Hnrnpab (heterogeneous nuclear ribonucleoprotein A/B)

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Gene: Hnrnpab (heterogeneous nuclear ribonucleoprotein A/B) Rattus norvegicus

Analyze

Symbol:

Hnrnpab

Name:

heterogeneous nuclear ribonucleoprotein A/B

RGD ID:

69255

Description:

Enables sequence-specific double-stranded DNA binding activity. Involved in cellular response to amino acid stimulus and regulation of intracellular mRNA localization. Located in dendrite; neuronal ribonucleoprotein granule; and nucleus. Part of messenger ribonucleoprotein complex. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B); PARTICIPATES IN spliceosome pathway; INTERACTS WITH (S)-AMPA; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

A1F-C1; heterogeneous nuclear ribonucleoprotein A/B-like; Hnrpab; LOC100910156; LOC103689931

RGD Orthologs

Human

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	35,857,040 - 35,862,935 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	35,857,041 - 35,863,344 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	40,551,497 - 40,557,391 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	40,041,789 - 40,047,683 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	35,545,198 - 35,551,092 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	34,955,713 - 34,961,662 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	34,955,716 - 34,961,608 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	10	37,049,677 - 37,055,282 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	36,821,682 - 36,827,630 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	37,117,285 - 37,123,177 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	27,570,905 - 27,583,441 (+)	NCBI
Celera	10	35,213,782 - 35,219,674 (-)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Mammary Neoplasms (ISO)

hepatocellular carcinoma (ISO)

transient cerebral ischemia (IDA)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-AMPA (EXP)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3',5'-cyclic UMP (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

Aroclor 1254 (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bleomycin A5 (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

chromium(6+) (ISO)

chrysene (ISO)

cisplatin (EXP)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP,ISO)

dioxygen (EXP,ISO)

enzyme inhibitor (ISO)

flavonoids (EXP)

flutamide (EXP)

folic acid (ISO)

genistein (EXP)

gentamycin (EXP)

geraniol (ISO)

hydrogen cyanide (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

ivermectin (ISO)

lovastatin (ISO)

methotrexate (ISO)

methylseleninic acid (ISO)

nefazodone (EXP)

oxycodone (EXP)

ozone (ISO)

paclitaxel (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

potassium cyanide (ISO)

progesterone (EXP)

quartz (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

sodium fluoride (ISO)

T-2 toxin (EXP)

tamoxifen (EXP,ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trichloroethene (EXP,ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

warfarin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to amino acid stimulus (IEP)

epithelial to mesenchymal transition (ISO,ISS)

mRNA modification (ISO)

negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

positive regulation of DNA-templated transcription (ISO,ISS)

regulation of cellular localization (IMP)

regulation of gene expression (IBA)

regulation of intracellular mRNA localization (IMP)

Cellular Component

cytoplasm (ISO,ISS)

dendrite (IDA)

messenger ribonucleoprotein complex (IDA)

neuronal ribonucleoprotein granule (IDA)

nucleoplasm (IBA,ISO)

nucleus (IDA,ISO,ISS)

presynaptic cytosol (ISO)

ribonucleoprotein complex (ISO)

RNA polymerase II transcription regulator complex (ISO,ISS)

Molecular Function

protein binding (IPI,ISO)

protein-containing complex binding (IDA)

RNA binding (IBA,ISO)

