Kcnj6 (potassium inwardly-rectifying channel, subfamily J, member 6) - Rat Genome Database

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Gene: Kcnj6 (potassium inwardly-rectifying channel, subfamily J, member 6) Rattus norvegicus
Analyze
Symbol: Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
RGD ID: 2959
Description: Enables G-protein alpha-subunit binding activity and inward rectifier potassium channel activity. Involved in cellular response to morphine and response to electrical stimulus. Located in several cellular components, including cell surface; dendrite; and neuronal cell body membrane. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BIR1; G protein-activated inward rectifier potassium channel 2; GIRK-2; GIRK2; inward rectifier K(+) channel Kir3.2; KATP-2; LOC360252; potassium channel, inwardly rectifying subfamily J member 6; potassium channel, inwardly rectifying subfamily J, member 6; Potassium inwardly-rectifying channel subfamily J member 6; potassium voltage-gated channel subfamily J member 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,531,312 - 47,778,348 (-)NCBIGRCr8
mRatBN7.21134,061,702 - 34,308,758 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,061,708 - 34,308,758 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,718,859 - 42,966,801 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,390,234 - 35,638,172 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01134,536,231 - 34,783,241 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01135,011,007 - 35,262,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1135,024,196 - 35,099,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,602,645 - 38,692,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,025,118 - 35,116,500 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11135,096,649 - 35,172,743NCBI
Celera1134,144,832 - 34,389,786 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Notes
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Original Reference(s)
Kcnj6Ratalcohol use disorder  ISOKCNJ6 (Homo sapiens)6483053DNA:SNP:promoter:rs2836016 (human)RGD 
Kcnj6RatDown syndrome  ISOKcnj6 (Mus musculus)6483052protein:increased expression:hippocampusRGD 
Kcnj6Ratheroin dependence  ISOKCNJ6 (Homo sapiens)6483055DNA:SNP: :rs2070995 (human)RGD 
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Original Reference(s)
Kcnj6Ratamyotrophic lateral sclerosis type 1  ISOKCNJ6 (Homo sapiens)8554872ClinVar Annotator: match by term: Amyotrophic lateral sclerosis type 1ClinVarPMID:17237124 more ...
Kcnj6Ratautosomal dominant intellectual developmental disorder 7  ISOKCNJ6 (Homo sapiens)8554872ClinVar Annotator: match by term: DYRK1A-related intellectual disability syndromeClinVarPMID:17237124 more ...
Kcnj6Ratepilepsy  ISOKCNJ6 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVar 
Kcnj6RatFamilial Platelet Disorder with Associated Myeloid Malignancy  ISOKCNJ6 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1ClinVarPMID:17237124 more ...
Kcnj6Ratgenetic disease  ISOKCNJ6 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Kcnj6Ratimmunodeficiency 28  ISOKCNJ6 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 28ClinVarPMID:17237124 more ...
Kcnj6RatKeppen-Lubinsky Syndrome  ISOKCNJ6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:19610118 more ...
Kcnj6Ratschizophrenia  ISOKCNJ6 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVar 
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Original Reference(s)
Kcnj6RatNerve Degeneration  ISOKCNJ6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15256069
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Original Reference(s)
Kcnj6RatKeppen-Lubinsky Syndrome  ISOKCNJ6 (Homo sapiens)7240710 OMIM 

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Kcnj6Rat(+)-catechin multiple interactionsISOKCNJ6 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of KCNJ6 mRNACTDPMID:24763279
Kcnj6Rat(S)-duloxetine hydrochloride multiple interactionsISOKcnj6 (Mus musculus)6480464Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]CTDPMID:22164246
