| 2257 | Calm1 | calmodulin 1 | ENCODES a protein that exhibits calcium ion binding; calcium-dependent protein binding; nitric-oxide synthase binding; INVOLVED IN establishment of protein localization to membrane; establishment of protein localization to mitochondrial membrane; positive regulation of nitric-oxide synthase activity ; PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence; alcohol withdrawal syndrome; type 2 diabetes mellitus; FOUND IN chromatin; growth cone; mitochondrial membrane; INTERACTS WITH (R)-lipoic acid; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 6 | 125217191 | 125227855 | Rat | 470 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735369 | CALM1 | calmodulin 1 | This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript v ariants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia.[provided by RefSeq, May 2020] | 14 | 90396502 | 90408268 | Human | 498 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735370 | Calm1 | calmodulin 1 | This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes , including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] | 12 | 100165694 | 100176083 | Mouse | 478 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8824130 | Calm1 | calmodulin 1 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | NW_004955438 | 12842437 | 12854028 | Chinchilla | 163 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11706332 | CALM1 | calmodulin 1 | ENCODES a protein that exhibits calcium channel inhibitor activity (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); cellular response to interferon-beta (ortholog); cellular response to type II interferon (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); growth cone (ortholog) | 14 | 71015099 | 71026322 | Bonobo | 190 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12359409 | CALM1 | calmodulin 1 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | 8 | 61398231 | 61408874 | Dog | 164 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12566003 | Calm1 | calmodulin 1 | ENCODES a protein that exhibits adenylate cyclase binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN establishment of protein localization to membrane (ortholog); establishment of protein localization to mitochondrial membrane (ortholog); G2 /M transition of mitotic cell cycle (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN chromatin (ortholog); growth cone (ortholog); mitochondrial membrane (ortholog) | NW_004936488 | 17580425 | 17588480 | Squirrel | 173 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14031372 | CALM1 | calmodulin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); nitric-oxide synthase binding (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); cellular response to interferon-beta (ortholog); cellular response to type II interferon (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN chromatin (ortholog); growth cone (ortholog); mitochondrial membrane (ortholog); INTERACTS WITH graphene oxide | | | | Pig | 170 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18410965 | CALM1 | calmodulin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); nitric-oxide synthase binding (ortholog); INVOLVED IN establishment of protein localization to membrane (ortholog); establishment of protein localization to mitochondrial membrane (ortholog) ; G2/M transition of mitotic cell cycle (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN chromatin (ortholog); growth cone (ortholog); mitochondrial membrane (ortholog) | | | | Green Monkey | 188 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18933973 | Calm1 | calmodulin 1 | ENCODES a protein that exhibits calcium channel inhibitor activity (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); cellular response to interferon-beta (ortholog); cellular response to type II interferon (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); growth cone (ortholog) | | | | Naked Mole-Rat | 174 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155253912 | calm1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405859134 | calm1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860919 | calm1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862276 | calm1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862343 | calm1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626174380 | calm1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626183216 | calm1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626185588 | calm1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253913 | calm1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 41069368 | Calm1-ps1 | calmodulin 1, pseudogene 1 | | 7 | 102356733 | 102357177 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1586689 | Calm1-ps2 | calmodulin 1, pseudogene 2 | | 1 | 21529629 | 21530330 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 10278 | Calm2 | calmodulin 2 | Enables calcium-dependent protein binding activity. Involved in negative regulation of calcium ion export across plasma membrane; negative regulation of calcium ion transmembrane transporter activity; and presynaptic endocytosis. Acts upstream of or within G2/M transition of mitotic cell cycle and r egulation of calcium-mediated signaling. Located in membrane; myelin sheath; and vesicle. Part of voltage-gated potassium channel complex. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in long QT syndrome 15. Orthologous to human CALM2 (calmodulin 2). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 87740829 | 87754363 | Mouse | 328 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 736342 | CALM2 | calmodulin 2 | This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progressio n and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] | 2 | 47160082 | 47176936 | Human | 382 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 10282 | Calm3 | calmodulin 3 | Predicted to enable several functions, including enzyme activator activity; enzyme binding activity; and titin binding activity. Involved in presynaptic endocytosis. Acts upstream of or within G2/M transition of mitotic cell cycle. Located in myelin sheath. Part of voltage-gated potassium channel co mplex. Is active in calyx of Held. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and long QT syndrome 16. Orthologous to human CALM3 (calmodulin 3). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 16649304 | 16657957 | Mouse | 314 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737387 | CALM3 | calmodulin 3 | This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by Re fSeq, Aug 2016] | 19 | 46601074 | 46610782 | Human | 348 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 16561663 | AL512791.1 | novel transcript, antisense to CALM1 | | | | | Human | | name | gene, lncrna |
| 16565678 | AC004987.3 | calmodulin 1 (phosphorylase kinase, delta) (CALM1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1345562 | CALM1P1 | calmodulin 1 pseudogene 1 | | X | 95499608 | 95500112 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1344159 | CALM1P2 | calmodulin 1 pseudogene 2 | | 7 | 55259682 | 55260294 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 18428962 | CALM2 | calmodulin 2 | ENCODES a protein that exhibits calcium ion binding (ortholog); nitric-oxide synthase binding (ortholog); nitric-oxide synthase regulator activity (ortholog); INVOLVED IN establishment of protein localization to membrane (ortholog); establishment of protein localization to mitochondrial membrane (or tholog); G2/M transition of mitotic cell cycle (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); cannabis abuse (ortholog); FOUND IN growth cone (ortholog); mitochondrial membrane (ortholog); nucleus (ortholog) | | | | Green Monkey | 142 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18429590 | CALM3 | calmodulin 3 | ENCODES a protein that exhibits calcium ion binding (ortholog); nitric-oxide synthase binding (ortholog); nitric-oxide synthase regulator activity (ortholog); INVOLVED IN establishment of protein localization to membrane (ortholog); establishment of protein localization to mitochondrial membrane (or tholog); G2/M transition of mitotic cell cycle (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Cardiac Arrhythmias (ortholog); FOUND IN growth cone (ortholog); mitochondrial membrane (ortholog); nucleus (ortholog) | | | | Green Monkey | 132 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 68458 | PDE1A | phosphodiesterase 1A | Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin ( see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009] | 2 | 182140041 | 182716797 | Human | 149 | description | gene, protein-coding, VALIDATED [RefSeq] |
