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Gene: SLX4 (SLX4 structure-specific endonuclease subunit) Pan paniscus

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Symbol:

SLX4

Name:

SLX4 structure-specific endonuclease subunit

RGD ID:

11744853

Description:

ENCODES a protein that exhibits DNA binding (inferred); enzyme activator activity (inferred); zinc ion binding (inferred); INVOLVED IN response to intra-S DNA damage checkpoint signaling (ortholog); ASSOCIATED WITH breast cancer (ortholog); Breast Cancer, Familial (ortholog); epilepsy (ortholog); FOUND IN ERCC4-ERCC1 complex (ortholog); Holliday junction resolvase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

SLX4 structure-specific endonuclease subunit homolog; structure-specific endonuclease subunit SLX4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	4,106,721 - 4,136,566 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	7,890,349 - 7,920,138 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	2,502,334 - 2,532,172 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	3,678,018 - 3,707,934 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	3,678,018 - 3,707,842 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

Breast Cancer, Familial (ISO)

epilepsy (ISO)

Fanconi anemia (ISO)

Fanconi anemia complementation group A (ISO)

Fanconi anemia complementation group P (ISO)

Fanconi-like syndrome (ISO)

genetic disease (ISO)

glioblastoma (ISO)

hepatoblastoma (ISO)

Hereditary Neoplastic Syndromes (ISO)

idiopathic generalized epilepsy (ISO)

microcephaly (ISO)

Pituitary Stalk Interruption Syndrome (ISO)

Rubinstein-Taybi syndrome (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA double-strand break processing involved in repair via single-strand annealing (IEA)

DNA metabolic process (IEA)

DNA recombination (IEA)

DNA repair (IEA)

DNA replication (IEA)

double-strand break repair via homologous recombination (IEA)

negative regulation of telomere maintenance via telomere lengthening (IEA)

nucleotide-excision repair (IEA)

positive regulation of t-circle formation (IEA)

positive regulation of telomere maintenance (IEA)

resolution of meiotic recombination intermediates (IEA)

response to intra-S DNA damage checkpoint signaling (IEA,ISO)

t-circle formation (IEA)

telomeric D-loop disassembly (IEA)

Cellular Component

chromatin (IEA)

chromosome, telomeric region (IEA)

ERCC4-ERCC1 complex (IEA,ISO)

Holliday junction resolvase complex (IEA,ISO)

nucleoplasm (IEA)

nucleus (IEA)

Slx1-Slx4 complex (IEA)

Molecular Function

DNA binding (IEA)

enzyme activator activity (IEA)

protein binding (ISO)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SLX4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	4,106,721 - 4,136,566 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	7,890,349 - 7,920,138 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	2,502,334 - 2,532,172 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	3,678,018 - 3,707,934 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	3,678,018 - 3,707,842 (-)	Ensembl	panpan1.1		panPan2

SLX4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	3,581,181 - 3,611,606 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	3,581,181 - 3,611,606 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	3,631,182 - 3,661,607 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	3,571,183 - 3,601,586 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	3,837,948 - 3,868,351 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	3,600,446 - 3,630,802 (-)	NCBI		HuRef
CHM1_1	16	3,631,183 - 3,661,586 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	3,608,449 - 3,638,875 (-)	NCBI		T2T-CHM13v2.0

Slx4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	3,796,969 - 3,821,708 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	3,796,969 - 3,821,634 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	3,979,105 - 4,003,829 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	3,979,105 - 4,003,770 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	3,979,123 - 4,001,680 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	3,894,351 - 3,918,984 (-)	NCBI		MGSCv36	mm8
Celera	16	4,610,428 - 4,633,144 (-)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI
cM Map	16	2.34	NCBI