Kcnj6Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects response to substanceISOKcnj6 (Mus musculus)6480464KCNJ6 affects the susceptibility to 1-Methyl-4-phenyl-1 more ...CTDPMID:8172626
Kcnj6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOKCNJ6 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of KCNJ6 mRNACTDPMID:11489354
Kcnj6Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of KCNJ6 mRNACTDPMID:32109520
Kcnj6Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Kcnj6Rat4,4'-sulfonyldiphenol decreases methylationISOKcnj6 (Mus musculus)6480464bisphenol S results in decreased methylation of KCNJ6 exonCTDPMID:33297965
Kcnj6Rat4,4'-sulfonyldiphenol affects methylationISOKcnj6 (Mus musculus)6480464bisphenol S affects the methylation of KCNJ6 geneCTDPMID:31683443
Kcnj6Rat4,4'-sulfonyldiphenol decreases methylationISOKCNJ6 (Homo sapiens)6480464bisphenol S results in decreased methylation of KCNJ6 geneCTDPMID:31601247
Kcnj6Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of KCNJ6 mRNACTDPMID:24780913
Kcnj6Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of KCNJ6 mRNACTDPMID:24780913
Kcnj6Rataflatoxin B1 decreases methylationISOKCNJ6 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of KCNJ6 geneCTDPMID:27153756
Kcnj6Ratamosite asbestos increases expressionISOKcnj6 (Mus musculus)6480464Asbestos and Amosite results in increased expression of KCNJ6 mRNACTDPMID:23917077
Kcnj6Ratamoxapine multiple interactionsISOKcnj6 (Mus musculus)6480464Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]CTDPMID:22164246
Kcnj6Ratbaclofen increases response to substanceISOKcnj6 (Mus musculus)6480464KCNJ6 results in increased susceptibility to BaclofenCTDPMID:12836919
Kcnj6Ratbenzo[a]pyrene increases expressionEXP 6480464Benzo(a)pyrene results in increased expression of KCNJ6 mRNACTDPMID:21839799
Kcnj6Ratbenzo[a]pyrene decreases expressionISOKCNJ6 (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of KCNJ6 mRNACTDPMID:38036013
Kcnj6Ratbenzo[a]pyrene increases methylationISOKCNJ6 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of KCNJ6 exon and Benzo(a)pyrene results in increased methylation of KCNJ6 promoterCTDPMID:27901495
Kcnj6Ratbenzo[a]pyrene affects methylationISOKCNJ6 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of KCNJ6 5' UTR and Benzo(a)pyrene affects the methylation of KCNJ6 intronCTDPMID:27901495 and PMID:30157460
Kcnj6Ratbenzo[a]pyrene affects methylationISOKcnj6 (Mus musculus)6480464Benzo(a)pyrene affects the methylation of KCNJ6 intronCTDPMID:27901495

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Biological Process
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Original Reference(s)
Kcnj6Ratcellular response to morphine  IEP 6483056 RGD 
Kcnj6Ratmonoatomic cation transmembrane transport involved_inIEAGO:00052421600115GO_REF:0000108GOCGO_REF:0000108
Kcnj6Ratmonoatomic cation transmembrane transport involved_inIEAGO:00154671600115GO_REF:0000108GOCGO_REF:0000108
Kcnj6Ratmonoatomic ion transmembrane transport involved_inIEAUniProtKB-KW:KW-0407 and UniProtKB-KW:KW-08511600115GO_REF:0000043UniProtGO_REF:0000043
Kcnj6Ratmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
Kcnj6Ratpotassium ion import across plasma membrane involved_inIBAMGI:107501 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcnj6Ratpotassium ion transmembrane transport involved_inIEAGO:00154671600115GO_REF:0000108GOCGO_REF:0000108
Kcnj6Ratpotassium ion transmembrane transport involved_inIEAGO:00052421600115GO_REF:0000108GOCGO_REF:0000108
Kcnj6Ratpotassium ion transport involved_inIEAUniProtKB-KW:KW-06331600115GO_REF:0000043UniProtGO_REF:0000043
Kcnj6Ratpotassium ion transport involved_inIEAInterPro:IPR003275 and InterPro:IPR0164491600115GO_REF:0000002InterProGO_REF:0000002
Kcnj6Ratregulation of monoatomic ion transmembrane transport involved_inIBAMGI:1100508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcnj6Ratregulation of presynaptic membrane potential involved_inIEAGO:00995081600115GO_REF:0000108GOCGO_REF:0000108
