Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Phc2 | Mouse | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of PHC2 mRNA | CTD | PMID:17555576 | Phc2 | Mouse | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of PHC2 mRNA | CTD | PMID:17942748 | Phc2 | Mouse | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHC2 mRNA | CTD | PMID:17942748 | Phc2 | Mouse | 17beta-estradiol | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [Estradiol co-treated with Norethindrone Acetate] results in increased expression of PHC2 mRNA | CTD | PMID:22217510 | Phc2 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHC2 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PHC2 gene] | CTD | PMID:17942748 and PMID:20819909 | Phc2 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Phc2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PHC2 mRNA | CTD | PMID:34747641 | Phc2 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PHC2 mRNA | CTD | PMID:21570461 | Phc2 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PHC2 mRNA | CTD | PMID:17942748 and PMID:20819909 | Phc2 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PHC2 mRNA | CTD | PMID:20159946 | Phc2 | Mouse | 2,4-dinitrotoluene | affects expression | ISO | Phc2 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of PHC2 mRNA | CTD | PMID:21346803 | Phc2 | Mouse | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHC2 mRNA | CTD | PMID:28628672 | Phc2 | Mouse | 4,4'-sulfonyldiphenol | decreases methylation | EXP | | 6480464 | bisphenol S results in decreased methylation of PHC2 exon | CTD | PMID:33297965 | Phc2 | Mouse | 4,4'-sulfonyldiphenol | affects methylation | EXP | | 6480464 | bisphenol S affects the methylation of PHC2 gene | CTD | PMID:31683443 | Phc2 | Mouse | aflatoxin B1 | decreases methylation | ISO | PHC2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PHC2 gene | CTD | PMID:27153756 | Phc2 | Mouse | Aflatoxin B2 alpha | decreases methylation | ISO | PHC2 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of PHC2 exon | CTD | PMID:30157460 | Phc2 | Mouse | arsane | affects methylation | ISO | PHC2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PHC2 gene | CTD | PMID:25304211 | Phc2 | Mouse | arsenic atom | affects methylation | ISO | PHC2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PHC2 gene | CTD | PMID:25304211 | Phc2 | Mouse | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of PHC2 mRNA | CTD | PMID:22228805 | Phc2 | Mouse | benzo[a]pyrene | decreases methylation | ISO | PHC2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PHC2 5' UTR | CTD | PMID:27901495 | Phc2 | Mouse | bisphenol A | increases expression | ISO | Phc2 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PHC2 mRNA | CTD | PMID:25181051 more ... | Phc2 | Mouse | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PHC2 mRNA | CTD | PMID:32156529 and PMID:33221593 | Phc2 | Mouse | bisphenol A | affects expression | ISO | PHC2 (Homo sapiens) | 6480464 | bisphenol A affects the expression of PHC2 mRNA | CTD | PMID:30903817 | Phc2 | Mouse | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of PHC2 promoter | CTD | PMID:27312807 | Phc2 | Mouse | bisphenol F | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHC2 mRNA | CTD | PMID:28628672 | Phc2 | Mouse | C60 fullerene | increases expression | ISO | Phc2 (Rattus norvegicus) | 6480464 | fullerene C60 results in increased expression of PHC2 mRNA | CTD | PMID:19167457 | Phc2 | Mouse | cadmium dichloride | decreases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of PHC2 mRNA | CTD | PMID:38568856 | Phc2 | Mouse | carmustine | affects response to substance | ISO | PHC2 (Homo sapiens) | 6480464 | PHC2 mRNA affects the susceptibility to Carmustine | CTD | PMID:16365179 | Phc2 | Mouse | CGP 52608 | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PHC2 gene] | CTD | PMID:28238834 | Phc2 | Mouse | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of PHC2 mRNA | CTD | PMID:32715474 | Phc2 | Mouse | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of PHC2 mRNA | CTD | PMID:37019170 | Phc2 | Mouse | copper(II) sulfate | increases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PHC2 mRNA | CTD | PMID:19549813 | Phc2 | Mouse | cyclosporin A | increases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PHC2 mRNA | CTD | PMID:25562108 | Phc2 | Mouse | dexamethasone | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHC2 mRNA | CTD | PMID:28628672 | Phc2 | Mouse | Dibutyl phosphate | affects expression | ISO | PHC2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PHC2 mRNA | CTD | PMID:37042841 | Phc2 | Mouse | dorsomorphin | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Phc2 | Mouse | doxorubicin | increases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of PHC2 mRNA | CTD | PMID:29803840 | Phc2 | Mouse | entinostat | decreases expression | ISO | PHC2 (Homo sapiens) | 6480464 | entinostat results in decreased expression of PHC2 mRNA | CTD | PMID:26272509 | Phc2 | Mouse | entinostat | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHC2 mRNA | CTD | PMID:27188386 | Phc2 | Mouse | fenthion | decreases expression | EXP | | 6480464 | Fenthion results in decreased expression of PHC2 mRNA | CTD | PMID:34813904 | Phc2 | Mouse | folic acid | increases expression | EXP | | 6480464 | Folic Acid results in increased expression of PHC2 mRNA | CTD | PMID:25629700 | Phc2 | Mouse | formaldehyde | decreases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PHC2 mRNA | CTD | PMID:20655997 | Phc2 | Mouse | FR900359 | affects phosphorylation | ISO | PHC2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PHC2 protein | CTD | PMID:37730182 | Phc2 | Mouse | gentamycin | increases expression | ISO | Phc2 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of PHC2 mRNA | CTD | PMID:22061828 | Phc2 | Mouse | hydralazine | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of PHC2 mRNA | CTD | PMID:17183730 | Phc2 | Mouse | indometacin | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHC2 mRNA | CTD | PMID:28628672 | Phc2 | Mouse | lead(0) | affects expression | ISO | PHC2 (Homo sapiens) | 6480464 | Lead affects the expression of PHC2 mRNA | CTD | PMID:28903495 | Phc2 | Mouse | methidathion | affects expression | EXP | | 6480464 | methidathion affects the expression of PHC2 mRNA | CTD | PMID:34813904 | Phc2 | Mouse | methoxychlor | affects methylation | ISO | Phc2 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of PHC2 gene | CTD | PMID:35440735 | Phc2 | Mouse | ozone | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of PHC2 mRNA | CTD | PMID:35430440 | Phc2 | Mouse | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of PHC2 mRNA | CTD | PMID:17562736 | Phc2 | Mouse | paracetamol | increases expression | ISO | Phc2 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of PHC2 mRNA | CTD | PMID:33387578 | Phc2 | Mouse | paracetamol | decreases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PHC2 mRNA | CTD | PMID:26690555 | Phc2 | Mouse | pentachlorophenol | increases expression | EXP | | 6480464 | Pentachlorophenol results in increased expression of PHC2 mRNA | CTD | PMID:23892564 | Phc2 | Mouse | perfluorohexanesulfonic acid | decreases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in decreased expression of PHC2 mRNA | CTD | PMID:37995155 | Phc2 | Mouse | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of PHC2 mRNA | CTD | PMID:18301758 | Phc2 | Mouse | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of PHC2 mRNA | CTD | PMID:17426115 | Phc2 | Mouse | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PHC2 mRNA | CTD | PMID:19710929 | Phc2 | Mouse | raloxifene | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHC2 mRNA | CTD | PMID:19059307 | Phc2 | Mouse | SB 431542 | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Phc2 | Mouse | sodium arsenite | decreases expression | ISO | PHC2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PHC2 mRNA | CTD | PMID:38568856 | Phc2 | Mouse | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of PHC2 mRNA | CTD | PMID:35364107 | Phc2 | Mouse | sunitinib | increases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PHC2 mRNA | CTD | PMID:31533062 | Phc2 | Mouse | tamoxifen | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PHC2 mRNA | CTD | PMID:19059307 | Phc2 | Mouse | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of PHC2 mRNA | CTD | PMID:17555576 | Phc2 | Mouse | temozolomide | affects response to substance | ISO | PHC2 (Homo sapiens) | 6480464 | PHC2 mRNA affects the susceptibility to temozolomide | CTD | PMID:16365179 | Phc2 | Mouse | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of PHC2 mRNA | CTD | PMID:27339419 and PMID:31919559 | Phc2 | Mouse | thioacetamide | increases expression | ISO | Phc2 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of PHC2 mRNA | CTD | PMID:34492290 | Phc2 | Mouse | thiram | decreases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Thiram results in decreased expression of PHC2 mRNA | CTD | PMID:38568856 | Phc2 | Mouse | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of PHC2 mRNA | CTD | PMID:29264374 | Phc2 | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of PHC2 gene and titanium dioxide results in decreased methylation of PHC2 promoter | CTD | PMID:35295148 | Phc2 | Mouse | trichostatin A | increases expression | ISO | PHC2 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of PHC2 mRNA | CTD | PMID:22723015 | Phc2 | Mouse | triclosan | increases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Triclosan results in increased expression of PHC2 mRNA | CTD | PMID:30510588 | Phc2 | Mouse | triphenyl phosphate | affects expression | ISO | PHC2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of PHC2 mRNA | CTD | PMID:37042841 | Phc2 | Mouse | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of PHC2 mRNA | CTD | PMID:33045310 | Phc2 | Mouse | valproic acid | multiple interactions | ISO | PHC2 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of PHC2 mRNA more ... | CTD | PMID:17183730 and PMID:27188386 | Phc2 | Mouse | valproic acid | decreases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PHC2 mRNA | CTD | PMID:23179753 more ... | Phc2 | Mouse | valproic acid | affects expression | ISO | PHC2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PHC2 mRNA | CTD | PMID:25979313 | Phc2 | Mouse | vitamin E | increases expression | ISO | PHC2 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of PHC2 mRNA | CTD | PMID:19244175 | |