Grk3 (G protein-coupled receptor kinase 3) - Rat Genome Database

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Gene: Grk3 (G protein-coupled receptor kinase 3) Mus musculus
Analyze
Symbol: Grk3
Name: G protein-coupled receptor kinase 3
RGD ID: 10112
MGI Page MGI
Description: Enables G protein-coupled receptor kinase activity. Predicted to be involved in several processes, including desensitization of G protein-coupled receptor signaling pathway; inositol phosphate metabolic process; and rhodopsin metabolic process. Predicted to be located in several cellular components, including Z disc; dendrite; and sperm midpiece. Predicted to be active in glutamatergic synapse; postsynaptic density; and presynapse. Is expressed in several structures, including adrenal gland; gut gland; nervous system; submandibular gland primordium; and thymus primordium. Orthologous to human GRK3 (G protein-coupled receptor kinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4833444A01Rik; Adrb; Adrbk; Adrbk-2; Adrbk2; adrenergic receptor kinase, beta 2; AI851927; AW551196; Bark; Bark-2; beta ARK2; beta-adrenergic receptor kinase 2; beta-ARK-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,058,344 - 113,163,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,058,348 - 113,163,657 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385112,910,478 - 113,015,660 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5112,910,482 - 113,015,791 (-)Ensemblmm10GRCm38
MGSCv375113,339,498 - 113,444,534 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365113,150,781 - 113,255,817 (-)NCBIMGSCv36mm8
Celera5110,031,311 - 110,133,492 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.29NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[ghi]perylene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
desipramine  (ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
dichlorine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (EXP)
glyphosate  (ISO)
Heliotrine  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
methacholine chloride  (EXP)
methimazole  (ISO)
methoxychlor  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nitrofen  (ISO)
nitroprusside  (EXP)
ozone  (ISO)
paracetamol  (EXP)
parathion  (ISO)
PCB138  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
Senkirkine  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sunitinib  (ISO)
terbufos  (ISO)
tetraphene  (EXP)
theophylline  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP)
triclosan  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7.
2. The changes in beta-adrenoceptor-mediated cardiac function in experimental hypothyroidism: the possible contribution of cardiac beta3-adrenoceptors. Arioglu E, etal., Mol Cell Biochem. 2010 Feb;335(1-2):59-66. Epub 2009 Sep 1.
3. The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. Arriza JL, etal., J Neurosci 1992 Oct;12(10):4045-55.
4. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
5. Gender differences in beta-adrenoceptor system in cardiac hypertrophy due to arteriovenous fistula. Dent MR, etal., J Cell Physiol. 2011 Jan;226(1):181-6.
6. Prolonged Morphine Treatment Alters Expression and Plasma Membrane Distribution of ß-Adrenergic Receptors and Some Other Components of Their Signaling System in Rat Cerebral Cortex. Hejnova L, etal., J Mol Neurosci. 2017 Dec;63(3-4):364-376. doi: 10.1007/s12031-017-0987-9. Epub 2017 Oct 28.
7. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. beta2- and beta1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases. Monto F, etal., J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299.
11. Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables. Montó F, etal., Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H368-76. doi: 10.1152/ajpheart.01061.2011. Epub 2012 Jun 8.
12. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. Peppel K, etal., J Biol Chem. 1997 Oct 10;272(41):25425-8.
13. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients. Rao JS, etal., Int J Neuropsychopharmacol. 2009 Jul;12(6):851-60. Epub 2009 Apr 29.
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
20. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30.
21. Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. Álvaro-Bartolomé M and García-Sevilla JA, Neuroscience. 2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29.
