Erc1 (ELKS/RAB6-interacting/CAST family member 1) - Rat Genome Database

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Gene: Erc1 (ELKS/RAB6-interacting/CAST family member 1) Rattus norvegicus
Analyze
Symbol: Erc1
Name: ELKS/RAB6-interacting/CAST family member 1
RGD ID: 628733
Description: Enables PDZ domain binding activity. Predicted to be involved in several processes, including I-kappaB phosphorylation; maintenance of presynaptic active zone structure; and positive regulation of NF-kappaB transcription factor activity. Located in membrane; postsynaptic density; and synaptic vesicle. Is active in presynaptic active zone cytoplasmic component. Orthologous to human ERC1 (ELKS/RAB6-interacting/CAST family member 1); PARTICIPATES IN interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CAST; Cast2; CAZ-associated structural protein 2; Elks; ERC; ERC protein 1; ERC-1; ERC1b; Rab6 interacting protein 2; Rab6-interacting protein 2; Rab6ip2; RIM-Binding Protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84154,435,936 - 154,727,987 (-)NCBIGRCr8
mRatBN7.24152,763,664 - 153,055,724 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4152,767,419 - 153,055,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4159,025,966 - 159,332,211 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04154,809,683 - 155,115,934 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,433,030 - 153,739,286 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04152,087,393 - 152,380,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4152,087,379 - 152,380,184 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04219,174,705 - 219,465,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44155,931,377 - 156,221,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14156,234,169 - 156,465,945 (-)NCBI
Celera4141,623,820 - 141,910,539 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Erc1RatHyperphosphatemic Familial Tumoral Calcinosis 1  ISOERC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Tumoral calcinosis more ...ClinVarPMID:25378588 and PMID:29389098
Erc1RatMacrocephaly, Dysmorphic Facies, and Psychomotor Retardation  ISOERC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Macrocephaly more ...ClinVarPMID:25741868

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Erc1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOERC1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ERC1 mRNACTDPMID:22079256
Erc1Rat(1->4)-beta-D-glucan multiple interactionsISOErc1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ERC1 mRNACTDPMID:36331819
Erc1Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of ERC1 mRNACTDPMID:32145629
Erc1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of ERC1 mRNACTDPMID:22298810
Erc1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ERC1 mRNACTDPMID:33387578 and PMID:34747641
Erc1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOErc1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ERC1 mRNACTDPMID:21570461
Erc1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Erc1Rat2,5-hexanedione increases expressionEXP 64804642 and 5-hexanedione results in increased expression of ERC1 mRNACTDPMID:22952946
Erc1Rat3,3',4,4'-tetrachlorobiphenyl multiple interactionsISOErc1 (Mus musculus)64804643 more ...CTDPMID:19467301
Erc1Rat4,4'-sulfonyldiphenol increases expressionISOERC1 (Homo sapiens)6480464bisphenol S results in increased expression of ERC1 proteinCTDPMID:34186270
Erc1Rat4-hydroxyphenyl retinamide decreases expressionISOErc1 (Mus musculus)6480464Fenretinide results in decreased expression of ERC1 mRNACTDPMID:28973697
Erc1Rat5-aza-2'-deoxycytidine affects expressionISOERC1 (Homo sapiens)6480464Decitabine affects the expression of ERC1 mRNACTDPMID:23300844
Erc1Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of ERC1 mRNACTDPMID:31881176
Erc1Ratacrolein multiple interactionsISOERC1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ERC1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of ERC1 mRNACTDPMID:32699268
Erc1Rataflatoxin B1 decreases expressionISOERC1 (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of ERC1 mRNACTDPMID:21641981
Erc1Rataflatoxin B1 increases methylationISOERC1 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of ERC1 geneCTDPMID:27153756
Erc1RatAflatoxin B2 alpha decreases methylationISOERC1 (Homo sapiens)6480464aflatoxin B2 results in decreased methylation of ERC1 intronCTDPMID:30157460
Erc1Ratalpha-pinene multiple interactionsISOERC1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ERC1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of ERC1 mRNACTDPMID:32699268
Erc1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of ERC1 mRNACTDPMID:16483693
Erc1Ratamphetamine decreases expressionEXP 6480464Amphetamine results in decreased expression of ERC1 mRNACTDPMID:30779732