Kcnj6Ratresponse to electrical stimulus  IEP 2316513 RGD 
Kcnj6Ratthyroid hormone metabolic process acts_upstream_of_or_withinISOKcnj6 (Mus musculus)1624291MGI:1856525RGDMGI:85368
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Cellular Component
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Molecular Function
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Original Reference(s)
Kcnj6RatG-protein activated inward rectifier potassium channel activity enablesISOKcnj6 (Mus musculus) and PR:P48542-21624291 PMID:7499385RGDPMID:7499385
Kcnj6RatG-protein activated inward rectifier potassium channel activity enablesISOKcnj6 (Mus musculus)1624291 PMID:7926018RGDPMID:7926018
Kcnj6RatG-protein activated inward rectifier potassium channel activity enablesIEAInterPro:IPR0032751600115GO_REF:0000002InterProGO_REF:0000002
Kcnj6RatG-protein activated inward rectifier potassium channel activity contributes_toISOKcnj6 (Mus musculus)1624291 PMID:10341034RGDPMID:10341034
Kcnj6RatG-protein alpha-subunit binding  IDA 2316504 RGD 
Kcnj6Ratinward rectifier potassium channel activity enablesISOKcnj6 (Mus musculus) and PR:P48542-51624291 PMID:10562331RGDPMID:10562331
Kcnj6Ratinward rectifier potassium channel activity enablesIEAUniProtKB:P48051 and ensembl:ENSP000004774371600115GO_REF:0000107EnsemblGO_REF:0000107
Kcnj6Ratinward rectifier potassium channel activity enablesIBAFB:FBgn0039081 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcnj6Ratinward rectifier potassium channel activity enablesIEAInterPro:IPR0164491600115GO_REF:0000002InterProGO_REF:0000002
Kcnj6Ratinward rectifier potassium channel activity enablesISOKCNJ6 (Homo sapiens)1624291 PMID:10659995RGDPMID:10659995
Kcnj6Ratinward rectifier potassium channel activity enablesIDA 728997PMID:7601286UniProt 
Kcnj6Ratinward rectifier potassium channel activity enablesIDA 408345221PMID:9486652UniProt 
Kcnj6Ratinward rectifier potassium channel activity enablesISOKcnj6 (Mus musculus) and PR:P48542-31624291 PMID:8573147RGDPMID:8573147
Kcnj6Ratinward rectifier potassium channel activity enablesISOKcnj6 (Mus musculus) and PR:P48542-21624291 PMID:7926018RGDPMID:7926018
Kcnj6Ratpotassium channel activity enablesISOKcnj6 (Mus musculus)1624291 PMID:20393461RGDPMID:20393461
Kcnj6Ratprotein binding enablesIPIUniProtKB:Q8K4V48554502PMID:17828261UniProt 
Kcnj6Ratprotein binding enablesISOKCNJ6 (Homo sapiens)1624291UniProtKB:A0PK00 more ...RGDPMID:12297500 and PMID:32296183
Kcnj6Ratvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential enablesISOKcnj6 (Mus musculus)1624291 PMID:10956667RGDPMID:10956667
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Reference Title
Reference Citation
1. Effects of gonadal steroid hormones on GIRK2 gene transcription in the rat central nervous system. Ahangar N, etal., Neurosci Lett. 2008 Feb 6;431(3):201-5. Epub 2007 Dec 3.
2. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. Best TK, etal., Exp Neurol. 2012 Feb;233(2):749-57. Epub 2011 Dec 8.
3. Cloning and functional expression of the cDNA encoding an inwardly-rectifying potassium channel expressed in pancreatic beta-cells and in the brain. Bond CT, etal., FEBS Lett 1995 Jun 19;367(1):61-6.
4. Inwardly rectifying potassium channels in rat retinal ganglion cells. Chen L, etal., Eur J Neurosci. 2004 Aug;20(4):956-64.
5. Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Chung HJ, etal., Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):629-34. Epub 2008 Dec 31.
6. KCNJ6 is associated with adult alcohol dependence and involved in gene x early life stress interactions in adolescent alcohol drinking. Clarke TK, etal., Neuropsychopharmacology. 2011 May;36(6):1142-8. Epub 2011 Feb 9.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Huang CL, etal., Nature. 1998 Feb 19;391(6669):803-6. doi: 10.1038/35882.
10. Signal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channel. Koike-Tani M, etal., J Physiol. 2005 Apr 15;564(Pt 2):489-500. Epub 2005 Feb 24.
11. A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size. Lotsch J, etal., Pharmacogenet Genomics. 2010 May;20(5):291-7.
