Symbol:
Ntrk2
Name:
neurotrophic receptor tyrosine kinase 2
RGD ID:
3213
Description:
Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor receptor activity; and protein homodimerization activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of intracellular signal transduction; and regulation of neuron projection development. Acts upstream of or within positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway. Located in several cellular components, including dendritic spine; distal axon; and perikaryon. Is active in glutamatergic synapse; postsynaptic membrane; and presynapse. Used to study several diseases, including alcohol use disorder; brain disease (multiple); cognitive disorder (multiple); drug dependence (multiple); and glaucoma. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; anxiety disorder (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autistic disorder; developmental and epileptic encephalopathy 58; heroin dependence; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-AMPA; 17alpha-ethynylestradiol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
BDNF/NT-3 growth factors receptor; GP145-TrkB/GP95-TrkB; Neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; RATTRKB1; Tkrb; trk-B; trkB; trkB tyrosine kinase; TRKB1
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NTRK2 (neurotrophic receptor tyrosine kinase 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Ntrk2 (neurotrophic receptor tyrosine kinase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NTRK2 (neurotrophic receptor tyrosine kinase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NTRK2 (neurotrophic receptor tyrosine kinase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ntrk2 (neurotrophic receptor tyrosine kinase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NTRK2 (neurotrophic receptor tyrosine kinase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
NTRK2 (neurotrophic receptor tyrosine kinase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ntrk2 (neurotrophic receptor tyrosine kinase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
NTRK2 (neurotrophic receptor tyrosine kinase 2)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
ntrk2a (neurotrophic tyrosine kinase, receptor, type 2a)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
ntrk2b (neurotrophic tyrosine kinase, receptor, type 2b)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
ntrk2
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PhylomeDB)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 17 5,560,558 - 5,875,899 (-) NCBI GRCr8 mRatBN7.2 17 5,558,992 - 5,870,299 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 17 5,559,043 - 5,869,136 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 17 5,584,315 - 5,894,662 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 17 7,120,448 - 7,429,363 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 17 5,580,732 - 5,891,094 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 17 5,934,651 - 6,245,778 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 17 5,933,729 - 6,244,676 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 17 8,156,432 - 8,464,522 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 17 11,494,463 - 11,811,654 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 17 11,494,462 - 11,811,645 (-) NCBI Celera 17 5,673,895 - 6,828,108 (-) NCBI Celera Cytogenetic Map 17 p14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Ntrk2 Rat (+)-pilocarpine multiple interactions EXP 6480464 Ketamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA] more ... CTD PMID:19686240 and PMID:8635431 Ntrk2 Rat (+)-pilocarpine increases expression EXP 6480464 Pilocarpine results in increased expression of NTRK2 mRNA CTD PMID:15183516 more ... Ntrk2 Rat (+)-syringaresinol beta-D-glucoside multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein CTD PMID:31077737 Ntrk2 Rat (20S)-ginsenoside Rg3 multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] more ... CTD PMID:24394491 Ntrk2 Rat (20S)-ginsenoside Rg3 multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form] more ... CTD PMID:24394491 Ntrk2 Rat (S)-AMPA multiple interactions EXP 6480464 [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of NTRK2 protein CTD PMID:15287886 Ntrk2 Rat (S)-amphetamine increases expression ISO Ntrk2 (Mus musculus) 6480464 Dextroamphetamine results in increased expression of NTRK2 mRNA CTD PMID:18681898 Ntrk2 Rat (S)-nicotine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Nicotine co-treated with Quartz] results in increased phosphorylation of NTRK2 protein and staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of NTRK2 protein] CTD PMID:36868510 Ntrk2 Rat (S)-nicotine multiple interactions ISO NTRK2 (Homo sapiens) 6480464 methyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein] CTD PMID:16790237 Ntrk2 Rat (S)-nicotine increases expression ISO NTRK2 (Homo sapiens) 6480464 Nicotine results in increased expression of NTRK2 protein CTD PMID:16790237 Ntrk2 Rat 1,2-dichloroethane decreases expression ISO Ntrk2 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of NTRK2 mRNA CTD PMID:28960355 Ntrk2 Rat 1,2-dimethylhydrazine decreases expression ISO Ntrk2 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of NTRK2 mRNA CTD PMID:22206623 Ntrk2 Rat 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Citalopram results in increased phosphorylation of and results in increased activity of NTRK2 protein CTD PMID:21666748 Ntrk2 Rat 1-fluoro-2,4-dinitrobenzene increases expression ISO NTRK2 (Homo sapiens) 6480464 Dinitrofluorobenzene results in increased expression of NTRK2 mRNA CTD PMID:23999411 Ntrk2 Rat 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of NTRK2 mRNA CTD PMID:12075121 and PMID:15901920 Ntrk2 Rat 17beta-estradiol decreases expression ISO Ntrk2 (Mus musculus) 6480464 Estradiol results in decreased expression of NTRK2 mRNA CTD PMID:25210133 and PMID:39298647 Ntrk2 Rat 17beta-estradiol multiple interactions ISO Ntrk2 (Mus musculus) 6480464 ESR1 protein promotes the reaction [Estradiol results in decreased expression of NTRK2 mRNA] CTD PMID:25210133 Ntrk2 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of NTRK2 gene CTD PMID:21212295 Ntrk2 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of NTRK2 mRNA CTD PMID:33387578 Ntrk2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of NTRK2 mRNA CTD PMID:34747641 Ntrk2 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Ntrk2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of NTRK2 mRNA CTD PMID:26290441 Ntrk2 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Ntrk2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of NTRK2 mRNA CTD PMID:26377647 and PMID:28922406 Ntrk2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Ntrk2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of NTRK2 mRNA CTD PMID:19465110 Ntrk2 Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Ntrk2 (Mus musculus) 6480464 2 more ... CTD PMID:38648751 Ntrk2 Rat 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 and PMID:32119087 Ntrk2 Rat 3,4-methylenedioxymethamphetamine multiple interactions EXP 6480464 [N-Methyl-3 and 4-methylenedioxyamphetamine co-treated with arachidonylcyclopropylamide co-treated with 2-Amino-5-phosphonovalerate] results in decreased expression of NTRK2 protein CTD PMID:28167133 Ntrk2 Rat 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3 more ... CTD PMID:28167133 and PMID:30071829 Ntrk2 Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTRK2 mRNA CTD PMID:28628672 Ntrk2 Rat 3-nitropropanoic acid multiple interactions EXP 6480464 N(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of NTRK2 protein] CTD PMID:36509115 Ntrk2 Rat 3-nitropropanoic acid decreases phosphorylation EXP 6480464 3-nitropropionic acid results in decreased phosphorylation of NTRK2 protein CTD PMID:36509115 Ntrk2 Rat 4,4'-sulfonyldiphenol decreases expression ISO Ntrk2 (Mus musculus) 6480464 bisphenol S results in decreased expression of NTRK2 mRNA CTD PMID:30951980 Ntrk2 Rat 4,4'-sulfonyldiphenol decreases expression ISO NTRK2 (Homo sapiens) 6480464 bisphenol S results in decreased expression of NTRK2 protein CTD PMID:33749030 Ntrk2 Rat 4,4'-sulfonyldiphenol multiple interactions ISO NTRK2 (Homo sapiens) 6480464 6 and 7-dihydroxyflavone inhibits the reaction [bisphenol S results in decreased expression of NTRK2 protein] CTD PMID:33749030 Ntrk2 Rat 4,4'-sulfonyldiphenol affects expression ISO Ntrk2 (Mus musculus) 6480464 bisphenol S affects the expression of NTRK2 mRNA CTD PMID:39298647 Ntrk2 Rat 4-hydroxyphenyl retinamide decreases expression ISO Ntrk2 (Mus musculus) 6480464 Fenretinide results in decreased expression of NTRK2 mRNA CTD PMID:28973697 Ntrk2 Rat 5-aza-2'-deoxycytidine increases expression ISO NTRK2 (Homo sapiens) 6480464 Decitabine results in increased expression of NTRK2 mRNA CTD PMID:19151715 Ntrk2 Rat 5-fluorouracil decreases expression ISO NTRK2 (Homo sapiens) 6480464 Fluorouracil results in decreased expression of NTRK2 protein CTD PMID:15352031 Ntrk2 Rat 5-fluorouracil affects response to substance ISO NTRK2 (Homo sapiens) 6480464 NTRK2 protein affects the susceptibility to Fluorouracil CTD PMID:15352031 Ntrk2 Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of NTRK2 mRNA CTD PMID:24780913 Ntrk2 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of NTRK2 mRNA CTD PMID:30047161 Ntrk2 Rat acrolein decreases expression EXP 6480464 Acrolein results in decreased expression of NTRK2 protein CTD PMID:29355571 Ntrk2 Rat acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of NTRK2 mRNA CTD PMID:28959563 Ntrk2 Rat acrylamide decreases expression ISO NTRK2 (Homo sapiens) 6480464 Acrylamide results in decreased expression of NTRK2 mRNA CTD PMID:32763439 Ntrk2 Rat acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of NTRK2 mRNA CTD PMID:28959563 and PMID:36328537 Ntrk2 Rat aflatoxin B1 decreases methylation ISO NTRK2 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of NTRK2 gene CTD PMID:27153756 Ntrk2 Rat aldrin multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 Ntrk2 Rat all-trans-retinoic acid multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK2 mRNA CTD PMID:17085092 Ntrk2 Rat all-trans-retinoic acid multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of NTRK2 mRNA CTD PMID:36189433 Ntrk2 Rat all-trans-retinoic acid decreases expression ISO Ntrk2 (Mus musculus) 6480464 Tretinoin results in decreased expression of NTRK2 mRNA CTD PMID:36189433 Ntrk2 Rat all-trans-retinoic acid increases expression ISO NTRK2 (Homo sapiens) 6480464 Tretinoin results in increased expression of NTRK2 mRNA and Tretinoin results in increased expression of NTRK2 protein CTD PMID:16051641 more ... Ntrk2 Rat alpha-Solamarine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of NTRK2 protein] CTD PMID:35350913 Ntrk2 Rat alpha-Zearalanol multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of NTRK2 mRNA CTD PMID:35163327 Ntrk2 Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of NTRK2 mRNA CTD PMID:30047161 Ntrk2 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of NTRK2 mRNA CTD PMID:16483693 Ntrk2 Rat amphotericin B decreases expression ISO NTRK2 (Homo sapiens) 6480464 Amphotericin B analog results in decreased expression of NTRK2 mRNA CTD PMID:28534445 Ntrk2 Rat amphotericin B increases expression ISO NTRK2 (Homo sapiens) 6480464 Amphotericin B analog results in increased expression of NTRK2 mRNA CTD PMID:28534445 Ntrk2 Rat androgen antagonist multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat aniracetam multiple interactions EXP 6480464 [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of NTRK2 protein CTD PMID:15287886 Ntrk2 Rat Aroclor 1254 multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] more ... CTD PMID:24394491 Ntrk2 Rat Aroclor 1254 multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form] and [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)] CTD PMID:24394491 Ntrk2 Rat Aroclor 1254 decreases expression ISO Ntrk2 (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form CTD PMID:24394491 Ntrk2 Rat arsane decreases phosphorylation EXP 6480464 Arsenic results in decreased phosphorylation of NTRK2 protein CTD PMID:28903487 Ntrk2 Rat arsane multiple interactions EXP 6480464 BDNF protein inhibits the reaction [Arsenic results in decreased phosphorylation of NTRK2 protein] and NOG protein inhibits the reaction [Arsenic results in decreased phosphorylation of NTRK2 protein] CTD PMID:28903487 Ntrk2 Rat arsanilic acid multiple interactions EXP 6480464 Dexamethasone inhibits the reaction [Arsanilic Acid results in decreased expression of NTRK2 mRNA] more ... CTD PMID:30628712 Ntrk2 Rat arsanilic acid decreases expression EXP 6480464 Arsanilic Acid results in decreased expression of NTRK2 mRNA and Arsanilic Acid results in decreased expression of NTRK2 protein CTD PMID:30628712 Ntrk2 Rat arsenic atom decreases phosphorylation EXP 6480464 Arsenic results in decreased phosphorylation of NTRK2 protein CTD PMID:28903487 Ntrk2 Rat arsenic atom multiple