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37 records found for search term Ercc4
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RGD IDSymbolNameDescriptionChrStartStopSpeciesAnnotationsMatchType
1312517ERCC4ERCC excision repair 4, endonuclease catalytic subunitThe protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation grou161392015413952348Human599symbol , COSMIC , Human Proteome Mapgene, protein-coding, REVIEWED [RefSeq]
1312518Ercc4excision repair cross-complementing rodent repair deficiency, complementation group 4Enables TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Acts upstream of or within DNA repair; UV protection; and regulation of autophagy. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of ERCC4161292760012969873Mouse250symbol , PhenoGen , descriptiongene, protein-coding, VALIDATED [RefSeq]
1560340Ercc4ERCC excision repair 4, endonuclease catalytic subunitENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); damaged DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN cellular response to UV (ortholog); DNA repair (ortholog); double-strand break repair via homologous recombination (ortholog)1029260852958176Rat200symbol , old_gene_name , PhenoGen , descriptiongene, protein-coding, MODEL [RefSeq]
8826709Ercc4ERCC excision repair 4, endonuclease catalytic subunitENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); damaged DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN cellular response to UV (ortholog); DNA repair (ortholog); double-strand break repair via homologous recombination (ortholog)NW_00495544248334534861201Chinchilla90symbol , descriptiongene, protein-coding, MODEL [RefSeq]
11769062ERCC4ERCC excision repair 4, endonuclease catalytic subunitENCODES a protein that exhibits DNA endonuclease activity (ortholog); protein-macromolecule adaptor activity (ortholog); telomerase inhibitor activity (ortholog); INVOLVED IN DNA repair (ortholog); nucleotide-excision repair (ortholog); regulation of autophagy (ortholog); PARTICIPATES IN altered nuc161284833412880480Bonobo105symbol , descriptiongene, protein-coding, MODEL [RefSeq]
12203329ERCC4ERCC excision repair 4, endonuclease catalytic subunitENCODES a protein that exhibits DNA endonuclease activity (ortholog); protein-macromolecule adaptor activity (ortholog); telomerase inhibitor activity (ortholog); INVOLVED IN DNA repair (ortholog); nucleotide-excision repair (ortholog); regulation of autophagy (ortholog); PARTICIPATES IN altered nuc62919319229226935Dog105symbol , descriptiongene, protein-coding, MODEL [RefSeq]
12485049Ercc4ERCC excision repair 4, endonuclease catalytic subunitENCODES a protein that exhibits DNA endonuclease activity (ortholog); protein-macromolecule adaptor activity (ortholog); telomerase inhibitor activity (ortholog); INVOLVED IN DNA repair (ortholog); nucleotide-excision repair (ortholog); regulation of autophagy (ortholog); PARTICIPATES IN altered nucNW_00493650123010722329346Squirrel105symbol , descriptiongene, protein-coding, MODEL [RefSeq]
14065194ERCC4ERCC excision repair 4, endonuclease catalytic subunitENCODES a protein that exhibits DNA endonuclease activity (ortholog); protein-macromolecule adaptor activity (ortholog); telomerase inhibitor activity (ortholog); INVOLVED IN DNA repair (ortholog); nucleotide-excision repair (ortholog); regulation of autophagy (ortholog); PARTICIPATES IN altered nucPig105symbol , descriptiongene, protein-coding, MODEL [RefSeq]
18460077ERCC4ERCC excision repair 4, endonuclease catalytic subunitENCODES a protein that exhibits DNA endonuclease activity (ortholog); protein-macromolecule adaptor activity (ortholog); telomerase inhibitor activity (ortholog); INVOLVED IN DNA repair (ortholog); nucleotide-excision repair (ortholog); regulation of autophagy (ortholog); PARTICIPATES IN altered nucGreen Monkey105symbol , descriptiongene, protein-coding, MODEL [RefSeq]
18925919Ercc4ERCC excision repair 4, endonuclease catalytic subunitENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); DNA binding (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN cellular response to UV (ortholog); DNA repair (ortholog); double-strand break repair via nonhomologous end joining (orNaked Mole-Rat99symbol , descriptiongene, protein-coding, MODEL [RefSeq]
155237641ercc4Tropical Clawed Frogsymbolgene, null
155237642ercc4.LAfrican Clawed Frogsymbolgene, null
