| 1311754 | Prc1 | protein regulator of cytokinesis 1 | ENCODES a protein that exhibits identical protein binding (ortholog); kinesin binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of cell population proliferation (ortholog); regulation of cytokinesis (ortholog); ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hepatocellular carcinoma (ortholog); FOUND IN contractile ring (ortholog); microtubule cytoskeleton (ortholog); midbody (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 1 | 143659312 | 143681019 | Rat | 251 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1323372 | PRC1 | protein regulator of cytokinesis 1 | This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mit otic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] | 15 | 90966040 | 90994535 | Human | 261 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323373 | Prc1 | protein regulator of cytokinesis 1 | Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell population proliferation; and regulation of cytokinesis. Predicted to act upst ream of or within microtubule bundle formation. Predicted to be located in several cellular components, including contractile ring; intercellular bridge; and midbody. Predicted to be active in cytoplasm and mitotic spindle midzone. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 79944224 | 79966007 | Mouse | 271 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8776633 | Prc1 | protein regulator of cytokinesis 1 | ENCODES a protein that exhibits identical protein binding (ortholog); kinesin binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of cell population proliferation (ortholog); regulation of cytokinesis (ortholog); ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hepatocellular carcinoma (ortholog); FOUND IN contractile ring (ortholog); microtubule cytoskeleton (ortholog); midbody (ortholog) | NW_004955416 | 15023620 | 15045958 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12044263 | PRC1 | protein regulator of cytokinesis 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN microtubule cytoskeleton organization (inferred); mitotic spindle midzone assembly (inferred); positive regulation of cell population proliferation (inferred); ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hepatocellular carcinoma (ortholog); FOUND IN contractile ring (inferred); cytoplasm (inferred); microtubule cytoskeleton (inferred) | 15 | 69659420 | 69687707 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12244611 | PRC1 | protein regulator of cytokinesis 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN microtubule cytoskeleton organization (inferred); positive regulation of cell population proliferation (inferred); regulation of cytokinesis (inferred); ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neopla sms (ortholog); hepatocellular carcinoma (ortholog); FOUND IN contractile ring (inferred); microtubule cytoskeleton (inferred); midbody (inferred) | 3 | 53252893 | 53279717 | Dog | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12444766 | Prc1 | protein regulator of cytokinesis 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN microtubule cytoskeleton organization (inferred); mitotic spindle midzone assembly (inferred); positive regulation of cell population proliferation (inferred); ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hepatocellular carcinoma (ortholog); FOUND IN contractile ring (inferred); cytoplasm (inferred); microtubule cytoskeleton (inferred) | NW_004936483 | 16034577 | 16061856 | Squirrel | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13981299 | PRC1 | protein regulator of cytokinesis 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN microtubule cytoskeleton organization (inferred); positive regulation of cell population proliferation (inferred); protein transport (inferred); ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ort holog); hepatocellular carcinoma (ortholog); FOUND IN clathrin-coated vesicle (inferred); contractile ring (inferred); late endosome membrane (inferred); INTERACTS WITH cadmium atom | | | | Pig | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14371762 | PRC1 | | | | | | Yeast | | symbol | gene, null |
| 18665280 | PRC1 | protein regulator of cytokinesis 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN microtubule cytoskeleton organization (inferred); mitotic spindle midzone assembly (inferred); positive regulation of cell population proliferation (inferred); ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hepatocellular carcinoma (ortholog); FOUND IN contractile ring (inferred); cytoplasm (inferred); microtubule cytoskeleton (inferred) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932892 | Prc1 | protein regulator of cytokinesis 1 | ENCODES a protein that exhibits identical protein binding (ortholog); kinesin binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of cell population proliferation (ortholog); regulation of cytokinesis (ortholog); ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hepatocellular carcinoma (ortholog); FOUND IN contractile ring (ortholog); microtubule cytoskeleton (ortholog); midbody (ortholog) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233748 | prc1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625841134 | Prc1 | protein regulator of cytokinesis 1 | ENCODES a protein that exhibits identical protein binding (ortholog); kinesin binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of cell population proliferation (ortholog); regulation of cytokinesis (ortholog); ASSOCIATED WITH Breast Cancer, Familial (ortholog); Breast Neoplasms (ortholog); hepatocellular carcinoma (ortholog); FOUND IN contractile ring (ortholog); microtubule cytoskeleton (ortholog); midbody (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236197 | prc1.