interactions EXP 6480464 BDNF protein inhibits the reaction [Arsenic results in decreased phosphorylation of NTRK2 protein] and NOG protein inhibits the reaction [Arsenic results in decreased phosphorylation of NTRK2 protein] CTD PMID:28903487 Ntrk2 Rat arsenous acid increases sumoylation ISO NTRK2 (Homo sapiens) 6480464 Arsenic Trioxide results in increased sumoylation of NTRK2 protein CTD PMID:28318385 Ntrk2 Rat arsenous acid multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Arsenic Trioxide promotes the reaction [Reserpine results in decreased expression of NTRK2 protein] CTD PMID:26114099 Ntrk2 Rat arsenous acid increases expression ISO NTRK2 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of NTRK2 mRNA and Arsenic Trioxide results in increased expression of NTRK2 protein CTD PMID:16569477 and PMID:29898774 Ntrk2 Rat arsenous acid decreases expression ISO NTRK2 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of NTRK2 mRNA and Arsenic Trioxide results in decreased expression of NTRK2 protein CTD PMID:16711005 and PMID:26705709 Ntrk2 Rat atrazine decreases expression ISO NTRK2 (Homo sapiens) 6480464 Atrazine results in decreased expression of NTRK2 mRNA CTD PMID:22378314 Ntrk2 Rat atrazine affects methylation EXP 6480464 Atrazine affects the methylation of NTRK2 gene CTD PMID:28931070 and PMID:35440735 Ntrk2 Rat benzo[a]pyrene multiple interactions ISO Ntrk2 (Mus musculus) 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of NTRK2 mRNA] CTD PMID:22228805 Ntrk2 Rat benzo[a]pyrene increases methylation ISO Ntrk2 (Mus musculus) 6480464 Benzo(a)pyrene results in increased methylation of NTRK2 3' UTR and Benzo(a)pyrene results in increased methylation of NTRK2 exon CTD PMID:27901495 Ntrk2 Rat benzo[a]pyrene affects methylation ISO NTRK2 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of NTRK2 5' UTR and Benzo(a)pyrene affects the methylation of NTRK2 promoter CTD PMID:27901495 and PMID:30157460 Ntrk2 Rat benzo[a]pyrene increases methylation ISO NTRK2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of NTRK2 3' UTR and Benzo(a)pyrene results in increased methylation of NTRK2 promoter CTD PMID:27901495 Ntrk2 Rat benzo[a]pyrene decreases expression ISO Ntrk2 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of NTRK2 mRNA CTD PMID:21569818 and PMID:22610609 Ntrk2 Rat benzo[a]pyrene increases expression ISO Ntrk2 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of NTRK2 mRNA CTD PMID:22228805 Ntrk2 Rat benzo[e]pyrene decreases methylation ISO NTRK2 (Homo sapiens) 6480464 benzo(e)pyrene results in decreased methylation of NTRK2 promoter CTD PMID:30157460 Ntrk2 Rat bis(2-chloroethyl) sulfide decreases expression ISO Ntrk2 (Mus musculus) 6480464 Mustard Gas results in decreased expression of NTRK2 mRNA CTD PMID:15674843 Ntrk2 Rat bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of NTRK2 mRNA CTD PMID:12075121 Ntrk2 Rat bisphenol A increases methylation ISO NTRK2 (Homo sapiens) 6480464 bisphenol A results in increased methylation of NTRK2 gene CTD PMID:31601247 Ntrk2 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NTRK2 mRNA and bisphenol A results in decreased expression of NTRK2 protein CTD PMID:30816183 more ... Ntrk2 Rat bisphenol A decreases expression ISO Ntrk2 (Mus musculus) 6480464 bisphenol A results in decreased expression of NTRK2 mRNA CTD PMID:30951980 Ntrk2 Rat bisphenol A increases expression ISO NTRK2 (Homo sapiens) 6480464 bisphenol A results in increased expression of NTRK2 mRNA CTD PMID:27685785 Ntrk2 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of NTRK2 mRNA CTD PMID:25181051 Ntrk2 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA more ... CTD PMID:25607892 and PMID:32153214 Ntrk2 Rat bisphenol A increases expression ISO Ntrk2 (Mus musculus) 6480464 bisphenol A results in increased expression of NTRK2 mRNA CTD PMID:26869994 Ntrk2 Rat bisphenol F multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTRK2 mRNA CTD PMID:28628672 Ntrk2 Rat bisphenol F decreases expression ISO Ntrk2 (Mus musculus) 6480464 bisphenol F results in decreased expression of NTRK2 mRNA CTD PMID:30951980 Ntrk2 Rat buprenorphine decreases phosphorylation EXP 6480464 Buprenorphine results in decreased phosphorylation of NTRK2 protein CTD PMID:24321744 Ntrk2 Rat buta-1,3-diene decreases expression ISO Ntrk2 (Mus musculus) 6480464 1 and 3-butadiene results in decreased expression of NTRK2 mRNA CTD PMID:29038090 Ntrk2 Rat butanal increases expression ISO NTRK2 (Homo sapiens) 6480464 butyraldehyde results in increased expression of NTRK2 mRNA CTD PMID:26079696 Ntrk2 Rat Butylparaben multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA and [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat cadmium atom multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of NTRK2 mRNA CTD PMID:31904401 Ntrk2 Rat cadmium dichloride multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of NTRK2 mRNA CTD PMID:31904401 Ntrk2 Rat caffeine multiple interactions EXP 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of NTRK2 mRNA] CTD PMID:35917217 Ntrk2 Rat caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of NTRK2 mRNA CTD PMID:35917217 Ntrk2 Rat cannabidiol affects methylation EXP 6480464 Cannabidiol affects the methylation of NTRK2 gene CTD PMID:30521419 Ntrk2 Rat carbon nanotube affects expression ISO Ntrk2 (Mus musculus) 6480464 Nanotubes and Carbon affects the expression of NTRK2 mRNA CTD PMID:25620056 Ntrk2 Rat carbon nanotube increases expression ISO Ntrk2 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 Ntrk2 Rat carbon nanotube decreases expression ISO Ntrk2 (Mus musculus) 6480464 Nanotubes and Carbon analog results in decreased expression of NTRK2 mRNA CTD PMID:25620056 Ntrk2 Rat CGP 52608 multiple interactions ISO NTRK2 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to NTRK2 gene] CTD PMID:28238834 Ntrk2 Rat CGS-21680 multiple interactions EXP 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of NTRK2 mRNA] CTD PMID:35917217 Ntrk2 Rat CGS-21680 increases expression EXP 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of NTRK2 mRNA CTD PMID:35917217 Ntrk2 Rat chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of NTRK2 mRNA CTD PMID:18502319 Ntrk2 Rat choline multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Dietary Fats co-treated with Choline deficiency] results in increased expression of NTRK2 mRNA more ... CTD PMID:20938992 and PMID:29246445 Ntrk2 Rat citalopram multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Citalopram results in increased phosphorylation of and results in increased activity of NTRK2 protein CTD PMID:21666748 Ntrk2 Rat Citreoviridin increases expression ISO Ntrk2 (Mus musculus) 6480464 citreoviridin results in increased expression of NTRK2 mRNA CTD PMID:30071239 Ntrk2 Rat clomipramine increases phosphorylation ISO Ntrk2 (Mus musculus) 6480464 Clomipramine results in increased phosphorylation of NTRK2 protein CTD PMID:22396798 Ntrk2 Rat cocaine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Cocaine affects the reaction [NTRK2 protein affects the expression of KCNA2 mRNA] more ... CTD PMID:20947769 Ntrk2 Rat cocaine decreases phosphorylation ISO Ntrk2 (Mus musculus) 6480464 Cocaine results in decreased phosphorylation of NTRK2 protein CTD PMID:24358339 Ntrk2 Rat cocaine affects expression EXP 6480464 Cocaine affects the expression of NTRK2 mRNA and Cocaine affects the expression of NTRK2 protein CTD PMID:12358776 and PMID:20187946 Ntrk2 Rat cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of NTRK2 mRNA CTD PMID:16423334 Ntrk2 Rat cocaine decreases expression ISO NTRK2 (Homo sapiens) 6480464 Cocaine results in decreased expression of NTRK2 mRNA CTD PMID:15009677 and PMID:16710320 Ntrk2 Rat colforsin daropate hydrochloride increases expression EXP 6480464 Colforsin results in increased expression of NTRK2 mRNA CTD PMID:35917217 Ntrk2 Rat copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of NTRK2 mRNA CTD PMID:26033743 Ntrk2 Rat copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of NTRK2 mRNA CTD PMID:26033743 Ntrk2 Rat Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of NTRK2 mRNA CTD PMID:26577399 and PMID:27523638 Ntrk2 Rat curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NTRK2 protein] CTD PMID:29723552 Ntrk2 Rat cyclophosphamide multiple interactions EXP 6480464 Cyclophosphamide results in increased phosphorylation of and results in increased expression of NTRK2 protein CTD PMID:12412144 Ntrk2 Rat cyclosporin A increases methylation ISO NTRK2 (Homo sapiens) 6480464 Cyclosporine results in increased methylation of NTRK2 promoter CTD PMID:27989131 Ntrk2 Rat cypermethrin decreases expression EXP 6480464 cypermethrin results in decreased expression of NTRK2 mRNA CTD PMID:22528246 Ntrk2 Rat cyproconazole increases expression ISO Ntrk2 (Mus musculus) 6480464 cyproconazole results in increased expression of NTRK2 mRNA CTD PMID:22045034 Ntrk2 Rat DDD multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 Ntrk2 Rat DDE multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat DDE multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 Ntrk2 Rat DDT multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 Ntrk2 Rat deoxynivalenol decreases expression ISO NTRK2 (Homo sapiens) 6480464 deoxynivalenol results in decreased expression of NTRK2 mRNA CTD PMID:31863870 Ntrk2 Rat dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of NTRK2 mRNA CTD PMID:29111458 Ntrk2 Rat dexamethasone multiple interactions EXP 6480464 Dexamethasone inhibits the reaction [Arsanilic Acid results in decreased expression of NTRK2 mRNA] more ... CTD PMID:30628712 Ntrk2 Rat dexamethasone multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTRK2 mRNA CTD PMID:28628672 Ntrk2 Rat diarsenic trioxide increases sumoylation ISO NTRK2 (Homo sapiens) 6480464 Arsenic Trioxide results in increased sumoylation of NTRK2 protein CTD PMID:28318385 Ntrk2 Rat diarsenic trioxide multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Arsenic Trioxide promotes the reaction [Reserpine results in decreased expression of NTRK2 protein] CTD PMID:26114099 Ntrk2 Rat diarsenic trioxide decreases expression ISO NTRK2 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of NTRK2 mRNA and Arsenic Trioxide results in decreased expression of NTRK2 protein CTD PMID:16711005 and PMID:26705709 Ntrk2 Rat diarsenic trioxide increases expression ISO NTRK2 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of NTRK2 mRNA and Arsenic Trioxide results in increased expression of NTRK2 protein CTD PMID:16569477 and PMID:29898774 Ntrk2 Rat diazinon affects expression EXP 6480464 Diazinon affects the expression of NTRK2 mRNA CTD PMID:18502319 and PMID:19130878 Ntrk2 Rat dibutyl phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat dieldrin affects expression EXP 6480464 Dieldrin affects the expression of NTRK2 mRNA CTD PMID:19130878 Ntrk2 Rat dieldrin multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 Ntrk2 Rat dioxygen multiple interactions EXP 6480464 EPAS1 mutant form inhibits the reaction [Oxygen deficiency results in increased expression of NTRK2 mRNA] CTD PMID:26095976 Ntrk2 Rat dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of NTRK2 mRNA and Oxygen deficiency results in increased expression of NTRK2 protein CTD PMID:26095976 Ntrk2 Rat disodium selenite multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of NTRK2 mRNA and Sodium Selenite promotes the reaction [Hydrogen Peroxide results in decreased expression of NTRK2 mRNA] CTD PMID:17997286 and PMID:23274088 Ntrk2 Rat disodium selenite decreases expression ISO Ntrk2 (Mus musculus) 6480464 Sodium Selenite results in decreased expression of NTRK2 mRNA CTD PMID:23274088 Ntrk2 Rat diuron decreases expression EXP 6480464 Diuron results in decreased expression of NTRK2 mRNA CTD PMID:25152437 Ntrk2 Rat dorsomorphin multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Ntrk2 Rat doxorubicin decreases expression ISO NTRK2 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of NTRK2 mRNA CTD PMID:29803840 Ntrk2 Rat doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of NTRK2 mRNA CTD PMID:32289291 Ntrk2 Rat doxorubicin increases expression ISO NTRK2 (Homo sapiens) 6480464 Doxorubicin results in increased expression of NTRK2 mRNA CTD PMID:30031762 Ntrk2 Rat echinacoside multiple interactions EXP 6480464 echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein] and staurosporine aglycone inhibits the reaction [echinacoside results in increased phosphorylation of NTRK2 protein] CTD PMID:23189969 Ntrk2 Rat echinacoside multiple interactions ISO NTRK2 (Homo sapiens) 6480464 echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein] and staurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]] CTD PMID:23189969 Ntrk2 Rat echinacoside increases phosphorylation EXP 6480464 echinacoside results in increased phosphorylation of NTRK2 protein CTD PMID:23189969 Ntrk2 Rat endrin multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 Ntrk2 Rat entinostat decreases expression ISO NTRK2 (Homo sapiens) 6480464 