Hnrnpab (heterogeneous nuclear ribonucleoprotein A/B) - Rat Genome Database

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Gene: Hnrnpab (heterogeneous nuclear ribonucleoprotein A/B) Rattus norvegicus
Analyze
Symbol: Hnrnpab
Name: heterogeneous nuclear ribonucleoprotein A/B
RGD ID: 69255
Description: Enables sequence-specific double-stranded DNA binding activity. Involved in cellular response to amino acid stimulus and regulation of intracellular mRNA localization. Located in dendrite and neuronal ribonucleoprotein granule. Part of ribonucleoprotein complex. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B); PARTICIPATES IN spliceosome pathway; INTERACTS WITH (S)-AMPA; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A1F-C1; CArG-binding factor-A; CBF-A; Cgbf; Cgbfa; DBP40; heterogeneous nuclear ribonucleoprotein A/B-like; Hnrpab; LOC100910156; LOC103689931
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,358,004 - 36,363,898 (-)NCBIGRCr8
mRatBN7.21035,857,040 - 35,862,935 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,857,041 - 35,863,344 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,551,497 - 40,557,391 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,041,789 - 40,047,683 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,545,198 - 35,551,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01034,955,713 - 34,961,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,049,677 - 37,055,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,955,716 - 34,961,608 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01036,821,682 - 36,827,630 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,117,285 - 37,123,177 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,570,905 - 27,583,441 (+)NCBI
Celera1035,213,782 - 35,219,674 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HnrnpabRathepatocellular carcinoma severityISOHNRNPAB (Homo sapiens)10059322mRNA:increased expression:liver (human)RGD 
HnrnpabRattransient cerebral ischemia treatmentIDA 9999181 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
HnrnpabRatEhlers-Danlos syndrome dermatosparaxis type  ISOHNRNPAB (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome and dermatosparaxis typeClinVarPMID:16770806 more ...
HnrnpabRatSotos syndrome  ISOHNRNPAB (Homo sapiens)8554872ClinVar Annotator: match by term: Sotos syndromeClinVarPMID:16770806 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HnrnpabRatExperimental Mammary Neoplasms  ISOHNRNPAB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15538050

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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
HnrnpabRat(S)-AMPA increases expressionEXP 6480464alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased expression of HNRNPAB proteinCTDPMID:21471000
HnrnpabRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOHnrnpab (Mus musculus)6480464o and p'-DDT results in increased expression of HNRNPAB mRNACTDPMID:24096037
HnrnpabRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionEXP 6480464o and p'-DDT results in increased expression of HNRNPAB mRNACTDPMID:24096037
HnrnpabRat1,2-dimethylhydrazine multiple interactionsISOHnrnpab (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HNRNPAB mRNACTDPMID:22206623
HnrnpabRat1,2-dimethylhydrazine affects expressionISOHnrnpab (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of HNRNPAB mRNACTDPMID:22206623
HnrnpabRat17alpha-ethynylestradiol affects expressionISOHnrnpab (Mus musculus)6480464Ethinyl Estradiol affects the expression of HNRNPAB mRNACTDPMID:17555576
HnrnpabRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of HNRNPAB mRNACTDPMID:16174780 more ...
HnrnpabRat17alpha-ethynylestradiol increases expressionISOHnrnpab (Mus musculus)6480464Ethinyl Estradiol results in increased expression of HNRNPAB mRNACTDPMID:16174780 more ...
HnrnpabRat17alpha-ethynylestradiol multiple interactionsISOHnrnpab (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HNRNPAB mRNACTDPMID:17942748
HnrnpabRat17beta-estradiol increases expressionISOHNRNPAB (Homo sapiens)6480464Estradiol results in increased expression of HNRNPAB mRNACTDPMID:14605097 and PMID:31614463
HnrnpabRat17beta-estradiol increases expressionISOHnrnpab (Mus musculus)6480464Estradiol results in increased expression of HNRNPAB mRNACTDPMID:39298647
HnrnpabRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of HNRNPAB mRNACTDPMID:32145629
HnrnpabRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOHnrnpab (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of HNRNPAB mRNACTDPMID:24058054
HnrnpabRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of HNRNPAB mRNACTDPMID:32109520 and PMID:34747641
HnrnpabRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOHnrnpab (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of HNRNPAB mRNACTDPMID:17942748
HnrnpabRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOHnrnpab (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HNRNPAB mRNACTDPMID:17942748
HnrnpabRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHnrnpab (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of HNRNPAB mRNACTDPMID:21570461
HnrnpabRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
HnrnpabRat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionEXP 64804642 more ...CTDPMID:19954255
HnrnpabRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of HNRNPAB mRNACTDPMID:21346803

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Biological Process
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Object Symbol
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Reference
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Source
Original Reference(s)
HnrnpabRatcellular response to amino acid stimulus  IEP 9999187NMDA and AMPARGD 
HnrnpabRatepithelial to mesenchymal transition involved_inISOHnrnpab (Mus musculus)1624291 PMID:17273560RGDPMID:17273560
HnrnpabRatmRNA modification involved_inISOHNRNPAB (Homo sapiens)1624291 PMID:11134005RGDPMID:11134005
HnrnpabRatmRNA modification involved_inIEAUniProtKB:Q99729 and ensembl:ENSP000003511081600115GO_REF:0000107EnsemblGO_REF:0000107
HnrnpabRatnegative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay involved_inISOHNRNPAB (Homo sapiens)1624291 PMID:12881431RGDPMID:12881431
HnrnpabRatnegative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay involved_inIEAUniProtKB:Q99729 and ensembl:ENSP000003511081600115GO_REF:0000107EnsemblGO_REF:0000107
HnrnpabRatnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOHnrnpab (Mus musculus)1624291MGI:2443180 PMID:23907535RGDPMID:23907535
HnrnpabRatpositive regulation of DNA-templated transcription involved_inISOHnrnpab (Mus musculus)1624291 PMID:17273560RGDPMID:17273560
HnrnpabRatpositive regulation of macromolecule biosynthetic process involved_inIEAARBA:ARBA000274121600115GO_REF:0000117UniProtGO_REF:0000117
HnrnpabRatregulation of cellular localization  IMP 9999187mRNARGD 
HnrnpabRatregulation of gene expression involved_inIEAARBA:ARBA000283341600115GO_REF:0000117UniProtGO_REF:0000117
HnrnpabRatregulation of intracellular mRNA localization  IMP 9999187 RGD 
HnrnpabRatregulation of RNA metabolic process involved_inIEAARBA:ARBA000289181600115GO_REF:0000117UniProtGO_REF:0000117
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Cellular Component
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Object Symbol
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Original Reference(s)
HnrnpabRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
HnrnpabRatcytoplasm located_inISOHnrnpab (Mus musculus)1624291 PMID:17273560RGDPMID:17273560
HnrnpabRatdendrite  IDA 9999187 RGD 
HnrnpabRatglutamatergic synapse is_active_inISOHnrnpab (Mus musculus)1624291 PMID:21471000RGDPMID:21471000
HnrnpabRatneuronal ribonucleoprotein granule  IDA 9999187 RGD 
HnrnpabRatnucleoplasm located_inISOHNRNPAB (Homo sapiens) more ...1624291 RGDGO_REF:0000052
HnrnpabRatnucleoplasm located_inIEAUniProtKB:Q99729 and ensembl:ENSP000003511081600115GO_REF:0000107EnsemblGO_REF:0000107
HnrnpabRatnucleus located_inISOHnrnpab (Mus musculus)1624291 PMID:17273560RGDPMID:17273560
HnrnpabRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
HnrnpabRatnucleus located_inIEAUniProtKB:Q99729 and ensembl:ENSP000003511081600115GO_REF:0000107EnsemblGO_REF:0000107
HnrnpabRatnucleus located_inISOHNRNPAB (Homo sapiens)1624291 PMID:12881431RGDPMID:12881431
HnrnpabRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
HnrnpabRatpostsynapse is_active_inISOHnrnpab (Mus musculus)1624291 PMID:21471000RGDPMID:21471000
HnrnpabRatpresynaptic cytosol is_active_inISOHnrnpab (Mus musculus)1624291 PMID:21471000RGDPMID:21471000
HnrnpabRatribonucleoprotein complex  IDA 9999180 RGD 
HnrnpabRatribonucleoprotein complex part_ofIEAUniProtKB-KW:KW-06871600115GO_REF:0000043UniProtGO_REF:0000043
HnrnpabRatribonucleoprotein complex part_ofIEAUniProtKB:Q99729 and ensembl:ENSP000003511081600115GO_REF:0000107EnsemblGO_REF:0000107
HnrnpabRatribonucleoprotein complex part_ofISOHNRNPAB (Homo sapiens)1624291 PMID:17289661RGDPMID:17289661
HnrnpabRatRNA polymerase II transcription regulator complex part_ofISOHnrnpab (Mus musculus)1624291 PMID:17273560RGDPMID:17273560
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Molecular Function
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RGD Manual Annotations


  
Object Symbol
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Source
Original Reference(s)
HnrnpabRatspliceosome pathway   ISOHNRNPAB (Homo sapiens)9686091 RGD 

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#
Reference Title
Reference Citation
1. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Purification and cloning of type A/B hnRNP proteins involved in transcriptional activation from the Rat spi 2 gene GAGA box. Leverrier S, etal., Biol Chem. 2000 Nov;381(11):1031-40.
5. CArG binding factor A (CBF-A) is involved in transcriptional regulation of the rat Ha-ras promoter. Mikheev AM, etal., Nucleic Acids Res 2000 Oct 1;28(19):3762-70.
6. Landscape of the hnRNP K protein-protein interactome. Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
7. Microarray analysis of the global gene expression profile following hypothermia and transient focal cerebral ischemia. Nagel S, etal., Neuroscience. 2012 Apr 19;208:109-22. doi: 10.1016/j.neuroscience.2012.01.048. Epub 2012 Feb 10.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins. Percipalle P, etal., Nucleic Acids Res. 2002 Apr 15;30(8):1725-34.
10. In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements. Raju CS, etal., Mol Biol Cell. 2011 Jun 1;22(11):1864-77. doi: 10.1091/mbc.E10-11-0904. Epub 2011 Apr 6.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Functional domains involved in the interaction between Orc1 and transcriptional repressor AlF-C that bind to an origin/promoter of the rat aldolase B gene. Saitoh Y, etal., Nucleic Acids Res 2002 Dec 1;30(23):5205-12.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. A novel growth-related nuclear protein binds and inhibits rat aldolase B gene promoter. Yabuki T, etal., Gene 2001 Feb 7;264(1):123-9.
16. HNRNPAB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL. Zhou ZJ, etal., Cancer Res. 2014 May 15;74(10):2750-62. doi: 10.1158/0008-5472.CAN-13-2509. Epub 2014 Mar 17.
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PMID:15342744   PMID:17273560   PMID:17289661   PMID:22658674   PMID:22681889   PMID:23907535   PMID:24625528   PMID:35352799  



Hnrnpab
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,358,004 - 36,363,898 (-)NCBIGRCr8
mRatBN7.21035,857,040 - 35,862,935 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,857,041 - 35,863,344 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,551,497 - 40,557,391 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,041,789 - 40,047,683 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,545,198 - 35,551,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01034,955,713 - 34,961,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,049,677 - 37,055,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,955,716 - 34,961,608 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01036,821,682 - 36,827,630 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,117,285 - 37,123,177 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,570,905 - 27,583,441 (+)NCBI
Celera1035,213,782 - 35,219,674 (-)NCBICelera
Cytogenetic Map10q22NCBI
HNRNPAB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385178,204,533 - 178,211,163 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5178,204,533 - 178,211,163 (+)EnsemblGRCh38hg38GRCh38
GRCh375177,631,534 - 177,638,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365177,564,114 - 177,570,790 (+)NCBINCBI36Build 36hg18NCBI36
Build 345177,564,113 - 177,570,789NCBI
Celera5173,258,497 - 173,265,171 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5172,357,799 - 172,364,473 (+)NCBIHuRef
CHM1_15177,063,918 - 177,070,606 (+)NCBICHM1_1
T2T-CHM13v2.05178,754,824 - 178,761,448 (+)NCBIT2T-CHM13v2.0
Hnrnpab
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,490,927 - 51,497,708 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,490,927 - 51,497,674 (-)EnsemblGRCm39 Ensembl
GRCm381151,600,100 - 51,606,881 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1151,600,100 - 51,606,847 (-)EnsemblGRCm38mm10GRCm38
MGSCv371151,413,602 - 51,420,383 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,443,523 - 51,450,270 (-)NCBIMGSCv36mm8
Celera1156,171,430 - 56,178,210 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.11NCBI
Hnrnpab
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,060,829 - 2,065,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554082,060,288 - 2,064,998 (-)NCBIChiLan1.0ChiLan1.0
HNRNPAB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24173,146,592 - 173,153,282 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15171,286,162 - 171,292,839 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05173,364,301 - 173,370,974 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15180,622,362 - 180,628,209 (+)NCBIpanpan1.1PanPan1.1panPan2
HNRNPAB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,355,051 - 3,360,376 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,355,050 - 3,360,258 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha113,498,638 - 3,505,066 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0113,331,321 - 3,337,750 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,331,325 - 3,337,599 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,301,752 - 3,308,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,383,069 - 3,389,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,621,655 - 3,628,090 (-)NCBIUU_Cfam_GSD_1.0
Hnrnpab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213113,473,382 - 113,517,602 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936647478,443 - 484,570 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936647478,445 - 520,361 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPAB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1280,186,998 - 80,194,155 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2281,799,657 - 81,810,402 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPAB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,891,942 - 79,903,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607511,195,612 - 11,202,622 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpab
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473341,398,123 - 41,403,617 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473341,387,068 - 41,403,701 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Hnrnpab
14 total Variants

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:206
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000004885, ENSRNOT00000033056, ENSRNOT00000065584
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat

1 to 10 of 55 rows
RH138480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21035,856,612 - 35,856,776 (+)MAPPERmRatBN7.2
Rnor_6.01037,048,973 - 37,049,136NCBIRnor6.0
Rnor_6.01034,955,287 - 34,955,450NCBIRnor6.0
Rnor_5.01036,821,255 - 36,821,418UniSTSRnor5.0
Rnor_5.01034,727,633 - 34,727,796UniSTSRnor5.0
RGSC_v3.41037,116,856 - 37,117,019UniSTSRGSC3.4
Celera1035,213,353 - 35,213,516UniSTS
RH 3.4 Map10386.5UniSTS
Cytogenetic Map10q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19


1 to 20 of 20 rows
RefSeq Transcripts NM_031330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003750817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF216753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB780765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK473681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB886977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB886979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC944386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC944388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U44729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 20 of 20 rows

Ensembl Acc Id: ENSRNOT00000004885   ⟹   ENSRNOP00000004885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1035,857,055 - 35,862,827 (-)Ensembl
Rnor_6.0 Ensembl1034,956,052 - 34,961,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000033056   ⟹   ENSRNOP00000038183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1035,857,041 - 35,862,935 (-)Ensembl
Rnor_6.0 Ensembl1034,955,716 - 34,961,608 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000065584   ⟹   ENSRNOP00000062597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1035,857,042 - 35,863,344 (-)Ensembl
Rnor_6.0 Ensembl1037,049,677 - 37,055,282 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086193   ⟹   ENSRNOP00000069174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1037,049,677 - 37,055,282 (-)Ensembl
RefSeq Acc Id: NM_031330   ⟹   NP_112620
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,358,006 - 36,363,898 (-)NCBI
mRatBN7.21035,857,042 - 35,862,935 (-)NCBI
Rnor_6.01034,955,716 - 34,961,608 (-)NCBI
Rnor_5.01036,821,682 - 36,827,630 (-)NCBI
RGSC_v3.41037,117,285 - 37,123,177 (-)RGD
Celera1035,213,782 - 35,219,674 (-)RGD
Sequence:
RefSeq Acc Id: XM_063269960   ⟹   XP_063126030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,358,004 - 36,363,616 (-)NCBI
RefSeq Acc Id: NP_112620   ⟸   NM_031330
- UniProtKB: Q9QX80 (UniProtKB/TrEMBL),   E9PTS0 (UniProtKB/TrEMBL),   Q6NYB6 (UniProtKB/TrEMBL),   O88311 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062597   ⟸   ENSRNOT00000065584
Ensembl Acc Id: ENSRNOP00000038183   ⟸   ENSRNOT00000033056
Ensembl Acc Id: ENSRNOP00000069174   ⟸   ENSRNOT00000086193
Ensembl Acc Id: ENSRNOP00000004885   ⟸   ENSRNOT00000004885
RRM

Name Modeler Protein Id AA Range Protein Structure
AF-Q9QX81-F1-model_v2 AlphaFold Q9QX81 1-332 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697140
Promoter ID:EPDNEW_R7665
Type:single initiation site
Name:LOC103689931_1
Description:heterogeneous nuclear ribonucleoprotein A/B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01034,961,614 - 34,961,674EPDNEW


1 to 39 of 39 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-25198 BioCyc
Ensembl Genes ENSRNOG00000003645 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046272 Ensembl
Ensembl Transcript ENSRNOT00000004885 ENTREZGENE
  ENSRNOT00000004885.8 UniProtKB/TrEMBL
  ENSRNOT00000033056 ENTREZGENE
  ENSRNOT00000033056.6 UniProtKB/TrEMBL
  ENSRNOT00000065584.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621982 IMAGE-MGC_LOAD
InterPro CARG-binding_factor_N UniProtKB/TrEMBL
  hnRNPAB_RRM1 UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
KEGG Report rno:83498 UniProtKB/TrEMBL
MGC_CLONE MGC:72406 IMAGE-MGC_LOAD
NCBI Gene 83498 ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A/B UniProtKB/TrEMBL
  RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN UniProtKB/TrEMBL
Pfam CBFNT UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
PhenoGen Hnrnpab PhenoGen
PROSITE RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003645 RatGTEx
  ENSRNOG00000046272 RatGTEx
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8J8XXQ6_RAT UniProtKB/TrEMBL
  A6HE59 ENTREZGENE, UniProtKB/TrEMBL
  E9PTS0 ENTREZGENE
  F7F9P3_RAT UniProtKB/TrEMBL
  F7F9X0 ENTREZGENE, UniProtKB/TrEMBL
  O88311 ENTREZGENE, UniProtKB/TrEMBL
  Q6NYB6 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX80 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX81 ENTREZGENE
UniProt Secondary E9PTS0 UniProtKB/TrEMBL
  Q9QX81 UniProtKB/TrEMBL
1 to 39 of 39 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hnrnpab  heterogeneous nuclear ribonucleoprotein A/B  LOC103689931  heterogeneous nuclear ribonucleoprotein A/B  Data merged from RGD:9343685 737654 PROVISIONAL
2015-08-11 Hnrnpab  heterogeneous nuclear ribonucleoprotein A/B  LOC100910156  heterogeneous nuclear ribonucleoprotein A/B-like  Data merged from RGD:6499693 737654 APPROVED
2014-08-25 LOC103689931  heterogeneous nuclear ribonucleoprotein A/B      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100910156  heterogeneous nuclear ribonucleoprotein A/B-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-05-19 Hnrnpab  heterogeneous nuclear ribonucleoprotein A/B  Hnrpab  heterogeneous nuclear ribonucleoprotein A/B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hnrpab  heterogeneous nuclear ribonucleoprotein A/B      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_domains contains separate domains to bind DNA sequence-specifically and to repress transcription 628366
gene_expression enriched in fetal livers and regenerating livers 68198
gene_function binds to the rat aldolase B promoter 68198
gene_process may be involved in in repression of the Aldob gene 68198
gene_process binds directly to Orc1, a subunit of the origin recognition complex (ORC) and may mediate recruiting ORC to regulate replication initiation and/or transcription repression 628366
gene_product member of the hnRNP family containing two RNA-binding domains (RRM or RBD) 628366