Additional References at PubMed
PMID:1869533   PMID:7761854   PMID:8035170   PMID:8638670   PMID:8889548   PMID:8917529   PMID:8955126   PMID:9345023   PMID:9365243   PMID:9802886   PMID:10198406   PMID:10338466  
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12794091   PMID:14610273   PMID:15140929   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:17344394   PMID:17698926   PMID:17959804   PMID:18165681   PMID:18554416   PMID:20534436   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23223282   PMID:23935208   PMID:24629717  
PMID:28706196   PMID:29166587   PMID:30076211   PMID:32325033   PMID:34873237   PMID:35093170   PMID:36451830   PMID:37048054   PMID:38355793  


Genomics

Comparative Map Data
Grk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,058,344 - 113,163,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,058,348 - 113,163,657 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385112,910,478 - 113,015,660 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5112,910,482 - 113,015,791 (-)Ensemblmm10GRCm38
MGSCv375113,339,498 - 113,444,534 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365113,150,781 - 113,255,817 (-)NCBIMGSCv36mm8
Celera5110,031,311 - 110,133,492 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.29NCBI
GRK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382225,564,675 - 25,729,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2225,564,432 - 25,729,294 (+)Ensemblhg38GRCh38
GRCh372225,960,642 - 26,125,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,290,861 - 24,455,259 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342224,285,499 - 24,444,470NCBI
Celera229,765,035 - 9,929,436 (+)NCBICelera
Cytogenetic Map22q12.1ENTREZGENE
HuRef228,948,071 - 9,073,051 (+)NCBIHuRef
CHM1_12225,919,893 - 26,084,649 (+)NCBICHM1_1
T2T-CHM13v2.02226,025,826 - 26,190,440 (+)NCBIT2T-CHM13v2.0
Grk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,285,228 - 49,395,803 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1249,285,263 - 49,395,802 (+)EnsemblGRCr8
mRatBN7.21243,624,778 - 43,735,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,624,897 - 43,731,262 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1244,792,406 - 44,899,008 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,404,111 - 45,510,489 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,464,630 - 44,571,012 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01249,626,871 - 49,750,389 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,626,871 - 49,746,272 (+)Ensemblrn6Rnor6.0
Rnor_5.01251,433,367 - 51,510,797 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1245,261,279 - 45,319,394 (+)NCBICelera
Cytogenetic Map12q16NCBI
Grk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,640,145 - 19,785,803 (-)Ensembl
ChiLan1.0NW_00495544219,640,145 - 19,785,803 (-)NCBIChiLan1.0ChiLan1.0
GRK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22335,460,616 - 35,733,621 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12238,268,625 - 38,432,427 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0226,579,664 - 6,789,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12224,353,530 - 24,516,416 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2224,353,533 - 24,509,560 (+)EnsemblpanPan2panpan1.1
GRK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12619,385,059 - 19,512,528 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2619,385,058 - 19,516,077 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2619,249,805 - 19,382,153 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02619,749,680 - 19,882,193 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2619,749,732 - 19,878,611 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12619,454,629 - 19,586,996 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02619,720,438 - 19,852,665 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02619,789,809 - 19,922,140 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118115,345,722 - 115,443,919 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936657426,787 - 521,198 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936657425,902 - 522,331 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1443,224,930 - 43,442,965 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11443,305,255 - 43,445,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21446,128,694 - 46,270,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1198,438,543 - 8,601,652 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl198,438,380 - 8,600,359 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045117,529,573 - 117,694,607 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,576,681 - 1,758,201 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247471,567,540 - 1,758,251 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grk3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11640,964,557 - 41,072,559 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grk3
7005 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1429
Count of miRNA genes:732
Interacting mature miRNAs:907
Transcripts:ENSMUST00000065167
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045978Tir10_mtrypanosome infection response 10 (mouse)Not determined598019649114021986Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
25314310Syncl4_msynaptonemal complex length 4 (mouse)5103047866115538059Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
25314317Sccor3_msynaptonemal complex length to mean MLH1 count ratio 3 (mouse)5104347866114738061Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined598019649116876624Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
1357886Diht_mdopamine-induced hypothermia (mouse)Not determined5104498738115101540Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104386871120711986Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4141652Mrdq2_mmodifier of retinal degeneration QTL 2 (mouse)Not determined110253106118093673Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
AW551196  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385112,910,789 - 112,910,935UniSTSGRCm38
MGSCv375113,339,809 - 113,339,955UniSTSGRCm37
Celera5110,031,622 - 110,031,768UniSTS
Cytogenetic Map5FUniSTS
cM Map560.0UniSTS
Whitehead/MRC_RH51366.89UniSTS
UniSTS:235264  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385112,914,344 - 112,914,661UniSTSGRCm38
MGSCv375113,343,364 - 113,343,681UniSTSGRCm37
Celera5110,035,177 - 110,035,494UniSTS
Cytogenetic Map5FUniSTS
cM Map560.0UniSTS
AI851927  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385112,910,478 - 112,910,593UniSTSGRCm38
MGSCv375113,339,498 - 113,339,613UniSTSGRCm37
Celera5110,031,311 - 110,031,426UniSTS
Cytogenetic Map5FUniSTS
cM Map560.0UniSTS
Whitehead/MRC_RH51370.75UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001285806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_177078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003955659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_389274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_389275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_880393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_880394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI851927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY289705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY629884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ104587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000065167   ⟹   ENSMUSP00000070445
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,058,348 - 113,163,380 (-)Ensembl
GRCm38.p6 Ensembl5112,910,482 - 113,015,514 (-)Ensembl
Ensembl Acc Id: ENSMUST00000195928
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,067,928 - 113,073,664 (-)Ensembl
GRCm38.p6 Ensembl5112,920,062 - 112,925,798 (-)Ensembl
Ensembl Acc Id: ENSMUST00000197776   ⟹   ENSMUSP00000143427
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,108,410 - 113,163,369 (-)Ensembl
GRCm38.p6 Ensembl5112,960,544 - 113,015,503 (-)Ensembl
Ensembl Acc Id: ENSMUST00000197888   ⟹   ENSMUSP00000142968
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,065,611 - 113,163,657 (-)Ensembl
GRCm38.p6 Ensembl5112,917,745 - 113,015,791 (-)Ensembl
Ensembl Acc Id: ENSMUST00000199337
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,063,976 - 113,072,241 (-)Ensembl
GRCm38.p6 Ensembl5112,916,110 - 112,924,375 (-)Ensembl
Ensembl Acc Id: ENSMUST00000200332   ⟹   ENSMUSP00000142926
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5113,060,465 - 113,163,380 (-)Ensembl
GRCm38.p6 Ensembl5112,912,599 - 113,015,514 (-)Ensembl
RefSeq Acc Id: NM_001285806   ⟹   NP_001272735
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,058,344 - 113,163,404 (-)NCBI
GRCm385112,910,478 - 113,015,538 (-)NCBI
Celera5110,031,311 - 110,133,516 (-)NCBI
Sequence:
RefSeq Acc Id: NM_177078   ⟹   NP_796052
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,058,344 - 113,163,404 (-)NCBI
GRCm385112,910,478 - 113,015,538 (-)NCBI
MGSCv375113,339,498 - 113,444,534 (-)RGD
Celera5110,031,311 - 110,133,516 (-)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036165208   ⟹   XP_036021101
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,058,347 - 113,163,515 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003955659
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,071,823 - 113,163,518 (-)NCBI
GRCm385112,923,957 - 113,015,658 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004942525
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,058,347 - 113,163,513 (-)NCBI
Sequence:
RefSeq Acc Id: XR_389274
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,058,347 - 113,163,518 (-)NCBI
GRCm385112,910,481 - 113,015,660 (-)NCBI
Sequence:
RefSeq Acc Id: XR_389275
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,071,823 - 113,163,517 (-)NCBI
GRCm385112,923,957 - 113,015,657 (-)NCBI
Sequence:
RefSeq Acc Id: XR_880393
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,058,347 - 113,163,518 (-)NCBI
GRCm385112,910,481 - 113,015,658 (-)NCBI
Sequence:
RefSeq Acc Id: XR_880394
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395113,058,347 - 113,163,518 (-)NCBI
GRCm385112,910,481 - 113,015,659 (-)NCBI
Sequence:
RefSeq Acc Id: NP_796052   ⟸   NM_177078
- Peptide Label: isoform 1
- UniProtKB: Q3UYH7 (UniProtKB/Swiss-Prot),   F8VPM8 (UniProtKB/Swiss-Prot),   Q8BVT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272735   ⟸   NM_001285806
- Peptide Label: isoform 3
- UniProtKB: Q8BVT9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000070445   ⟸   ENSMUST00000065167
Ensembl Acc Id: ENSMUSP00000143427   ⟸   ENSMUST00000197776
Ensembl Acc Id: ENSMUSP00000142968   ⟸   ENSMUST00000197888
Ensembl Acc Id: ENSMUSP00000142926   ⟸   ENSMUST00000200332
RefSeq Acc Id: XP_036021101   ⟸   XM_036165208
- Peptide Label: isoform X1
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UYH7-F1-model_v2 AlphaFold Q3UYH7 1-688 view protein structure

Promoters
RGD ID:6887616
Promoter ID:EPDNEW_M7259
Type:initiation region
Name:Grk3_1
Description:Mus musculus G protein-coupled receptor kinase 3 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385113,015,490 - 113,015,550EPDNEW
RGD ID:6836999
Promoter ID:MM_KWN:43450
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain
Transcripts:NM_001035531,   NM_177078,   UC008YTU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365113,444,304 - 113,444,804 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87941 AgrOrtholog
Ensembl Genes ENSMUSG00000042249 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000065167 ENTREZGENE
  ENSMUST00000065167.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.1270 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  GPCR_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:320129 UniProtKB/Swiss-Prot
MGD MGI:87941 ENTREZGENE
NCBI Gene Grk3 ENTREZGENE
PANTHER BETA-ADRENERGIC RECEPTOR KINASE 2 UniProtKB/Swiss-Prot
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam PF00169 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
PhenoGen Grk3 PhenoGen
PRINTS GPCRKINASE UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
SMART RGS UniProtKB/Swiss-Prot
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF48097 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2JEW1_MOUSE UniProtKB/TrEMBL
  ARBK2_MOUSE UniProtKB/Swiss-Prot
  F8VPM8 ENTREZGENE
  Q3UYH7 ENTREZGENE
  Q8BVT9 ENTREZGENE, UniProtKB/TrEMBL
  Q8BX71_MOUSE UniProtKB/TrEMBL
UniProt Secondary F8VPM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Grk3  G protein-coupled receptor kinase 3  Adrbk2  adrenergic receptor kinase, beta 2  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Adrbk2  adrenergic receptor kinase, beta 2  Grk3  G protein-coupled receptor kinase 3  Symbol and/or name change 5135510 APPROVED
2016-09-20 Grk3  G protein-coupled receptor kinase 3  Adrbk2  adrenergic receptor kinase, beta 2  Symbol and/or name change 5135510 APPROVED