SMCR8 (SMCR8-C9orf72 complex subunit) - Rat Genome Database

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Gene: SMCR8 (SMCR8-C9orf72 complex subunit) Canis lupus familiaris
Analyze
Symbol: SMCR8
Name: SMCR8-C9orf72 complex subunit
RGD ID: 40908626
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN autophagy (inferred); negative regulation of autophagosome assembly (inferred); negative regulation of gene expression (inferred); ASSOCIATED WITH autistic disorder (ortholog); common variable immunodeficiency 2 (ortholog); genetic disease (ortholog); FOUND IN Atg1/ULK1 kinase complex (ortholog); guanyl-nucleotide exchange factor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: guanine nucleotide exchange protein SMCR8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.0541,356,732 - 41,369,920 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,361,422 - 41,369,287 (-)EnsemblROS_Cfam_1.0 Ensembl


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
SMCR8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.0541,356,732 - 41,369,920 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,361,422 - 41,369,287 (-)EnsemblROS_Cfam_1.0 Ensembl
SMCR8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,315,293 - 18,328,056 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,315,293 - 18,328,056 (+)EnsemblGRCh38hg38GRCh38
GRCh371718,218,607 - 18,231,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,159,319 - 18,172,095 (+)NCBINCBI36Build 36hg18NCBI36
Build 341718,159,440 - 18,167,109NCBI
Celera1719,159,665 - 19,172,441 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,972,126 - 17,984,902 (+)NCBIHuRef
CHM1_11718,227,353 - 18,240,129 (+)NCBICHM1_1
T2T-CHM13v2.01718,262,099 - 18,274,862 (+)NCBIT2T-CHM13v2.0
Smcr8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,668,351 - 60,679,113 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,668,350 - 60,679,113 (+)EnsemblGRCm39 Ensembl
GRCm381160,777,525 - 60,788,287 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,777,524 - 60,788,287 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,591,027 - 60,601,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,593,737 - 60,597,262 (+)NCBIMGSCv36mm8
MGSCv361161,208,627 - 61,212,152 (+)NCBIMGSCv36mm8
Cytogenetic Map11B2NCBI
cM Map1137.83NCBI
Smcr8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,957,146 - 45,968,388 (+)NCBIGRCr8
mRatBN7.21045,457,962 - 45,465,101 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,457,605 - 45,468,876 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,159,207 - 50,166,360 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,649,603 - 49,656,756 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,153,192 - 45,160,345 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,019,326 - 47,026,465 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,018,974 - 47,026,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,791,502 - 46,798,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,924,224 - 46,931,363 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,712,528 - 44,719,666 (+)NCBICelera
Cytogenetic Map10q22NCBI
Smcr8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547811,002,174 - 11,015,123 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547811,002,174 - 11,015,123 (-)NCBIChiLan1.0ChiLan1.0
SMCR8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21952,939,905 - 52,952,684 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11757,651,042 - 57,663,823 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01732,858,205 - 32,871,132 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11737,884,037 - 37,897,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1737,884,037 - 37,896,972 (-)Ensemblpanpan1.1panPan2
Smcr8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,018,506 - 61,028,302 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,838,834 - 1,844,459 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,838,974 - 1,848,742 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMCR8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,435,273 - 60,443,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,435,276 - 60,443,525 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SMCR8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,358,952 - 17,367,323 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,359,577 - 17,366,851 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660593,537,962 - 3,546,697 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smcr8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,149,121 - 3,159,273 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,147,251 - 3,159,358 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845035676   ⟹   ENSCAFP00845027913
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl541,361,422 - 41,369,287 (-)Ensembl
RefSeq Acc Id: XM_038665784   ⟹   XP_038521712
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0541,356,732 - 41,369,915 (-)NCBI
RefSeq Acc Id: XM_038665785   ⟹   XP_038521713
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0541,361,695 - 41,369,920 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038521712 (Get FASTA)   NCBI Sequence Viewer  
  XP_038521713 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000026969.2
  ENSCAFP00030000693.1
  ENSCAFP00040004086.1
  ENSCAFP00845027913
  ENSCAFP00845027913.1
Reference Protein Sequences
RefSeq Acc Id: XP_038521712   ⟸   XM_038665784
- Peptide Label: isoform X1
- UniProtKB: A0A8C0R9I0 (UniProtKB/TrEMBL),   A0A8C0L4K3 (UniProtKB/TrEMBL),   A0A8I3P118 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038521713   ⟸   XM_038665785
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845027913   ⟸   ENSCAFT00845035676
Protein Domains
uDENN FLCN/SMCR8-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018255 UniProtKB/TrEMBL
  ENSCAFG00030000491 UniProtKB/TrEMBL
  ENSCAFG00040002498 UniProtKB/TrEMBL
  ENSCAFG00845020264 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029000.4 UniProtKB/TrEMBL
  ENSCAFT00030000805.1 UniProtKB/TrEMBL
  ENSCAFT00040004762.1 UniProtKB/TrEMBL
  ENSCAFT00845035676 ENTREZGENE
  ENSCAFT00845035676.1 UniProtKB/TrEMBL
InterPro FLCN/SMCR8_DENN UniProtKB/TrEMBL
  Folliculin/SMCR8_longin UniProtKB/TrEMBL
NCBI Gene SMCR8 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE PROTEIN SMCR8 UniProtKB/TrEMBL
  SMITH-MAGENIS SYNDROME REGION GENE 8 PROTEIN UniProtKB/TrEMBL
Pfam Folliculin UniProtKB/TrEMBL
PROSITE DENN_FLCN_SMCR8 UniProtKB/TrEMBL
UniProt A0A8C0L4K3 ENTREZGENE
  A0A8C0R9I0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P118 ENTREZGENE, UniProtKB/TrEMBL