| 3728 | Snap25 | synaptosome associated protein 25 | ENCODES a protein that exhibits calcium-dependent protein binding; myosin binding; protein domain specific binding; INVOLVED IN axonogenesis; calcium ion-regulated exocytosis of neurotransmitter; endosomal transport; PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH attention deficit hypera ctivity disorder (ortholog); bipolar disorder (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN actin cytoskeleton; axon; axonal growth cone; INTERACTS WITH 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 3,3',5,5'-tetrabromobisphenol A | 3 | 144494579 | 144576449 | Rat | 359 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 734151 | SNAP25 | synaptosome associated protein 25 | Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one o f which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] | 20 | 10218830 | 10307418 | Human | 432 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 734152 | Snap25 | synaptosomal-associated protein 25 | Enables SNAP receptor activity and syntaxin-1 binding activity. Involved in presynaptic dense core vesicle exocytosis and regulation of neuron projection development. Acts upstream of or within several processes, including associative learning; long-term synaptic potentiation; and neurotransmitter s ecretion. Located in several cellular components, including presynaptic membrane; synaptic vesicle; and trans-Golgi network. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Is active in glutamatergic synapse. Is expressed in adrenal gland; jaw; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; obesity; schizophrenia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 136555359 | 136624348 | Mouse | 426 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8936614 | Snap25 | synaptosome associated protein 25 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); lipid binding (ortholog); myosin binding (ortholog); INVOLVED IN associative learning (ortholog); axonogenesis (ortholog); calcium ion-regulated exocytosis of neurotransmitter (ortholog); PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); bipolar disorder (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); axon (ortholog); axonal growth cone (ortholog) | NW_004955415 | 20133361 | 20218840 | Chinchilla | 180 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12022102 | SNAP25 | synaptosome associated protein 25 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); lipid binding (ortholog); myosin binding (ortholog); INVOLVED IN associative learning (ortholog); axonogenesis (ortholog); calcium ion-regulated exocytosis of neurotransmitter (ortholog); PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); bipolar disorder (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); axonal growth cone (ortholog); endosome (ortholog) | 20 | 10164236 | 10252856 | Bonobo | 189 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12081542 | SNAP25 | synaptosome associated protein 25 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); lipid binding (ortholog); myosin binding (ortholog); INVOLVED IN associative learning (ortholog); axonogenesis (ortholog); calcium ion-regulated exocytosis of neurotransmitter (ortholog); PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); bipolar disorder (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); axonal growth cone (ortholog); endosome (ortholog) | 24 | 12003005 | 12081385 | Dog | 177 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12539048 | Snap25 | synaptosome associated protein 25 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); lipid binding (ortholog); myosin binding (ortholog); INVOLVED IN associative learning (ortholog); axonogenesis (ortholog); calcium ion-regulated exocytosis of neurotransmitter (ortholog); PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); bipolar disorder (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); axonal growth cone (ortholog); endosome (ortholog) | NW_004936485 | 9198744 | 9279854 | Squirrel | 186 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14098519 | SNAP25 | synaptosome associated protein 25 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); lipid binding (ortholog); myosin binding (ortholog); INVOLVED IN associative learning (ortholog); axonogenesis (ortholog); calcium ion-regulated exocytosis of neurotransmitter (ortholog); PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); bipolar disorder (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); axonal growth cone (ortholog); endosome (ortholog) | | | | Pig | 179 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14386628 | Snap25 | | | | | | Fly | | symbol | gene, null |
| 18616293 | SNAP25 | synaptosome associated protein 25 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); lipid binding (ortholog); myosin binding (ortholog); INVOLVED IN associative learning (ortholog); axonogenesis (ortholog); calcium ion-regulated exocytosis of neurotransmitter (ortholog); PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); bipolar disorder (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); axonal growth cone (ortholog); endosome (ortholog) | | | | Green Monkey | 187 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911764 | Snap25 | synaptosome associated protein 25 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); lipid binding (ortholog); myosin binding (ortholog); INVOLVED IN associative learning (ortholog); axonogenesis (ortholog); calcium ion-regulated exocytosis of neurotransmitter (ortholog); PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); bipolar disorder (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); axonal growth cone (ortholog); BLOC-1 complex (ortholog) | | | | Naked Mole-Rat | 188 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155236589 | snap25 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625948826 | Snap25 | synaptosome associated protein 25 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); lipid binding (ortholog); myosin binding (ortholog); INVOLVED IN associative learning (ortholog); axonogenesis (ortholog); calcium ion-regulated exocytosis of neurotransmitter (ortholog); PARTICIPATES IN insulin secretion pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); bipolar disorder (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); axon (ortholog); axonal growth cone (ortholog) | | | | Black Rat | 179 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248957 | snap25.