Ntrk2 (neurotrophic receptor tyrosine kinase 2) - Rat Genome Database

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Gene: Ntrk2 (neurotrophic receptor tyrosine kinase 2) Chinchilla lanigera
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Symbol: Ntrk2
Name: neurotrophic receptor tyrosine kinase 2
RGD ID: 8842814
Description: ENCODES a protein that exhibits brain-derived neurotrophic factor binding (ortholog); brain-derived neurotrophic factor-activated receptor activity (ortholog); neurotrophin binding (ortholog); INVOLVED IN aging (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); calcium-mediated signaling using intracellular calcium source (ortholog); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); attention deficit hyperactivity disorder (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: BDNF/NT-3 growth factors receptor; neurotrophic tyrosine kinase, receptor, type 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554322,288,898 - 2,630,878 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554322,284,283 - 2,629,631 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
brain-derived neurotrophic factor receptor signaling pathway  (ISO)
calcium-mediated signaling using intracellular calcium source  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to brain-derived neurotrophic factor stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
central nervous system neuron development  (ISO)
cerebral cortex development  (ISO)
circadian rhythm  (ISO)
feeding behavior  (ISO)
glutamate secretion  (ISO)
inflammatory response  (ISO)
learning  (ISO)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
mechanoreceptor differentiation  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neuromuscular junction development  (ISO)
neuron differentiation  (ISO)
neuron migration  (ISO)
neuronal action potential propagation  (ISO)
oligodendrocyte differentiation  (ISO)
peripheral nervous system neuron development  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
protein autophosphorylation  (ISO)
regulation of dendrite development  (ISO)
regulation of GTPase activity  (ISO)
regulation of MAPK cascade  (ISO)
regulation of metabolic process  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of protein kinase B signaling  (ISO)
response to auditory stimulus  (ISO)
response to light stimulus  (ISO)
retina development in camera-type eye  (ISO)
retinal rod cell development  (ISO)
trans-synaptic signaling by BDNF, modulating synaptic transmission  (ISO)
trans-synaptic signaling by neuropeptide, modulating synaptic transmission  (ISO)
vasculogenesis  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Ntrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554322,288,898 - 2,630,878 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554322,284,283 - 2,629,631 (-)NCBIChiLan1.0ChiLan1.0
NTRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl984,668,551 - 85,027,054 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl984,668,551 - 85,027,070 (+)EnsemblGRCh38hg38GRCh38
GRCh38984,668,458 - 85,027,070 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37987,283,437 - 87,641,969 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36986,473,286 - 86,828,325 (+)NCBINCBI36hg18NCBI36
Build 34984,514,246 - 84,866,963NCBI
Celera957,854,390 - 58,209,019 (+)NCBI
Cytogenetic Map9q21.33NCBI
HuRef957,108,647 - 57,463,914 (+)NCBIHuRef
CHM1_1987,429,880 - 87,788,555 (+)NCBICHM1_1
Ntrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391358,954,286 - 59,281,784 (+)NCBIGRCm39mm39
GRCm39 Ensembl1358,954,383 - 59,281,784 (+)Ensembl
GRCm381358,806,472 - 59,133,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1358,806,569 - 59,133,970 (+)EnsemblGRCm38mm10GRCm38
MGSCv371358,907,957 - 59,231,337 (+)NCBIGRCm37mm9NCBIm37
MGSCv361358,816,219 - 59,139,599 (+)NCBImm8
Celera1359,869,829 - 60,184,466 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1331.2NCBI
Ntrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2175,558,992 - 5,870,299 (-)NCBI
Rnor_6.0 Ensembl175,933,729 - 6,244,676 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0175,934,651 - 6,245,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0178,156,432 - 8,464,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41711,494,463 - 11,811,654 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11711,494,462 - 11,811,645 (-)NCBI
Celera175,673,895 - 6,828,108 (-)NCBICelera
Cytogenetic Map17p14NCBI
NTRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1984,022,677 - 84,378,307 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl984,021,837 - 84,372,678 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0939,663,986 - 40,208,770 (-)NCBIMhudiblu_PPA_v0panPan3
NTRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1174,447,927 - 74,777,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl174,449,060 - 74,777,032 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha175,211,260 - 75,538,451 (-)NCBI
ROS_Cfam_1.0174,754,263 - 75,081,259 (-)NCBI
UMICH_Zoey_3.1174,562,918 - 74,890,457 (-)NCBI
UNSW_CanFamBas_1.0174,331,860 - 74,658,907 (-)NCBI
UU_Cfam_GSD_1.0175,035,216 - 75,362,564 (-)NCBI
Ntrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947121,116,646 - 121,472,444 (-)NCBI
SpeTri2.0NW_004936680267,850 - 621,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1030,033,379 - 30,429,882 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11030,030,050 - 30,429,938 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21034,211,939 - 34,350,822 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTRK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11295,477,612 - 95,836,734 (+)NCBI
ChlSab1.1 Ensembl1295,479,447 - 95,620,364 (+)Ensembl
Ntrk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248098,274,736 - 8,622,287 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000006845   ⟹   ENSCLAP00000006735
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554322,288,898 - 2,630,878 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000006846   ⟹   ENSCLAP00000006736
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554322,288,898 - 2,630,878 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000006847   ⟹   ENSCLAP00000006737
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554322,493,210 - 2,629,855 (-)Ensembl
RefSeq Acc Id: XM_005387931   ⟹   XP_005387988
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554322,284,283 - 2,629,631 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005387932   ⟹   XP_005387989
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554322,284,283 - 2,629,631 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005387933   ⟹   XP_005387990
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554322,430,351 - 2,629,569 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005387934   ⟹   XP_005387991
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554322,430,353 - 2,629,569 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013516029   ⟹   XP_013371483
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554322,284,283 - 2,628,154 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005387989   ⟸   XM_005387932
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005387988   ⟸   XM_005387931
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005387991   ⟸   XM_005387934
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005387990   ⟸   XM_005387933
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013371483   ⟸   XM_013516029
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000006737   ⟸   ENSCLAT00000006847
RefSeq Acc Id: ENSCLAP00000006736   ⟸   ENSCLAT00000006846
RefSeq Acc Id: ENSCLAP00000006735   ⟸   ENSCLAT00000006845


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004746 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000006735 ENTREZGENE
  ENSCLAP00000006736 ENTREZGENE
  ENSCLAP00000006737 ENTREZGENE
Ensembl Transcript ENSCLAT00000006845 ENTREZGENE
  ENSCLAT00000006846 ENTREZGENE
  ENSCLAT00000006847 ENTREZGENE
NCBI Gene Ntrk2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Ntrk2  neurotrophic receptor tyrosine kinase 2    neurotrophic tyrosine kinase, receptor, type 2  Symbol and/or name change 5135510 APPROVED