entinostat results in decreased expression of NTRK2 mRNA CTD PMID:27188386 Ntrk2 Rat enzacamene multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA and [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat epoxiconazole multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat ethanol increases expression ISO Ntrk2 (Mus musculus) 6480464 Ethanol results in increased expression of NTRK2 mRNA CTD PMID:30319688 and PMID:35863473 Ntrk2 Rat ethanol increases expression EXP 401938616 Ethanol increases expression of Ntrk2 protein in amygdala RGD Ntrk2 Rat ethanol decreases phosphorylation ISO Ntrk2 (Mus musculus) 6480464 Ethanol results in decreased phosphorylation of NTRK2 protein CTD PMID:35863473 Ntrk2 Rat ethanol affects expression EXP 6480464 Ethanol affects the expression of NTRK2 mRNA CTD PMID:34547370 Ntrk2 Rat ethanol decreases expression ISO Ntrk2 (Mus musculus) 6480464 Ethanol results in decreased expression of NTRK2 protein CTD PMID:35181401 Ntrk2 Rat ethanol multiple interactions ISO Ntrk2 (Mus musculus) 6480464 1-(quinoxalin-6-ylcarbonyl)piperidine inhibits the reaction [Ethanol results in decreased expression of NTRK2 protein] more ... CTD PMID:30319688 more ... Ntrk2 Rat fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of NTRK2 mRNA CTD PMID:30307764 Ntrk2 Rat fenvalerate decreases expression ISO Ntrk2 (Mus musculus) 6480464 fenvalerate results in decreased expression of NTRK2 mRNA CTD PMID:34358930 Ntrk2 Rat fipronil decreases expression EXP 6480464 fipronil results in decreased expression of NTRK2 mRNA CTD PMID:34044035 Ntrk2 Rat flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of NTRK2 mRNA CTD PMID:18035473 Ntrk2 Rat fluoxetine increases expression EXP 6480464 Fluoxetine results in increased expression of NTRK2 mRNA and Fluoxetine results in increased expression of NTRK2 mRNA alternative form CTD PMID:15456934 and PMID:8601816 Ntrk2 Rat fluoxetine multiple interactions EXP 6480464 Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 Ntrk2 Rat fluoxetine increases phosphorylation ISO Ntrk2 (Mus musculus) 6480464 Fluoxetine results in increased phosphorylation of NTRK2 protein CTD PMID:22396798 Ntrk2 Rat fluoxetine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Fluoxetine inhibits the reaction [NTRK2 protein binds to AP2A2 protein] more ... CTD PMID:21666748 and PMID:31631060 Ntrk2 Rat folic acid multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NTRK2 mRNA CTD PMID:20938992 Ntrk2 Rat folic acid increases expression ISO Ntrk2 (Mus musculus) 6480464 Folic Acid results in increased expression of NTRK2 mRNA and Folic Acid results in increased expression of NTRK2 protein CTD PMID:30920123 Ntrk2 Rat folic acid decreases expression ISO Ntrk2 (Mus musculus) 6480464 Folic Acid results in decreased expression of NTRK2 mRNA CTD PMID:25629700 Ntrk2 Rat gamma-hexachlorocyclohexane multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 Ntrk2 Rat genistein increases expression EXP 6480464 Genistein results in increased expression of NTRK2 mRNA CTD PMID:12075121 Ntrk2 Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of NTRK2 mRNA CTD PMID:33387578 Ntrk2 Rat glyphosate increases expression ISO Ntrk2 (Mus musculus) 6480464 Glyphosate results in increased expression of NTRK2 mRNA CTD PMID:32067069 Ntrk2 Rat graphite affects expression EXP 6480464 Graphite affects the expression of NTRK2 mRNA CTD PMID:29933104 Ntrk2 Rat heroin increases expression ISO NTRK2 (Homo sapiens) 6480464 Heroin results in increased expression of NTRK2 mRNA CTD PMID:16710320 Ntrk2 Rat homocysteine multiple interactions EXP 6480464 Rivastigmine inhibits the reaction [Homocysteine results in decreased expression of NTRK2 protein] CTD PMID:39357784 Ntrk2 Rat homocysteine decreases expression EXP 6480464 Homocysteine results in decreased expression of NTRK2 protein CTD PMID:39357784 Ntrk2 Rat hydrogen peroxide decreases expression ISO Ntrk2 (Mus musculus) 6480464 Hydrogen Peroxide results in decreased expression of NTRK2 mRNA CTD PMID:17997286 Ntrk2 Rat hydrogen peroxide decreases expression ISO NTRK2 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of NTRK2 mRNA CTD PMID:26339600 Ntrk2 Rat hydrogen peroxide multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Sodium Selenite promotes the reaction [Hydrogen Peroxide results in decreased expression of NTRK2 mRNA] CTD PMID:17997286 Ntrk2 Rat imidacloprid increases expression EXP 6480464 imidacloprid results in increased expression of NTRK2 mRNA CTD PMID:39002876 Ntrk2 Rat imipramine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Imipramine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] more ... CTD PMID:21666748 more ... Ntrk2 Rat imipramine increases phosphorylation ISO Ntrk2 (Mus musculus) 6480464 Imipramine results in increased phosphorylation of NTRK2 protein CTD PMID:22396798 Ntrk2 Rat indometacin multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTRK2 mRNA CTD PMID:28628672 Ntrk2 Rat inulin multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of NTRK2 mRNA CTD PMID:36331819 Ntrk2 Rat isotretinoin increases expression ISO NTRK2 (Homo sapiens) 6480464 Isotretinoin results in increased expression of NTRK2 mRNA CTD PMID:20436886 Ntrk2 Rat kainic acid increases expression EXP 6480464 Kainic Acid results in increased expression of NTRK2 mRNA CTD PMID:19700661 Ntrk2 Rat ketamine multiple interactions EXP 6480464 Ketamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA] CTD PMID:8635431 Ntrk2 Rat ketamine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Ketamine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 Ntrk2 Rat L-ascorbic acid increases expression ISO Ntrk2 (Mus musculus) 6480464 Ascorbic Acid results in increased expression of NTRK2 mRNA CTD PMID:15305145 Ntrk2 Rat L-methionine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NTRK2 mRNA CTD PMID:20938992 Ntrk2 Rat lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of NTRK2 protein CTD PMID:27492863 Ntrk2 Rat lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of NTRK2 mRNA CTD PMID:33862172 Ntrk2 Rat lead(0) multiple interactions EXP 6480464 Lead results in decreased expression of [NTRK2 protein binds to NGFR protein] and Lead results in decreased phosphorylation of and results in decreased expression of NTRK2 protein CTD PMID:22345308 Ntrk2 Rat lead(0) affects splicing ISO NTRK2 (Homo sapiens) 6480464 Lead affects the splicing of NTRK2 mRNA CTD PMID:28903495 Ntrk2 Rat linuron multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat lipopolysaccharide decreases methylation ISO Ntrk2 (Mus musculus) 6480464 Lipopolysaccharides results in decreased methylation of NTRK2 gene CTD PMID:21212295 Ntrk2 Rat lipopolysaccharide multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of NTRK2 gene CTD PMID:21212295 Ntrk2 Rat lycopene increases expression EXP 6480464 Lycopene results in increased expression of NTRK2 protein CTD PMID:32153214 Ntrk2 Rat lycopene multiple interactions EXP 6480464 Lycopene inhibits the reaction [bisphenol A results in decreased expression of NTRK2 protein] CTD PMID:32153214 Ntrk2 Rat malathion increases expression ISO NTRK2 (Homo sapiens) 6480464 Malathion results in increased expression of NTRK2 mRNA CTD PMID:32069766 Ntrk2 Rat maneb multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA more ... CTD PMID:23963992 Ntrk2 Rat manganese(II) chloride decreases expression ISO Ntrk2 (Mus musculus) 6480464 manganese chloride results in decreased expression of NTRK2 protein modified form CTD PMID:25698507 Ntrk2 Rat melatonin multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA] and Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein] CTD PMID:23963992 and PMID:29476728 Ntrk2 Rat melittin decreases phosphorylation ISO Ntrk2 (Mus musculus) 6480464 Melitten results in decreased phosphorylation of NTRK2 protein CTD PMID:37678661 Ntrk2 Rat metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [Streptozocin results in increased expression of NTRK2 mRNA] CTD PMID:35414346 Ntrk2 Rat methamphetamine decreases expression ISO Ntrk2 (Mus musculus) 6480464 Methamphetamine results in decreased expression of NTRK2 protein CTD PMID:34461196 Ntrk2 Rat methapyrilene decreases methylation ISO NTRK2 (Homo sapiens) 6480464 Methapyrilene results in decreased methylation of NTRK2 promoter CTD PMID:30157460 Ntrk2 Rat methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of NTRK2 mRNA CTD PMID:30047161 Ntrk2 Rat methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of NTRK2 gene CTD PMID:23303685 Ntrk2 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of NTRK2 gene CTD PMID:35440735 Ntrk2 Rat methylglyoxal multiple interactions ISO NTRK2 (Homo sapiens) 6480464 sulforaphane inhibits the reaction [Pyruvaldehyde results in decreased expression of NTRK2 protein] CTD PMID:25933243 Ntrk2 Rat methylglyoxal decreases expression ISO NTRK2 (Homo sapiens) 6480464 Pyruvaldehyde results in decreased expression of NTRK2 protein CTD PMID:25933243 Ntrk2 Rat methyllycaconitine multiple interactions ISO NTRK2 (Homo sapiens) 6480464 methyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein] CTD PMID:16790237 Ntrk2 Rat methylmercury chloride affects expression ISO Ntrk2 (Mus musculus) 6480464 methylmercuric chloride affects the expression of NTRK2 mRNA CTD PMID:21613230 Ntrk2 Rat methylphenidate multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] CTD PMID:24394491 Ntrk2 Rat mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Arsanilic Acid results in decreased expression of NTRK2 mRNA]] and Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Arsanilic Acid results in decreased expression of NTRK2 protein]] CTD PMID:30628712 Ntrk2 Rat mono(2-ethylhexyl) phthalate multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of NTRK2 mRNA CTD PMID:36189433 Ntrk2 Rat morin multiple interactions EXP 6480464 morin inhibits the reaction [Streptozocin results in increased expression of NTRK2 mRNA] CTD PMID:35414346 Ntrk2 Rat N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of NTRK2 gene CTD PMID:33148267 Ntrk2 Rat N-acetyl-L-cysteine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein] CTD PMID:28499986 Ntrk2 Rat N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of NTRK2 protein] CTD PMID:38642822 Ntrk2 Rat N-ethyl-N-nitrosourea increases mutagenesis EXP 6480464 Ethylnitrosourea results in increased mutagenesis of NTRK2 gene CTD PMID:16495775 Ntrk2 Rat naphthalene increases expression ISO Ntrk2 (Mus musculus) 6480464 naphthalene results in increased expression of NTRK2 mRNA CTD PMID:18978301 Ntrk2 Rat naphthalenes increases expression EXP 6480464 Naphthalenes results in increased expression of NTRK2 protein CTD PMID:17337753 Ntrk2 Rat nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of NTRK2 mRNA CTD PMID:19130878 Ntrk2 Rat nicotine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Nicotine co-treated with Quartz] results in increased phosphorylation of NTRK2 protein and staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of NTRK2 protein] CTD PMID:36868510 Ntrk2 Rat nicotine multiple interactions ISO NTRK2 (Homo sapiens) 6480464 methyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein] CTD PMID:16790237 Ntrk2 Rat nicotine increases expression ISO NTRK2 (Homo sapiens) 6480464 Nicotine results in increased expression of NTRK2 protein CTD PMID:16790237 Ntrk2 Rat nicotinic acid increases expression EXP 6480464 Niacin results in increased expression of NTRK2 protein CTD PMID:20671245 Ntrk2 Rat Nonylphenol multiple interactions EXP 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of NTRK2 protein] more ... CTD PMID:38642822 Ntrk2 Rat Nonylphenol decreases expression EXP 6480464 nonylphenol results in decreased expression of NTRK2 mRNA more ... CTD PMID:35662570 Ntrk2 Rat Nonylphenol decreases expression ISO Ntrk2 (Mus musculus) 6480464 nonylphenol results in decreased expression of NTRK2 protein modified form CTD PMID:35662570 Ntrk2 Rat Nonylphenol multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [BDNF protein results in decreased susceptibility to nonylphenol] which results in increased expression of NTRK2 protein and BDNF protein inhibits the reaction [nonylphenol results in decreased expression of NTRK2 protein modified form] CTD PMID:35662570 Ntrk2 Rat oleuropein multiple interactions ISO Ntrk2 (Mus musculus) 6480464 oleuropein inhibits the reaction [Rotenone results in decreased expression of and results in decreased phosphorylation of NTRK2 protein] CTD PMID:36774383 Ntrk2 Rat papaverine increases expression EXP 6480464 Papaverine results in increased expression of NTRK2 mRNA CTD PMID:8601816 Ntrk2 Rat paracetamol multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat paracetamol multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Acetaminophen co-treated with (3R)-((2 more ... CTD PMID:30165669 Ntrk2 Rat paraquat decreases expression ISO Ntrk2 (Mus musculus) 6480464 Paraquat results in decreased expression of NTRK2 mRNA CTD PMID:21371552 Ntrk2 Rat paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of NTRK2 mRNA and Paraquat results