12. A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Lunn ML, etal., Nat Neurosci. 2007 Oct;10(10):1249-59. Epub 2007 Sep 2.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Alteration in expression of G-protein-activated inward rectifier K+-channel subunits GIRK1 and GIRK2 in the rat brain following electroconvulsive shock. Pei Q, etal., Neuroscience. 1999 May;90(2):621-7.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. Stoffel M, etal., Biochem Biophys Res Commun 1995 Jul 26;212(3):894-9.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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PMID:7926018   PMID:11883954   PMID:16780588   PMID:16797547   PMID:17296805   PMID:18698588   PMID:19118199   PMID:19558451   PMID:21653876   PMID:22098295   PMID:26199148   PMID:26460748  
PMID:28291959   PMID:28951616   PMID:31386893   PMID:36602604  



Kcnj6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,531,312 - 47,778,348 (-)NCBIGRCr8
mRatBN7.21134,061,702 - 34,308,758 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,061,708 - 34,308,758 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,718,859 - 42,966,801 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,390,234 - 35,638,172 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01134,536,231 - 34,783,241 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01135,011,007 - 35,262,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1135,024,196 - 35,099,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,602,645 - 38,692,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,025,118 - 35,116,500 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11135,096,649 - 35,172,743NCBI
Celera1134,144,832 - 34,389,786 (+)NCBICelera
Cytogenetic Map11q11NCBI
KCNJ6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382137,607,373 - 37,916,457 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2137,607,373 - 38,121,345 (-)EnsemblGRCh38hg38GRCh38
GRCh372138,979,675 - 39,288,760 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,918,655 - 38,210,566 (-)NCBINCBI36Build 36hg18NCBI36
Build 342137,918,656 - 38,210,566NCBI
Celera2124,194,896 - 24,487,265 (-)NCBICelera
Cytogenetic Map21q22.13NCBI
HuRef2124,470,127 - 24,761,921 (-)NCBIHuRef
CHM1_12138,557,922 - 38,850,112 (-)NCBICHM1_1
T2T-CHM13v2.02135,989,771 - 36,299,971 (-)NCBIT2T-CHM13v2.0
Kcnj6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391694,545,839 - 94,798,719 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1694,549,495 - 94,798,560 (-)EnsemblGRCm39 Ensembl
GRCm381694,744,980 - 94,997,696 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,748,636 - 94,997,701 (-)EnsemblGRCm38mm10GRCm38
MGSCv371694,970,290 - 95,219,303 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361694,857,497 - 95,106,494 (-)NCBIMGSCv36mm8
Celera1695,836,339 - 96,085,607 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.44NCBI
Kcnj6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540736,659,627 - 36,924,024 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540736,670,824 - 36,923,960 (-)NCBIChiLan1.0ChiLan1.0
KCNJ6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22233,721,642 - 34,033,922 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12128,581,161 - 28,895,193 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02123,983,485 - 24,284,759 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12137,339,201 - 37,634,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2137,340,738 - 37,558,688 (-)Ensemblpanpan1.1panPan2
KCNJ6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13132,752,585 - 33,010,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3132,755,899 - 32,934,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3131,821,629 - 32,081,491 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03132,062,846 - 32,322,567 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3132,066,922 - 32,322,588 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13131,937,274 - 32,196,786 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03131,945,083 - 32,204,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03132,428,866 - 32,689,562 (-)NCBIUU_Cfam_GSD_1.0
