:23027865   PMID:23219390   PMID:23291478   PMID:23392225   PMID:23448468   PMID:23525089  
PMID:23685627   PMID:23870125   PMID:24135897   PMID:24275123   PMID:24317201   PMID:24671035   PMID:24895007   PMID:24954904   PMID:25040165   PMID:25541949   PMID:25680463   PMID:25686248  
PMID:25980607   PMID:26018823   PMID:26098576   PMID:26138443   PMID:26213203   PMID:26310906   PMID:26365490   PMID:26371245   PMID:26384021   PMID:26649827   PMID:26687681   PMID:27021405  
PMID:27046250   PMID:27096368   PMID:27153534   PMID:27166947   PMID:27203176   PMID:27304681   PMID:27545895   PMID:27617292   PMID:27670885   PMID:28011640   PMID:28356270   PMID:28381396  
PMID:28430962   PMID:28474670   PMID:28916822   PMID:29056340   PMID:29099309   PMID:29109831   PMID:29425491   PMID:29680658   PMID:29866515   PMID:29875237   PMID:30021155   PMID:30053525  
PMID:30103670   PMID:30245008   PMID:30409884   PMID:30581007   PMID:30596474   PMID:30979586   PMID:31059511   PMID:31123703   PMID:31160490   PMID:31257024   PMID:31362587   PMID:31434755  
PMID:31721614   PMID:31837371   PMID:32093570   PMID:32141576   PMID:32273498   PMID:32414840   PMID:32544365   PMID:32804155   PMID:32868073   PMID:32876528   PMID:32968282   PMID:32980459  
PMID:33109685   PMID:33255287   PMID:33448372   PMID:33450483   PMID:33461007   PMID:33669246   PMID:33743351   PMID:34242585   PMID:34278675   PMID:34287052   PMID:34658916   PMID:34749750  
PMID:34820053   PMID:35410572  


Genomics

Comparative Map Data
Ulk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,932,355 - 110,957,991 (-)NCBIGRCm39mm39
GRCm39 Ensembl5110,932,354 - 110,957,963 (-)Ensembl
GRCm385110,784,489 - 110,810,120 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,784,488 - 110,810,097 (-)EnsemblGRCm38mm10GRCm38
MGSCv375111,213,508 - 111,239,100 (-)NCBIGRCm37mm9NCBIm37
MGSCv365111,024,791 - 111,050,383 (-)NCBImm8
Celera5107,916,517 - 107,942,075 (-)NCBICelera
Cytogenetic Map5FNCBI
ULK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812131,894,622 - 131,923,150 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12131,894,622 - 131,923,150 (+)EnsemblGRCh38hg38GRCh38
GRCh3712132,379,167 - 132,407,695 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612130,945,232 - 130,973,649 (+)NCBINCBI36hg18NCBI36
Build 3412131,045,508 - 131,073,926NCBI
Celera12132,008,428 - 132,026,099 (+)NCBI
Cytogenetic Map12q24.33NCBI
HuRef12129,276,372 - 129,293,381 (+)NCBIHuRef
CHM1_112132,200,212 - 132,228,619 (+)NCBICHM1_1
T2T-CHM13v2.012131,939,343 - 131,971,098 (+)NCBI
Ulk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21245,851,710 - 45,877,966 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1245,851,710 - 45,877,966 (+)Ensembl
Rnor_6.01251,908,105 - 51,934,704 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,908,448 - 51,934,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01253,646,513 - 53,673,055 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,996,251 - 46,022,505 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1247,411,122 - 47,437,376 (+)NCBICelera
Cytogenetic Map12q16NCBI
Ulk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955482761,811 - 777,133 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955482760,200 - 777,133 (-)NCBIChiLan1.0ChiLan1.0
ULK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112133,980,316 - 134,007,687 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v012129,549,399 - 129,579,087 (+)NCBIMhudiblu_PPA_v0panPan3
ULK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126968,714 - 982,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26970,138 - 982,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,012,410 - 1,033,785 (-)NCBI
ROS_Cfam_1.0261,030,431 - 1,051,812 (-)NCBI
ROS_Cfam_1.0 Ensembl261,030,432 - 1,051,789 (-)Ensembl
UMICH_Zoey_3.126967,560 - 988,930 (-)NCBI
UNSW_CanFamBas_1.0261,064,168 - 1,085,536 (-)NCBI
UU_Cfam_GSD_1.026987,330 - 1,008,708 (-)NCBI
Ulk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118122,532,232 - 122,560,686 (-)NCBI