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Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Erc1RatI-kappaB phosphorylation involved_inISOERC1 (Homo sapiens)1624291 PMID:15218148RGDPMID:15218148
Erc1Ratmaintenance of presynaptic active zone structure involved_inIBAFB:FBgn0259246 and PANTHER:PTN0004292741600115GO_REF:0000033GO_CentralGO_REF:0000033
Erc1Ratpositive regulation of NF-kappaB transcription factor activity involved_inISOERC1 (Homo sapiens)1624291 PMID:15218148RGDPMID:15218148
Erc1Ratprotein transport involved_inIEAUniProtKB-KW:KW-06531600115GO_REF:0000043UniProtGO_REF:0000043
Erc1Ratregulation of calcium-dependent activation of synaptic vesicle fusion involved_inISOErc1 (Mus musculus)1624291 PMID:25209271RGDPMID:25209271
Erc1Ratregulation of DNA-templated transcription involved_inIEAUniProtKB:Q8IUD2 and ensembl:ENSP000003541581600115GO_REF:0000107EnsemblGO_REF:0000107
Erc1Ratregulation of DNA-templated transcription involved_inISOERC1 (Homo sapiens)1624291 PMID:15218148RGDPMID:15218148
Erc1Ratregulation of presynaptic cytosolic calcium ion concentration involved_inISOErc1 (Mus musculus)1624291 PMID:25209271RGDPMID:25209271
Erc1Ratretrograde transport, endosome to Golgi involved_inISSUniProtKB:Q99MI11600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Erc1Ratretrograde transport, endosome to Golgi acts_upstream_of_or_withinISOErc1 (Mus musculus)1624291 PMID:11929610RGDPMID:11929610
Erc1Ratsynaptic vesicle priming involved_inISOErc1 (Mus musculus)1624291 PMID:27253063RGDPMID:27253063
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Cellular Component
1 to 20 of 39 rows

  
Object Symbol
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Evidence
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Reference
Notes
Source
Original Reference(s)
Erc1Ratanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Erc1Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Erc1Ratcentrosome located_inIEAUniProtKB:Q8IUD2 and ensembl:ENSP000003541581600115GO_REF:0000107EnsemblGO_REF:0000107
Erc1Ratcentrosome located_inIEAUniProtKB-SubCell:SL-00481600115GO_REF:0000044UniProtGO_REF:0000044
Erc1Ratcentrosome located_inISOERC1 (Homo sapiens)1624291 PMID:27224062RGDPMID:27224062
Erc1Ratciliary basal body located_inIEAUniProtKB:Q8IUD2 and ensembl:ENSP000003541581600115GO_REF:0000107EnsemblGO_REF:0000107
Erc1Ratciliary basal body located_inISOERC1 (Homo sapiens)1624291 PMID:27224062RGDPMID:27224062
Erc1Ratcytoplasm located_inIEAUniProtKB:Q8IUD2 and ensembl:ENSP000003541581600115GO_REF:0000107EnsemblGO_REF:0000107
Erc1Ratcytoplasm located_inISOERC1 (Homo sapiens)1624291 PMID:15218148RGDPMID:15218148
Erc1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Erc1Ratcytoplasm located_inISOErc1 (Mus musculus)1624291 PMID:11929610RGDPMID:11929610
Erc1Ratcytoplasm located_inISSUniProtKB:Q99MI11600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Erc1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Erc1Ratcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Erc1Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Erc1Ratendomembrane system located_inIEAUniProtKB-SubCell:SL-01471600115GO_REF:0000044UniProtGO_REF:0000044
Erc1RatGABA-ergic synapse is_active_inISOErc1 (Mus musculus)1624291 PMID:25209271RGDPMID:25209271
Erc1Ratglutamatergic synapse is_active_inISOErc1 (Mus musculus)1624291 PMID:27253063RGDPMID:27253063
Erc1RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Erc1RatGolgi membrane located_inIEAUniProtKB-SubCell:SL-01341600115GO_REF:0000044UniProtGO_REF:0000044
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Imported Annotations - PID (archival)