Kcnj6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497132,225,573 - 32,465,141 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365005,065,107 - 5,239,854 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365005,002,668 - 5,164,511 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13201,243,609 - 201,525,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113201,231,803 - 201,525,943 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213211,406,250 - 211,613,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,569,659 - 81,878,047 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660549,424,667 - 9,732,757 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474525,947,561 - 26,127,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474525,879,671 - 26,130,998 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Kcnj6
2185 total Variants

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:70
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000066940
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 16 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat

1 to 10 of 16 rows
D11Rat97  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81147,576,607 - 47,576,735 (+)Marker Load Pipeline
mRatBN7.21134,107,000 - 34,107,128 (+)MAPPERmRatBN7.2
Rnor_6.01135,056,301 - 35,056,428NCBIRnor6.0
Rnor_5.01138,650,211 - 38,650,338UniSTSRnor5.0
RGSC_v3.41135,072,772 - 35,072,900RGDRGSC3.4
RGSC_v3.41135,072,773 - 35,072,900UniSTSRGSC3.4
RGSC_v3.11135,128,969 - 35,129,320RGD
Celera1134,344,651 - 34,344,778UniSTS
SHRSP x BN Map1110.4299RGD
SHRSP x BN Map1110.4299UniSTS
Cytogenetic Map11q11UniSTS
D14Rat111  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8141,704,281 - 1,704,496 (+)Marker Load Pipeline
mRatBN7.2141,559,312 - 1,559,527 (+)MAPPERmRatBN7.2
Rnor_6.0142,564,744 - 2,564,958NCBIRnor6.0
Rnor_5.0142,563,788 - 2,564,002UniSTSRnor5.0
Rnor_5.01138,631,875 - 38,632,089UniSTSRnor5.0
RGSC_v3.4142,107,017 - 2,107,231UniSTSRGSC3.4
RGSC_v3.4142,107,016 - 2,107,231RGDRGSC3.4
RGSC_v3.41135,054,436 - 35,054,651RGDRGSC3.4
RGSC_v3.41135,054,437 - 35,054,651UniSTSRGSC3.4
RGSC_v3.1142,107,017 - 2,107,231RGD
Celera141,580,055 - 1,580,269UniSTS
RH 3.4 Map1426.6UniSTS
RH 3.4 Map1426.6RGD
RH 2.0 Map1419.9RGD
SHRSP x BN Map140.0RGD
Cytogenetic Map14p22UniSTS
Cytogenetic Map11q11UniSTS
D11Mco6  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81147,697,343 - 47,697,696 (+)Marker Load Pipeline
mRatBN7.21134,227,744 - 34,228,097 (+)MAPPERmRatBN7.2
Rnor_6.01135,177,895 - 35,178,247NCBIRnor6.0
Rnor_5.01138,769,861 - 38,770,213UniSTSRnor5.0
RGSC_v3.41135,208,370 - 35,208,723RGDRGSC3.4
RGSC_v3.41135,208,371 - 35,208,723UniSTSRGSC3.4
RGSC_v3.11135,264,613 - 35,264,966RGD
Celera1134,223,332 - 34,223,684UniSTS
Cytogenetic Map11q11UniSTS
UniSTS:143667  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,148,949 - 34,149,213 (+)MAPPERmRatBN7.2
Rnor_6.01135,098,241 - 35,098,504NCBIRnor6.0
Rnor_5.01138,692,371 - 38,692,634UniSTSRnor5.0
RGSC_v3.41135,115,900 - 35,116,163UniSTSRGSC3.4
Celera1134,302,962 - 34,303,225UniSTS
Cytogenetic Map11q11UniSTS
RH132210  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,061,760 - 34,061,946 (+)MAPPERmRatBN7.2
Rnor_6.01135,011,066 - 35,011,251NCBIRnor6.0
Rnor_5.01138,602,696 - 38,602,881UniSTSRnor5.0
RGSC_v3.41135,025,169 - 35,025,354UniSTSRGSC3.4
Celera1134,389,550 - 34,389,735UniSTS
Cytogenetic Map11q11UniSTS
RH94617  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,076,099 - 34,076,242 (+)MAPPERmRatBN7.2
Rnor_6.01135,025,402 - 35,025,544NCBIRnor6.0
Rnor_5.01138,617,984 - 38,618,126UniSTSRnor5.0
RGSC_v3.41135,040,457 - 35,040,599UniSTSRGSC3.4
Celera1134,375,363 - 34,375,505UniSTS
Cytogenetic Map11q11UniSTS
AI412840  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,075,075 - 34,075,234 (+)MAPPERmRatBN7.2
Rnor_6.01135,024,378 - 35,024,536NCBIRnor6.0
Rnor_5.01138,616,960 - 38,617,118UniSTSRnor5.0
RGSC_v3.41135,039,433 - 35,039,591UniSTSRGSC3.4
Celera1134,376,371 - 34,376,529UniSTS
RH 3.4 Map11254.81UniSTS
Cytogenetic Map11q11UniSTS
UniSTS:259101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,149,013 - 34,149,267 (+)MAPPERmRatBN7.2
Rnor_6.01135,098,305 - 35,098,558NCBIRnor6.0
Rnor_5.01138,692,435 - 38,692,688UniSTSRnor5.0
RGSC_v3.41135,115,964 - 35,116,217UniSTSRGSC3.4
Celera1134,302,908 - 34,303,161UniSTS
Cytogenetic Map11q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 9 20 106 38 42 15 16 15 6 85 52 91 4 34 27


1 to 16 of 16 rows