Slx4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	12,032,131 - 12,055,685 (+)	NCBI		GRCr8
mRatBN7.2	10	11,526,623 - 11,549,313 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	11,528,424 - 11,549,295 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	16,234,089 - 16,256,809 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	15,722,918 - 15,745,639 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	11,392,149 - 11,414,867 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	11,787,756 - 11,808,326 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	11,786,121 - 11,807,928 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	10,542,217 - 10,563,267 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	11,778,216 - 11,816,839 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	10,485,070 - 10,505,983 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

Slx4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	13,770,340 - 13,791,314 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	13,765,660 - 13,792,106 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLX4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	37,648,297 - 37,666,584 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	37,647,976 - 37,703,190 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	38,976,853 - 38,995,126 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	37,863,103 - 37,881,377 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	37,860,796 - 37,881,349 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	37,646,259 - 37,664,532 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	37,539,374 - 37,557,647 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	37,950,110 - 37,968,384 (+)	NCBI		UU_Cfam_GSD_1.0

Slx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	105,964,986 - 105,988,936 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936694	722,481 - 744,600 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936694	720,585 - 744,477 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLX4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	38,646,938 - 38,670,168 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	38,646,904 - 38,670,173 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	39,968,849 - 39,987,767 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLX4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	3,281,468 - 3,308,296 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666068	27,507,222 - 27,536,853 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slx4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624824	1,395,434 - 1,420,622 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624824	1,398,258 - 1,423,652 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003815133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034939686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000064762 ⟹ ENSPPAP00000041836

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	3,678,018 - 3,707,842 (-)	Ensembl

RefSeq Acc Id:

XM_003815133 ⟹ XP_003815181

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	4,106,721 - 4,136,566 (-)	NCBI
NHGRI_mPanPan1	16	7,890,349 - 7,920,138 (-)	NCBI
Mhudiblu_PPA_v0	16	2,502,334 - 2,532,172 (-)	NCBI
PanPan1.1	16	3,678,018 - 3,707,934 (-)	NCBI

Sequence:

show sequence

GTTAAGAAGGTGCCGCGGCGGCGCCGGAGATGTGTAATTAAGTGAACCATATATGTTTCATCAT
CATGGAGATCTTGGAGAATTATCTGAGCACCAGGTTCATATGTATTCGATCTCAGAGGCATCTA
TTGGACAACAAAACACTCTTTCAGTTGTGAACTTTATTTATTTATTATTATTATTTTTTGAGAC
AGAGTTTTGCTCTTGTTGCCCAGGTTAGACTGCAGTGGCACGATCTCGGCTCACTGCAATCTCC
GCCTCCCAGGTTCAAGGGATTCTCTTGCCTCTGCCTCCCGAGTAGCTGGGATTACAGGCGTCTG
CTGCCACGCCTGGCCAATTTTTTGTATTTTCAGTTGAAACGAGGTTTCACCATATTGGCCAGGC
TGGTCTCAAACTTCTGACCTCAGGTGATCCACCCCCTGCCTCGTCCTCCAAAAGAGCTGGGATT
ACAAGTGTGAGCCACCGCGCCCGGCCCAGTTGTGGACTTTAACAGAGGGAAGCTTTAAACATGT
TTAACCACAGGCCCAATTTGAACAAAGATACTTCAATCATTATAGAGAGGAAAACAGTACTTTT
TGTTCAATTGTGCAAACTCTCCAAGTATCTAATGGAGAAGTAGAGAGGAACCCATGAAACTGAG
TGTGAATGAGGCTCAGCTAGGCTTCTACTTGGGTTCACTTTCTCATCTGTCTGCCTGTCCTGGG
ATTGACCCTCGCTCCTCTGAAGACCAGCCTGAAAGCCTTAAAATTGGTCAGATGATGGATGAGT
CTGATGAGGACTTTAAAGAACTCTGCGCTAGCTTTTTCCAAAGGGTGAAAAAACATGGAATCAA
GGAAGTGTCAGGAGAAAGGAAGACACAAAAGGCTGCCTCAAACGGCACTCAGATAAGAAGCAAA
TTGAAAAGGACCAAACAAACTGCTACCAAGACCAAAACCCTTCAAGGCCCTGCAGAGAAGAAAC
CTCCATCTGGCAGCCAGGCCCCTAGGACTAAAAAGCAAGGGGTAACCAAATGGCAAGCAAGTGA
ACCGGCCCTCTCTGTGAATGGGGAGGAGGGTGTGCTTGCCTCTGCTCCAGATCCACCTGTGCTC
TGGGAAACAGCACAAAACACCCAGACGGGTAACCAGCAAGAACCATCGCCAAACCTTTCCAGAG
AGAAAACCAGAGAGAATGTCCCCAACAGCGACTCCCAGCCTCCTCCTTCCTGTTTGACAACAGC
AGTGCCAAGTCCCTCCAAACCCCGCACAGCTCAATTGGTCCTACAGCGAATGCAGCAGTTCAAG
AGAGCAGACCCCGAGCGTTTGAGACACGCTTCAGAAGAGTGCTCCCTCGAGGCTGCGCGGGAAG
AAAATGTCCCAAAGGATCCTCAAGAGGAGACGATGGTGGGGAATGTGTATGGGCTTGGGCCCCC
TGCCCCAGAGAGCGACGCTGCGGTGGCCTTGACCCTGCAGCAGGAGTTTGCACGGGTAGGAGCA
TCGGCACATGATGATAGCCTGGAGGAAAAGGGTTTGTTCTTCTGCCAGATTTGTCAAAAGAACC
TCTCAGCCATGAACGTGACCCGAAGGGAACAGCATGTGAACAGGTGCTTGGATGAAGCTGAAAA
GACACTAAGACCTTCTGTGTCTCAGATCCCTGAGTGCCCGATTTGTGGGAAACCGTTTCTTACC
TTAAAGAGCAGAACCAGTCACTTGAAGCAGTGTGCTGTGAAGATGGAGGTTGGCCCCCAGCTCC
TGCTGCAGGCTGTGCGGCTGCAGACAGCACAGCCTCAGGGTAGCAGCAGCCCGCCCGTGTTCAG
