Phenominer Database Results (102 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SR/Jr systolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 7 serial mean 144.0 mmHg 4.0 10.58 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11695 119
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 341.0 beats/min 1.79 4.0 intra-aortic thoracic radiotelemetry 0.0 0 103156 2787
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 310.0 beats/min 4.47 10.0 intra-aortic thoracic radiotelemetry 0.0 0 103160 2787
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 389.0 beats/min 10.73 24.0 intra-aortic thoracic radiotelemetry 0.0 5 min 103162 2787
SR/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.4 hours) then ambient air (for 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 5 sampling once per minute 124.0 breaths/min 3.13 7.0 spirometry 0.0 0 103180 2787
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.9 hours) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 436.0 beats/min 8.5 19.0 intra-aortic thoracic radiotelemetry 0.0 25 min 103193 2787
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 112.0 mmHg 1.34 3.0 intra-aortic thoracic radiotelemetry 0.0 0 103199 2787
SR/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 5 sampling once per minute 150.0 breaths/min 9.84 22.0 spirometry 0.0 0 103211 2787
SR/Jr heart weight controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart mass not specified 84 days 5 1.12 g 0.04 0.08 post excision weight measurement 0.0 0 103144 2787
SR/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 0 hours) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 6 mean of 3 samples of undefined duration between 7am and 12pm serial mean 124.0 mmHg 4.4 10.78 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102293 2661
SR/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 17 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 6 mean of 3 samples of undefined duration between 7am and 12pm serial mean 120.0 mmHg 2.2 5.39 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102304 2661
SR/Jr systolic blood pressure controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 16 137.0 mmHg 3.0 12.0 vascular transducer tipped catheter 0.0 0 103246 2802
SR/Jr diastolic blood pressure controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 16 91.0 mmHg 3.0 12.0 vascular transducer tipped catheter 0.0 0 103254 2802
SR/Jr diastolic blood pressure controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 13 85.0 mmHg 4.0 14.42 vascular transducer tipped catheter 0.0 0 103255 2802
SR/Jr plasma total cholesterol level controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. blood cholesterol amount male 63 days 13 72.59 mg/dl 2.7 9.74 plasma total cholesterol measurement test 0.0 0 103263 2802
SR/Jr body weight controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. body mass male 63 days 13 225.0 g 8.0 28.84 body weighing method 0.0 0 103235 2802
SR/Jr ouabain-sensitive red blood cell Na+ export rate controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 16 3500.0 umol/l/h 91.0 200.0 Na+/K+ ATPase activity assay 0.0 0 110981 2802
SR/Jr artery neointimal hyperplastic lesion area balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 8 0.04 mm2 0.01 0.03 ex vivo light microscopy with digital image analysis 0.0 0 110468 3107
SR/Jr artery neointimal hyperplastic lesion area to total wall area ratio balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 8 21.9 % 4.98 14.09 ex vivo light microscopy with digital image analysis 0.0 0 110479 3107
SR/Jr bumetanide-sensitive red blood cell K+ import rate controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 16 773.0 umol/l/h 61.0 244.0 Na-K-Cl cotransport activity assay 0.0 0 111049 2802
SR/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 3 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 6 mean of 3 samples of undefined duration between 7am and 12pm serial mean 131.0 mmHg 4.5 11.02 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102297 2661
SR/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 89.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11701 119
SR/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 83.0 mmHg 1.0 2.83 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11702 119
SR/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 7 serial mean 105.0 mmHg 4.0 10.58 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11697 119
SR/Jr systolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 7 serial mean 138.0 mmHg 4.0 10.58 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11696 119
SR/Jr body weight controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 112 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 147 days 10 365.0 g 6.4 20.24 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 12187 222
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.6 hours) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 468.0 beats/min 1.79 4.0 intra-aortic thoracic radiotelemetry 0.0 0 103189 2787
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 114.0 mmHg 2.24 5.0 intra-aortic thoracic radiotelemetry 0.0 0 103207 2787
SR/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.4 hours) then ambient air (for 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 5 sampling once per minute 89.0 breaths/min 6.26 14.0 spirometry 0.0 0 103213 2787
