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Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9.

Authors: Rapp, JP  Garrett, MR  Dene, H  Meng, H  Hoebee, B  Lathrop, GM 
Citation: Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
Pubmed: (View Article at PubMed) PMID:9722941
DOI: Full-text: DOI:10.1006/geno.1998.5394

A blood pressure quantitative trait locus was found (LOD = 5.0) on rat chromosome 9 using a large F2 population (N = 233) derived from Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. The F2 rats were fed 8% NaCl diet for 8 weeks. A congenic strain introgressing the R low-blood-pressure QTL allele on chromosome 9 into the S strain was constructed. The congenic strain, designated S.R(chr 9), had a lower blood pressure (19 mm Hg, P < 0.0001) and lower heart weight (112 mg, P < 0.0001) than S rats (2% NaCl diet for 24 days), proving the existence of a blood pressure QTL in the congenic region of about 21 cM.


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RGD Object Information
RGD ID: 61053
Created: 2000-12-21
Species: All species
Last Modified: 2002-01-28
Status: ACTIVE


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