KCNJ6 (potassium inwardly rectifying channel subfamily J member 6) - Rat Genome Database

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Gene: KCNJ6 (potassium inwardly rectifying channel subfamily J member 6) Sus scrofa
Analyze
Symbol: KCNJ6
Name: potassium inwardly rectifying channel subfamily J member 6
RGD ID: 14279311
Description: ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN cellular response to morphine (ortholog); monoatomic ion transmembrane transport (ortholog); regulation of presynaptic membrane potential (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); FOUND IN axon (ortholog); cell surface (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G protein-activated inward rectifier potassium channel 2; potassium voltage-gated channel subfamily J member 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13201,243,609 - 201,525,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113201,231,803 - 201,525,943 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213211,406,250 - 211,613,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNJ6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13201,243,609 - 201,525,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113201,231,803 - 201,525,943 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213211,406,250 - 211,613,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382137,607,373 - 37,916,457 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2137,607,373 - 38,121,345 (-)EnsemblGRCh38hg38GRCh38
GRCh372138,979,675 - 39,288,760 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,918,655 - 38,210,566 (-)NCBINCBI36Build 36hg18NCBI36
Build 342137,918,656 - 38,210,566NCBI
Celera2124,194,896 - 24,487,265 (-)NCBICelera
Cytogenetic Map21q22.13NCBI
HuRef2124,470,127 - 24,761,921 (-)NCBIHuRef
CHM1_12138,557,922 - 38,850,112 (-)NCBICHM1_1
T2T-CHM13v2.02135,989,771 - 36,299,971 (-)NCBIT2T-CHM13v2.0
Kcnj6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391694,545,839 - 94,798,719 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1694,549,495 - 94,798,560 (-)EnsemblGRCm39 Ensembl
GRCm381694,744,980 - 94,997,696 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,748,636 - 94,997,701 (-)EnsemblGRCm38mm10GRCm38
MGSCv371694,970,290 - 95,219,303 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361694,857,497 - 95,106,494 (-)NCBIMGSCv36mm8
Celera1695,836,339 - 96,085,607 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.44NCBI
Kcnj6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,531,312 - 47,778,348 (-)NCBIGRCr8
mRatBN7.21134,061,702 - 34,308,758 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,061,708 - 34,308,758 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,718,859 - 42,966,801 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,390,234 - 35,638,172 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01134,536,231 - 34,783,241 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01135,011,007 - 35,262,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1135,024,196 - 35,099,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,602,645 - 38,692,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,025,118 - 35,116,500 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11135,096,649 - 35,172,743NCBI
Celera1134,144,832 - 34,389,786 (+)NCBICelera
Cytogenetic Map11q11NCBI
Kcnj6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540736,659,627 - 36,924,024 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540736,670,824 - 36,923,960 (-)NCBIChiLan1.0ChiLan1.0
KCNJ6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22233,721,642 - 34,033,922 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12128,581,161 - 28,895,193 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02123,983,485 - 24,284,759 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12137,339,201 - 37,634,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2137,340,738 - 37,558,688 (-)Ensemblpanpan1.1panPan2
KCNJ6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13132,752,585 - 33,010,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3132,755,899 - 32,934,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3131,821,629 - 32,081,491 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03132,062,846 - 32,322,567 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3132,066,922 - 32,322,588 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13131,937,274 - 32,196,786 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03131,945,083 - 32,204,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03132,428,866 - 32,689,562 (-)NCBIUU_Cfam_GSD_1.0