CTTCAGTGATCACAGTAGAGGTCTGAAACGGAGAGGACCCACCAGCAAGAAAGAGCCACGGAAG
AGGCGGAAGGTGGACGAGGCACCGTCCGAGGACCTGCTGGTGGCCATGGCTCTGTCCCGGTCGG
AGATGGAGCCGGGTGCGGCTGTGCCAGCCCTCAGGCTGGAAAGTGCCTTTTCTGAGGGGATAAG
ACCAGAAGCAGAGAAGAAAAGTCGCAAGAAGAAACCCCCGGTATCCCCCCCATTGTTGTTAGTC
CAGGACTCTGAAACCACAGGCCGACAGATAGAGGACCGTGTGGCCCTGCTCCTCTCTGAGGAAG
TGGAATTGTCTAGCACGCCACCACTTCCTGCCAGCAGGATTTTAAAGGAAGGGTGGGAAAGAGC
GGGCCAGTGTCCTCCTCCACCTGAACGCAAGCAGAGCTTTCTGTGGGAGGGCAGCGCACTGACT
GGGGCCTGGGCCATGGAGGACTTCTACACGGCCAGGCTGGTCCCTCCTCTCATGCCCCAGTGGC
CTGCCCAGGGCCTCATGCAGGAGCCCGTGCCGCCTCTGGTGCCACCTGAGCACTCAGAGCCGAG
CGAGCGAAGGTCACCCGCTCTCCACGGCACCCCCACTGCAGGCTGTAGCTCCAGGGGCCCGTCG
CCTTCGGCCAGCCAGAGGGAGCACCAGGCCCTGCAGGACCTCGTGGACCTGGCGAGGGAGGGAC
TGAGCGCCAGCCCGTGGCCCGGCAGTGGGGGCCTGGCTGGCTCGGAAGGGACTGCAGGGTTGGA
CGTGGTGCCCGGCGGCCTTCCTCTGACTGGGTTTGTGGTGCCATCGCAGGACAAGCACCCGGAC
AGGGGCGGCCGCACCTCGCTCTCCCTCGGGCTGCTGGTTGCTGACTTTGGTGCCATGGTCAATA
ACCCACACCTGAGTGATGTCCAGTTTCAGACGGACAGCGGGGAGGTGCTTTACGCCCACAAGTT
CGTGCTTTATGCCCGATGCCCGCTCCTCATCCAGTATGTGAACAATGAAGGCTTCTCCACTGTA
GAGGACGGGGTTCTGACCCAGCGTGTCCTGCTGGGTGACGTGAGCACCGAGGCCGCCCGCACGT
TCCTGCACTATCTCTACACTGCGGACACTGGCCTTCCTCCTGGCCTTAGCTCTGAGCTGAGCTC
CCTGGCCCACAGGTTTGGCGTGAGTGAGCTCGTTCACCTGTGCGAACAGGTGCCTATTGCCACT
GACTCAGAGGGCAAACCATGGGAGGAGAAGGAAGCAGAGAATTGCGAAAGCAGGGCCGAGAATT
TCCAGGAACTCTTGAGGTCAATGTGGGCAGATGAAGAGGAGGAAGCGGAGACTTTGTTGAAATC
CAAGGACCACGAAGAAGATCAAGAAAACGTGAATGAAGCAGAAATGGAAGAAATTTATGAATTT
GCAGCTACTCAGCGAAAGCTTCTCCAGGAAGAAAGGGCAGCGGGTGCCGGCGAGGACGCTGACT
GGCTGGAGGGTGGCAGTCCGGTTTCTGGGCAACTCCTAGCAGGTGTCCAGGTGCAGAAACAGTG
GGACAAGGTGGAGGAGATGGAGCCGTTGGAGCCAGGAAGAGATGAGGCCGCCACCACCTGGGAG
AAGATGGGACAGTGCGCTCTCCCGCCACCCCAGGGCCAGCACTCAGGGGCACGGGGAGCAGAGG
CCCCTGAGCAGGAGGCGCCAGAGGAGGCGCTTGGCCATTCCAGCTGCTCCAGCCCTTCCAGGGA
CTGCCGGGCAGAGAGAAAAGAAGGCTCTCTTCCGCACTCAGATGATGCTGGGGATTACGAACAG
CTCTTCTCATCAACTCAGGGAGAGATCTCAGAGCCGTCCCAAATAAGTGAGCCCGAGGAACAAA
