Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Strain Registration

Strain: SR/Jr

Symbol: SR/Jr
Strain: SR
Substrain: Jr
Full Name: Salt Resistant
RGD ID: 10040
Citation ID: RRID:RRRC_00056
Ontology ID: RS:0000786
Also Known As: SR/JrMco
Type: inbred
Available Source: Rat Resource and Research Center
Origination: Dr. John P. Rapp, Medical College of Ohio, USA
Description: Originated from a Sprague-Dawley outbred colony developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for resistance to salt-induced hypertension (Dahl et al 1962a,b).
Genetic Markers: c
Coat Color: Albino
Inbred Generations: F54.
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm





Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
weight loss  (IAGP)

References

References - curated
# Reference Title Reference Citation
1. Spectrum of aerobic endurance running performance in eleven inbred strains of rats. Barbato JC, etal., J Appl Physiol 1998 Aug;85(2):530-6.
2. Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. Cicila GT, etal., J Hypertens 1994 Jun;12(6):643-51
3. Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats. Cicila GT, etal., Mamm Genome 1997 Dec;8(12):896-902.
4. Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats. Cicila GT, etal., Mamm Genome 1999 Feb;10(2):112-6.
5. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
6. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
7. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
8. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
9. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
10. Estimate of the genetic divergence between inbred Dahl salt-sensitive and salt-resistant rats. Ginn DI, etal., J Hypertens 1993 May;11(5):477-81.
11. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
12. Modulation of blood pressure in the Dahl SS/jr rat by embryo transfer. Kubisch HM, etal., Hypertension. 1998 Jan;31(1 Pt 2):540-5.
13. Mitochondrial polymorphisms in rat genetic models of hypertension. Kumarasamy S, etal., Mamm Genome. 2010 May 5.
14. Hereditary cataracts in the John Rapp inbred strain of Dahl salt-sensitive rat. Margo CE, etal., Invest Ophthalmol Vis Sci. 1987 Aug;28(8):1422-8.
15. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
16. Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
17. RGD Strain RSO annotation pipeline RGD Automated Pipelines
18. Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. St. Lezin EM, etal., J Clin Invest 1996 Jan 15;97(2):522-7
19. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Zhang QY, etal., Mamm Genome 1997 Sep;8(9):636-41

Region

Strain QTL Data
Symbol Name Trait
Bp167 Blood pressure QTL 167 arterial blood pressure trait   (VT:2000000)    
Bp24 Blood pressure QTL 24 arterial blood pressure trait   (VT:2000000)    
Bp25 Blood pressure QTL 25 arterial blood pressure trait   (VT:2000000)    
Bp34 Blood pressure QTL 34 arterial blood pressure trait   (VT:2000000)    
Bp39 Blood pressure QTL 39 arterial blood pressure trait   (VT:2000000)    
Bp41 Blood pressure QTL 41 blood pressure trait   (VT:0000183)    
Bp61 Blood pressure QTL 61 arterial blood pressure trait   (VT:2000000)    
Cm1 Cardiac mass QTL 1 heart mass   (VT:0007028)    
Cm13 Cardiac mass QTL 13 heart mass   (VT:0007028)    
Cm14 Cardiac mass QTL 14 heart mass   (VT:0007028)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Hypertension and vascular and renal lesions do not develop on a high (8%) salt diet (cf SS, see for example, Pontremoli et al, 1992). Mild hydronephrosis at 4 months of age that is probably genetically determined (Rapp and Dene 1985). Has mutant form of cytochrome P450(11-beta)(Matsukawa et al, 1993). Has lower transepithelial, unidirectional, sodium flux than SS and Sprague-Dawley which may be associated with its resistance to the development of hypertension on a high salt diet (Kudo et al, 1994). 61037
strain_life_disease Hypertension and vascular and renal lesions do not develop on a high (8%) salt diet (cf SS, see for example, Pontremoli et al, 1992). Mild hydronephrosis at 4 months of age that is probably genetically determined (Rapp and Dene 1985). Has mutant form of cytochrome P450(11-beta)(Matsukawa et al, 1993). Has lower transepithelial, unidirectional, sodium flux than SS and Sprague-Dawley which may be associated with its resistance to the development of hypertension on a high salt diet (Kudo et al, 1994). 61053
strain_other These performed significantly greater amount of work in the aerobic endurance performance as compared to the COP strain (lowest performer). 1358977
strain_other These are genetically different from SS/Jr, according to the restriction fragment length polymorphism (RFLP) there is a mutation in every 1532 base pairs. 1358976
strain_other Mitochondrial DNA is 16,309 bp in size 2325144

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-18 SR/Jr  Salt Resistant  SR/Jr  Salt Resistant  Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00056 RGD