Kcnj6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497132,225,573 - 32,465,141 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365005,065,107 - 5,239,854 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365005,002,668 - 5,164,511 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,569,659 - 81,878,047 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660549,424,667 - 9,732,757 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474525,947,561 - 26,127,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474525,879,671 - 26,130,998 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNJ6
13400 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system respiratory system
High
Medium 1 12
Low 2 2 2 11
Below cutoff 4 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000013197   ⟹   ENSSSCP00000012845
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13201,247,705 - 201,525,630 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000064153   ⟹   ENSSSCP00000057704
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13201,243,609 - 201,525,820 (-)Ensembl
RefSeq Acc Id: XM_021070975   ⟹   XP_020926634
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113201,231,803 - 201,525,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070976   ⟹   XP_020926635
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113201,247,717 - 201,525,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070977   ⟹   XP_020926636
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113201,247,717 - 201,524,288 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070978   ⟹   XP_020926637
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113201,247,717 - 201,450,875 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020926634   ⟸   XM_021070975
- UniProtKB: A0A4X1TQP6 (UniProtKB/TrEMBL),   A0A287BMI4 (UniProtKB/TrEMBL),   F1SGV4 (UniProtKB/TrEMBL),   A0A8D1HQN3 (UniProtKB/TrEMBL),   A0A8D1RRI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926635   ⟸   XM_021070976
- UniProtKB: A0A4X1TQP6 (UniProtKB/TrEMBL),   A0A287BMI4 (UniProtKB/TrEMBL),   F1SGV4 (UniProtKB/TrEMBL),   A0A8D1HQN3 (UniProtKB/TrEMBL),   A0A8D1RRI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926636   ⟸   XM_021070977
- UniProtKB: A0A4X1TQP6 (UniProtKB/TrEMBL),   A0A287BMI4 (UniProtKB/TrEMBL),   F1SGV4 (UniProtKB/TrEMBL),   A0A8D1HQN3 (UniProtKB/TrEMBL),   A0A8D1RRI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020926637   ⟸   XM_021070978
- UniProtKB: A0A4X1TQP6 (UniProtKB/TrEMBL),   A0A287BMI4 (UniProtKB/TrEMBL),   F1SGV4 (UniProtKB/TrEMBL),   A0A8D1HQN3 (UniProtKB/TrEMBL),   A0A8D1RRI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000057704   ⟸   ENSSSCT00000064153
RefSeq Acc Id: ENSSSCP00000012845   ⟸   ENSSSCT00000013197
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012065 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005001587 UniProtKB/TrEMBL
  ENSSSCG00015011476 UniProtKB/TrEMBL
  ENSSSCG00025003813 UniProtKB/TrEMBL
  ENSSSCG00030039948 UniProtKB/TrEMBL
  ENSSSCG00035072284 UniProtKB/TrEMBL
  ENSSSCG00045016907 UniProtKB/TrEMBL
  ENSSSCG00050050971 UniProtKB/TrEMBL
  ENSSSCG00055023850 UniProtKB/TrEMBL
  ENSSSCG00060014839 UniProtKB/TrEMBL
  ENSSSCG00065069320 UniProtKB/TrEMBL
  ENSSSCG00070010925 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000064153 ENTREZGENE
  ENSSSCT00000064153.3 UniProtKB/TrEMBL
  ENSSSCT00005002307.1 UniProtKB/TrEMBL
  ENSSSCT00005002315.1 UniProtKB/TrEMBL
  ENSSSCT00015015120.1 UniProtKB/TrEMBL
  ENSSSCT00025005042.1 UniProtKB/TrEMBL
  ENSSSCT00030055621.1 UniProtKB/TrEMBL
  ENSSSCT00035097819.1 UniProtKB/TrEMBL
  ENSSSCT00045028848.1 UniProtKB/TrEMBL
  ENSSSCT00045028909.1 UniProtKB/TrEMBL
  ENSSSCT00050069395.1 UniProtKB/TrEMBL
  ENSSSCT00055046954.1 UniProtKB/TrEMBL
  ENSSSCT00060019686.1 UniProtKB/TrEMBL
  ENSSSCT00065095191.1 UniProtKB/TrEMBL
  ENSSSCT00070021191.1 UniProtKB/TrEMBL
  ENSSSCT00070021198.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  2.60.40.1400 UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir3.2 UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/TrEMBL
  Kir_TM UniProtKB/TrEMBL
NCBI Gene KCNJ6 ENTREZGENE
PANTHER PTHR11767 UniProtKB/TrEMBL
  PTHR11767:SF19 UniProtKB/TrEMBL
Pfam IRK UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
PIRSF GIRK_kir UniProtKB/TrEMBL
PRINTS KIR32CHANNEL UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A287BMI4 ENTREZGENE
  A0A4X1TQP6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1HQN3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1RRI5 ENTREZGENE, UniProtKB/TrEMBL
  F1SGV4 ENTREZGENE
  F4YE93_PIG UniProtKB/TrEMBL
UniProt Secondary A0A287BMI4 UniProtKB/TrEMBL
  F1SGV4 UniProtKB/TrEMBL
VGNC ID VGNC:89360 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-23 KCNJ6  potassium inwardly rectifying channel subfamily J member 6  KCNJ6  potassium voltage-gated channel subfamily J member 6  Symbol and/or name change 5135510 APPROVED