1304845Ercc4l1excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1ENCODES a protein that exhibits DNA binding (inferred); DNA endonuclease activity (inferred); endonuclease activity (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); PARTICIPATES IN nucleotide excision repair pathway; FOUND IN nucleus (inferred); INTERACTS WITH bisphenol1014621461500409Rat23symbol , PhenoGen , old_gene_symbolgene, protein-coding, MODEL [RefSeq]
16563618AC010401.1novel transcript, antisense to ERCC4Humannamegene, lncrna
1306992Ercc1ERCC excision repair 1, endonuclease non-catalytic subunitENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); damaged DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN embryonic organ development; response to cadmium ion; response to immobilization stress; PARTICIPATES IN nucleotide excision 18809930888135966Rat361descriptiongene, protein-coding, PROVISIONAL [RefSeq]
1315921ERCC1ERCC excision repair 1, endonuclease non-catalytic subunitThe product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ... (more)194540733445451547Human511descriptiongene, protein-coding, REVIEWED [RefSeq]
9014010Ercc1ERCC excision repair 1, endonuclease non-catalytic subunitENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); damaged DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN cell development (ortholog); cell population proliferation (ortholog); chromosome organization (ortholog); PARTICIPATES IN nuNW_00495555523935102430180Chinchilla152descriptiongene, protein-coding, MODEL [RefSeq]
11956747ERCC1ERCC excision repair 1, endonuclease non-catalytic subunitENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (inferred); catalytic activity, acting on DNA (inferred); damaged DNA binding (inferred); INVOLVED IN cell development (ortholog); cell population proliferation (ortholog); chromosome organization (ortholo194235603942427754Bonobo170descriptiongene, protein-coding, MODEL [RefSeq]
12660757Ercc1ERCC excision repair 1, endonuclease non-catalytic subunitENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (inferred); damaged DNA binding (inferred); DNA binding (inferred); INVOLVED IN cell development (ortholog); cell population proliferation (ortholog); chromosome organization (ortholog); PARTICIPATES IN nuNW_00493670618549381867521Squirrel167descriptiongene, protein-coding, MODEL [RefSeq]
13856568ERCC1ERCC excision repair 1, endonuclease non-catalytic subunitENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (inferred); damaged DNA binding (inferred); DNA binding (inferred); INVOLVED IN cell development (ortholog); cell population proliferation (ortholog); chromosome organization (ortholog); PARTICIPATES IN nuPig167descriptiongene, protein-coding, PROVISIONAL [RefSeq]
18598397ERCC1ERCC excision repair 1, endonuclease non-catalytic subunitENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (inferred); damaged DNA binding (inferred); DNA binding (inferred); INVOLVED IN cell development (ortholog); cell population proliferation (ortholog); chromosome organization (ortholog); PARTICIPATES IN nuGreen Monkey167descriptiongene, protein-coding, MODEL [RefSeq]
626017075Ercc1ERCC excision repair 1, endonuclease non-catalytic subunitENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); damaged DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN cell development (ortholog); cell population proliferation (ortholog); chromosome organization (ortholog); PARTICIPATES IN nuBlack Rat152descriptiongene, protein-coding, MODEL [RefSeq]
1323679MUS81MUS81 structure-specific endonuclease subunitThis gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded pro116585967465867653Human125descriptiongene, protein-coding, REVIEWED [RefSeq]
1566009Slx4SLX4 structure-specific endonuclease subunitENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN DNA double-strand break processing involved in repair via single-strand annealing (ortholog); DNA repair (ortholog); double-strand break repair via homologous recombination (ortholog); ASSOCIATED WITH breast cancer (or101203213112055685Rat126descriptiongene, protein-coding, VALIDATED [RefSeq]
8881492Slx4SLX4 structure-specific endonuclease subunitENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN DNA double-strand break processing involved in repair via single-strand annealing (ortholog); DNA repair (ortholog); double-strand break repair via homologous recombination (ortholog); ASSOCIATED WITH breast cancer (orNW_0049554421376566013792106Chinchilla48descriptiongene, protein-coding, MODEL [RefSeq]
