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Gene: Grk3 (G protein-coupled receptor kinase 3) Mus musculus
Symbol: Grk3
Name: G protein-coupled receptor kinase 3
RGD ID: 10112
Description: Exhibits G protein-coupled receptor kinase activity. Predicted to be involved in several processes, including cellular protein metabolic process; desensitization of G protein-coupled receptor signaling pathway; and inositol phosphate metabolic process. Predicted to localize to several cellular components, including Z disc; dendrite; and sperm midpiece. Is expressed in several structures, including adrenal gland; gut gland; nervous system; retina; and submandibular gland primordium. Orthologous to human GRK3 (G protein-coupled receptor kinase 3); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; corticotropin-releasing hormone signaling pathway; INTERACTS WITH 1,1-dichloroethene; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4833444A01Rik; Adrb; Adrbk; Adrbk-2; Adrbk2; adrenergic receptor kinase, beta 2; AI851927; AW551196; Bark; Bark-2; beta ARK2; beta-adrenergic receptor kinase 2; beta-ARK-2
Homo sapiens (human) : GRK3 (G protein-coupled receptor kinase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grk3 (G protein-coupled receptor kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk3 (G protein-coupled receptor kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK3 (G protein-coupled receptor kinase 3)
Canis lupus familiaris (dog) : GRK3 (G protein-coupled receptor kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk3 (G protein-coupled receptor kinase 3)
Sus scrofa (pig) : GRK3 (G protein-coupled receptor kinase 3)
Chlorocebus sabaeus (African green monkey) : GRK3 (G protein-coupled receptor kinase 3)
Heterocephalus glaber (naked mole-rat) : Grk3 (G protein-coupled receptor kinase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5112,910,482 - 113,015,791 (-)EnsemblGRCm38mm10GRCm38
GRCm385112,910,478 - 113,015,660 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375113,339,498 - 113,444,534 (-)NCBIGRCm37mm9NCBIm37
MGSCv365113,150,781 - 113,255,817 (-)NCBImm8
Celera5110,031,311 - 110,133,492 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Grk3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10112
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.