SR/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 10 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 6 mean of 3 samples of undefined duration between 7am and 12pm serial mean 124.0 mmHg 3.2 7.84 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102300 2661
SR/Jr systolic blood pressure controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 13 138.0 mmHg 3.0 10.82 vascular transducer tipped catheter 0.0 0 103247 2802
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 13 107.0 mmHg 4.0 14.42 vascular transducer tipped catheter 0.0 0 103251 2802
SR/Jr plasma triglyceride level controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. blood triglyceride amount male 63 days 13 0.61 mmol/l 0.16 0.58 plasma triglyceride analysis 0.0 0 103259 2802
SR/Jr plasma total cholesterol level controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. blood cholesterol amount male 63 days 16 69.88 mg/dl 6.95 27.8 plasma total cholesterol measurement test 0.0 0 103262 2802
SR/Jr hematocrit controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte quantity male 63 days 16 45.8 % 0.4 1.6 hematocrit analysis 0.0 0 103266 2802
SR/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 0 hours) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 6 mean of 3 samples of undefined duration between 7am and 12pm serial mean 120.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102292 2661
SR/Jr maximum rate of positive change in left ventricular blood pressure to left ventricular systolic blood pressure ratio controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart left ventricular blood pressure trait not specified 84 days 5 LVdP/dtmax/P 72.0 /s 4.02 1.0 vascular transducer tipped catheter 0.0 0 106816 2787
SR/Jr ouabain-sensitive red blood cell Na+ export rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 13 3483.0 umol/l/h 104.0 374.98 Na+/K+ ATPase activity assay 0.0 0 111034 2802
SR/Jr ouabain-sensitive red blood cell K+ import rate controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 16 4275.0 umol/l/h 135.0 540.0 Na+/K+ ATPase activity assay 0.0 0 111045 2802
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 314.0 beats/min 5.37 12.0 intra-aortic thoracic radiotelemetry 0.0 0 103158 2787
SR/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 28 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait male 63 days 10 serial mean 143.0 mmHg 1.9 6.01 tail cuff plethysmography tail 0 0 11910 222
SR/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 56 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait male 91 days 10 serial mean 142.0 mmHg 2.2 6.96 tail cuff plethysmography tail 0 0 12164 222
SR/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 168 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait male 203 days 10 serial mean 141.0 mmHg 3.2 10.12 tail cuff plethysmography tail 0 0 12166 222
SR/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 168 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait male 203 days 10 serial mean 156.0 mmHg 4.0 12.65 tail cuff plethysmography tail 0 0 12170 222
SR/Jr body weight controlled sodium content diet (0.2 %) (for 112 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 147 days 10 379.0 g 5.7 18.02 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 12182 222
SR/Jr heart weight to body weight ratio controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart mass not specified 84 days 5 3.22 g/kg 0.12 0.27 post excision weight measurement 0.0 0 103146 2787
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 109.0 mmHg 0.89 2.0 intra-aortic thoracic radiotelemetry 0.0 0 103168 2787
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 103.0 mmHg 0.45 1.0 intra-aortic thoracic radiotelemetry 0.0 0 103172 2787
SR/Jr respiration rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 5 sampling once per minute 120.0 breaths/min 1.79 4.0 spirometry 0.0 0 103176 2787
SR/Jr respiration rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (10 %) (for 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 5 sampling once per minute 144.0 breaths/min 1.34 3.0 spirometry 0.0 0 103178 2787
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.9 and 1 hours) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 472.0 beats/min 4.47 10.0 intra-aortic thoracic radiotelemetry 0.0 25 min 103195 2787
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.9 and 1.3 hours) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 463.0 beats/min 1.79 4.0 intra-aortic thoracic radiotelemetry 0.0 25 min 103197 2787
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 117.0 mmHg 1.34 3.0 intra-aortic thoracic radiotelemetry 0.0 0 103201 2787
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 114.0 mmHg 2.24 5.0 intra-aortic thoracic radiotelemetry 0.0 0 103203 2787
SR/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 20 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 6 mean of 3 samples of undefined duration between 7am and 12pm serial mean 125.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102308 2661
SR/Jr single kidney wet weight to body weight ratio controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. kidney mass male 63 days 13 8.13 g/kg 0.15 0.54 post excision weight measurement 0.0 0 103243 2802
SR/Jr plasma triglyceride level controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. blood triglyceride amount male 63 days 16 0.43 mmol/l 0.11 0.44 plasma triglyceride analysis 0.0 0 103258 2802
SR/Jr ouabain- and bumetanide-resistant red blood cell Na+ import rate controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 16 3586.0 umol/l/h 110.0 440.0 Na+ passive permeability assay 0.0 0 111041 2802
SR/Jr ouabain- and bumetanide-resistant red blood cell Na+ import rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 13 3407.0 umol/l/h 114.0 411.03 Na+ passive permeability assay 0.0 0 111042 2802
SR/Jr ouabain-sensitive red blood cell K+ import rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 13 4255.0 umol/l/h 130.0 468.72 Na+/K+ ATPase activity assay 0.0 0 111046 2802
SR/Jr ouabain- and bumetanide-resistant red blood cell K+ import rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 13 408.0 umol/l/h 14.0 50.48 Na+ passive permeability assay 0.0 0 111054 2802
SR/Jr body weight controlled sodium content diet (0.2 %) (for 168 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 203 days 10 422.0 g 5.4 17.08 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 64709 222
SR/Jr diastolic blood pressure controlled sodium content diet (8 %) (between 48 and 55 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait male 70 days-77 days 7 serial mean 95.0 mmHg 4.0 10.58 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11698 119
SR/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 56 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait male 91 days 10 serial mean 159.0 mmHg 2.0 6.32 tail cuff plethysmography tail 0 0 12168 222
SR/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 112 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait male 147 days 10 serial mean 150.0 mmHg 2.3 7.27 tail cuff plethysmography tail 0 0 12169 222
SR/Jr body weight controlled sodium content diet (0.2 %) (for 28 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 63 days 10 238.0 g 4.7 14.86 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 12180 222
SR/Jr body weight controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 56 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 91 days 10 309.0 g 6.3 19.92 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 12186 222
SR/Jr body weight controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 168 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 203 days 10 407.0 g 5.7 18.02 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 12189 222
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 84 days 5 415.0 beats/min 9.39 21.0 vascular transducer tipped catheter 0.0 0 103148 2787
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (for 0.4 hours) then ambient air (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 356.0 beats/min 10.73 24.0 intra-aortic thoracic radiotelemetry 0.0 25 min 103164 2787
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 102.0 mmHg 0.45 1.0 intra-aortic thoracic radiotelemetry 0.0 0 103166 2787
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 107.0 mmHg 1.34 3.0 intra-aortic thoracic radiotelemetry 0.0 0 103170 2787
SR/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 3 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 6 mean of 3 samples of undefined duration between 7am and 12pm serial mean 129.0 mmHg 2.9 7.1 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102296 2661
SR/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 20 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 6 mean of 3 samples of undefined duration between 7am and 12pm serial mean 126.0 mmHg 1.5 3.67 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102309 2661
SR/Jr heart weight to body weight ratio controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. heart mass male 63 days 13 2.56 g/kg 0.04 0.14 post excision weight measurement 0.0 0 103239 2802
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. arterial blood pressure trait male 63 days 16 113.0 mmHg 2.0 8.0 vascular transducer tipped catheter 0.0 0 103250 2802
SR/Jr hematocrit controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte quantity male 63 days 13 43.5 % 0.5 1.8 hematocrit analysis 0.0 0 103267 2802
SR/Jr minimum rate of positive change in left ventricular blood pressure controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart left ventricular blood pressure trait not specified 84 days 5 LVdP/dtmin 8.2 10E3 mmHg/s 4.47 1.2 vascular transducer tipped catheter 0.0 0 minimum rate of positive change in left ventricular blood pressure 106818 2787
SR/Jr artery neointimal hyperplastic lesion area including tunica media balloon angioplasty Assadnia S, etal., Circ Res. 1999 Jun 11;84(11):1252-7. doi: 10.1161/01.res.84.11.1252. iliac artery integrity trait male 119 days-133 days 8 0.16 mm2 0.01 0.03 ex vivo light microscopy with digital image analysis 0.0 0 110457 3107
SR/Jr bumetanide-sensitive red blood cell K+ import rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 13 698.0 umol/l/h 73.0 263.21 Na-K-Cl cotransport activity assay 0.0 0 111050 2802
SR/Jr systolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to darkness St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 128.0 mmHg 2.0 5.66 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min nightly for a week 11699 119
SR/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 112 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait male 147 days 10 serial mean 132.0 mmHg 3.1 9.8 tail cuff plethysmography tail 0 0 12165 222
SR/Jr systolic blood pressure controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 28 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 arterial blood pressure trait male 63 days 10 serial mean 150.0 mmHg 3.5 11.07 tail cuff plethysmography tail 0 0 12167 222