in decreased expression of NTRK2 protein CTD PMID:32680482 and PMID:32738378 Ntrk2 Rat paraquat multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA more ... CTD PMID:23963992 Ntrk2 Rat perfluorohexanesulfonic acid increases expression ISO Ntrk2 (Mus musculus) 6480464 perfluorohexanesulfonic acid results in increased expression of NTRK2 mRNA CTD PMID:37315490 and PMID:37995155 Ntrk2 Rat perfluorononanoic acid increases phosphorylation ISO NTRK2 (Homo sapiens) 6480464 perfluoro-n-nonanoic acid results in increased phosphorylation of NTRK2 protein CTD PMID:34394001 Ntrk2 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of NTRK2 mRNA CTD PMID:36331819 Ntrk2 Rat perfluorooctanoic acid multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of NTRK2 mRNA CTD PMID:35163327 Ntrk2 Rat permethrin multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of NTRK2 gene CTD PMID:33148267 Ntrk2 Rat Phenelzine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Phenelzine inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 Ntrk2 Rat phenobarbital increases expression ISO Ntrk2 (Mus musculus) 6480464 Phenobarbital results in increased expression of NTRK2 mRNA CTD PMID:21335049 Ntrk2 Rat phenobarbital decreases expression ISO Ntrk2 (Mus musculus) 6480464 Phenobarbital results in decreased expression of NTRK2 mRNA CTD PMID:23091169 Ntrk2 Rat phenylmercury acetate increases expression ISO NTRK2 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of NTRK2 mRNA CTD PMID:26272509 Ntrk2 Rat phenylmercury acetate multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK2 mRNA CTD PMID:27188386 Ntrk2 Rat phorbol 13-acetate 12-myristate multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of NTRK2 mRNA CTD PMID:31904401 Ntrk2 Rat physostigmine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Physostigmine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein] CTD PMID:28499986 Ntrk2 Rat pirinixic acid decreases expression ISO Ntrk2 (Mus musculus) 6480464 pirinixic acid results in decreased expression of NTRK2 mRNA CTD PMID:23811191 Ntrk2 Rat ponatinib decreases activity ISO NTRK2 (Homo sapiens) 6480464 ponatinib results in decreased activity of NTRK2 protein CTD PMID:19878872 Ntrk2 Rat pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of NTRK2 mRNA CTD PMID:30047161 Ntrk2 Rat prochloraz multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat procymidone multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat Ptaquiloside multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of NTRK2 mRNA CTD PMID:23274088 Ntrk2 Rat Ptaquiloside decreases expression ISO Ntrk2 (Mus musculus) 6480464 ptaquiloside results in decreased expression of NTRK2 mRNA CTD PMID:23274088 Ntrk2 Rat quartz multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Nicotine co-treated with Quartz] results in increased phosphorylation of NTRK2 protein and staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of NTRK2 protein] CTD PMID:36868510 Ntrk2 Rat reboxetine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 reboxetine results in increased phosphorylation of and results in increased activity of NTRK2 protein CTD PMID:21666748 Ntrk2 Rat reserpine decreases expression ISO Ntrk2 (Mus musculus) 6480464 Reserpine results in decreased expression of NTRK2 protein CTD PMID:26114099 Ntrk2 Rat reserpine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 arsenic trioxide promotes the reaction [Reserpine results in decreased expression of NTRK2 protein] CTD PMID:26114099 Ntrk2 Rat rivastigmine multiple interactions EXP 6480464 Rivastigmine inhibits the reaction [Homocysteine results in decreased expression of NTRK2 protein] CTD PMID:39357784 Ntrk2 Rat rolipram increases expression EXP 6480464 Rolipram results in increased expression of NTRK2 mRNA CTD PMID:8601816 Ntrk2 Rat rolipram multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Rolipram inhibits the reaction [NTRK2 protein binds to AP2M1 protein] CTD PMID:31631060 Ntrk2 Rat rotenone decreases phosphorylation EXP 6480464 Rotenone results in decreased phosphorylation of NTRK2 protein CTD PMID:23189969 Ntrk2 Rat rotenone multiple interactions ISO Ntrk2 (Mus musculus) 6480464 oleuropein inhibits the reaction [Rotenone results in decreased expression of and results in decreased phosphorylation of NTRK2 protein] and Rotenone results in decreased expression of and results in decreased phosphorylation of NTRK2 protein CTD PMID:36774383 Ntrk2 Rat rotenone multiple interactions EXP 6480464 echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein] CTD PMID:23189969 Ntrk2 Rat rotenone decreases phosphorylation ISO NTRK2 (Homo sapiens) 6480464 Rotenone results in decreased phosphorylation of NTRK2 protein CTD PMID:23189969 Ntrk2 Rat rotenone multiple interactions ISO NTRK2 (Homo sapiens) 6480464 echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein] and staurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]] CTD PMID:23189969 Ntrk2 Rat sarin increases expression ISO NTRK2 (Homo sapiens) 6480464 Sarin results in increased expression of NTRK2 mRNA CTD PMID:19522546 Ntrk2 Rat SB 431542 multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Ntrk2 Rat scopolamine multiple interactions EXP 6480464 Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA] CTD PMID:8635431 Ntrk2 Rat scopolamine decreases expression ISO Ntrk2 (Mus musculus) 6480464 Scopolamine results in decreased expression of NTRK2 protein CTD PMID:29476728 Ntrk2 Rat scopolamine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein more ... CTD PMID:29476728 and PMID:31077737 Ntrk2 Rat sevoflurane multiple interactions ISO Ntrk2 (Mus musculus) 6480464 alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of NTRK2 protein] CTD PMID:35350913 Ntrk2 Rat sevoflurane decreases phosphorylation ISO Ntrk2 (Mus musculus) 6480464 Sevoflurane results in decreased phosphorylation of NTRK2 protein CTD PMID:35350913 Ntrk2 Rat simvastatin multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 Ntrk2 Rat sodium arsenate increases expression ISO Ntrk2 (Mus musculus) 6480464 sodium arsenate results in increased expression of NTRK2 mRNA CTD PMID:30953684 Ntrk2 Rat sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of NTRK2 protein CTD PMID:29723552 Ntrk2 Rat sodium arsenite decreases expression ISO Ntrk2 (Mus musculus) 6480464 sodium arsenite results in decreased expression of NTRK2 mRNA CTD PMID:37682722 Ntrk2 Rat sodium arsenite multiple interactions EXP 6480464 Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NTRK2 protein] CTD PMID:29723552 Ntrk2 Rat sodium dodecyl sulfate affects response to substance ISO NTRK2 (Homo sapiens) 6480464 NTRK2 SNP affects the susceptibility to Sodium Dodecyl Sulfate CTD PMID:27206134 Ntrk2 Rat sodium fluoride decreases expression EXP 6480464 Sodium Fluoride results in decreased expression of NTRK2 protein CTD PMID:30130557 Ntrk2 Rat sodium fluoride decreases expression ISO NTRK2 (Homo sapiens) 6480464 Sodium Fluoride results in decreased expression of NTRK2 protein CTD PMID:30130557 Ntrk2 Rat sodium fluoride multiple interactions ISO NTRK2 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sodium Fluoride results in decreased expression of NTRK2 protein] CTD PMID:30130557 Ntrk2 Rat Soman increases expression EXP 6480464 Soman results in increased expression of NTRK2 mRNA CTD PMID:19281266 Ntrk2 Rat sterigmatocystin decreases expression EXP 6480464 Sterigmatocystin results in decreased expression of NTRK2 mRNA CTD PMID:34126181 Ntrk2 Rat streptozocin decreases phosphorylation ISO Ntrk2 (Mus musculus) 6480464 Streptozocin results in decreased phosphorylation of NTRK2 protein CTD PMID:28499986 Ntrk2 Rat streptozocin multiple interactions EXP 6480464 Metformin inhibits the reaction [Streptozocin results in increased expression of NTRK2 mRNA] and morin inhibits the reaction [Streptozocin results in increased expression of NTRK2 mRNA] CTD PMID:35414346 Ntrk2 Rat streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of NTRK2 mRNA CTD PMID:35414346 Ntrk2 Rat streptozocin multiple interactions ISO Ntrk2 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein] and Physostigmine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein] CTD PMID:28499986 Ntrk2 Rat sulfadimethoxine decreases expression EXP 6480464 Sulfadimethoxine results in decreased expression of NTRK2 mRNA CTD PMID:30047161 Ntrk2 Rat sulforaphane multiple interactions ISO NTRK2 (Homo sapiens) 6480464 sulforaphane inhibits the reaction [Pyruvaldehyde results in decreased expression of NTRK2 protein] CTD PMID:25933243 Ntrk2 Rat sulforaphane increases expression ISO NTRK2 (Homo sapiens) 6480464 sulforaphane results in increased expression of NTRK2 protein CTD PMID:25933243 Ntrk2 Rat T-2 toxin decreases expression ISO NTRK2 (Homo sapiens) 6480464 T-2 Toxin results in decreased expression of NTRK2 mRNA CTD PMID:31863870 Ntrk2 Rat tacrine multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein CTD PMID:31077737 Ntrk2 Rat tamibarotene multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [tamibarotene co-treated with BDNF] results in increased expression of NTRK2 CTD PMID:19182380 Ntrk2 Rat tamibarotene increases expression EXP 6480464 tamibarotene results in increased expression of NTRK2 CTD PMID:19182380 Ntrk2 Rat tamibarotene multiple interactions EXP 6480464 BDNF affects the reaction [tamibarotene results in increased phosphorylation of NTRK2 protein] CTD PMID:19457078 Ntrk2 Rat tamibarotene increases phosphorylation EXP 6480464 tamibarotene results in increased phosphorylation of NTRK2 protein CTD PMID:19457078 Ntrk2 Rat tert-butyl hydroperoxide decreases expression ISO NTRK2 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of NTRK2 mRNA CTD PMID:15336504 Ntrk2 Rat testosterone increases expression EXP 6480464 Testosterone results in increased expression of NTRK2 protein CTD PMID:17131419 Ntrk2 Rat Tetrachlorobisphenol A decreases expression ISO NTRK2 (Homo sapiens) 6480464 tetrachlorodian results in decreased expression of NTRK2 mRNA CTD PMID:31326446 Ntrk2 Rat titanium dioxide affects expression ISO Ntrk2 (Mus musculus) 6480464 titanium dioxide affects the expression of NTRK2 mRNA CTD PMID:23557971 Ntrk2 Rat titanium dioxide decreases methylation ISO Ntrk2 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of NTRK2 gene and titanium dioxide results in decreased methylation of NTRK2 promoter CTD PMID:35295148 Ntrk2 Rat titanium dioxide increases methylation ISO Ntrk2 (Mus musculus) 6480464 titanium dioxide results in increased methylation of NTRK2 promoter CTD PMID:35295148 Ntrk2 Rat toluene increases expression ISO Ntrk2 (Mus musculus) 6480464 Toluene results in increased expression of NTRK2 mRNA CTD PMID:19932712 Ntrk2 Rat tranylcypromine increases expression EXP 6480464 Tranylcypromine results in increased expression of NTRK2 mRNA CTD PMID:8601816 Ntrk2 Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of NTRK2 mRNA CTD PMID:33387578 Ntrk2 Rat triclosan increases expression ISO NTRK2 (Homo sapiens) 6480464 Triclosan results in increased expression of NTRK2 mRNA CTD PMID:30510588 Ntrk2 Rat trimellitic anhydride decreases expression ISO Ntrk2 (Mus musculus) 6480464 trimellitic anhydride results in decreased expression of NTRK2 mRNA CTD PMID:19042947 Ntrk2 Rat undecane increases expression EXP 6480464 undecane results in increased expression of NTRK2 protein CTD PMID:17337753 Ntrk2 Rat valproic acid increases expression ISO Ntrk2 (Mus musculus) 6480464 Valproic Acid results in increased expression of NTRK2 mRNA CTD PMID:22045034 Ntrk2 Rat valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of NTRK2 mRNA CTD PMID:29427782 Ntrk2 Rat valproic acid increases expression ISO NTRK2 (Homo sapiens) 6480464 Valproic Acid results in increased expression of NTRK2 mRNA CTD PMID:23179753 more ... Ntrk2 Rat valproic acid multiple interactions ISO NTRK2 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK2 mRNA CTD PMID:27188386 Ntrk2 Rat venlafaxine hydrochloride decreases expression EXP 6480464 Venlafaxine Hydrochloride results in decreased expression of NTRK2 mRNA CTD PMID:25423262 Ntrk2 Rat vinclozolin multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 Ntrk2 Rat vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of NTRK2 mRNA CTD PMID:19015723 Ntrk2 Rat vorinostat decreases expression ISO NTRK2 (Homo sapiens) 6480464 vorinostat results in decreased expression of NTRK2 mRNA CTD PMID:27188386 Ntrk2 Rat WIN 55212-2 multiple interactions ISO Ntrk2 (Mus musculus) 6480464 [Acetaminophen co-treated with (3R)-((2 more ... CTD PMID:30165669 Ntrk2 Rat zalcitabine multiple interactions EXP 6480464 [gp120 protein and Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NTRK2 mRNA alternative form CTD PMID:18606552 Ntrk2 Rat zinc atom increases expression ISO NTRK2 (Homo sapiens) 6480464 Zinc deficiency results in increased expression of NTRK2 mRNA CTD PMID:18356318 Ntrk2 Rat zinc atom decreases phosphorylation ISO Ntrk2 (Mus musculus) 6480464 Zinc deficiency results in decreased phosphorylation of NTRK2 protein CTD PMID:20101602 Ntrk2 Rat zinc(0) increases expression ISO NTRK2 (Homo sapiens) 6480464 Zinc deficiency results in increased expression of NTRK2 mRNA CTD PMID:18356318 Ntrk2 Rat zinc(0) decreases phosphorylation ISO Ntrk2 (Mus musculus) 6480464 Zinc deficiency results in decreased phosphorylation of NTRK2 protein CTD PMID:20101602 Ntrk2 Rat zoledronic acid increases expression ISO NTRK2 (Homo sapiens) 6480464 zoledronic acid results in increased expression of NTRK2 mRNA CTD PMID:24714768
