Il1a Gene Search Result

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14 records found for search term Il1a

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
2890	Il1a	interleukin 1 alpha	ENCODES a protein that exhibits copper ion binding (ortholog); cytokine activity (ortholog); INVOLVED IN heart development; keratinization; negative regulation of establishment of Sertoli cell barrier; PARTICIPATES IN interleukin-1 signaling pathway; apoptotic cell death pathway; cytokine mediated s ... (more) ignaling pathway; ASSOCIATED WITH Anorexia; aspiration pneumonia; Brain Injuries; FOUND IN cell surface; extracellular space; cytosol (ortholog); INTERACTS WITH (+)-taxifolin; (R)-lipoic acid; (R,R,R)-alpha-tocopherol	3	136979804	136990236	Rat	1059	symbol , PhenoGen	gene, protein-coding, PROVISIONAL [RefSeq]
10789	Il1a	interleukin 1 alpha	Enables cytokine activity. Involved in positive regulation of angiogenesis and positive regulation of vascular endothelial growth factor production. Acts upstream of or within several processes, including connective tissue replacement involved in inflammatory response wound healing; ectopic germ cel ... (more) l programmed cell death; and extrinsic apoptotic signaling pathway in absence of ligand. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha). [provided by Alliance of Genome Resources, Jul 2025]	2	129141530	129151892	Mouse	1108	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
735707	IL1A	interleukin 1 alpha	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically ... (more) processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]	2	112773925	112784493	Human	1077	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
8794402	Il1a	interleukin 1 alpha	ENCODES a protein that exhibits copper ion binding (ortholog); cytokine activity (ortholog); INVOLVED IN cellular response to heat (ortholog); connective tissue replacement involved in inflammatory response wound healing (ortholog); cytokine-mediated signaling pathway (ortholog); PARTICIPATES IN int ... (more) erleukin-1 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); cytosol (ortholog); extracellular space (ortholog)	NW_004955470	1527710	1538418	Chinchilla	203	symbol	gene, protein-coding, MODEL [RefSeq]
11971197	IL1A	interleukin 1 alpha	ENCODES a protein that exhibits copper ion binding (inferred); cytokine activity (inferred); interleukin-1 receptor binding (inferred); INVOLVED IN connective tissue replacement involved in inflammatory response wound healing (ortholog); ectopic germ cell programmed cell death (ortholog); extrinsic ... (more) apoptotic signaling pathway in absence of ligand (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)	2A	89273482	89284421	Bonobo	232	symbol	gene, protein-coding, MODEL [RefSeq]
12334798	IL1A	interleukin 1 alpha	ENCODES a protein that exhibits copper ion binding (ortholog); INVOLVED IN cellular response to heat (ortholog); connective tissue replacement involved in inflammatory response wound healing (ortholog); ectopic germ cell programmed cell death (ortholog); PARTICIPATES IN interleukin-1 signaling pathw ... (more) ay; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); cytosol (ortholog); extracellular space (ortholog)	17	36969581	36979445	Dog	240	symbol	gene, protein-coding, PROVISIONAL [RefSeq]
12621947	Il1a	interleukin 1 alpha	ENCODES a protein that exhibits copper ion binding (inferred); cytokine activity (inferred); interleukin-1 receptor binding (inferred); INVOLVED IN connective tissue replacement involved in inflammatory response wound healing (ortholog); ectopic germ cell programmed cell death (ortholog); extrinsic ... (more) apoptotic signaling pathway in absence of ligand (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)	NW_004936783	1210715	1218315	Squirrel	226	symbol	gene, protein-coding, MODEL [RefSeq]
18912575	Il1a	interleukin 1 alpha	ENCODES a protein that exhibits copper ion binding (ortholog); INVOLVED IN cellular response to heat (ortholog); connective tissue replacement involved in inflammatory response wound healing (ortholog); ectopic germ cell programmed cell death (ortholog); PARTICIPATES IN interleukin-1 signaling pathw ... (more) ay; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)				Naked Mole-Rat	219	symbol	gene, protein-coding, MODEL [RefSeq]
14209343	IL1A	interleukin 1 alpha	ENCODES a protein that exhibits copper ion binding (ortholog); INVOLVED IN cellular response to heat (ortholog); connective tissue replacement involved in inflammatory response wound healing (ortholog); ectopic germ cell programmed cell death (ortholog); PARTICIPATES IN interleukin-1 signaling pathw ... (more) ay; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); cytosol (ortholog); extracellular space (ortholog); INTERACTS WITH bethanechol; cadmium atom; cadmium dichloride				Pig	258	symbol	gene, protein-coding, PROVISIONAL [RefSeq]
626046680	Il1a	interleukin 1 alpha	ENCODES a protein that exhibits copper ion binding (ortholog); cytokine activity (ortholog); INVOLVED IN cellular response to heat (ortholog); connective tissue replacement involved in inflammatory response wound healing (ortholog); cytokine-mediated signaling pathway (ortholog); PARTICIPATES IN int ... (more) erleukin-1 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); cytosol (ortholog); extracellular space (ortholog)				Black Rat	203	symbol	gene, protein-coding, MODEL [RefSeq]
18680075	IL1A	interleukin 1 alpha	ENCODES a protein that exhibits copper ion binding (inferred); cytokine activity (inferred); interleukin-1 receptor binding (inferred); INVOLVED IN connective tissue replacement involved in inflammatory response wound healing (ortholog); ectopic germ cell programmed cell death (ortholog); extrinsic ... (more) apoptotic signaling pathway in absence of ligand (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); allergic bronchopulmonary aspergillosis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)				Green Monkey	232	symbol	gene, protein-coding, MODEL [RefSeq]
1352690	IL1R2	interleukin 1 receptor type 2	The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that in ... (more) hibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]	2	101991960	102028544	Human	250	description	gene, protein-coding, REVIEWED [RefSeq]
1344540	IL1RN	interleukin 1 receptor antagonist	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory respon ... (more) ses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]	2	113099360	113134014	Human	798	description	gene, protein-coding, REVIEWED [RefSeq]
1317278	IL36B	interleukin 36 beta	The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gen ... (more) e and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]	2	113022089	113052867	Human	75	description	gene, protein-coding, REVIEWED [RefSeq]