GTGGTGCTGTCAGGGAAAGGGGGCTGGAGGTTTCTCATCGCCTGGCTCCCTGGCAGGCGTCTCC
ACCGCACCCGTGCCGCTTCCTATTGGGGCCTCCCCAGGGCGGGAGTCCCCGCGGGTCTCATCAC
ACAAGTGGGTCGTCCCTGTCAACACCCCAGTCCCGTGGCGGAACTTCCCAGGTGGGCTCCCCAA
CCTTGCTGTCTCCAGCTGTGCCATCAAAGCAGAAAAGGGACAGGAGCATCCTCACGCTGTCTAA
AGAGCCAGGGCACCAGAAAGGCAAACAGCGTCGGTCCGTGCTGGAGTGCAGAAATAAGGGGGTC
CTGATGTTCCCAGAAAAATCTCTGTCTATTGACCTAACCCAGTCAAATCCTGACCATTCGAGCT
CCAGATCTCAGAAATCTTCATCCAAACTGAATAAAGAAGATGAGGTCATCCTCTTACTGGACTC
GGATGAGGAGCTGGAGCTAGAACAAACCAAAATGAAGTCCATTTCTAGTGATCCTCTGGAAGAA
AGGAAAGCTCTAGAAATTAGCCCTAGGTCCTGTGAGCTGTTTTCCATCATTGATGTTGATGCAG
ATCAGGAACCTTCCCAGAGCCCACCAAGAAGCGAAGCTGTGCTGCAGCAGGAGGATGAGGGGGC
GCTGCCAGAGAATCGGGGCTCTTTGGGCAGCAGAGGGGCTCCCTGGCTGTTCTGTGACCGTGAG
AGCAGCCCCAGCGAGGCCAGCACCACAGACACCTCGTGGCTGGTGCCCGCCACCCCGCTGGCCA
GCAGAAGCCGTGACTGTTCTTCCCAGACCCAAATCAGCAGCCTCAGGAGCGGGCTGGCCATGCA
GGCGGTGACTCAGCACACGCCCAGGGCCTCAGTAGGAAACAGGGAAGGGAACGAAGCCGCACAG
AAGTTTTCTGTCATCAGGCCCCAGACACCACCGCCCCAGACACCGTCCTCATGCCTCACTCCCG
TCTCTCCAGGAACTTCTGACGGCAGAAGGCAAGGCCACAGAAGCCCTTCCCGTCCCCACCCCGG
GGGCCACCCGCACTCCTCTCCACTGGCTCCACATCCCATCTCAGGGGACCGCGCCCACTTCAGC
AGGCGGTTCCTGAAACACTCGCCGCCTGGGCCAAGCTTCCTGAACCAGACCCCAGCGGGTGAAG
TGGTGGAAGTCGGAGACAGTGATGATGAGCAGGAGGTGGCCTCCCATCAGGCCAACAGCAGCCC
CCCACTGGACAGTGACCCCCCAATTCCAATTGACGACTGCTGCTGGCACATGGAGCCCCTCTCG
CCAATTCCCATTGACCACTGGAACCTGGAGCGGACCGGCCCCCTGAGCACCAGCAGCCCCAGCC
GCAGGATGAACGAGGCCGCCGACAGCCGTGACTGTCGCTCCCCGGGACTCCTGGACACCACCCC
CATCCGAGGAAGCTGCACTACCCAGAGGAAATTGCAAGAGAAGTCCTCGGGCGCGGGCTCCCCG
GGGAACAGCAGGCCGAGCTTTCTGAATTCGGCTCTGTGGGATGTTTGGGACGGGGAAGAGCAGA
GGCCTCCAGAGACCCCTCCTCCGGCCCAGATGCTAAGCGCTGGTGGAGCTCAGAAGCCCGAAGG
GTTAGAGACACCCAAAGGTGCTAATCGGAAGAAGAACTTGCCCCCCAAAGTGCCCATAACGCCG
ATGCCACAGTATTCCATTATGGAGACGCCGGTGCTGAAGAAGGAACTGGATAGGTTTGGAGTCC
GCCCTCTGCCTAAACGCCAGATGGTTCTGAAGCTGAAGGAGATATTCCAGTACACTCACCAGAC