RefSeq Transcripts NM_001393803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB073753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB073754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB073755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB073756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY095171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF156275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U21087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000066940   ⟹   ENSRNOP00000059308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,061,708 - 34,308,758 (-)Ensembl
Rnor_6.0 Ensembl1135,025,988 - 35,099,383 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079955   ⟹   ENSRNOP00000069879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,067,409 - 34,150,092 (-)Ensembl
Rnor_6.0 Ensembl1135,024,196 - 35,098,883 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119355   ⟹   ENSRNOP00000079589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,067,409 - 34,308,758 (-)Ensembl
RefSeq Acc Id: NM_001393803   ⟹   NP_001380732
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,531,312 - 47,778,348 (-)NCBI
mRatBN7.21134,061,702 - 34,308,758 (-)NCBI
RefSeq Acc Id: NM_013192   ⟹   NP_037324
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,531,312 - 47,778,348 (-)NCBI
mRatBN7.21134,061,702 - 34,308,758 (-)NCBI
Rnor_6.01135,011,015 - 35,262,362 (-)NCBI
Rnor_5.01138,602,645 - 38,692,971 (-)NCBI
RGSC_v3.41135,025,118 - 35,116,500 (-)RGD
Celera1134,144,832 - 34,389,786 (+)RGD
Sequence:
RefSeq Acc Id: XM_063270313   ⟹   XP_063126383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,531,317 - 47,778,122 (-)NCBI
RefSeq Acc Id: NP_037324   ⟸   NM_013192
- Peptide Label: isoform 1
- UniProtKB: P48550 (UniProtKB/Swiss-Prot),   Q54A91 (UniProtKB/TrEMBL),   A0A8I6G5I5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069879   ⟸   ENSRNOT00000079955
Ensembl Acc Id: ENSRNOP00000059308   ⟸   ENSRNOT00000066940
Ensembl Acc Id: ENSRNOP00000079589   ⟸   ENSRNOT00000119355
RefSeq Acc Id: NP_001380732   ⟸   NM_001393803
- Peptide Label: isoform 2
- UniProtKB: P48550 (UniProtKB/Swiss-Prot),   F1LS53 (UniProtKB/TrEMBL),   A0A9K3Y8C1 (UniProtKB/TrEMBL),   Q8QZW1 (UniProtKB/TrEMBL)
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane

Name Modeler Protein Id AA Range Protein Structure
AF-P48550-F1-model_v2 AlphaFold P48550 1-425 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-21751 BioCyc
Ensembl Genes ENSRNOG00000001658 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000066940 ENTREZGENE
  ENSRNOT00000119355 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  2.60.40.1400 UniProtKB/Swiss-Prot
InterPro Ig_E-set UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir3.2 UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot
  Kir_TM UniProtKB/Swiss-Prot
KEGG Report rno:25743 UniProtKB/Swiss-Prot
NCBI Gene 25743 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot
  PTHR11767:SF19 UniProtKB/Swiss-Prot
Pfam IRK UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
PharmGKB KCNJ6 RGD
PhenoGen Kcnj6 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot
PRINTS KIR32CHANNEL UniProtKB/Swiss-Prot
  KIRCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001658 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC234590
UniProt A0A0G2JWH0_RAT UniProtKB/TrEMBL
  A0A8I6G5I5 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y8C1 ENTREZGENE, UniProtKB/TrEMBL
  F1LS53 ENTREZGENE
  KCNJ6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q54A91 ENTREZGENE, UniProtKB/TrEMBL
  Q8QZW1 ENTREZGENE, UniProtKB/TrEMBL
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-19 Kcnj6  potassium inwardly-rectifying channel, subfamily J, member 6  Kcnj6  potassium voltage-gated channel subfamily J member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Kcnj6  potassium voltage-gated channel subfamily J member 6  Kcnj6  potassium channel, inwardly rectifying subfamily J, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj6  potassium channel, inwardly rectifying subfamily J, member 6  Kcnj6  potassium inwardly-rectifying channel, subfamily J, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Kcnj6  potassium inwardly-rectifying channel, subfamily J, member 6  Kcnj6_predicted  potassium inwardly-rectifying channel, subfamily J, member 6 (predicted)  Data merged from RGD:1305763 737654 APPROVED
2005-01-12 Kcnj6_predicted  potassium inwardly-rectifying channel, subfamily J, member 6 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Kcnj6  Potassium inwardly-rectifying, channel, subfamily J, member 6      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed in brain and insulinoma cells 728997