Imported Annotations - KEGG (archival)
alcohol dependence (ISO) alcohol use disorder (IDA,IEP,ISO) alcohol withdrawal syndrome (IDA,IEP) Alcohol-Related Disorders (IEP) Alcoholic Intoxication (ISO) Alzheimer's disease (IEP,ISO) amphetamine abuse (IEP,ISO) Anhedonia (IEP) anxiety disorder (IEP,ISO) attention deficit hyperactivity disorder (IEP) autism spectrum disorder (ISO) autistic disorder (ISO) bacterial meningitis (ISO) bipolar disorder (ISO) borna disease (IEP) cannabis abuse (IEP) cerebral infarction (ISO) Charcot-Marie-Tooth disease (ISO) Chronic Pain (IEP) cocaine abuse (ISO) cocaine dependence (IMP) Cocaine-Related Disorders (ISO) cognitive disorder (IMP) colitis (IEP) congestive heart failure (IEP) depressive disorder (IEP,IMP,ISO) developmental and epileptic encephalopathy 58 (ISO) Developmental Disabilities (ISO) Developmental Disease (ISO) Diabetic Nephropathies (IMP) diabetic neuropathy (IEP) epilepsy (IDA,ISO) Escherichia Coli Infections (IEP) Experimental Diabetes Mellitus (IEP) Experimental Seizures (IEP) genetic disease (ISO) glaucoma (IDA,IEP) heroin dependence (ISO) high grade glioma (ISO) Hyperalgesia (IEP,ISO) Hyperkinesis (ISO) Hyperphagia (ISO) idiopathic pulmonary fibrosis (ISO) Inflammation (IEP) intestinal disease (IDA) Lewy body dementia (ISO) major depressive disorder (ISO) malignant astrocytoma (ISO) Memory Disorders (IDA) middle cerebral artery infarction (IDA,IEP) morbid obesity (ISO) morphine dependence (IEP,IMP,ISO) morphine withdrawal syndrome (IEP,IMP) neuroblastoma (ISO) nicotine dependence (IEP,ISO) non-arteritic anterior ischemic optic neuropathy (ISO) obesity (ISO) Obesity, Hyperphagia, and Developmental Delay (ISO) Oculomotor Nerve Injuries (IEP) opiate withdrawal syndrome (IMP) Optic Nerve Injuries (IDA) Parkinsonism (IDA) Pneumococcal Meningitis (IEP) post-traumatic stress disorder (IEP) Postherpetic Neuralgia (IEP) Postoperative Cognitive Dysfunction (IEP,ISO) Prenatal Exposure Delayed Effects (IEP) pulmonary fibrosis (ISO) schizophrenia (ISO) Spinal Cord Injuries (IDA,IEP,IMP) status epilepticus (ISO) Stroke (IEP) Subarachnoid Hemorrhage (IDA) temporal lobe epilepsy (IEP) transient cerebral ischemia (IEP) traumatic brain injury (IEP) trigeminal neuralgia (IEP) vascular dementia (IEP) withdrawal disorder (ISO)
(+)-pilocarpine (EXP) (+)-syringaresinol beta-D-glucoside (ISO) (20S)-ginsenoside Rg3 (ISO) (S)-AMPA (EXP) (S)-amphetamine (ISO) (S)-nicotine (ISO) 1,2-dichloroethane (ISO) 1,2-dimethylhydrazine (ISO) 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile (ISO) 1-fluoro-2,4-dinitrobenzene (ISO) 17alpha-ethynylestradiol (EXP) 17beta-estradiol (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO) 3,3',4,4',5-pentachlorobiphenyl (EXP) 3,4-methylenedioxymethamphetamine (EXP) 3-isobutyl-1-methyl-7H-xanthine (ISO) 3-nitropropanoic acid (EXP) 4,4'-sulfonyldiphenol (ISO) 4-hydroxyphenyl retinamide (ISO) 5-aza-2'-deoxycytidine (ISO) 5-fluorouracil (ISO) 6-propyl-2-thiouracil (EXP) acrolein (EXP) acrylamide (EXP,ISO) aflatoxin B1 (ISO) aldrin (ISO) all-trans-retinoic acid (ISO) alpha-Solamarine (ISO) alpha-Zearalanol (EXP) amitrole (EXP) ammonium chloride (EXP) amphotericin B (ISO) androgen antagonist (EXP) aniracetam (EXP) Aroclor 1254 (ISO) arsane (EXP) arsanilic acid (EXP) arsenic atom (EXP) arsenous acid (ISO) atrazine (EXP,ISO) benzo[a]pyrene (ISO) benzo[e]pyrene (ISO) bis(2-chloroethyl) sulfide (ISO) bis(2-ethylhexyl) phthalate (EXP) bisphenol A (EXP,ISO) bisphenol F (ISO) buprenorphine (EXP) buta-1,3-diene (ISO) butanal (ISO) Butylparaben (EXP) cadmium atom (ISO) cadmium dichloride (ISO) caffeine (EXP) cannabidiol (EXP) carbon nanotube (ISO) CGP 52608 (ISO) CGS-21680 (EXP) chlorpyrifos (EXP) choline (ISO) citalopram (ISO) Citreoviridin (ISO) clomipramine (ISO) cocaine (EXP,ISO) colforsin daropate hydrochloride (EXP) copper atom (EXP) copper(0) (EXP) Cuprizon (EXP) curcumin (EXP) cyclophosphamide (EXP) cyclosporin A (ISO) cypermethrin (EXP) cyproconazole (ISO) DDD (ISO) DDE (EXP,ISO) DDT (ISO) deoxynivalenol (ISO) dexamethasone (EXP,ISO) diarsenic trioxide (ISO) diazinon (EXP) dibutyl phthalate (EXP) dieldrin (EXP,ISO) dioxygen (EXP) disodium selenite (ISO) diuron (EXP) dorsomorphin (ISO) doxorubicin (EXP,ISO) echinacoside (EXP,ISO) endrin (ISO) entinostat (ISO) enzacamene (EXP) epoxiconazole (EXP) ethanol (EXP,ISO) fenvalerate (EXP,ISO) fipronil (EXP) flavonoids (EXP) fluoxetine (EXP,ISO) folic acid (ISO) gamma-hexachlorocyclohexane (ISO) genistein (EXP) gentamycin (EXP) glyphosate (ISO) graphite (EXP) heroin (ISO) homocysteine (EXP) hydrogen peroxide (ISO) imidacloprid (EXP) imipramine (ISO) indometacin (ISO) inulin (ISO) isotretinoin (ISO) kainic acid (EXP) ketamine (EXP,ISO) L-ascorbic acid (ISO) L-methionine (ISO) lead diacetate (EXP) lead(0) (EXP,ISO) linuron (EXP) lipopolysaccharide (ISO) lycopene (EXP) malathion (ISO) maneb (ISO) manganese(II) chloride (ISO) melatonin (ISO) melittin (ISO) metformin (EXP) methamphetamine (ISO) methapyrilene (ISO) methimazole (EXP) methoxychlor (EXP) methylglyoxal (ISO) methyllycaconitine (ISO) methylmercury chloride (ISO) methylphenidate (ISO) mifepristone (EXP) mono(2-ethylhexyl) phthalate (ISO) morin (EXP) N,N-diethyl-m-toluamide (EXP) N-acetyl-L-cysteine (EXP,ISO) N-ethyl-N-nitrosourea (EXP) naphthalene (ISO) naphthalenes (EXP) nickel atom (EXP) nicotine (ISO) nicotinic acid (EXP) Nonylphenol (EXP,ISO) oleuropein (ISO) papaverine (EXP) paracetamol (EXP,ISO) paraquat (EXP,ISO) perfluorohexanesulfonic acid (ISO) perfluorononanoic acid (ISO) perfluorooctane-1-sulfonic acid (ISO) perfluorooctanoic acid (EXP) permethrin (EXP) Phenelzine (ISO) phenobarbital (ISO) phenylmercury acetate (ISO) phorbol 13-acetate 12-myristate (ISO) physostigmine (ISO) pirinixic acid (ISO) ponatinib (ISO) pregnenolone 16alpha-carbonitrile (EXP) prochloraz (EXP) procymidone (EXP) Ptaquiloside (ISO) quartz (ISO) reboxetine (ISO) reserpine (ISO) rivastigmine (EXP) rolipram (EXP,ISO) rotenone (EXP,ISO) sarin (ISO) SB 431542 (ISO) scopolamine (EXP,ISO) sevoflurane (ISO) simvastatin (ISO) sodium arsenate (ISO) sodium arsenite (EXP,ISO) sodium dodecyl sulfate (ISO) sodium fluoride (EXP,ISO) Soman (EXP) sterigmatocystin (EXP) streptozocin (EXP,ISO) sulfadimethoxine (EXP) sulforaphane (ISO) T-2 toxin (ISO) tacrine (ISO) tamibarotene (EXP,ISO) tert-butyl hydroperoxide (ISO) testosterone (EXP) Tetrachlorobisphenol A (ISO) titanium dioxide (ISO) toluene (ISO) tranylcypromine (EXP) trichloroethene (EXP) triclosan (ISO) trimellitic anhydride (ISO) undecane (EXP) valproic acid (EXP,ISO) venlafaxine hydrochloride (EXP) vinclozolin (EXP) vorinostat (ISO) WIN 55212-2 (ISO) zalcitabine (EXP) zinc atom (ISO) zinc(0) (ISO) zoledronic acid (ISO)
Biological Process
brain-derived neurotrophic factor receptor signaling pathway (IDA,IEA,IMP,ISO) cell communication (IEA) cell differentiation (IEA) cell surface receptor protein serine/threonine kinase signaling pathway (IEA) cell surface receptor protein tyrosine kinase signaling pathway (IBA,IEA) cellular response to amino acid stimulus (IEA,ISO) cellular response to brain-derived neurotrophic factor stimulus (IBA,IEP) cellular response to nerve growth factor stimulus (IEP) cellular response to tumor necrosis factor (IEP) central nervous system neuron development (IEA,ISO,ISS) cerebral cortex development (IEA,ISO,ISS) circadian rhythm (IEA,ISO) feeding behavior (IEA,ISO) glutamate secretion (IEA,ISO) learning (IEA,ISO,ISS) long-term memory (IDA) long-term synaptic potentiation (IEA,ISO) mechanoreceptor differentiation (IEA,ISO) myelination in peripheral nervous system (IEA,ISO) negative regulation of amyloid-beta formation (IEA,ISO) negative regulation of anoikis (IEA,ISO) negative regulation of apoptotic process (IMP) negative regulation of neuron apoptotic process (IMP) nervous system development (IEA) neuron differentiation (IEA,ISO,ISS) neuron migration (IEA,ISO,ISS) neuronal action potential propagation (IEA,ISO) neurotrophin signaling pathway (IEA) oligodendrocyte differentiation (IEA,ISO) peptidyl-serine phosphorylation (ISO) peripheral nervous system neuron development (IEA,ISO) positive regulation of axonogenesis (IMP) positive regulation of cell population proliferation (IDA) positive regulation of excitatory postsynaptic potential (IMP) positive regulation of gene expression (IEA,ISO,ISS) positive regulation of long-term synaptic depression (IMP) positive regulation of MAPK cascade (IDA,IMP) positive regulation of neuron projection development (IBA,IEA,ISO,ISS) positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway (IGI) positive regulation of peptidyl-serine phosphorylation (ISO) positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IBA,IMP) positive regulation of synapse assembly (IEA,ISO) positive regulation of synaptic transmission, glutamatergic (IMP) protein autophosphorylation (IDA,IMP) regulation of cytosolic calcium ion concentration (IDA) regulation of dendrite development (IMP) regulation of MAPK cascade (IDA) regulation of metabolic process (IEA,ISO) regulation of neurotransmitter secretion (IDA) regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO) response to auditory stimulus (IEP) response to ethanol (IEP) response to light stimulus (IEP) retina development in camera-type eye (IEA,ISO) retinal rod cell development (IEA,ISO) trans-synaptic signaling by BDNF, modulating synaptic transmission (IEA,ISO) vasculogenesis (IEA,ISO)
Cellular Component
axon (IBA,IDA,IEA) axon terminus (IBA,IDA) cell projection (IEA) cell surface (IDA) cytoplasm (IEA) cytosol (IEA,ISO) dendrite (IDA,IEA) dendritic spine (IBA,IDA) early endosome (IEA,ISO,ISS) early endosome membrane (IEA) endosome (IEA,ISO) endosome membrane (IEA) excitatory synapse (IDA) glutamatergic synapse (IDA,IMP) Golgi membrane (TAS) growth cone (IDA) membrane (IEA) neuronal cell body (IDA) perikaryon (IDA) perinuclear region of cytoplasm (IDA,IEA) plasma membrane (IBA,IDA,IEA,ISO,TAS) postsynapse (IDA,IMP) postsynaptic density (IBA,IEA,ISO) postsynaptic membrane (IDA) presynapse (IDA) presynaptic active zone (IDA) receptor complex (IBA,IEA,ISO) synapse (IEA) terminal bouton (IEA,ISO)
Molecular Function
ATP binding (IEA) brain-derived neurotrophic factor binding (IBA,IDA,IEA,IMP,ISO) brain-derived neurotrophic factor receptor activity (IBA,IDA,IEA,ISO) kinase activity (IEA) neurotrophin binding (IDA,IEA,ISO,ISS) neurotrophin receptor activity (IDA,IEA,IMP) nucleotide binding (IEA) protease binding (IEA,ISO) protein binding (IPI,ISO) protein homodimerization activity (IDA) protein kinase activity (IEA) protein tyrosine kinase activity (IEA,TAS) receptor tyrosine kinase binding (IPI) transferase activity (IEA) transmembrane receptor protein serine/threonine kinase activity (TAS) transmembrane receptor protein tyrosine kinase activity (IEA,IMP)
1.
Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala.
Agassandian K and Cassell MD, Brain Res. 2008 Aug 21;1226:39-55. Epub 2008 Jun 11.
2.
Effects of Morphine and Maternal Care on Behaviors and Protein Expression of Male Offspring.
Akbarabadi A, etal., Neuroscience. 2021 Jul 1;466:58-76. doi: 10.1016/j.neuroscience.2021.04.011. Epub 2021 Apr 26.
3.
A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy.
Ali Shariati M, etal., Curr Eye Res. 2018 Dec;43(12):1489-1499. doi: 10.1080/02713683.2018.1508726. Epub 2018 Oct 1.
4.
Association of contextual cues with morphine reward increases neural and synaptic plasticity in the ventral hippocampus of rats.
Alvandi MS, etal., Addict Biol. 2017 Nov;22(6):1883-1894. doi: 10.1111/adb.12547. Epub 2017 Sep 22.
5.
7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats.
Andero R, etal., Hippocampus. 2010 Dec 6.
6.
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals.
Andres-Alonso M, etal., Nat Commun. 2019 Nov 29;10(1):5448. doi: 10.1038/s41467-019-13224-z.
7.
Localization of brain-derived neurotrophic factor and TrkB receptors to postsynaptic densities of adult rat cerebral cortex.
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8.
Temporal and spatial differences in expression of TrkB isoforms in rat retina during constant light exposure.
Asai N, etal., Exp Eye Res. 2007 Sep;85(3):346-55. Epub 2007 Jun 15.
9.
The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase.
Atwal JK, etal., Neuron. 2000 Aug;27(2):265-77.
10.
Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis.
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11.
Patterns of expression of brain-derived neurotrophic factor and tyrosine kinase B mRNAs and distribution and ultrastructural localization of their proteins in the visual pathway of the adult rat.