SpeTri2.0NW_0049366602,160,394 - 2,188,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ULK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1423,423,696 - 23,448,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11423,423,693 - 23,448,130 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21424,875,257 - 24,913,433 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ULK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111127,276,172 - 127,304,270 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl11127,276,210 - 127,304,497 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037117,654,277 - 117,669,065 (-)NCBIVero_WHO_p1.0
Ulk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474727,681,033 - 27,695,966 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474727,680,994 - 27,697,342 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AU041434  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385110,784,722 - 110,784,848UniSTSGRCm38
MGSCv375111,213,741 - 111,213,867UniSTSGRCm37
Celera5107,916,750 - 107,916,876UniSTS
Cytogenetic Map5FUniSTS
Whitehead/MRC_RH51351.2UniSTS
Ulk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385110,784,588 - 110,785,664UniSTSGRCm38
MGSCv375111,213,607 - 111,214,683UniSTSGRCm37
Celera5107,916,616 - 107,917,686UniSTS
Cytogenetic Map5FUniSTS
cM Map5 UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
10045978Tir10_mtrypanosome infection response 10 (mouse)Not determined598019649114021986Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined598019649116876624Mouse
1301877Bbaa3_mB.burgdorferi-associated arthritis 3 (mouse)Not determined599455285112465722Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
25314310Syncl4_msynaptonemal complex length 4 (mouse)5103047866115538059Mouse
25314317Sccor3_msynaptonemal complex length to mean MLH1 count ratio 3 (mouse)5104347866114738061Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104386871120711986Mouse
1357886Diht_mdopamine-induced hypothermia (mouse)Not determined5104498738115101540Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
1357901Mdmsc2_mmodifier of muscularity 2 (mouse)Not determined5107561006112434786Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141652Mrdq2_mmodifier of retinal degeneration QTL 2 (mouse)Not determined110253106118093673Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:768
Count of miRNA genes:447
Interacting mature miRNAs:535
Transcripts:ENSMUST00000031490
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001347394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006534852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000031490   ⟹   ENSMUSP00000031490
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,932,354 - 110,957,963 (-)Ensembl
GRCm38.p6 Ensembl5110,784,488 - 110,810,097 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196094   ⟹   ENSMUSP00000143380
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,933,866 - 110,935,811 (-)Ensembl
GRCm38.p6 Ensembl5110,786,000 - 110,787,945 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196440
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,940,262 - 110,943,663 (-)Ensembl
GRCm38.p6 Ensembl5110,792,396 - 110,795,797 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196883
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,939,539 - 110,941,271 (-)Ensembl
GRCm38.p6 Ensembl5110,791,673 - 110,793,405 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197768
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,936,123 - 110,937,332 (-)Ensembl
GRCm38.p6 Ensembl5110,788,257 - 110,789,466 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198470
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,941,467 - 110,943,700 (-)Ensembl
GRCm38.p6 Ensembl5110,793,601 - 110,795,834 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198561   ⟹   ENSMUSP00000143308
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,933,888 - 110,936,919 (-)Ensembl
GRCm38.p6 Ensembl5110,786,022 - 110,789,053 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199568
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,935,757 - 110,936,533 (-)Ensembl
GRCm38.p6 Ensembl5110,787,891 - 110,788,667 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199717
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,933,905 - 110,935,087 (-)Ensembl
GRCm38.p6 Ensembl5110,786,039 - 110,787,221 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200099
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,939,264 - 110,940,058 (-)Ensembl