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236590 | snap25.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6893014 | SNAP25-AS1 | SNAP25 antisense RNA 1 | Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 10023812 | 10219506 | Human | 11 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 708439 | Srcin1 | SRC kinase signaling inhibitor 1 | ENCODES a protein that exhibits protein domain specific binding; protein kinase binding (ortholog); INVOLVED IN behavioral response to cocaine; conditioned place preference; negative regulation of protein secretion; ASSOCIATED WITH cocaine dependence; Cocaine-Related Disorders (ortholog); FOUND IN a ctin cytoskeleton; axon; dendrite; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide | 10 | 82999295 | 83066359 | Rat | 145 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1606779 | SRCIN1 | SRC kinase signaling inhibitor 1 | Enables protein kinase binding activity. Involved in several processes, including postsynaptic actin cytoskeleton organization; regulation of protein tyrosine kinase activity; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and cytoplasm. Is active in glutamatergic syn apse. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 38530031 | 38607025 | Human | 134 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 628671 | Zwint | ZW10 interacting kinetochore protein | INVOLVED IN establishment of localization in cell (ortholog); homologous chromosome orientation in meiotic metaphase I (ortholog); mitotic sister chromatid segregation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN dendrite; cytoplasm (ortholog); cytos ol (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 20 | 15502559 | 15953701 | Rat | 233 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1347195 | ZWINT | ZW10 interacting kinetochore protein | This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 10 | 56357227 | 56361273 | Human | 234 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1321311 | NIPSNAP1 | nipsnap homolog 1 | This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011] | 22 | 29554808 | 29581113 | Human | 132 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1345241 | NIPSNAP2 | nipsnap homolog 2 | This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. The encoded protein is localized to mitochondria and plays a role in oxidative phosphorylation. A pseudogene of this gene is located on the long arm of chromosome 2. Alternatively spliced transc ript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011] | 7 | 55964585 | 56000179 | Human | 90 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1310419 | Nipsnap1 | nipsnap homolog 1 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); INVOLVED IN mitophagy (ortholog); sensory perception of pain (ortholog); FOUND IN membrane (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestrad iol; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 83957714 | 83981579 | Rat | 136 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1321312 | Nipsnap1 | nipsnap homolog 1 | Predicted to enable protein-macromolecule adaptor activity. Involved in mitophagy and sensory perception of pain. Located in membrane and mitochondrion. Is active in synaptic membrane. Is expressed in several structures, including gonad; gut; nervous system; submandibular gland primordium; and tooth . Orthologous to human NIPSNAP1 (nipsnap homolog 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 4823951 | 4844201 | Mouse | 139 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1604652 | SNAP23 | synaptosome associated protein 23 | Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associat ed protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] | 15 | 42491129 | 42533058 | Human | 161 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1615164 | Snapin | SNAP-associated protein | Predicted to enable SNARE binding activity. Involved in anterograde synaptic vesicle transport; negative regulation of neuron projection development; and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including lysosomal lumen acidification; terminal button organization; and vesicle organization. Located in acrosomal vesicle; cytosol; and manchette. Part of BLOC-1 complex. Is active in microvesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SNAPIN (SNAP associated protein). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 90395333 | 90398320 | Mouse | 166 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735746 | SNAP29 | synaptosome associated protein 29 | This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and med iate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008] | 22 | 20859007 | 20891214 | Human | 206 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737072 | ITSN1 | intersectin 1 | The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle re cycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008] | 21 | 33642501 | 33899861 | Human | 255 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1314155 | SNPH | syntaphilin | Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Exp ression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] | 20 | 1266294 | 1309327 | Human | 65 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 736120 | VAMP1 | vesicle associated membrane protein 1 | Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014] | 12 | 6462237 | 6470677 | Human | 246 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735448 | VAMP2 | vesicle associated membrane protein 2 | The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in th e docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008] | 17 | 8159147 | 8162948 | Human | 274 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1320258 | VAMP4 | vesicle associated membrane protein 4 | Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a mem ber of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008] | 1 | 171700160 | 171742065 | Human | 126 | description | gene, protein-coding, REVIEWED [RefSeq] |