Object Symbol
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Term
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Evidence
With
Reference
Notes
Source
Original Reference(s)
Erc1Ratinterleukin-1 signaling pathway   ISOERC1 (Homo sapiens)6484113 PIDPID:200089
Erc1Ratnuclear factor kappa B signaling pathway   ISOERC1 (Homo sapiens)6484113 PIDPID:200031

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Kaeser PS, etal., Cell. 2011 Jan 21;144(2):282-95. doi: 10.1016/j.cell.2010.12.029.
3. Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide. Lu J, etal., J Mol Biol. 2005 Sep 16;352(2):455-66.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression. Mochida S, etal., Cell Rep. 2016 Sep 13;16(11):2901-2913. doi: 10.1016/j.celrep.2016.08.020.
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. Wang Y, etal., Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14464-9.
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PMID:11929610   PMID:14723704   PMID:15218148   PMID:16716196   PMID:19515363   PMID:21700703   PMID:21712437   PMID:23791195   PMID:25209271   PMID:25468996   PMID:27224062   PMID:27253063  
PMID:27537483   PMID:28264913  



Erc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84154,435,936 - 154,727,987 (-)NCBIGRCr8
mRatBN7.24152,763,664 - 153,055,724 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4152,767,419 - 153,055,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4159,025,966 - 159,332,211 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04154,809,683 - 155,115,934 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,433,030 - 153,739,286 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04152,087,393 - 152,380,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4152,087,379 - 152,380,184 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04219,174,705 - 219,465,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44155,931,377 - 156,221,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14156,234,169 - 156,465,945 (-)NCBI
Celera4141,623,820 - 141,910,539 (-)NCBICelera
Cytogenetic Map4q42NCBI
ERC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812989,959 - 1,495,933 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12990,509 - 1,495,933 (+)EnsemblGRCh38hg38GRCh38
GRCh37121,100,389 - 1,605,099 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612970,665 - 1,472,958 (+)NCBINCBI36Build 36hg18NCBI36
Celera122,707,077 - 3,211,656 (+)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef12952,225 - 1,457,980 (+)NCBIHuRef
CHM1_1121,099,408 - 1,604,090 (+)NCBICHM1_1
T2T-CHM13v2.012985,850 - 1,490,194 (+)NCBIT2T-CHM13v2.0
Erc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396119,547,757 - 119,830,985 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6119,547,757 - 119,825,128 (-)EnsemblGRCm39 Ensembl
GRCm386119,570,796 - 119,848,184 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6119,570,796 - 119,848,167 (-)EnsemblGRCm38mm10GRCm38
MGSCv376119,520,814 - 119,798,168 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366119,540,864 - 119,813,753 (-)NCBIMGSCv36mm8
Celera6121,405,104 - 121,685,429 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map656.86NCBI
Erc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554543,586,667 - 4,031,130 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554543,584,910 - 4,036,276 (+)NCBIChiLan1.0ChiLan1.0
ERC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2106,489,987 - 7,025,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1126,486,819 - 7,022,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,066,034 - 1,597,562 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,027,967 - 1,550,182 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,027,967 - 1,545,431 (+)Ensemblpanpan1.1panPan2
ERC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12743,004,243 - 43,544,260 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2743,038,544 - 43,678,843 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,140,420 - 3,679,170 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02743,365,560 - 43,911,683 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2743,365,538 - 43,911,649 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12743,303,937 - 43,842,830 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02743,275,814 - 43,815,242 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,498,548 - 3,038,339 (-)NCBIUU_Cfam_GSD_1.0
Erc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945107,470,207 - 107,982,754 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366061,201,657 - 1,708,551 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366061,201,420 - 1,713,894 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl568,223,729 - 68,608,703 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1568,223,722 - 68,608,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2570,490,274 - 70,873,482 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111989,376 - 1,530,470 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl111,030,294 - 1,524,817 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660636,812,077 - 7,356,786 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473511,400,159 - 11,841,920 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473511,398,603 - 11,907,553 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Erc1
1603 total Variants