11744853SLX4SLX4 structure-specific endonuclease subunitENCODES a protein that exhibits DNA binding (inferred); enzyme activator activity (inferred); metal ion binding (inferred); INVOLVED IN response to intra-S DNA damage checkpoint signaling (ortholog); ASSOCIATED WITH breast cancer (ortholog); Breast Cancer, Familial (ortholog); Fanconi anemia (orthol1625023342532172Bonobo60descriptiongene, protein-coding, MODEL [RefSeq]
12279825SLX4SLX4 structure-specific endonuclease subunitENCODES a protein that exhibits DNA binding (inferred); enzyme activator activity (inferred); metal ion binding (inferred); INVOLVED IN response to intra-S DNA damage checkpoint signaling (ortholog); ASSOCIATED WITH breast cancer (ortholog); Breast Cancer, Familial (ortholog); Fanconi anemia (orthol63764829737666584Dog60descriptiongene, protein-coding, MODEL [RefSeq]
12588135Slx4SLX4 structure-specific endonuclease subunitENCODES a protein that exhibits DNA binding (inferred); enzyme activator activity (inferred); metal ion binding (inferred); INVOLVED IN response to intra-S DNA damage checkpoint signaling (ortholog); ASSOCIATED WITH breast cancer (ortholog); Breast Cancer, Familial (ortholog); Fanconi anemia (ortholNW_004936694720585744477Squirrel61descriptiongene, protein-coding, MODEL [RefSeq]
13856028SLX4SLX4 structure-specific endonuclease subunitENCODES a protein that exhibits DNA binding (inferred); enzyme activator activity (inferred); metal ion binding (inferred); INVOLVED IN positive regulation of t-circle formation (ortholog); response to intra-S DNA damage checkpoint signaling (ortholog); ASSOCIATED WITH breast cancer (ortholog); BreaPig61descriptiongene, protein-coding, MODEL [RefSeq]
18522806SLX4SLX4 structure-specific endonuclease subunitENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN DNA double-strand break processing involved in repair via single-strand annealing (ortholog); DNA repair (ortholog); double-strand break repair via homologous recombination (ortholog); ASSOCIATED WITH breast cancer (orGreen Monkey48descriptiongene, protein-coding, MODEL [RefSeq]
18909214Slx4SLX4 structure-specific endonuclease subunitENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN DNA double-strand break processing involved in repair via single-strand annealing (ortholog); double-strand break repair via homologous recombination (ortholog); negative regulation of telomere maintenance via telomereNaked Mole-Rat59descriptiongene, protein-coding, MODEL [RefSeq]
626132087Slx4SLX4 structure-specific endonuclease subunitENCODES a protein that exhibits enzyme activator activity (ortholog); INVOLVED IN DNA double-strand break processing involved in repair via single-strand annealing (ortholog); DNA repair (ortholog); double-strand break repair via homologous recombination (ortholog); ASSOCIATED WITH breast cancer (orBlack Rat44descriptiongene, protein-coding, MODEL [RefSeq]
619823Xrcc1X-ray repair cross complementing 1ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); ADP-D-ribose modification-dependent protein binding (ortholog); enzyme binding (ortholog); INVOLVED IN base-excision repair; DNA damage response; response to hypoxia; PARTICIPATES IN base excis18926872189296619Rat440descriptiongene, protein-coding, PROVISIONAL [RefSeq]
732969Xrcc1X-ray repair complementing 1Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in DNA metabolic process and negative regulation of protection from non-homologous end joining at telomere. Acts upstream of or within DNA repair and hippocampus development. Located in chromosome, telomeric regi72424612424272863Mouse495descriptiongene, protein-coding, VALIDATED [RefSeq]
8865835Xrcc1X-ray repair cross complementing 1ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); ADP-D-ribose modification-dependent protein binding (ortholog); enzyme binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); DNA repair (ortholog); PANW_00495555512934161315839Chinchilla191descriptiongene, protein-coding, MODEL [RefSeq]
626104033Xrcc1X-ray repair cross complementing 1ENCODES a protein that exhibits 3' overhang single-stranded DNA endodeoxyribonuclease activity (ortholog); ADP-D-ribose modification-dependent protein binding (ortholog); enzyme binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA damage response (ortholog); DNA repair (ortholog); PABlack Rat191descriptiongene, protein-coding, MODEL [RefSeq]
1550337Xrcc4X-ray repair complementing 4Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of protection from non-homologous end joining at telomere; and telomeric DNA-containing double minutes formation. Acts upstream of 138999703390237727Mouse242descriptiongene, protein-coding, VALIDATED [RefSeq]