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Gene: Slx4 (SLX4 structure-specific endonuclease subunit) Rattus norvegicus
Symbol: Slx4
Name: SLX4 structure-specific endonuclease subunit
RGD ID: 1566009
Description: Predicted to contribute to 3'-flap endonuclease activity; 5'-flap endonuclease activity; and crossover junction endodeoxyribonuclease activity. Predicted to be involved in DNA metabolic process; regulation of telomere maintenance; and response to intra-S DNA damage checkpoint signaling. Predicted to colocalize with Holliday junction resolvase complex and nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group P. Orthologous to human SLX4 (SLX4 structure-specific endonuclease subunit); INTERACTS WITH amphetamine; bisphenol A; testosterone.
Type: protein-coding
RefSeq Status: MODEL
Also known as: BTB (POZ) domain containing 12; Btbd12; LOC302953; RGD1566009; similar to BTB (PO)Z domain containing 12; SLX4 structure-specific endonuclease subunit homolog; SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae); structure-specific endonuclease subunit SLX4
Homo sapiens (human) : SLX4 (SLX4 structure-specific endonuclease subunit)  HGNC  Alliance
Mus musculus (house mouse) : Slx4 (SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slx4 (SLX4 structure-specific endonuclease subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : SLX4 (SLX4 structure-specific endonuclease subunit)
Canis lupus familiaris (dog) : SLX4 (SLX4 structure-specific endonuclease subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slx4 (SLX4 structure-specific endonuclease subunit)
Sus scrofa (pig) : SLX4 (SLX4 structure-specific endonuclease subunit)
Chlorocebus sabaeus (African green monkey) : SLX4 (SLX4 structure-specific endonuclease subunit)
Heterocephalus glaber (naked mole-rat) : Slx4 (SLX4 structure-specific endonuclease subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01011,787,756 - 11,808,326 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,786,121 - 11,807,928 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,542,217 - 10,563,267 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,778,216 - 11,816,839 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1010,485,070 - 10,505,983 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Slx4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1566009
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.