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:58
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000012397
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat

1 to 10 of 46 rows
D4Rat107  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84154,597,593 - 154,597,827 (+)Marker Load Pipeline
mRatBN7.24152,925,326 - 152,925,562 (+)MAPPERmRatBN7.2
Rnor_6.04152,249,616 - 152,249,849NCBIRnor6.0
Rnor_5.04219,336,960 - 219,337,193UniSTSRnor5.0
RGSC_v3.44156,090,003 - 156,090,237RGDRGSC3.4
RGSC_v3.44156,090,004 - 156,090,237UniSTSRGSC3.4
RGSC_v3.14156,334,845 - 156,335,078RGD
Celera4141,780,453 - 141,780,686UniSTS
RH 3.4 Map4978.8UniSTS
RH 3.4 Map4978.8RGD
RH 2.0 Map4972.5RGD
SHRSP x BN Map477.0299RGD
Cytogenetic Map4q42UniSTS
BE108954  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84154,677,093 - 154,677,273 (+)Marker Load Pipeline
mRatBN7.24153,004,831 - 153,005,011 (+)MAPPERmRatBN7.2
Rnor_6.04152,329,598 - 152,329,777NCBIRnor6.0
Rnor_5.04219,416,860 - 219,417,039UniSTSRnor5.0
RGSC_v3.44156,170,532 - 156,170,711UniSTSRGSC3.4
Celera4141,859,984 - 141,860,163UniSTS
RH 3.4 Map4978.9UniSTS
Cytogenetic Map4q42UniSTS
BE095665  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,868,812 - 152,868,967 (+)MAPPERmRatBN7.2
Rnor_6.04152,193,101 - 152,193,255NCBIRnor6.0
Rnor_5.04219,280,713 - 219,280,867UniSTSRnor5.0
RGSC_v3.44156,032,819 - 156,032,973UniSTSRGSC3.4
Celera4141,724,043 - 141,724,197UniSTS
RH 3.4 Map4978.7UniSTS
Cytogenetic Map4q42UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 20 of 20 rows
RefSeq Transcripts NM_001394882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_172210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF541926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 20 of 20 rows

