RGD Reference Report - beta2- and beta1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases. - Rat Genome Database

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beta2- and beta1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases.

Authors: Monto, F  Oliver, E  Vicente, D  Buendia, F  Rueda, J  Aguero, J  Almenar, L  Valldecabres, C  Rovira, E  Muedra, V  Noguera, MA  Ivorra, MD  D'Ocon, P 
Citation: Monto F, etal., J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299.
RGD ID: 11535540
Pubmed: PMID:26248277   (View Abstract at PubMed)
DOI: DOI:10.1097/FJC.0000000000000299   (Journal Full-text)

To explore if genic expression of beta(1)- or beta(2)-adrenoceptors (ARs) exhibits a common regulatory pattern with G protein-coupled receptor kinase (GRK) 2, GRK3, or GRK5 expression, we determined messenger RNA levels for these genes in different tissues from human and animal models of cardiovascular disease. We measured genic expression by qRT polymerase chain reaction in the left and right ventricles or peripheral blood mononuclear cells from healthy (n = 21), hypertensive (n = 20), heart failure (n = 24), and heart transplanted patients (n = 17) or in left ventricle, peripheral blood mononuclear cells, and kidney from spontaneously hypertensive rats or L-N-methyl-arginine-induced hypertensive rats and their respective controls (n = 4-5). In diseased versus healthy subjects and rats, parallel changes in messenger RNA levels of GRK2 and beta(2)-AR or GRK5 and beta(1)-AR were observed in each territory. Therefore, without excluding other regulatory mechanisms, the parallelism observed suggests a common regulatory pattern for the beta(1)-AR/GRK5 and beta(2)-AR/GRK2 genes, which is independent of cellular type or pathology. This highlights the need to focus not only on GRKs but also on beta(1)- or beta(2)-AR changes to completely understand the involvement of beta-AR/GRK pathways in cardiovascular diseases.



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Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
GRK2Humancongestive heart failure  IEP mRNA:decreased expression:peripheral blood mononuclear cell (human)RGD 
GRK5Humancongestive heart failure  IEP mRNA:decreased expression:peripheral blood mononuclear cell (human)RGD 
Grk2Ratcongestive heart failure  ISOGRK2 (Homo sapiens)mRNA:decreased expression:peripheral blood mononuclear cell (human)RGD 
Grk2Mousecongestive heart failure  ISOGRK2 (Homo sapiens)mRNA:decreased expression:peripheral blood mononuclear cell (human)RGD 
Grk5Ratcongestive heart failure  ISOGRK5 (Homo sapiens)mRNA:decreased expression:peripheral blood mononuclear cell (human)RGD 
Grk5Mousecongestive heart failure  ISOGRK5 (Homo sapiens)mRNA:decreased expression:peripheral blood mononuclear cell (human)RGD 
GRK3Humanhypertension  ISOGrk3 (Rattus norvegicus)mRNA:increased expression:heart left ventricle and kidney (rat)RGD 
GRK5Humanhypertension  ISOGrk5 (Rattus norvegicus)mRNA:increased expression:heart left ventricle and kidney (rat)RGD 
Grk3Rathypertension  IEP mRNA:increased expression:heart left ventricle and kidney (rat)RGD 
Grk3Mousehypertension  ISOGrk3 (Rattus norvegicus)mRNA:increased expression:heart left ventricle and kidney (rat)RGD 
Grk5Rathypertension  IEP mRNA:increased expression:heart left ventricle and kidney (rat)RGD 
Grk5Mousehypertension  ISOGrk5 (Rattus norvegicus)mRNA:increased expression:heart left ventricle and kidney (rat)RGD 
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Genes (Rattus norvegicus)
Grk2  (G protein-coupled receptor kinase 2) Grk3  (G protein-coupled receptor kinase 3) Grk5  (G protein-coupled receptor kinase 5)

Genes (Mus musculus)
Grk2  (G protein-coupled receptor kinase 2) Grk3  (G protein-coupled receptor kinase 3) Grk5  (G protein-coupled receptor kinase 5)

Genes (Homo sapiens)
GRK2  (G protein-coupled receptor kinase 2) GRK3  (G protein-coupled receptor kinase 3) GRK5  (G protein-coupled receptor kinase 5)