Avwenagha O, etal., Neuroscience. 2006 Jul 7;140(3):913-28. Epub 2006 Apr 19.
12.
Up-regulation of high-affinity neurotrophin receptor, trk B-like protein on western blots of rat cortex after chronic ethanol treatment.
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13.
An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma.
Bai Y, etal., Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4722-31. Epub 2010 Mar 31.
14.
Effects of cocaine base paste on anxiety-like behavior and immediate-early gene expression in nucleus accumbens and medial prefrontal cortex of female mice.
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15.
Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans.
Beuten J, etal., Biol Psychiatry. 2007 Jan 1;61(1):48-55. doi: 10.1016/j.biopsych.2006.02.023. Epub 2006 May 19.
16.
Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis.
Briones TL and Woods J, Neuroscience. 2013 Dec 19;254:324-34. doi: 10.1016/j.neuroscience.2013.09.031. Epub 2013 Sep 25.
17.
Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor.
Cao XH, etal., J Neurochem. 2010 Sep 1;114(5):1460-75. Epub 2010 Jun 24.
18.
Hippocampal neurogenesis interferes with extinction and reinstatement of methamphetamine-associated reward memory in mice.
Che X, etal., Neuropharmacology. 2021 Sep 15;196:108717. doi: 10.1016/j.neuropharm.2021.108717. Epub 2021 Jul 15.
19.
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.
Cheung ZH, etal., PLoS Biol. 2007 Apr;5(4):e63.
20.
Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism.
Correia CT, etal., Genes Brain Behav. 2010 Oct;9(7):841-8. doi: 10.1111/j.1601-183X.2010.00627.x. Epub 2010 Aug 19.
21.
Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes.
Cortese GP, etal., J Neurosci. 2011 Mar 16;31(11):4274-9.
22.
SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population.
Cozza A, etal., J Alzheimers Dis. 2008 Sep;15(1):61-70.
23.
[Effects of chaihu shugan powder on the behavior and expressions of BDNF and TrkB in the hippocampus, amygdala, and the frontal lobe in rat model of depression].
Deng Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Oct;31(10):1373-8.
24.
Adolescent cocaine self-administration induces habit behavior in adulthood: sex differences and structural consequences.
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25.
7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease.
Devi L and Ohno M, Neuropsychopharmacology. 2012 Jan;37(2):434-44. doi: 10.1038/npp.2011.191. Epub 2011 Sep 7.
26.
Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.
Dong C, etal., Mol Psychiatry. 2009 Dec;14(12):1105-18. Epub 2009 Oct 20.
27.
Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring.
Dong E, etal., Neuropharmacology. 2018 Sep 15;140:76-85. doi: 10.1016/j.neuropharm.2018.07.010. Epub 2018 Aug 4.
28.
Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling.
Eide FF, etal., J Neurosci. 1996 May 15;16(10):3123-9.
29.
Anxiogenic-like effects of chronic cannabidiol administration in rats.
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30.
Alteration in messenger RNA neurotrophin 4 and tyrosine kinase receptors B expression levels following spinal cord injury.
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31.
Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury.
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32.
A TrkB antibody agonist promotes plasticity following cervical spinal cord injury in adult rats.
Fouad K, etal., J Neurotrauma. 2010 Jul 2.
33.
Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity.
Fujita Y, etal., EMBO J. 2011 Apr 6;30(7):1389-401. doi: 10.1038/emboj.2011.55. Epub 2011 Mar 1.
34.
BDNF Controls Bidirectional Endocannabinoid Plasticity at Corticostriatal Synapses.
Gangarossa G, etal., Cereb Cortex. 2020 Jan 10;30(1):197-214. doi: 10.1093/cercor/bhz081.
35.
Intermittent noxious stimulation following spinal cord contusion injury impairs locomotor recovery and reduces spinal brain-derived neurotrophic factor-tropomyosin-receptor kinase signaling in adult rats.
Garraway SM, etal., Neuroscience. 2011 Dec 29;199:86-102. Epub 2011 Oct 18.
36.
2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure.
Garriga-Canut M, etal., Nat Neurosci. 2006 Nov;9(11):1382-7. doi: 10.1038/nn1791. Epub 2006 Oct 15.
37.
Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro.
Gascon E, etal., Eur J Neurosci. 2005 Jan;21(1):69-80.
38.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
39.
Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression.
Ge H, etal., Sci Rep. 2019 Oct 10;9(1):14619. doi: 10.1038/s41598-019-51124-w.
40.
Rat ISS GO annotations from GOA human gene data--August 2006
GOA data from the GO Consortium
41.
The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons.
Gomes RA, etal., J Neurosci. 2006 Nov 1;26(44):11487-500.
42.
Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward.
Graham DL, etal., Biol Psychiatry. 2009 Apr 15;65(8):696-701. doi: 10.1016/j.biopsych.2008.09.032. Epub 2008 Nov 6.
43.
Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity.
Gray J, etal., Int J Obes (Lond). 2007 Feb;31(2):359-64. Epub 2006 May 16.
44.
Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota.
Gu F, etal., Food Funct. 2020 Jul 1;11(7):6148-6157. doi: 10.1039/d0fo00373e. Epub 2020 Jun 24.
45.
Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons.
Gu F, etal., Neurobiol Dis. 2018 May;113:45-58. doi: 10.1016/j.nbd.2018.01.018. Epub 2018 Feb 2.
46.
Neuronal changes induced by Varicella Zoster Virus in a rat model of postherpetic neuralgia.
Guedon JM, etal., Virology. 2015 Aug;482:167-80. doi: 10.1016/j.virol.2015.03.046. Epub 2015 Apr 11.
47.
TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders.
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48.
Physical Exercise Promotes Beneficial Changes on Neurotrophic Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement of the Endogenous Opioid System.
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49.
Therapeutic potential of a TrkB agonistic antibody for ischemic brain injury.
Han F, etal., Neurobiol Dis. 2019 Jul;127:570-581. doi: 10.1016/j.nbd.2019.04.009. Epub 2019 Apr 11.
50.
Rapid Activation of the Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Signaling Pathway by Electroconvulsive Shock in the Rat Prefrontal Cortex Is Not Associated with TrkB Neurotrophin Receptor Activation.
Hansen HH, etal., Cell Mol Neurobiol. 2007 Apr 20;.
51.
Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats.
Hasegawa Y, etal., Stroke. 2011 Feb;42(2):477-83. Epub 2010 Dec 30.
52.
Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.
He XP, etal., J Neurosci. 2010 May 5;30(18):6188-96.
53.
Calycosin Preserves BDNF/TrkB Signaling and Reduces Post-Stroke Neurological Injury after Cerebral Ischemia by Reducing Accumulation of Hypertrophic and TNF-α-Containing Microglia in Rats.
Hsu CC, etal., J Neuroimmune Pharmacol. 2020 Jun;15(2):326-339. doi: 10.1007/s11481-019-09903-9. Epub 2020 Jan 11.
54.
JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1.
Huang SH, etal., J Neurosci. 2011 Jul 20;31(29):10602-14. doi: 10.1523/JNEUROSCI.0436-11.2011.
55.
Treadmill exercise improves spatial learning ability by enhancing brain-derived neurotrophic factor expression in the attention-deficit/hyperactivity disorder rats.
Jeong HI, etal., J Exerc Rehabil. 2014 Jun 30;10(3):162-7. doi: 10.12965/jer.140111. eCollection 2014 Jun.
56.
The antidepressant-like effects of the water extract of Panax ginseng and Polygala tenuifolia are mediated via the BDNF-TrkB signaling pathway and neurogenesis in the hippocampus.
Jiang N, etal., J Ethnopharmacol. 2021 Mar 1;267:113625. doi: 10.1016/j.jep.2020.113625. Epub 2020 Nov 25.
57.
Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial activation and BDNF expression.
Jiang Y, etal., Food Funct. 2020 Jan 29;11(1):378-391. doi: 10.1039/c9fo01780a.
58.
Formation of aversive memories associated with conditioned drug withdrawal requires BDNF expression in the amygdala in acute morphine-dependent rats.
Ju YY, etal., Acta Pharmacol Sin. 2015 Dec;36(12):1437-43. doi: 10.1038/aps.2015.94. Epub 2015 Nov 16.
59.
Synectin in the nervous system: expression pattern and potential as a binding partner of neurotrophin receptors.
Kato H, etal., FEBS Lett. 2004 Aug 13;572(1-3):123-8.
60.
Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons.
Kim YI, etal., J Neurosci Res. 2006 Nov 15;84(7):1512-20.
61.
Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats.
Kishi T, etal., J Cardiol. 2012 Dec;60(6):489-94. doi: 10.1016/j.jjcc.2012.08.004. Epub 2012 Sep 2.
62.
Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients.
Kohli MA, etal., Arch Gen Psychiatry. 2010 Apr;67(4):348-59. Epub 2010 Feb 1.
63.
Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation.
Lambert WM, etal., Mol Cell Biol. 2013 Sep;33(18):3700-14. doi: 10.1128/MCB.00150-13. Epub 2013 Jul 22.
64.
Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.
Levran O, etal., Pharmacogenomics. 2013 May;14(7):755-68. doi: 10.2217/pgs.13.58.
65.
Dynamic changes of TrkB gene expression in Streptococcus pneumoniae meningitis after treatment with antibiotics and dexamethasone.
Li L, etal., World J Pediatr. 2011 Aug;7(3):250-6. Epub 2011 May 20.
66.
Detecting genetic interactions for quantitative traits with U-statistics.
Li M, etal., Genet Epidemiol. 2011 Sep;35(6):457-68. doi: 10.1002/gepi.20594. Epub 2011 May 26.
67.
Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.
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68.
Protection against acute cerebral ischemia/reperfusion injury by Leonuri Herba Total Alkali via modulation of BDNF-TrKB-PI3K/Akt signaling pathway in rats.
Li Y, etal., Biomed Pharmacother. 2021 Jan;133:111021. doi: 10.1016/j.biopha.2020.111021. Epub 2020 Nov 20.
69.
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.
Lin YT, etal., J Neuroinflammation. 2011 Sep 30;8:126. doi: 10.1186/1742-2094-8-126.
70.
The Mammalian Circadian Clock Exhibits Chronic Ethanol Tolerance and Withdrawal-Induced Glutamate Hypersensitivity, Accompanied by Changes in Glutamate and TrkB Receptor Proteins.
Lindsay JH and Prosser RA, Alcohol Clin Exp Res. 2018 Feb;42(2):315-328. doi: 10.1111/acer.13554. Epub 2017 Dec 27.
71.
BDNF-TrkB pathway mediates antidepressant-like roles of H2 S in diabetic rats via promoting hippocampal autophagy.
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72.
Effects of palmatine on BDNF/TrkB-mediated trigeminal neuralgia.
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73.
Surgical incision induces learning impairment in mice partially through inhibition of the brain-derived neurotrophic factor signaling pathway in the hippocampus and amygdala.
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74.
Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus.
Lunden JW and Kirby LG, Neuroscience. 2013 Dec 19;254:160-72. doi: 10.1016/j.neuroscience.2013.08.071. Epub 2013 Sep 20.
75.
7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents.
Luo D, etal., Neurosci Lett. 2016 May 4;620:43-9. doi: 10.1016/j.neulet.2016.03.042. Epub 2016 Mar 24.
76.
Histone Deacetylases May Mediate Surgery-Induced Impairment of Learning, Memory, and Dendritic Development.
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77.
Activation of brain-derived neurotrophic factor signaling in the basal forebrain reverses acute sleep deprivation-induced fear memory impairments.
Ma T, etal., Brain Behav. 2020 Apr;10(4):e01592. doi: 10.1002/brb3.1592. Epub 2020 Mar 10.
78.
Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction.
McCarty JH and Feinstein SC, Oncogene. 1998 Apr 2;16(13):1691-700.
79.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
80.
Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system: a novel insight into understanding the initial processes of alcohol addiction.
Miki T, etal., J Neural Transm (Vienna). 2014 Feb;121(2):201-10. doi: 10.1007/s00702-013-1085-y. Epub 2013 Sep 6.
81.
The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain.
Miller R, etal., Brain Res 2002 Sep 20;950(1-2):137-47.
82.
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.
Miyamoto Y, etal., Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10444-9. Epub 2006 Jun 26.
83.
Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure.
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84.
Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure.
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85.
Differential regulation of the expression of neurotrophin receptors in rat extraocular motoneurons after lesion.
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86.
Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure.
Moreira da Silva Santos A, etal., Neurosci Lett. 2020 Jan 10;715:134606. doi: 10.1016/j.neulet.2019.134606. Epub 2019 Nov 3.
87.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
88.
Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis in MCAO rats though BDNF-TrkB signaling pathway.
Ni GX, etal., Biomed Pharmacother. 2020 Oct;130:110353. doi: 10.1016/j.biopha.2020.110353. Epub 2020 Jul 16.
89.
Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter.
Numakawa T, etal., Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):647-52. doi: 10.1073/pnas.0800888106. Epub 2009 Jan 6.
90.
Low-Level Inhibition of GABAergic Synapses Enhances Gene Expressions Crucial for Neuronal Plasticity in the Hippocampus After Ischemic Stroke.
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91.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
92.
Lactobacillus Rhamnosus GG Affects the BDNF System in Brain Samples of Wistar Rats with Pepsin-Trypsin-Digested Gliadin (PTG)-Induced Enteropathy.
Orlando A, etal., Nutrients. 2020 Feb 27;12(3):629. doi: 10.3390/nu12030629.
93.
Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism.
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94.
7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence.
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95.
Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma.
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96.
Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus.
Pereira DB, etal., J Neurosci Res. 2006 Apr;83(5):832-44.
97.
Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation.
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98.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
99.