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155233747 | prc1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236451 | prc1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7245141 | PRC1-AS1 | PRC1 antisense RNA 1 | INTERACTS WITH all-trans-retinoic acid; cadmium atom; cadmium dichloride | 15 | 90966369 | 90988624 | Human | 4 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 2322676 | Prc1-ps1 | protein regulator of cytokinesis 1, pseudogene 1 | | 17 | 26035253 | 26037167 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 155243730 | prc1.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244269 | prc1.2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 407447809 | TBC1D3 | TBC1 domain family member 3 | Predicted to enable GTPase activator activity. Predicted to be located in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 38181659 | 38192555 | Human | 19 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1605183 | TBC1D3B | TBC1 domain family member 3B | This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are multiple copies of this gene located within a cluster of chemokin e genes on chromosome 17q. [provided by RefSeq, Apr 2009] | 17 | 36165683 | 36176636 | Human | 14 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1605182 | TBC1D3C | TBC1 domain family member 3C | This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014] | 17 | 38057693 | 38070301 | Human | 14 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 11568725 | TBC1D3D | TBC1 domain family member 3D | Predicted to enable GTPase activator activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 38002322 | 38014908 | Human | 8 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10059095 | TBC1D3E | TBC1 domain family member 3E | Predicted to enable GTPase activator activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 38124106 | 38138868 | Human | 17 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1604121 | TBC1D3F | TBC1 domain family member 3F | Predicted to enable GTPase activator activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 36428612 | 36439521 | Human | 18 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1602782 | TBC1D3I | TBC1 domain family member 3I | Predicted to enable GTPase activator activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 36253639 | 36264604 | Human | 6 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1316582 | Bmi1 | Bmi1 polycomb ring finger protot-oncogene | Enables promoter-specific chromatin binding activity and ubiquitin-protein transferase activator activity. Involved in positive regulation of B cell proliferation and positive regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including chordate embr yonic development; negative regulation of macromolecule biosynthetic process; and regulation of adaxial/abaxial pattern formation. Located in heterochromatin and nuclear body. Part of PRC1 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 18681953 | 18691440 | Mouse | 443 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1348038 | BMI1 | BMI1 proto-oncogene, polycomb ring finger | This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and se lf-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015] | 10 | 22321099 | 22331706 | Human | 251 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1348844 | CBX4 | chromobox 4 | Enables SUMO binding activity; SUMO ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocel lular carcinoma. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 79833156 | 79839440 | Human | 190 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1353483 | CBX7 | chromobox 7 | This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefS eq, Oct 2016] | 22 | 39130772 | 39152680 | Human | 179 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1550491 | Cbx7 | chromobox 7 | Enables chromatin binding activity; histone H3K9me2/3 reader activity; and single-stranded RNA binding activity. Acts upstream of or within sebaceous gland development. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in brain. Human or tholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 79800005 | 79855344 | Mouse | 179 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1351003 | CBX8 | chromobox 8 | Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma. [provided by Alliance of Genome Resources, Apr 2025] | 17 | 79792132 | 79797077 | Human | 124 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1558087 | Cbx8 | chromobox 8 | Enables single-stranded RNA binding activity and ubiquitin-protein transferase activator activity. Predicted to be involved in positive regulation of cell population proliferation; positive regulation of collagen biosynthetic process; and regulation of nucleobase-containing compound metabolic proces s. Predicted to act upstream of or within heterochromatin formation. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in several structures, including brain. Orthologous to human CBX8 (chromobox 8). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 118929262 | 118931739 | Mouse | 113 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2302260 | CDKN2B-AS1 | CDKN2B and CDKN2A antisense cis and trans regulatory RNA 1 | This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. T his region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014] | 9 | 21994791 | 22128142 | Human | 19 | description | gene, ncrna, REVIEWED [RefSeq] |