CCTGGACTCAGACTCCGAGGACGAGAGCCAGTCCTCACAGCCGCTGTTGCAGGCGCCTCGCTGC
CAGACCCTCGCCTCCCAGACCTACAAGCCTTCAAGGGCAGGGGTCCGTGCCCAGCAGGAGGCCA
CCACAGGACCTGGGGCCCAAAGGCCCAAGGGACCTGCTAAGACCAAGGGCCCCCAACATCAAAG
GAAGCATCATGAAAGCATCACACCCCCAAGCAGGTCGCCCACCAAGGAGGCACCTCCAGGCCTC
GATGATGACGCCCAGATCCCAGCCTCTCAAGAATCCGTGGCCACCTCTGTGGATGGCAGTGACA
GCTCCTTGAGCTCACAGAGTTCTTCCTCCTGTGAGTTTGGAGCGGCATTTGAGTCTGCAGGTGA
AGAGGAGGGCGAGGGGGAGGTCAGTGCCTCGCAGGCAGCCGTGCAGGCGGCGGACACAGACGAG
GCGCTGAGGTGCTACATCCGCTCCAAGCCGGCCCTGTACCAGAAGGTGCTGCTGTACCAGCCCT
TTGAGCTGCGGGAGCTGCAGGCAGAGCTGAAGCAGAATGGCCTCCGTGTGTCCTCGCGCAGGCT
GTTGGACTTCCTGGACACCCACTGTATCACCTTCACTACTGCCGCCACCCGCAGGGAGAAGCTC
CAGGGCAGGAGGCGGCAGCCTCGGGGCAAGAAGAAGGTGGAGCGGAACTGATGGGGCCGTCCCG
ACCCCACCCCAACCTGCCATCAGCAGCCCCCACCCCGCCATTTGCAGGGAAGACCTGGGACACC
CAGCGTGGGTCAGGCCTCCACAGGCATTTCTGGGCCTGGGGACCACATCAGCTCTGCGCTGTGA
TGATGACCACAGCCCAATCCAGGGCTTCCTCTGGGCTCTGCTTTCTAGGGTGGCATTTGGAGCA
TGTCACCCACTGGATTTAGAGACTCCAGCCCCTTCCTCTGTCCGTGCTCACAGTGTGTCTCCCT
TTTTGGTTTTCTTTTTTTTTCTTTTTGAGACAGTCGTGCTGTGTCACCTAGGCTGGGGTGCAGT
GGCACAATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCT
CCCAGATAGCTGGGACTACAGGCACACGCTGCCACGCCCAGCTAATTTTTTATATTTTAGTAGA
AACGGGGTTTCACCATGTTGCTCAGGCTGGTCACAAACTCCAGAGCTCAGGCAATCCGCCTGCT
GCGGCCTCCCAAAGTGCTGGGATTCCAGGCGTCAGCCACTGTGCCCAGCCCAGTGCGTCTCCCT
TTAACCCAATAGGGCTCTCAGGTGGCCCAGGGGTCAGTGGACCATCACCAGCTGGCCAGGGCAT
GGCCTATTCTGCCACATTTGCCACCCTCTGAGCCCACCAGTCCTGGGCACAGCTGCCCTACACG
TCTGTCCTGAGATGGACGTCAGGTCCAGCCTGCCCCGGCAGCCCGGGCCCGTCCTCCTCAGCAC
TCAGGCCAACCCCAGCCACCACCAGCCTGAGACCAGGTTGTCCTGAGGCTCCCTGCACTGCCAC
AGCCCAGATGCAGTTCTCCTGACCCAGCCGTGCTACCCGGACACTTGTCATTGTTACCAGCAGT
CTCCAAACTGGACAGTGCACAAGGGCCAAGAACAACTCTGATGCCACCACAAAACAAACATGTT
CACTAGCGGGTTCCATTCTTTGGGTTAAAGCTGCCTCCAGCCTCAGGAGCAGTGTGGAGGAAGA
TGAGGGCCAGGAAAGAAGGAAACCTTGGTTTCTCCATCCTTGTGAATATCCTCGTCTGTTTCAA
ATACAGTGCAGTCAGTTTTATATGATGTGCAATAAACCAAAAAGGCTTTATTAAAA