SR/Jr body weight controlled sodium content diet (0.2 %) (for 56 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 91 days 10 313.0 g 4.8 15.18 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 12181 222
SR/Jr body weight controlled sodium content diet (0.2 %) (for 5 days) then controlled sodium content diet (8 %) (for 28 days) Garrett MR, et al., Genome Res 1998 Jul;8(7):711-23 body mass male 63 days 10 243.0 g 5.5 17.39 body weighing method 0 0 4 rats per cage, 2 SR/Jr 2 LEW/NCrl 12184 222
SR/Jr left ventricular end-diastolic blood pressure controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart left ventricular blood pressure trait not specified 84 days 5 1.0 mmHg 0.45 1.0 vascular transducer tipped catheter 0.0 0 103152 2787
SR/Jr maximum rate of positive change in left ventricular blood pressure controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart left ventricular blood pressure trait not specified 84 days 5 LVdP/dtmax 8600.0 mmHg/s 715.54 1600.0 vascular transducer tipped catheter 0.0 0 E3 X mmHg/s 103154 2787
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 101.0 mmHg 0.89 2.0 intra-aortic thoracic radiotelemetry 0.0 0 103174 2787
SR/Jr heart rate controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) (between 0.5 and 0.6 hours) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart pumping trait not specified 86 days 5 sampling once per minute 455.0 beats/min 4.47 10.0 intra-aortic thoracic radiotelemetry 0.0 5 min 103191 2787
SR/Jr mean arterial blood pressure controlled sodium chloride content diet (0.3 %) (for 42 days) then controlled sodium chloride content diet (8 %) (for 42 days) then atropine (1 mg/kg) then 10% CO2, 20% O2, 70% N2 (between 0 and 0.4 hours) then ambient air (between 0 and 0.1 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. arterial blood pressure trait not specified 86 days 5 sampling once per minute 115.0 mmHg 2.24 5.0 intra-aortic thoracic radiotelemetry 0.0 0 103205 2787
SR/Jr respiration rate controlled sodium content diet (0.3 %) (for 42 days) then controlled sodium content diet (8 %) (for 42 days) then atropine (1 mg/kg) then ambient air (between 0 and 0.4 hours) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. respiratory function trait not specified 86 days 5 sampling once per minute 100.0 breaths/min 8.94 20.0 spirometry 0.0 0 103209 2787
SR/Jr body weight controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. body mass not specified 84 days 5 349.0 g 10.29 23.0 body weighing method 0.0 0 103142 2787
SR/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 10 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 6 mean of 3 samples of undefined duration between 7am and 12pm serial mean 122.0 mmHg 1.3 3.18 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102301 2661
SR/Jr systolic blood pressure controlled vancomycin content drinking water (50 mg/kg/d) (for 3 days) and controlled meropenem content drinking water (50 mg/kg/d) (for 3 days) and controlled omeprazole content oral gavage (50 ml/kg/d) (for 3 days) then controlled cecal material content oral gavage (2 ml) (for 17 days) Mell B, et al., Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31. arterial blood pressure trait male 0 days 6 mean of 3 samples of undefined duration between 7am and 12pm serial mean 121.0 mmHg 2.1 5.14 intra-aortic abdominal radiotelemetry via femoral cannulation 0.0 0 102305 2661
SR/Jr single kidney wet weight to body weight ratio controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. kidney mass male 63 days 16 7.24 g/kg 0.1 0.4 post excision weight measurement 0.0 0 103242 2802
SR/Jr body weight controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. body mass male 63 days 16 218.0 g 9.0 36.0 body weighing method 0.0 0 103234 2802
SR/Jr bumetanide-sensitive red blood cell Na+ export rate controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 16 163.0 umol/l/h 70.0 280.0 Na-K-Cl cotransport activity assay 0.0 0 111037 2802
SR/Jr bumetanide-sensitive red blood cell Na+ export rate controlled sodium chloride content diet (8 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 13 194.0 umol/l/h 78.0 281.23 Na-K-Cl cotransport activity assay 0.0 0 111038 2802
SR/Jr ouabain- and bumetanide-resistant red blood cell K+ import rate controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. erythrocyte ion transport trait male 63 days 16 382.0 umol/l/h 13.0 52.0 Na+ passive permeability assay 0.0 0 111053 2802
SR/Jr systolic blood pressure controlled sodium content diet (8 %) (between 62 and 69 days) then controlled exposure to ambient light St. Lezin EM, et al., J Clin Invest 1996 Jan 15;97(2):522-7 arterial blood pressure trait female 56 days-63 days 8 serial mean 124.0 mmHg 2.0 5.66 intra-aortic abdominal radiotelemetry 604800.0 0 5 s every 5 min daily for a week 11700 119
SR/Jr left ventricular systolic blood pressure controlled sodium chloride content diet (0.3 %) (for 21 days) then controlled sodium chloride content diet (8 %) (for 42 days) then pentobarbital, sodium (20 mg/kg) Sobajima M, et al., Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2214-20. doi: 10.1152/ajpheart.00615.2010. Epub 2011 Mar 18. heart left ventricular blood pressure trait not specified 84 days 5 119.0 mmHg 4.02 9.0 vascular transducer tipped catheter 0.0 0 103150 2787
SR/Jr heart weight to body weight ratio controlled sodium chloride content diet (0.3 %) (for 35 days) Vokurkov? M, et al., Hypertens Res. 2003 May;26(5):397-404. heart mass male 63 days 16 2.53 g/kg 0.02 0.08 post excision weight measurement 0.0 0 103238 2802