| 12348534 | COMMD3 | COMM domain containing 3 | ENCODES a protein that exhibits metal ion binding (inferred); promoter-specific chromatin binding (inferred); zinc ion binding (inferred); INVOLVED IN chromatin organization (inferred); DNA-templated transcription (inferred); negative regulation of gene expression, epigenetic (inferred); FOUND IN nu cleus (inferred); PRC1 complex (inferred) | 2 | 10829693 | 10833643 | Dog | 20 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18925441 | LOC101712616 | polyhomeotic-like protein 1 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); histone binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); FOUND IN nucleus (inferred); PRC1 complex (inferred) | | | | Naked Mole-Rat | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 1550113 | Pcgf2 | polycomb group ring finger 2 | Enables chromatin binding activity. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; chordate embryonic development; and negative regulation of transcription by RNA polymerase II. Located in nuclear body and sex chromatin. Part of PRC1 ht:700;'>PRC1 complex. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; eye; and genitourinary system. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 97579647 | 97593260 | Mouse | 197 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1306904 | Pcgf6 | polycomb group ring finger 6 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN chromatin remodeling (ortholog); negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN histone modific ation pathway; FOUND IN nucleus (ortholog); PcG protein complex (ortholog); PRC1 complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 1 | 255866709 | 255886306 | Rat | 74 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8762010 | Pcgf6 | polycomb group ring finger 6 | INVOLVED IN chromatin remodeling (ortholog); negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN nucleus (ortholog); PcG protein complex (ortholog); PRC1 nt-weight:700;'>PRC1 complex (ortholog) | NW_004955485 | 7196626 | 7228918 | Chinchilla | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12027300 | PCGF6 | polycomb group ring finger 6 | INVOLVED IN chromatin remodeling (ortholog); negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN nucleus (ortholog); PcG protein complex (ortholog); PRC1 nt-weight:700;'>PRC1 complex (ortholog) | 10 | 99901760 | 99949733 | Bonobo | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12602749 | Pcgf6 | polycomb group ring finger 6 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN chromatin remodeling (inferred); DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); PARTICIPATES IN histone modification pathway; FOUND IN nucleu s (inferred); PcG protein complex (inferred); PRC1 complex (inferred) | NW_004936600 | 2714883 | 2741418 | Squirrel | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 14253804 | PCGF6 | polycomb group ring finger 6 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN chromatin remodeling (inferred); DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); PARTICIPATES IN histone modification pathway; FOUND IN nucleu s (inferred); PcG protein complex (inferred); PRC1 complex (inferred) | | | | Pig | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 18456849 | PCGF6 | polycomb group ring finger 6 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN chromatin remodeling (inferred); DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (inferred); PARTICIPATES IN histone modification pathway; FOUND IN nucleu s (inferred); PcG protein complex (inferred); PRC1 complex (inferred) | | | | Green Monkey | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 18929971 | Pcgf6 | polycomb group ring finger 6 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN chromatin remodeling (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN PRC1 an> complex (ortholog) | | | | Naked Mole-Rat | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 626105294 | Pcgf6 | polycomb group ring finger 6 | INVOLVED IN chromatin remodeling (ortholog); negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN nucleus (ortholog); PcG protein complex (ortholog); PRC1 nt-weight:700;'>PRC1 complex (ortholog) | | | | Black Rat | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 1317381 | Phc2 | polyhomeotic 2 | Predicted to enable chromatin binding activity; histone binding activity; and identical protein binding activity. Acts upstream of or within spermatogenesis. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in several structures, includ ing central nervous system and retina nuclear layer. Orthologous to human PHC2 (polyhomeotic homolog 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 128548448 | 128646674 | Mouse | 165 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1317513 | PHC3 | polyhomeotic homolog 3 | Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of PRC1 complex. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 170087584 | 170181733 | Human | 101 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1332085 | Ring1 | ring finger protein 1 | Enables chromatin binding activity and ubiquitin-protein transferase activator activity. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within anterior/posterior pattern specification; camera-type eye morphogenesis; and negative regulation of DNA-tem plated transcription. Located in nuclear body and sex chromatin. Part of PRC1 complex. Is expressed in several structures, including central nervous system; epithelium; hemolymphoid system; reproductive system; and urinary system. Orthologous to human RING1 (ring finger protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 34239766 | 34243654 | Mouse | 118 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11865784 | RING1 | ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (inferred); metal ion binding (inferred); transferase activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); camera-type eye morphogenesis (ortholog); chromatin organization (ortholog); PARTICIPATES IN histone modificat ion pathway; FOUND IN PcG protein complex (ortholog); PRC1 complex (ortholog) | 6 | 32780699 | 32784922 | Bonobo | 67 | description | gene, protein-coding, MODEL [RefSeq] |