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Qi YH, etal., Mol Med Rep. 2019 Apr;19(4):3114-3122. doi: 10.3892/mmr.2019.9954. Epub 2019 Feb 14.
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Colitis elicits differential changes in the expression levels of receptor tyrosine kinase TrkA and TrkB in colonic afferent neurons: a possible involvement of axonal transport.
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101.
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102.
BDNF receptor antagonism during the induction of morphine dependence exacerbates the severity of physical dependence and ameliorates psychological dependence in rats.
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103.
GOA pipeline
RGD automated data pipeline
104.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
105.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
106.
Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA.
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107.
Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection.
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108.
TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice.
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109.
The effect of age and tongue exercise on BDNF and TrkB in the hypoglossal nucleus of rats.
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110.
Acupuncture Alleviates Anxiety and 22-kHz Ultrasonic Vocalizations in Rats Subjected to Repeated Alcohol Administration by Modulating the Brain-Derived Neurotrophic Factor/Corticotropin-Releasing Hormone Signaling Pathway.
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Time-dependent changes in striatal monoamine levels and gene expression following single and repeated amphetamine administration in rats.
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Functional Genetic Variation in the 3'-UTRNTRK2 is Associated with Risk of Ischemic Stroke.
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Treadmill exercise alleviates impairment of spatial learning ability through enhancing cell proliferation in the streptozotocin-induced Alzheimer's disease rats.
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Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling.
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Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder.
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116.
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.
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117.
Myosin Va mediates BDNF-induced postendocytic recycling of full-length TrkB and its translocation into dendritic spines.
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118.
Regulation by nicotine of Gpr51 and Ntrk2 expression in various rat brain regions.
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119.
Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor.
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121.
Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder.
Takei S, etal., J Psychiatr Res. 2011 Apr;45(4):460-8. Epub 2010 Sep 21.
122.
Increased expression of BDNF and proliferation of dentate granule cells after bacterial meningitis.
Tauber SC, etal., J Neuropathol Exp Neurol. 2005 Sep;64(9):806-15.
123.
Tentative Sequence Identification Numbers
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
124.
Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders.
Thompson Ray M, etal., J Psychiatry Neurosci. 2011 May;36(3):195-203.
125.
Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent.
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126.
BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions.
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127.
Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex.
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Systemic treatment with 7,8-Dihydroxiflavone activates TtkB and affords protection of two different retinal ganglion cell populations against axotomy in adult rats.
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Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure.
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7,8-Dihydroxyflavone Alleviates Anxiety-Like Behavior Induced by Chronic Alcohol Exposure in Mice Involving Tropomyosin-Related Kinase B in the Amygdala.
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Bushenhuoxue improves cognitive function and activates brain-derived neurotrophic factor-mediated signaling in a rat model of vascular dementia.
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Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats.
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Ntrk2 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 17 5,560,558 - 5,875,899 (-) NCBI GRCr8 mRatBN7.2 17 5,558,992 - 5,870,299 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 17 5,559,043 - 5,869,136 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 17 5,584,315 - 5,894,662 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 17 7,120,448 - 7,429,363 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 17 5,580,732 - 5,891,094 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 17 5,934,651 - 6,245,778 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 17 5,933,729 - 6,244,676 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 17 8,156,432 - 8,464,522 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 17 11,494,463 - 11,811,654 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 17 11,494,462 - 11,811,645 (-) NCBI Celera 17 5,673,895 - 6,828,108 (-) NCBI Celera Cytogenetic Map 17 p14 NCBI
NTRK2 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 9 84,668,522 - 85,027,054 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 9 84,668,375 - 85,095,751 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 9 87,283,437 - 87,641,969 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 9 86,473,286 - 86,828,325 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 9 84,514,246 - 84,866,963 NCBI Celera 9 57,854,390 - 58,209,019 (+) NCBI Celera Cytogenetic Map 9 q21.33 NCBI HuRef 9 57,108,647 - 57,463,914 (+) NCBI HuRef CHM1_1 9 87,429,973 - 87,785,074 (+) NCBI CHM1_1 T2T-CHM13v2.0 9 96,818,888 - 97,177,857 (+) NCBI T2T-CHM13v2.0
Ntrk2 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 13 58,954,363 - 59,281,782 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 13 58,954,383 - 59,281,784 (+) Ensembl GRCm39 Ensembl GRCm38 13 58,806,472 - 59,133,970 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 13 58,806,569 - 59,133,970 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 13 58,907,957 - 59,231,337 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 13 58,816,219 - 59,139,599 (+) NCBI MGSCv36 mm8 Celera 13 59,869,829 - 60,184,466 (+) NCBI Celera Cytogenetic Map 13 B1 NCBI cM Map 13 31.2 NCBI
Ntrk2 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955432 2,288,898 - 2,630,878 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955432 2,284,283 - 2,629,631 (-) NCBI ChiLan1.0 ChiLan1.0
NTRK2 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 11 83,829,141 - 84,374,078 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 9 83,835,183 - 84,380,018 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 9 39,663,986 - 40,208,770 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 9 84,022,677 - 84,378,307 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 9 84,021,837 - 84,372,678 (+) Ensembl panpan1.1 panPan2
NTRK2 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 1 74,447,927 - 74,777,910 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 1 74,449,060 - 74,777,032 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 1 75,211,260 - 75,538,451 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 1 74,754,263 - 75,081,259 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 1 74,755,372 - 75,083,341 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 1 74,562,918 - 74,890,457 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 1 74,331,860 - 74,658,907 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 1 75,035,216 - 75,362,564 (-) NCBI UU_Cfam_GSD_1.0
Ntrk2
NTRK2 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 10 30,033,405 - 30,429,882 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 10 30,030,050 - 30,429,938 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 10 34,211,939 - 34,350,822 (+) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
NTRK2 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 12 95,477,612 - 95,836,734 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 12 95,479,447 - 95,620,364 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666038 83,830,767 - 84,200,895 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Ntrk2
.
Predicted Target Of
Count of predictions: 545 Count of miRNA genes: 254 Interacting mature miRNAs: 310 Transcripts: ENSRNOT00000042145 Prediction methods: Microtar, Miranda, Pita, Targetscan Result types: miRGate_prediction
1354581 Bp247 Blood pressure QTL 247 4.5 arterial blood pressure trait (VT:2000000) pulse pressure (CMO:0000292) 17 1 69599340 Rat 1354613 Kidm14 Kidney mass QTL 14 6.2 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 17 4299130 35837242 Rat 631499 Stl1 Serum triglyceride level QTL 1 3.6 blood triglyceride amount (VT:0002644) blood triglyceride level (CMO:0000118) 17 3271398 27389946 Rat 2293664 Bmd28 Bone mineral density QTL 28 5.1 0.0001 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) 17 4354487 27028127 Rat 1300123 Bp194 Blood pressure QTL 194 2.82 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 17 2115149 34551001 Rat 2324619 Coatc4 Coat color QTL 4 0.001 coat/hair pigmentation trait (VT:0010463) pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811) 17 4299130 21293263 Rat 2303627 Vencon8 Ventilatory control QTL 8 0.001 respiration trait (VT:0001943) tidal volume (CMO:0000222) 17 4528038 49528038 Rat 70184 BpQTLcluster14 Blood pressure QTL cluster 14 3.38 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 17 1 31990913 Rat 631207 Niddm41 Non-insulin dependent diabetes mellitus QTL 41 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 17 1 37830672 Rat 1354651 Lmblg2 Limb length QTL 2 6 tibia length (VT:0004357) tibia length (CMO:0000450) 17 4299130 69599340 Rat 1354596 Bw32 Body weight QTL 32 4.5 body mass (VT:0001259) body weight (CMO:0000012) 17 4299130 60781592 Rat 10401807 Kidm52 Kidney mass QTL 52 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 17 1 31701463 Rat 10054088 Scort28 Serum corticosterone level QTL 28 2.04 0.0102 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 17 4528038 49528038 Rat 1354662 Rf49 Renal function QTL 49 2.9 blood creatinine amount (VT:0005328) plasma creatinine level (CMO:0000537) 17 1 69599340 Rat 1354630 Cm34 Cardiac mass QTL 34 8.7 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) 17 4299130 69599340 Rat 2293648 Bmd31 Bone mineral density QTL 31 4.5 0.0001 femur size trait (VT:1000369) femoral neck cortical cross-sectional area (CMO:0001702) 17 4354487 27028127 Rat 1354658 Spl8 Serum phospholipid level QTL 8 3.8 blood VLDL phospholipid amount (VT:0010507) blood very low density lipoprotein phospholipid level (CMO:0001571) 17 1 60781592 Rat 1641902 Colcr7 Colorectal carcinoma resistance QTL 7 3.35 0.0044 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) 17 2115149 21881669 Rat 1354638 Insul1 Insulin level QTL 1 4.8 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 17 4299130 69599340 Rat 9590316 Scort21 Serum corticosterone level QTL 21 4.75 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 17 1 22871563 Rat
D17Wox10
Rat Assembly Chr Position (strand) Source JBrowse Rnor_5.0 17 8,464,362 - 8,464,522 NCBI Rnor5.0 RGSC_v3.4 17 11,811,510 - 11,811,669 RGD RGSC3.4 RGSC_v3.1 17 11,811,510 - 11,811,669 RGD RH 3.4 Map 17 53.5 RGD RH 3.4 Map 17 53.5 UniSTS RH 2.0 Map 17 43.9 RGD Cytogenetic Map 17 p14 UniSTS
D17Rat4
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,705,480 - 5,705,653 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,081,441 - 6,081,613 NCBI Rnor6.0 Rnor_5.0 17 8,303,029 - 8,303,201 UniSTS Rnor5.0 RGSC_v3.4 17 11,642,374 - 11,642,546 UniSTS RGSC3.4 RGSC_v3.4 17 11,642,373 - 11,642,546 RGD RGSC3.4 RGSC_v3.1 17 11,642,374 - 11,642,546 RGD Celera 17 5,819,628 - 5,819,800 UniSTS RH 3.4 Map 17 53.6 RGD RH 3.4 Map 17 53.6 UniSTS RH 2.0 Map 17 41.7 RGD SHRSP x BN Map 17 5.9601 RGD Cytogenetic Map 17 p14 UniSTS
D17Got7