GRCm38.p6 Ensembl5110,791,398 - 110,792,192 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200299   ⟹   ENSMUSP00000143536
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5110,933,960 - 110,957,919 (-)Ensembl
GRCm38.p6 Ensembl5110,786,094 - 110,810,053 (-)Ensembl
RefSeq Acc Id: NM_001347394   ⟹   NP_001334323
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395110,932,355 - 110,957,947 (-)NCBI
GRCm385110,784,489 - 110,810,081 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009469   ⟹   NP_033495
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395110,932,355 - 110,957,947 (-)NCBI
GRCm385110,784,489 - 110,810,081 (-)NCBI
MGSCv375111,213,508 - 111,239,100 (-)RGD
Celera5107,916,517 - 107,942,075 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006534852   ⟹   XP_006534915
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395110,932,355 - 110,941,669 (-)NCBI
GRCm385110,784,489 - 110,793,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249419   ⟹   XP_011247721
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395110,932,355 - 110,957,991 (-)NCBI
GRCm385110,784,489 - 110,810,120 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011249420   ⟹   XP_011247722
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395110,932,355 - 110,957,991 (-)NCBI
GRCm385110,784,489 - 110,810,119 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033495   ⟸   NM_009469
- Peptide Label: isoform 2
- UniProtKB: O70405 (UniProtKB/Swiss-Prot),   A0A0R4J0B3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006534915   ⟸   XM_006534852
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011247722   ⟸   XM_011249420
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011247721   ⟸   XM_011249419
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001334323   ⟸   NM_001347394
- Peptide Label: isoform 1
- UniProtKB: Q6PB82 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000143308   ⟸   ENSMUST00000198561
RefSeq Acc Id: ENSMUSP00000031490   ⟸   ENSMUST00000031490
RefSeq Acc Id: ENSMUSP00000143380   ⟸   ENSMUST00000196094
RefSeq Acc Id: ENSMUSP00000143536   ⟸   ENSMUST00000200299
Protein Domains
DUF3543   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70405-F1-model_v2 AlphaFold O70405 1-1051 view protein structure

Promoters
RGD ID:6887564
Promoter ID:EPDNEW_M7232
Type:initiation region
Name:Ulk1_1
Description:Mus musculus unc-51 like kinase 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385110,810,054 - 110,810,114EPDNEW
RGD ID:6838593
Promoter ID:MM_KWN:43392
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000031490,   ENSMUST00000112410,   UC008YRR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365111,238,809 - 111,239,309 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1270126 AgrOrtholog
Ensembl Genes ENSMUSG00000029512 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000031490 ENTREZGENE
  ENSMUSP00000031490.7 UniProtKB/TrEMBL
  ENSMUSP00000143308.2 UniProtKB/TrEMBL
  ENSMUSP00000143380.2 UniProtKB/TrEMBL
  ENSMUSP00000143536 ENTREZGENE
  ENSMUSP00000143536.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031490 ENTREZGENE
  ENSMUST00000031490.11 UniProtKB/TrEMBL
  ENSMUST00000196094.5 UniProtKB/TrEMBL
  ENSMUST00000198561.2 UniProtKB/TrEMBL
  ENSMUST00000200299 ENTREZGENE
  ENSMUST00000200299.2 UniProtKB/TrEMBL
InterPro Atg1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kin_STPK_Ulk-1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1270126 ENTREZGENE
NCBI Gene 22241 ENTREZGENE
PANTHER PTHR24348 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3543 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ulk1 PhenoGen
PIRSF Ser/Thr_PK_STPK_ULK-1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JFU2_MOUSE UniProtKB/TrEMBL
  A0A0G2JG09_MOUSE UniProtKB/TrEMBL
  A0A0R4J0B3 ENTREZGENE, UniProtKB/TrEMBL
  O70405 ENTREZGENE
  Q3U0V5_MOUSE UniProtKB/TrEMBL
  Q3U350_MOUSE UniProtKB/TrEMBL
  Q3UFT4_MOUSE UniProtKB/TrEMBL
  Q6PB82 ENTREZGENE, UniProtKB/TrEMBL
  Q80TT3_MOUSE UniProtKB/TrEMBL
  Q8K0Q7_MOUSE UniProtKB/TrEMBL
  ULK1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6PGB2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-05 Ulk1  unc-51 like kinase 1  Ulk1  Unc-51 like kinase 1 (C. elegans)  Symbol and/or name change 5135510 APPROVED