| 12236321 | RING1 | ring finger protein 1 | ENCODES a protein that exhibits chromatin binding (inferred); metal ion binding (inferred); transferase activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); camera-type eye morphogenesis (ortholog); chromatin organization (ortholog); PARTICIPATES IN histone modificat ion pathway; FOUND IN PcG protein complex (ortholog); PRC1 complex (ortholog) | 12 | 2671578 | 2675488 | Dog | 67 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313549 | Rnf2 | ring finger protein 2 | Enables chromatin binding activity and histone H2AK119 ubiquitin ligase activity. Involved in germ cell development and negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within with a negative e ffect on gene expression. Acts upstream of or within anterior/posterior axis specification; gastrulation with mouth forming second; and mitotic cell cycle. Located in euchromatin; nuclear body; and sex chromatin. Part of PRC1 complex. Is active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; limb; and retina. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 151345159 | 151376562 | Mouse | 201 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1310271 | Samd11 | sterile alpha motif domain containing 11 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); PH domain binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); retinal rod cell development (ort holog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN nucleus (ortholog); PRC1 complex (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 172113900 | 172142026 | Rat | 93 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1353453 | SAMD11 | sterile alpha motif domain containing 11 | Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and retinal rod cell development. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025] | 1 | 923923 | 944574 | Human | 127 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1616550 | Samd11 | sterile alpha motif domain containing 11 | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and protein domain specific binding activity. Involved in retinal rod cell development. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PRC1 complex. Is expressed in photoreceptor layer; pineal gland; retina; retina layer; and retina outer nuclear layer. Orthologous to human SAMD11 (sterile alpha motif domain containing 11). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 156331423 | 156342409 | Mouse | 85 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8738402 | Samd11 | sterile alpha motif domain containing 11 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); PH domain binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); retinal rod cell development (ort holog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN nucleus (ortholog); PRC1 complex (ortholog) | NW_004955486 | 9763704 | 9781132 | Chinchilla | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 11911408 | SAMD11 | sterile alpha motif domain containing 11 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); PH domain binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); retinal rod cell development (ort holog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN nucleus (ortholog); PRC1 complex (ortholog) | | | | Bonobo | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12179255 | SAMD11 | sterile alpha motif domain containing 11 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); PH domain binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); retinal rod cell development (ort holog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN nucleus (ortholog); PRC1 complex (ortholog) | 5 | 56119207 | 56175267 | Dog | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 14240079 | SAMD11 | sterile alpha motif domain containing 11 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); PH domain binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); retinal rod cell development (ort holog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN nucleus (ortholog); PRC1 complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 18453159 | SAMD11 | sterile alpha motif domain containing 11 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); PH domain binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); retinal rod cell development (ort holog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN nucleus (ortholog); PRC1 complex (ortholog) | | | | Green Monkey | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 18933410 | Samd11 | sterile alpha motif domain containing 11 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); PH domain binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); retinal rod cell development (ort holog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN nucleus (ortholog); PRC1 complex (ortholog) | | | | Naked Mole-Rat | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 625916867 | Samd11 | sterile alpha motif domain containing 11 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); PH domain binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); retinal rod cell development (ort holog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); fundus dystrophy (ortholog); optic atrophy (ortholog); FOUND IN nucleus (ortholog); PRC1 complex (ortholog) | | | | Black Rat | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 1308931 | Samd7 | sterile alpha motif domain containing 7 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN negative regulation of gene expression (ortholog); negative regulation of gene expression, epigenetic (ortholog); retinal rod cell development (ortholog); ASSOCIATED WITH macular degeneration (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); PRC1 complex (ortholog); INTERACTS WITH bisphenol A; glyphosate; aflatoxin B1 (ortholog) | 2 | 114551633 | 114572774 | Rat | 30 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1318984 | SAMD7 | sterile alpha motif domain containing 7 | Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding activity; and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription; negative regulation of gene expression, epigenetic; and retinal rod cell development. Predicted to be located in cytoplasm. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. Implicated in macular degeneration. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 169911572 | 169939175 | Human | 41 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1553081 | Samd7 | sterile alpha motif domain containing 7 | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of gene expression, epigenetic and retinal rod cell development. Located in cytoplasm and nucleus. Part of PRC1 complex. Is expressed in central ner vous system; dorsal root ganglion; liver; metanephros; and neural retina. Human ortholog(s) of this gene implicated in macular degeneration. Orthologous to human SAMD7 (sterile alpha motif domain containing 7). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 30800481 | 30821323 | Mouse | 39 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9049852 | Samd7 | sterile alpha motif domain containing 7 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN negative regulation of gene expression (ortholog); negative regulation of gene expression, epigenetic (ortholog); retinal rod cell development (ortholog); ASSOCIATED WITH macular degeneration (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); PRC1 complex (ortholog) | NW_004955420 | 161353 | 178768 | Chinchilla | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 11724201 | SAMD7 | sterile alpha motif domain containing 7 | ENCODES a protein that exhibits chromatin binding (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); histone binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); negative regulation of gene expression (inferred); negative regulation of gene expression, epigenetic (inferred); ASSOCIATED WITH macular degeneration (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); PRC1 complex (inferred) | 3 | 166914164 | 166952937 | Bonobo | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 12249711 | SAMD7 | sterile alpha motif domain containing 7 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN negative regulation of gene expression (inferred); negative regulation of gene expression, epigenetic (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH macular degeneration (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); PRC1 complex (inferred) | 34 | 34518133 | 34537516 | Dog | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 12703112 | Samd7 | sterile alpha motif domain containing 7 | ENCODES a protein that exhibits chromatin binding (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); histone binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); negative regulation of gene expression (inferred); negative regulation of gene expression, epigenetic (inferred); ASSOCIATED WITH macular degeneration (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); PRC1 complex (inferred) | NW_004936593 | 2475199 | 2500593 | Squirrel | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 14076004 | SAMD7 | sterile alpha motif domain containing 7 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN negative regulation of gene expression (inferred); negative regulation of gene expression, epigenetic (inferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH macular degeneration (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); PRC1 complex (inferred) | | | | Pig | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 18535941 | SAMD7 | sterile alpha motif domain containing 7 | ENCODES a protein that exhibits chromatin binding (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); histone binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); negative regulation of gene expression (inferred); negative regulation of gene expression, epigenetic (inferred); ASSOCIATED WITH macular degeneration (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); PRC1 complex (inferred) | | | | Green Monkey | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 18918423 | Samd7 | sterile alpha motif domain containing 7 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN negative regulation of gene expression (ortholog); negative regulation of gene expression, epigenetic (ortholog); retinal rod cell development (ortholog); ASSOCIATED WITH macular degeneration (ortholog); FOUND IN cytoplasm (ortholog); PRC1 complex (ortholog) | | | | Naked Mole-Rat | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 625878008 | Samd7 | sterile alpha motif domain containing 7 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN negative regulation of gene expression (ortholog); negative regulation of gene expression, epigenetic (ortholog); retinal rod cell development (ortholog); ASSOCIATED WITH macular degeneration (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); PRC1 complex (ortholog) | | | | Black Rat | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 1619223 | Suz12 | SUZ12 polycomb repressive complex 2 subunit | This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009] | 11 | 79883932 | 79924949 | Mouse | 233 | description | gene, protein-coding, REVIEWED [RefSeq] |