Rat Assembly Chr Position (strand) Source JBrowse GRCr8 17 5,852,358 - 5,852,472 (+) Marker Load Pipeline mRatBN7.2 17 5,846,851 - 5,846,967 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,222,036 - 6,222,149 NCBI Rnor6.0 Rnor_5.0 17 8,441,931 - 8,442,044 UniSTS Rnor5.0 RGSC_v3.4 17 11,789,390 - 11,789,504 RGD RGSC3.4 RGSC_v3.4 17 11,789,391 - 11,789,504 UniSTS RGSC3.4 RGSC_v3.1 17 11,789,391 - 11,789,504 RGD Celera 17 5,959,620 - 5,959,733 UniSTS RH 3.4 Map 17 73.7 UniSTS RH 3.4 Map 17 73.7 RGD RH 2.0 Map 17 38.2 RGD Cytogenetic Map 17 p14 UniSTS
D17Arb15
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,868,983 - 5,869,137 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,244,475 - 6,244,628 NCBI Rnor6.0 Rnor_5.0 17 8,464,370 - 8,464,523 UniSTS Rnor5.0 RGSC_v3.4 17 11,811,516 - 11,811,669 RGD RGSC3.4 RGSC_v3.4 17 11,811,517 - 11,811,670 UniSTS RGSC3.4 RGSC_v3.1 17 11,811,516 - 11,811,669 RGD Celera 17 5,981,709 - 5,981,850 UniSTS Cytogenetic Map 17 p14 UniSTS
BF388200
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,683,917 - 5,684,106 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,060,589 - 6,060,777 NCBI Rnor6.0 Rnor_5.0 17 8,282,177 - 8,282,365 UniSTS Rnor5.0 RGSC_v3.4 17 11,620,134 - 11,620,322 UniSTS RGSC3.4 Celera 17 5,798,149 - 5,798,337 UniSTS RH 3.4 Map 17 73.7 UniSTS Cytogenetic Map 17 p14 UniSTS
RH135318
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,835,067 - 5,835,260 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,210,245 - 6,210,437 NCBI Rnor6.0 Rnor_5.0 17 8,430,140 - 8,430,332 UniSTS Rnor5.0 RGSC_v3.4 17 11,777,573 - 11,777,765 UniSTS RGSC3.4 Celera 17 5,947,917 - 5,948,109 UniSTS RH 3.4 Map 17 53.5 UniSTS Cytogenetic Map 17 p14 UniSTS
RH140355
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,559,068 - 5,559,315 (+) MAPPER mRatBN7.2 Rnor_6.0 17 5,934,716 - 5,934,962 NCBI Rnor6.0 Rnor_5.0 17 8,156,458 - 8,156,704 UniSTS Rnor5.0 RGSC_v3.4 17 11,494,489 - 11,494,735 UniSTS RGSC3.4 Celera 17 5,673,921 - 5,674,167 UniSTS Cytogenetic Map 17 p14 UniSTS
RH129925
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,739,292 - 5,739,485 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,114,720 - 6,114,912 NCBI Rnor6.0 Rnor_5.0 17 8,335,513 - 8,335,705 UniSTS Rnor5.0 RGSC_v3.4 17 11,676,780 - 11,676,972 UniSTS RGSC3.4 Celera 17 5,852,552 - 5,852,744 UniSTS RH 3.4 Map 17 54.5 UniSTS Cytogenetic Map 17 p14 UniSTS
RH133106
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,743,832 - 5,744,018 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,119,115 - 6,119,300 NCBI Rnor6.0 Rnor_5.0 17 8,339,908 - 8,340,093 UniSTS Rnor5.0 RGSC_v3.4 17 11,681,320 - 11,681,505 UniSTS RGSC3.4 Celera 17 5,857,092 - 5,857,277 UniSTS RH 3.4 Map 17 73.3 UniSTS Cytogenetic Map 17 p14 UniSTS
BF386266
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,715,697 - 5,715,860 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,091,659 - 6,091,821 NCBI Rnor6.0 Rnor_5.0 17 8,312,470 - 8,312,632 UniSTS Rnor5.0 RGSC_v3.4 17 11,652,039 - 11,652,201 UniSTS RGSC3.4 Celera 17 5,828,923 - 5,829,085 UniSTS RH 3.4 Map 17 73.4 UniSTS Cytogenetic Map 17 p14 UniSTS
BE097527
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,703,161 - 5,703,376 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,079,122 - 6,079,336 NCBI Rnor6.0 Rnor_5.0 17 8,300,710 - 8,300,924 UniSTS Rnor5.0 RGSC_v3.4 17 11,640,055 - 11,640,269 UniSTS RGSC3.4 Celera 17 5,817,362 - 5,817,576 UniSTS RH 3.4 Map 17 72.8 UniSTS Cytogenetic Map 17 p14 UniSTS
RH138199
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,667,249 - 5,667,431 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,043,939 - 6,044,120 NCBI Rnor6.0 Rnor_5.0 17 8,265,619 - 8,265,800 UniSTS Rnor5.0 RGSC_v3.4 17 11,603,648 - 11,603,829 UniSTS RGSC3.4 Celera 17 5,781,473 - 5,781,654 UniSTS RH 3.4 Map 17 53.4 UniSTS Cytogenetic Map 17 p14 UniSTS
RH138872
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,701,329 - 5,701,568 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,077,290 - 6,077,528 NCBI Rnor6.0 Rnor_5.0 17 8,298,878 - 8,299,116 UniSTS Rnor5.0 RGSC_v3.4 17 11,638,223 - 11,638,461 UniSTS RGSC3.4 Celera 17 5,815,530 - 5,815,768 UniSTS RH 3.4 Map 17 52.5 UniSTS Cytogenetic Map 17 p14 UniSTS
RH139520
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,559,212 - 5,559,432 (+) MAPPER mRatBN7.2 Rnor_6.0 17 5,934,860 - 5,935,079 NCBI Rnor6.0 Rnor_5.0 17 8,156,602 - 8,156,821 UniSTS Rnor5.0 RGSC_v3.4 17 11,494,633 - 11,494,852 UniSTS RGSC3.4 Celera 17 5,674,065 - 5,674,284 UniSTS RH 3.4 Map 17 55.0 UniSTS Cytogenetic Map 17 p14 UniSTS
BF390725
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 17 5,748,331 - 5,748,504 (+) MAPPER mRatBN7.2 Rnor_6.0 17 6,123,562 - 6,123,734 NCBI Rnor6.0 Rnor_5.0 17 8,344,193 - 8,344,365 UniSTS Rnor5.0 RGSC_v3.4 17 11,686,081 - 11,686,253 UniSTS RGSC3.4 Celera 17 5,861,597 - 5,861,769 UniSTS RH 3.4 Map 17 73.7 UniSTS Cytogenetic Map 17 p14 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
78
77
46
25
46
6
205
97
93
45
60
31
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Ensembl Acc Id:
ENSRNOT00000042145 ⟹ ENSRNOP00000045635
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 17 5,559,043 - 5,869,121 (-) Ensembl Rnor_6.0 Ensembl 17 5,934,690 - 6,244,612 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000082611 ⟹ ENSRNOP00000073595
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 17 5,559,043 - 5,869,121 (-) Ensembl Rnor_6.0 Ensembl 17 5,933,729 - 6,244,676 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000090914 ⟹ ENSRNOP00000070128
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 17 5,739,171 - 5,869,136 (-) Ensembl Rnor_6.0 Ensembl 17 6,114,598 - 6,244,627 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000100565 ⟹ ENSRNOP00000082641
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 17 5,784,667 - 5,869,136 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000101783 ⟹ ENSRNOP00000078799
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 17 5,784,517 - 5,869,136 (-) Ensembl
RefSeq Acc Id:
NM_001163168 ⟹ NP_001156640
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,744,682 - 5,874,628 (-) NCBI mRatBN7.2 17 5,739,171 - 5,869,126 (-) NCBI Rnor_6.0 17 6,114,598 - 6,244,627 (-) NCBI Rnor_5.0 17 8,156,432 - 8,464,522 (-) NCBI RGSC_v3.4 17 11,494,463 - 11,811,654 (-) RGD Celera 17 5,852,430 - 6,828,108 (-) NCBI
Sequence:
CTGTGTGCGAGTGCGTGTGCGTGCGTGCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAGCGTGTGTGTTTTTGGATTTCATACTAATTTTCTGGAGTTTCTGCCCCTG
hide sequence
RefSeq Acc Id:
NM_012731 ⟹ NP_036863
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,564,570 - 5,874,628 (-) NCBI mRatBN7.2 17 5,559,043 - 5,869,126 (-) NCBI Rnor_6.0 17 5,934,690 - 6,244,612 (-) NCBI Rnor_5.0 17 8,156,432 - 8,464,522 (-) NCBI RGSC_v3.4 17 11,494,463 - 11,811,654 (-) RGD Celera 17 5,673,895 - 6,828,108 (-) NCBI
Sequence:
TGTGCGTGCGTGCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAG
hide sequence
RefSeq Acc Id:
XM_006253507 ⟹ XP_006253569
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,689,411 - 5,874,756 (-) NCBI mRatBN7.2 17 5,683,893 - 5,868,087 (-) NCBI Rnor_6.0 17 6,060,564 - 6,244,716 (-) NCBI Rnor_5.0 17 8,156,432 - 8,464,522 (-) NCBI
Sequence:
GGCCGCTGGCACCAAGCCTCCTCCTCCCCGCTCGCCCCCAGATTCCCTCCCCTCCGCCTTGCTTTTGTCTGGAGGGTGCTATGCTATGCCTGTGTGCGAGTGCGTGTGCGTGCGTGCGTGTGTGTGTG
hide sequence
RefSeq Acc Id:
XM_008771425 ⟹ XP_008769647
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,560,558 - 5,874,756 (-) NCBI mRatBN7.2 17 5,560,666 - 5,869,126 (-) NCBI Rnor_6.0 17 5,934,651 - 6,244,725 (-) NCBI
Sequence:
TCTGCGCCTGGCCGCTGGCACCAAGCCTCCTCCTCCCCGCTCGCCCCCAGATTCCCTCCCCTCCGCCTTGCTTTTGTCTGGAGGGTGCTATGCTATGCCTGTGTGCGAGTGCGTGTGCGTGCGTGCGT
hide sequence
RefSeq Acc Id:
XM_008771426 ⟹ XP_008769648
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,560,558 - 5,875,798 (-) NCBI mRatBN7.2 17 5,560,666 - 5,870,171 (-) NCBI Rnor_6.0 17 5,934,651 - 6,245,662 (-) NCBI
Sequence:
CACTCGACGCTCGGGAATCATCTCACGTGTCCCCACTGAGACTCTAGGGCGCTGCCAGAGCCCAGCCTCTCCGTAGCTGGAAGCACGTCCTGCCTCGGGCAGCGCGGGTGCAGGGTACACGTTGGCGC
hide sequence
RefSeq Acc Id:
XM_008771427 ⟹ XP_008769649
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,689,411 - 5,874,756 (-) NCBI mRatBN7.2 17 5,689,623 - 5,868,087 (-) NCBI Rnor_6.0 17 6,060,564 - 6,244,715 (-) NCBI
Sequence:
GCCGCTGGCACCAAGCCTCCTCCTCCCCGCTCGCCCCCAGATTCCCTCCCCTCCGCCTTGCTTTTGTCTGGAGGGTGCTATGCTATGCCTGTGTGCGAGTGCGTGTGCGTGCGTGCGTGTGTGTGTGT
hide sequence
RefSeq Acc Id:
XM_017600456 ⟹ XP_017455945
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,560,558 - 5,875,801 (-) NCBI mRatBN7.2 17 5,560,666 - 5,870,299 (-) NCBI Rnor_6.0 17 5,934,651 - 6,245,778 (-) NCBI
Sequence:
ATGACTGCGGATATGCGGGCGGTCGGAGCCACAAATGGTGAGAGGAGGTTCGGACCACGCTCGC
hide sequence
RefSeq Acc Id:
XM_039095370 ⟹ XP_038951298
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,560,558 - 5,874,971 (-) NCBI mRatBN7.2 17 5,560,666 - 5,869,466 (-) NCBI
RefSeq Acc Id:
XM_063276069 ⟹ XP_063132139
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,560,558 - 5,875,798 (-) NCBI
RefSeq Acc Id:
XM_063276070 ⟹ XP_063132140
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,560,558 - 5,875,816 (-) NCBI
RefSeq Acc Id:
XM_063276071 ⟹ XP_063132141
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,560,558 - 5,872,206 (-) NCBI
RefSeq Acc Id:
XM_063276072 ⟹ XP_063132142
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,744,684 - 5,875,899 (-) NCBI
RefSeq Acc Id:
XM_063276073 ⟹ XP_063132143
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,744,684 - 5,875,816 (-) NCBI
RefSeq Acc Id:
XM_063276074 ⟹ XP_063132144
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 17 5,744,684 - 5,874,957 (-) NCBI
RefSeq Acc Id:
NP_036863 ⟸ NM_012731
- Peptide Label:
isoform 1 precursor
- UniProtKB:
Q63605 (UniProtKB/Swiss-Prot), Q63606 (UniProtKB/Swiss-Prot), Q63604 (UniProtKB/Swiss-Prot)
- Sequence:
MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLT
hide sequence
RefSeq Acc Id:
NP_001156640 ⟸ NM_001163168
- Peptide Label:
isoform 2 precursor
- UniProtKB:
A6KAJ1 (UniProtKB/TrEMBL), A0A8I5ZVM2 (UniProtKB/TrEMBL)
- Sequence:
MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSID
hide sequence
RefSeq Acc Id:
XP_006253569 ⟸ XM_006253507
- Peptide Label:
isoform X4
- UniProtKB:
A0A8I5ZVM2 (UniProtKB/TrEMBL)
- Sequence:
MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSID
hide sequence
RefSeq Acc Id:
XP_008769648 ⟸ XM_008771426
- Peptide Label:
isoform X1
- UniProtKB:
A0A0G2K5X6 (UniProtKB/TrEMBL)
- Sequence:
MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLT
hide sequence
RefSeq Acc Id:
XP_008769647 ⟸ XM_008771425
- Peptide Label:
isoform X1
- UniProtKB:
A0A0G2K5X6 (UniProtKB/TrEMBL)
- Sequence:
MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLT
hide sequence
RefSeq Acc Id:
XP_008769649 ⟸ XM_008771427
- Peptide Label:
isoform X5
- UniProtKB:
A0A8I5ZVM2 (UniProtKB/TrEMBL)
- Sequence:
MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLT
hide sequence
RefSeq Acc Id:
XP_017455945 ⟸ XM_017600456
- Peptide Label:
isoform X1
- UniProtKB:
A0A0G2K5X6 (UniProtKB/TrEMBL)
- Sequence:
MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSID
hide sequence
Ensembl Acc Id:
ENSRNOP00000073595 ⟸ ENSRNOT00000082611
Ensembl Acc Id:
ENSRNOP00000070128 ⟸ ENSRNOT00000090914
Ensembl Acc Id:
ENSRNOP00000045635 ⟸ ENSRNOT00000042145
RefSeq Acc Id:
XP_038951298 ⟸ XM_039095370
- Peptide Label:
isoform X1
- UniProtKB:
A0A0G2K5X6 (UniProtKB/TrEMBL)
Ensembl Acc Id:
ENSRNOP00000082641 ⟸ ENSRNOT00000100565
Ensembl Acc Id:
ENSRNOP00000078799 ⟸ ENSRNOT00000101783
RefSeq Acc Id:
XP_063132140 ⟸ XM_063276070
- Peptide Label:
isoform X2
- UniProtKB:
Q63606 (UniProtKB/Swiss-Prot), Q63605 (UniProtKB/Swiss-Prot), Q63604 (UniProtKB/Swiss-Prot)
RefSeq Acc Id:
XP_063132139 ⟸ XM_063276069
- Peptide Label:
isoform X2
- UniProtKB:
Q63606 (UniProtKB/Swiss-Prot), Q63605 (UniProtKB/Swiss-Prot), Q63604 (UniProtKB/Swiss-Prot)
RefSeq Acc Id:
XP_063132141 ⟸ XM_063276071
- Peptide Label:
isoform X3
RefSeq Acc Id:
XP_063132142 ⟸ XM_063276072
- Peptide Label:
isoform X6
- UniProtKB:
A6KAJ1 (UniProtKB/TrEMBL), A0A8I5ZVM2 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063132143 ⟸ XM_063276073
- Peptide Label:
isoform X6
- UniProtKB:
A6KAJ1 (UniProtKB/TrEMBL), A0A8I5ZVM2 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063132144 ⟸ XM_063276074
- Peptide Label:
isoform X6
- UniProtKB:
A6KAJ1 (UniProtKB/TrEMBL), A0A8I5ZVM2 (UniProtKB/TrEMBL)
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2016-04-14
Ntrk2
neurotrophic receptor tyrosine kinase 2
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2002-11-06
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
Neural receptor protein-tyrosine kinase (trkB)
Name updated
625702 APPROVED
2002-06-10
Ntrk2
Neural receptor protein-tyrosine kinase (trkB)
Symbol and Name status set to approved
70586 APPROVED
Note Type
Note
Reference
gene_function
responsible for tyrosine phosphorylation of voltage-gated potassium channel Kv1.3
633084
gene_regulation
activated by GM1 ganglioside
727459
