RGD Reference Report - Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9.

Authors: Rapp, JP  Garrett, MR  Dene, H  Meng, H  Hoebee, B  Lathrop, GM 
Citation: Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
RGD ID: 61053
Pubmed: PMID:9722941   (View Abstract at PubMed)
DOI: DOI:10.1006/geno.1998.5394   (Journal Full-text)

A blood pressure quantitative trait locus was found (LOD = 5.0) on rat chromosome 9 using a large F2 population (N = 233) derived from Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. The F2 rats were fed 8% NaCl diet for 8 weeks. A congenic strain introgressing the R low-blood-pressure QTL allele on chromosome 9 into the S strain was constructed. The congenic strain, designated S.R(chr 9), had a lower blood pressure (19 mm Hg, P < 0.0001) and lower heart weight (112 mg, P < 0.0001) than S rats (2% NaCl diet for 24 days), proving the existence of a blood pressure QTL in the congenic region of about 21 cM.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IDA 61053 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased heart weight inducedIAGPcontrolled sodium content diet61053compared to SS/JrRGD 
decreased systemic arterial blood pressure inducedIAGPcontrolled sodium content diet61053compared to SS/JrRGD 
increased systemic arterial blood pressure  QTM 61053 RGD 

Related Phenotype Data for this Reference

Phenominer Options:  View all phenotype data for this reference  |  Download all phenotype data for this reference

Select a value below to view phenotype data for a specific strain, measurment, or condition.

Objects Annotated

QTLs
Bp34  (Blood pressure QTL 34)

Strains
SR/Jr  (Salt Resistant)
SS.SR-Inha/Jr  (NA)
SS/Jr  (Salt Sensitive)

Objects referenced in this article
Marker D9Uia6 D9Uia6 Rattus norvegicus
Marker D9Uia9 D9Uia9 Rattus norvegicus
Gene Inha inhibin subunit alpha Rattus norvegicus

Additional Information