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Gene: GRK3 (G protein-coupled receptor kinase 3) Homo sapiens
Symbol: GRK3
Name: G protein-coupled receptor kinase 3
Description: Predicted to have beta-adrenergic receptor kinase activity. Involved in receptor internalization. Predicted to localize to cytosol and plasma membrane. Biomarker of bipolar disorder and congestive heart failure.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADRBK2; adrenergic, beta, receptor kinase 2; BARK2; beta-adrenergic receptor kinase 2; beta-ARK-2; G-protein-coupled receptor kinase 3
Mus musculus (house mouse) : Grk3 (G protein-coupled receptor kinase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grk3 (G protein-coupled receptor kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk3 (G protein-coupled receptor kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK3 (G protein-coupled receptor kinase 3)
Canis lupus familiaris (dog) : GRK3 (G protein-coupled receptor kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk3 (G protein-coupled receptor kinase 3)
Sus scrofa (pig) : GRK3 (G protein-coupled receptor kinase 3)
Chlorocebus sabaeus (African green monkey) : GRK3 (G protein-coupled receptor kinase 3)
Heterocephalus glaber (naked mole-rat) : Grk3 (G protein-coupled receptor kinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2225,564,675 - 25,729,294 (+)EnsemblGRCh38hg38GRCh38
GRCh382225,564,675 - 25,729,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372225,960,861 - 26,125,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,290,861 - 24,455,259 (+)NCBINCBI36hg18NCBI36
Build 342224,285,499 - 24,444,470NCBI
Celera229,765,035 - 9,929,436 (+)NCBI
Cytogenetic Map22q12.1ENTREZGENE
HuRef228,948,071 - 9,073,051 (+)NCBIHuRef
CHM1_12225,919,893 - 26,084,649 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GRK3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730840
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.