Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CDKN2B-AS1 (CDKN2B antisense RNA 1) Homo sapiens
Analyze
Symbol: CDKN2B-AS1
Name: CDKN2B antisense RNA 1
Description: This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]
Type: ncrna
RefSeq Status: REVIEWED
Also known as: ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; p15AS; PCAT12; RP11-145E5.4
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38921,994,791 - 22,121,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37921,994,790 - 22,121,096 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,984,790 - 22,111,094 (+)NCBINCBI36hg18NCBI36
Celera921,933,158 - 22,059,452 (+)NCBI
Cytogenetic Map9p21.3NCBI
HuRef921,958,059 - 22,084,368 (+)NCBIHuRef
CHM1_1921,994,619 - 22,120,920 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
References - uncurated

Genomics

Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CDKN2B-AS1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2302260
Created: 2008-12-05
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.