sequence-specific double-stranded DNA binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.	Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Purification and cloning of type A/B hnRNP proteins involved in transcriptional activation from the Rat spi 2 gene GAGA box.	Leverrier S, etal., Biol Chem. 2000 Nov;381(11):1031-40.
5.	CArG binding factor A (CBF-A) is involved in transcriptional regulation of the rat Ha-ras promoter.	Mikheev AM, etal., Nucleic Acids Res 2000 Oct 1;28(19):3762-70.
6.	Landscape of the hnRNP K protein-protein interactome.	Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
7.	Microarray analysis of the global gene expression profile following hypothermia and transient focal cerebral ischemia.	Nagel S, etal., Neuroscience. 2012 Apr 19;208:109-22. doi: 10.1016/j.neuroscience.2012.01.048. Epub 2012 Feb 10.
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins.	Percipalle P, etal., Nucleic Acids Res. 2002 Apr 15;30(8):1725-34.
10.	In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements.	Raju CS, etal., Mol Biol Cell. 2011 Jun 1;22(11):1864-77. doi: 10.1091/mbc.E10-11-0904. Epub 2011 Apr 6.
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Functional domains involved in the interaction between Orc1 and transcriptional repressor AlF-C that bind to an origin/promoter of the rat aldolase B gene.	Saitoh Y, etal., Nucleic Acids Res 2002 Dec 1;30(23):5205-12.
14.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15.	A novel growth-related nuclear protein binds and inhibits rat aldolase B gene promoter.	Yabuki T, etal., Gene 2001 Feb 7;264(1):123-9.
16.	HNRNPAB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL.	Zhou ZJ, etal., Cancer Res. 2014 May 15;74(10):2750-62. doi: 10.1158/0008-5472.CAN-13-2509. Epub 2014 Mar 17.

Additional References at PubMed

PMID:15342744	PMID:17273560	PMID:17289661	PMID:22658674	PMID:22681889	PMID:23907535	PMID:24625528

Genomics

Comparative Map Data

Hnrnpab
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	35,857,040 - 35,862,935 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	35,857,041 - 35,863,344 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	40,551,497 - 40,557,391 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	40,041,789 - 40,047,683 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	35,545,198 - 35,551,092 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	34,955,713 - 34,961,662 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	34,955,716 - 34,961,608 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	10	37,049,677 - 37,055,282 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	36,821,682 - 36,827,630 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	37,117,285 - 37,123,177 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	27,570,905 - 27,583,441 (+)	NCBI
Celera	10	35,213,782 - 35,219,674 (-)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

HNRNPAB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	178,204,533 - 178,211,163 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	178,204,533 - 178,211,163 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	177,631,534 - 177,638,164 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	177,564,114 - 177,570,790 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	177,564,113 - 177,570,789	NCBI
Celera	5	173,258,497 - 173,265,171 (+)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	172,357,799 - 172,364,473 (+)	NCBI		HuRef
CHM1_1	5	177,063,918 - 177,070,606 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	178,754,824 - 178,761,448 (+)	NCBI		T2T-CHM13v2.0

Hnrnpab
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	2,060,829 - 2,065,416 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	2,060,288 - 2,064,998 (-)	NCBI	ChiLan1.0	ChiLan1.0

HNRNPAB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	5	180,622,362 - 180,628,209 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	5	173,364,301 - 173,370,974 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

HNRNPAB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	3,355,051 - 3,360,376 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	3,355,050 - 3,360,258 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	3,498,638 - 3,505,066 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	3,331,321 - 3,337,750 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	3,331,325 - 3,337,599 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	3,301,752 - 3,308,179 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	3,383,069 - 3,389,498 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	3,621,655 - 3,628,090 (-)	NCBI		UU_Cfam_GSD_1.0

Hnrnpab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	113,473,382 - 113,517,602 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936647	478,445 - 520,361 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HNRNPAB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	80,186,998 - 80,194,155 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	81,799,657 - 81,810,402 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HNRNPAB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	79,891,942 - 79,903,289 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666075	11,195,612 - 11,202,622 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hnrnpab
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	41,398,123 - 41,403,617 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	41,387,068 - 41,403,701 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Position Markers

RH138480

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	35,856,612 - 35,856,776 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	37,048,973 - 37,049,136	NCBI	Rnor6.0
Rnor_6.0	10	34,955,287 - 34,955,450	NCBI	Rnor6.0
Rnor_5.0	10	36,821,255 - 36,821,418	UniSTS	Rnor5.0
Rnor_5.0	10	34,727,633 - 34,727,796	UniSTS	Rnor5.0
RGSC_v3.4	10	37,116,856 - 37,117,019	UniSTS	RGSC3.4
Celera	10	35,213,353 - 35,213,516	UniSTS
RH 3.4 Map	10	386.5	UniSTS
Cytogenetic Map	10	q22	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	cortical volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum total immunoglobulin E level (CMO:0001542)	10	22918268	36400810	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35392267	51793994	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	500
Count of miRNA genes:	206
Interacting mature miRNAs:	242
Transcripts:	ENSRNOT00000004885, ENSRNOT00000033056, ENSRNOT00000065584
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	55	39	19	39	2	2	70	34	35	11	2
Low		9	2	2		2	6	9	4	1	6		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003750817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC105470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF216753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ238854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ238855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC066664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB780765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK473681	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB886977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB886979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC944386	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC944388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U44729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000004885 ⟹ ENSRNOP00000004885

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	35,857,055 - 35,862,827 (-)	Ensembl
Rnor_6.0 Ensembl	10	34,956,052 - 34,961,349 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000033056 ⟹ ENSRNOP00000038183

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	35,857,041 - 35,862,935 (-)	Ensembl
Rnor_6.0 Ensembl	10	34,955,716 - 34,961,608 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000065584 ⟹ ENSRNOP00000062597

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	35,857,042 - 35,863,344 (-)	Ensembl
Rnor_6.0 Ensembl	10	37,049,677 - 37,055,282 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000086193 ⟹ ENSRNOP00000069174

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	37,049,677 - 37,055,282 (-)	Ensembl

RefSeq Acc Id:

NM_031330 ⟹ NP_112620

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	35,857,042 - 35,862,935 (-)	NCBI
Rnor_6.0	10	34,955,716 - 34,961,608 (-)	NCBI
Rnor_5.0	10	36,821,682 - 36,827,630 (-)	NCBI
RGSC_v3.4	10	37,117,285 - 37,123,177 (-)	RGD
Celera	10	35,213,782 - 35,219,674 (-)	RGD

Sequence:

show sequence

TGGCACCGCGCGGGACGGAGCTGAGGTCTTCCTTCTCGATAGCGTACGGCGGCTGCCGAGTAGA
GCGATAGGGTCTGTGGACCCGGACAAGCCCTAGGGGGGTCCGAGTGTGACCGCGGCCAAGCCCG
CGTCGCCTTCTGCGGCGAGTAGGGCCTCGCGGCGTCATCGGCGGCGAGGAGCCGCTGCGGCCTG
GCCGACCATGTCGGACGCGGCTGAGGAGCAGCCCATGGAGACGACGGGCGCCACCGAGAACGGA
CACGAGGCCGCCCCCGAAGGCGAGGCCCCGGTCGAGCCTAGCCCTGGGGCAGCGGCCCCCGCGA
CTCCGGCGGGGTCTGGGGGCGGGACCACGGCCGCCCCGAGCGGGAACCAGAACGGCGCCGAAGG
CGACCAGATCAACGCCAGCAAGAACGAGGAGGACGCGGGAAAAATGTTCGTTGGTGGTCTGAGC
TGGGATACCAGCAAAAAAGATCTAAAGGATTATTTTACTAAGTTTGGAGAGGTCGTTGACTGTA
CAATAAAAATGGATCCGAACACTGGTCGATCAAGAGGGTTTGGGTTTATTCTCTTCAAAGATTC
TTCTAGTGTGGAGAAGGTCTTAGATCAGAAGGAGCACAGACTGGATGGTCGTGTCATTGACCCT
AAAAAGGCTATGGCTATGAAGAAGGACCCTGTGAAGAAAATCTTTGTGGGAGGTCTAAACCCTG
AAGCCACAGAGGAAAAGATCAGAGAATACTTTGGCCAGTTTGGGGAGATTGAGGCCATTGAACT
TCCAATAGATCCCAAGTTGAACAAAAGACGGGGTTTTGTTTTTATTACATTTAAAGAGGAAGAC
CCTGTGAAGAAAGTTCTGGAGAAAAAATTCCATACTGTCAGTGGTAGCAAGTGTGAAATCAAGG
TTGCCCAGCCCAAAGAGGTGTACCAGCAACAGCAGTATGGCTCTGGGGGCCGAGGAAATCGCAA
TCGAGGGAACCGAGGCAGTGGTGGAGGTCAGGGTAGTACAAATTACGGGAAGAGCCAGCGACGT
GGTGGTCATCAGAATAACTACAAGCCATACTGAGAGGCAGCAGGAGCGGCCGAGTGACGACCGC
ACACGCTTTGTTTGGACGCGGAGTGAACACAATTATGTACCAAATTTAACTTGGCAAACTTTTA
TGGCCTGTCCCATGTGCATCTTATTTAAAATTTCCCCCGGAAATCACTCTCCTGTTTACTATTC
CAGAGCTCTAGTTGTTGTAGGCAGCGTGTGGCGTCTCAGAGGTCAGAGCGGCATTAGGGGGCTG
ATTTTATTACCAGGTTACCCTGTTCTAGATTGGAGGGTCTGCTTCCTGCTGCCGCTCTGCAGCC
TGGACCTGTGGACCCTGGTTGTAAAGAGTAAACTGTATCTTAGGAAACCAGTGTCACCTTTTTC
ACCTTTTAATTTTATATTATTTGTGTCATACATTTCCAGTAATGGAAGTGTTAATTTTACTGTA
CTTTTTGGTACCTTTTGGGAATCTAATGTATTGTAAGGTATTTTACACGTGTCCTGATTTTGCC
ACGACCTGGATATTGAAGCTATCCAAGCTTTTGAAATAAAAATTAAACAAAACCCC

hide sequence

RefSeq Acc Id:

XM_006246345 ⟹ XP_006246407

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	35,857,040 - 35,862,934 (-)	NCBI

Sequence:

show sequence

TGGTGCCCGGCTCCGGCATTATAAAGAGCTCCACGAGTTGGCATTGTCAGGCGGTGGCACCGCG
CGGGACGGAGCTGAGGTCTTCCTTCTCGATAGCGTACGGCGGCTGCCGAGTAGAGCGATAGGGT
CTGTGGACCCGGACAAGCCCTAGGGGGGTCCGAGTGTGACCGCGGCCAAGCCCGCGTCGCCTTC
TGCGGCGAGTAGGGCCTCGCGGCGTCATCGGCGGCGAGGAGCCGCTGCGGCCTGGCCGACCATG
TCGGACGCGGCTGAGGAGCAGCCCATGGAGACGACGGGCGCCACCGAGAACGGACACGAGGCCG
CCCCCGAAGGCGAGGCCCCGGTCGAGCCTAGCCCTGGGGCAGCGGCCCCCGCGACTCCGGCGGG
GTCTGGGGGCGGGACCACGGCCGCCCCGAGCGGGAACCAGAACGGCGCCGAAGGCGACCAGATC
AACGCCAGCAAGAACGAGGAGGACGCGGGAAAAATGTTCGTTGGTGGTCTGAGCTGGGATACCA
GCAAAAAAGATCTAAAGGATTATTTTACTAAGTTTGGAGAGGTCGTTGACTGTACAATAAAAAT
GGATCCGAACACTGGTCGATCAAGAGGGTTTGGGTTTATTCTCTTCAAAGATTCTTCTAGTGTG
GAGAAGGTCTTAGATCAGAAGGAGCACAGACTGGATGGTCGTGTCATTGACCCTAAAAAGGCTA
TGGCTATGAAGAAGGACCCTGTGAAGAAAATCTTTGTGGGAGGTCTAAACCCTGAAGCCACAGA
GGAAAAGATCAGAGAATACTTTGGCCAGTTTGGGGAGATTGAGGCCATTGAACTTCCAATAGAT
CCCAAGTTGAACAAAAGACGGGGTTTTGTTTTTATTACATTTAAAGAGGAAGACCCTGTGAAGA
AAGTTCTGGAGAAAAAATTCCATACTGTCAGTGGTAGCAAGTGTGAAATCAAGGTTGCCCAGCC
CAAAGAGGTGTACCAGCAACAGCAGTATGGCTCTGGGGGCCGAGGAAATCGCAATCGAGGGAAC
CGAGGCAGTGGTGGAGGTCAGAGTCAGAGTTGGAATCAGGGCTACGGCAACTACTGGAACCAGG
GCTACGGCTACCAGCAGGGCTACGGGCCGGGCTATGGCGGCTACGACTACTCGCCCTATGGCTA
TTACGGCTACGGCCCCGGCTACGACTACAGTCAGGGTAGTACAAATTACGGGAAGAGCCAGCGA
CGTGGTGGTCATCAGAATAACTACAAGCCATACTGAGAGGCAGCAGGAGCGGCCGAGTGACGAC
CGCACACGCTTTGTTTGGACGCGGAGTGAACACAATTATGTACCAAATTTAACTTGGCAAACTT
TTATGGCCTGTCCCATGTGCATCTTATTTAAAATTTCCCCCGGAAATCACTCTCCTGTTTACTA
TTCCAGAGCTCTAGTTGTTGTAGGCAGCGTGTGGCGTCTCAGAGGTCAGAGCGGCATTAGGGGG
CTGATTTTATTACCAGGTTACCCTGTTCTAGATTGGAGGGTCTGCTTCCTGCTGCCGCTCTGCA
GCCTGGACCTGTGGACCCTGGTTGTAAAGAGTAAACTGTATCTTAGGAAACCAGTGTCACCTTT
TTCACCTTTTAATTTTATATTATTTGTGTCATACATTTCCAGTAATGGAAGTGTTAATTTTACT
GTACTTTTTGGTACCTTTTGGGAATCTAATGTATTGTAAGGTATTTTACACGTGTCCTGATTTT
GCCACGACCTGGATATTGAAGCTATCCAAGCTTTTGAAATAAAAATTAAACAAAACCCCAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_112620	(Get FASTA)	NCBI Sequence Viewer
	XP_006246407	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB92079	(Get FASTA)	NCBI Sequence Viewer
	AAF31437	(Get FASTA)	NCBI Sequence Viewer
	AAH66664	(Get FASTA)	NCBI Sequence Viewer
	CAB62553	(Get FASTA)	NCBI Sequence Viewer
	CAB62554	(Get FASTA)	NCBI Sequence Viewer
	CBF67645	(Get FASTA)	NCBI Sequence Viewer
	CBF67646	(Get FASTA)	NCBI Sequence Viewer
	CBU92519	(Get FASTA)	NCBI Sequence Viewer
	CBU92520	(Get FASTA)	NCBI Sequence Viewer
	EDM04313	(Get FASTA)	NCBI Sequence Viewer
	EDM04314	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_112620 ⟸ NM_031330

- UniProtKB:

Q9QX80 (UniProtKB/TrEMBL), E9PTS0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSDAAEEQPMETTGATENGHEAAPEGEAPVEPSPGAAAPATPAGSGGGTTAAPSGNQNGAEGDQ
INASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDSSS
VEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGQFGEIEAIELPI
DPKLNKRRGFVFITFKEEDPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRG
NRGSGGGQGSTNYGKSQRRGGHQNNYKPY

hide sequence

RefSeq Acc Id:	XP_006246407 ⟸ XM_006246345
- Peptide Label:	isoform X1
- UniProtKB:	Q9QX81 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSDAAEEQPMETTGATENGHEAAPEGEAPVEPSPGAAAPATPAGSGGGTTAAPSGNQNGAEGDQ INASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDSSS VEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGQFGEIEAIELPI DPKLNKRRGFVFITFKEEDPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRG NRGSGGGQSQSWNQGYGNYWNQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQ RRGGHQNNYKPY hide sequence

RefSeq Acc Id:

ENSRNOP00000062597 ⟸ ENSRNOT00000065584

RefSeq Acc Id:

ENSRNOP00000038183 ⟸ ENSRNOT00000033056

RefSeq Acc Id:

ENSRNOP00000069174 ⟸ ENSRNOT00000086193

RefSeq Acc Id:

ENSRNOP00000004885 ⟸ ENSRNOT00000004885

Protein Domains

RRM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QX81-F1-model_v2	AlphaFold	Q9QX81	1-332	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697140

Promoter ID:

EPDNEW_R7665

Type:

single initiation site

Name:

LOC103689931_1

Description:

heterogeneous nuclear ribonucleoprotein A/B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	34,961,614 - 34,961,674	EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)

ACI/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69255	AgrOrtholog
BioCyc Gene	G2FUF-25198	BioCyc
Ensembl Genes	ENSRNOG00000003645	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000046272	Ensembl
Ensembl Protein	ENSRNOP00000004885	ENTREZGENE
	ENSRNOP00000004885.5	UniProtKB/TrEMBL
	ENSRNOP00000038183.5	UniProtKB/TrEMBL
	ENSRNOP00000062597	ENTREZGENE
	ENSRNOP00000062597.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004885	ENTREZGENE
	ENSRNOT00000004885.8	UniProtKB/TrEMBL
	ENSRNOT00000033056.6	UniProtKB/TrEMBL
	ENSRNOT00000065584	ENTREZGENE
	ENSRNOT00000065584.4	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.330	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5621982	IMAGE-MGC_LOAD
InterPro	CARG-binding_factor_N	UniProtKB/TrEMBL
	hnRNPAB_RRM1	UniProtKB/TrEMBL
	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	RRM_dom	UniProtKB/TrEMBL
KEGG Report	rno:83498	UniProtKB/TrEMBL
MGC_CLONE	MGC:72406	IMAGE-MGC_LOAD
NCBI Gene	83498	ENTREZGENE
Pfam	CBFNT	UniProtKB/TrEMBL
	RRM_1	UniProtKB/TrEMBL
PhenoGen	Hnrnpab	PhenoGen
PROSITE	RRM	UniProtKB/TrEMBL
SMART	RRM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54928	UniProtKB/TrEMBL
UniProt	A0A8J8XXQ6_RAT	UniProtKB/TrEMBL
	E9PTS0	ENTREZGENE
	F7F9P3_RAT	UniProtKB/TrEMBL
	Q9QX80	ENTREZGENE, UniProtKB/TrEMBL
	Q9QX81	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	E9PTS0	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	LOC103689931	heterogeneous nuclear ribonucleoprotein A/B	Data Merged	737654	PROVISIONAL
2015-08-11	Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	LOC100910156	heterogeneous nuclear ribonucleoprotein A/B-like	Data Merged	737654	APPROVED
2014-08-25	LOC103689931	heterogeneous nuclear ribonucleoprotein A/B			Symbol and Name status set to provisional	70820	PROVISIONAL
2012-07-05	LOC100910156	heterogeneous nuclear ribonucleoprotein A/B-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-05-19	Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	Hnrpab	heterogeneous nuclear ribonucleoprotein A/B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Hnrpab	heterogeneous nuclear ribonucleoprotein A/B			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains separate domains to bind DNA sequence-specifically and to repress transcription	628366
gene_expression	enriched in fetal livers and regenerating livers	68198
gene_function	binds to the rat aldolase B promoter	68198
gene_process	may be involved in in repression of the Aldob gene	68198
gene_process	binds directly to Orc1, a subunit of the origin recognition complex (ORC) and may mediate recruiting ORC to regulate replication initiation and/or transcription repression	628366
gene_product	member of the hnRNP family containing two RNA-binding domains (RRM or RBD)	628366

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

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Imported Disease Annotations - CTD

RGD Manual Annotations