Ensembl Acc Id: ENSRNOT00000012397   ⟹   ENSRNOP00000012397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,768,451 - 153,055,533 (-)Ensembl
Rnor_6.0 Ensembl4152,092,180 - 152,380,023 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091473   ⟹   ENSRNOP00000070778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,767,419 - 153,055,533 (-)Ensembl
Rnor_6.0 Ensembl4152,087,379 - 152,380,184 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102886   ⟹   ENSRNOP00000092904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,814,772 - 153,055,639 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109038   ⟹   ENSRNOP00000094050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,767,419 - 153,055,533 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115061   ⟹   ENSRNOP00000084657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4152,767,419 - 153,055,533 (-)Ensembl
RefSeq Acc Id: NM_001394882   ⟹   NP_001381811
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,435,936 - 154,727,987 (-)NCBI
mRatBN7.24152,763,664 - 153,055,724 (-)NCBI
RefSeq Acc Id: NM_001394883   ⟹   NP_001381812
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,435,936 - 154,727,987 (-)NCBI
mRatBN7.24152,763,664 - 153,055,724 (-)NCBI
RefSeq Acc Id: NM_001394884   ⟹   NP_001381813
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,435,936 - 154,727,987 (-)NCBI
mRatBN7.24152,763,664 - 153,055,724 (-)NCBI
RefSeq Acc Id: NR_172210
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,435,936 - 154,727,987 (-)NCBI
mRatBN7.24152,763,664 - 153,055,724 (-)NCBI
RefSeq Acc Id: XM_006237230   ⟹   XP_006237292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,435,936 - 154,727,851 (-)NCBI
mRatBN7.24152,763,664 - 153,055,704 (-)NCBI
Rnor_6.04152,087,393 - 152,380,021 (-)NCBI
Rnor_5.04219,174,705 - 219,465,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107148   ⟹   XP_038963076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,435,936 - 154,727,851 (-)NCBI
mRatBN7.24152,763,664 - 153,055,704 (-)NCBI
RefSeq Acc Id: XM_063285644   ⟹   XP_063141714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,435,936 - 154,727,851 (-)NCBI
RefSeq Acc Id: XM_063285645   ⟹   XP_063141715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,460,510 - 154,727,851 (-)NCBI
RefSeq Acc Id: XM_063285646   ⟹   XP_063141716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,460,510 - 154,727,851 (-)NCBI
RefSeq Acc Id: XM_063285647   ⟹   XP_063141717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,460,510 - 154,727,851 (-)NCBI
RefSeq Acc Id: XM_063285648   ⟹   XP_063141718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,460,510 - 154,727,851 (-)NCBI
RefSeq Acc Id: XM_063285649   ⟹   XP_063141719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,460,510 - 154,727,851 (-)NCBI
1 to 5 of 16 rows
1 to 5 of 16 rows
RefSeq Acc Id: XP_006237292   ⟸   XM_006237230
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AIL7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012397   ⟸   ENSRNOT00000012397
Ensembl Acc Id: ENSRNOP00000070778   ⟸   ENSRNOT00000091473
RefSeq Acc Id: XP_038963076   ⟸   XM_039107148
- Peptide Label: isoform X1
- UniProtKB: F1LPE9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092904   ⟸   ENSRNOT00000102886
FIP-RBD

Name Modeler Protein Id AA Range Protein Structure
AF-Q811U3-F1-model_v2 AlphaFold Q811U3 1-948 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693353
Promoter ID:EPDNEW_R3875
Type:multiple initiation site
Name:Erc1_1
Description:ELKS/RAB6-interacting/CAST family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04152,380,207 - 152,380,267EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-43216 BioCyc
Ensembl Genes ENSRNOG00000009264 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012397 ENTREZGENE
  ENSRNOT00000091473 ENTREZGENE
  ENSRNOT00000102886 ENTREZGENE
  ENSRNOT00000109038 ENTREZGENE
  ENSRNOT00000115061 ENTREZGENE
Gene3D-CATH 1.10.287.1490 UniProtKB/Swiss-Prot
InterPro ELKS/CAST UniProtKB/Swiss-Prot
NCBI Gene 266806 ENTREZGENE
PANTHER ELKS/RAB6-INTERACTING/CAST FAMILY MEMBER 1 UniProtKB/Swiss-Prot
  ELKS/RAB6-INTERACTING/CAST PROTEIN UniProtKB/Swiss-Prot
Pfam Cast UniProtKB/Swiss-Prot
PhenoGen Erc1 PhenoGen
RatGTEx ENSRNOG00000009264 RatGTEx
Superfamily-SCOP Tropomyosin UniProtKB/Swiss-Prot
UniProt A0A0G2JYT1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0L5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKZ4 ENTREZGENE, UniProtKB/TrEMBL
  A6IL87 ENTREZGENE, UniProtKB/TrEMBL
  A6IL88 ENTREZGENE, UniProtKB/TrEMBL
  A6IL89 ENTREZGENE, UniProtKB/TrEMBL
  F1LPE9 ENTREZGENE, UniProtKB/TrEMBL
  Q811U3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8CIY9 UniProtKB/Swiss-Prot
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Erc1  ELKS/RAB6-interacting/CAST family member 1  Rab6ip2  Rab6 interacting protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rab6ip2  Rab6 interacting protein 2  Elks  ELKS protein  Symbol and Name updated 1299863 APPROVED
2003-02-27 Elks  ELKS protein      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_transcript has two alternative splicing variants; one variant generates a longer transcript that does not bind to RIMs 632516