hide sequence

RefSeq Acc Id:

XM_034939686 ⟹ XP_034795577

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	4,106,721 - 4,136,566 (-)	NCBI
NHGRI_mPanPan1	16	7,890,349 - 7,920,138 (-)	NCBI
Mhudiblu_PPA_v0	16	2,502,334 - 2,529,798 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003815181	(Get FASTA)	NCBI Sequence Viewer
	XP_034795577	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000041836.1

RefSeq Acc Id:	XP_003815181 ⟸ XM_003815133
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9CIP7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKIGQMMDESDEDFKELCASFFQRVKK HGIKEVSGERKTQKAASNGTQIRSKLKRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQGVTKW QASEPALSVNGEEGVLASAPDPPVLWETAQNTQTGNQQEPSPNLSREKTRENVPNSDSQPPPSC LTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQEETMVGNVYG LGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKGLFFCQICQKNLSAMNVTRREQHVNRCLD EAEKTLRPSVSQIPECPICGKPFLTLKSRTSHLKQCAVKMEVGPQLLLQAVRLQTAQPQGSSSP PVFSFSDHSRGLKRRGPTSKKEPRKRRKVDEAPSEDLLVAMALSRSEMEPGAAVPALRLESAFS EGIRPEAEKKSRKKKPPVSPPLLLVQDSETTGRQIEDRVALLLSEEVELSSTPPLPASRILKEG WERAGQCPPPPERKQSFLWEGSALTGAWAMEDFYTARLVPPLMPQWPAQGLMQEPVPPLVPPEH SEPSERRSPALHGTPTAGCSSRGPSPSASQREHQALQDLVDLAREGLSASPWPGSGGLAGSEGT AGLDVVPGGLPLTGFVVPSQDKHPDRGGRTSLSLGLLVADFGAMVNNPHLSDVQFQTDSGEVLY AHKFVLYARCPLLIQYVNNEGFSTVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSS ELSSLAHRFGVSELVHLCEQVPIATDSEGKPWEEKEAENCESRAENFQELLRSMWADEEEEAET LLKSKDHEEDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQV QKQWDKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSS PSRDCRAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQISEPEEQSGAVRERGLEVSHRLAPW QASPPHPCRFLLGPPQGGSPRGSHHTSGSSLSTPQSRGGTSQVGSPTLLSPAVPSKQKRDRSIL TLSKEPGHQKGKQRRSVLECRNKGVLMFPEKSLSIDLTQSNPDHSSSRSQKSSSKLNKEDEVIL LLDSDEELELEQTKMKSISSDPLEERKALEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQE DEGALPENRGSLGSRGAPWLFCDRESSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSG LAMQAVTQHTPRASVGNREGNEAAQKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSR PHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDDEQEVASHQA NSSPPLDSDPPIPIDDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLL DTTPIRGSCTTQRKLQEKSSGAGSPGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMLSAGGAQ KPEGLETPKGANRKKNLPPKVPITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQY THQTLDSDSEDESQSSQPLLQAPRCQTLASQTYKPSRAGVRAQQEATTGPGAQRPKGPAKTKGP QHQRKHHESITPPSRSPTKEAPPGLDDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFE SAGEEEGEGEVSASQAAVQAADTDEALRCYIRSKPALYQKVLLYQPFELRELQAELKQNGLRVS SRRLLDFLDTHCITFTTAATRREKLQGRRRQPRGKKKVERN hide sequence

RefSeq Acc Id:	XP_034795577 ⟸ XM_034939686
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9CIP7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSPPAP00000041836 ⟸ ENSPPAT00000064762

Protein Domains

BTB UBZ4-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000043515	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000064762.1	UniProtKB/TrEMBL
InterPro	BTB/POZ_dom	UniProtKB/TrEMBL
	Rad18_UBZ4	UniProtKB/TrEMBL
	SKP1/BTB/POZ_sf	UniProtKB/TrEMBL
	Structure-sp_endonuc_su_Slx4	UniProtKB/TrEMBL
KEGG Report	pps:100974093	UniProtKB/TrEMBL
NCBI Gene	SLX4	ENTREZGENE
PANTHER	BTB POZ DOMAIN CONTAINING 12	UniProtKB/TrEMBL
	STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4	UniProtKB/TrEMBL
Pfam	BTB	UniProtKB/TrEMBL
	Slx4	UniProtKB/TrEMBL
PROSITE	BTB	UniProtKB/TrEMBL
	ZF_UBZ4	UniProtKB/TrEMBL
SMART	BTB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54695	UniProtKB/TrEMBL
UniProt	A0A2R9CIP7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM