En1 (engrailed homeobox 1) - Rat Genome Database

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Gene: En1 (engrailed homeobox 1) Rattus norvegicus
Analyze
Symbol: En1
Name: engrailed homeobox 1
RGD ID: 1595088
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in response to cocaine. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1); INTERACTS WITH alpha-Zearalanol; bisphenol A; perfluorooctanoic acid.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: engrailed 1; homeobox protein engrailed-1; LOC685360; similar to Homeobox protein engrailed-1 (Mo-En-1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81334,303,684 - 34,309,269 (+)NCBIGRCr8
mRatBN7.21331,750,892 - 31,756,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,751,545 - 31,755,943 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1334,309,142 - 34,314,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,596,963 - 35,602,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,871,391 - 32,876,977 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,532,758 - 36,537,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,532,758 - 36,537,093 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,634,070 - 41,638,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,623,592 - 31,629,063 (+)NCBICelera
Cytogenetic Map13q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
En1RatParkinson's disease  ISOEN1 (Homo sapiens)5687197DNA:SNP:enhancer: (rs1438852) (human)RGD 
En1RatParkinsonism  ISOEn1 (Mus musculus)5687199 RGD 
Object Symbol
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Evidence
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Reference
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Original Reference(s)
En1RatENDOVE SYNDROME, LIMB-BRAIN TYPE  ISOEN1 (Homo sapiens)8554872ClinVar Annotator: match by term: ENDOVE syndrome and limb-brain typeClinVarPMID:33568816
Object Symbol
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Original Reference(s)
En1Ratadenoid cystic carcinoma  ISOEN1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16762588
En1RatNeoplasm Invasiveness  ISOEN1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26213588
En1Ratnervous system disease  ISOEN1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21892157
En1RatSalivary Gland Neoplasms  ISOEN1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16762588
Object Symbol
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Original Reference(s)
En1RatParkinson's disease  ISSEn1 (Mus musculus)13592920 MouseDO 
Object Symbol
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Original Reference(s)
En1RatENDOVE SYNDROME, LIMB-BRAIN TYPE  ISOEN1 (Homo sapiens)7240710 OMIM 

1 to 20 of 44 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
En1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOEn1 (Mus musculus)6480464[EN1 protein co-treated with EN2 protein] inhibits the reaction [1-Methyl-4-phenyl-1 more ...CTDPMID:21892157
En1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOEn1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of EN1 mRNACTDPMID:24058054
En1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOEN1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EN1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of EN1 mRNACTDPMID:28628672
En1Rat4,4'-sulfonyldiphenol multiple interactionsISOEN1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of EN1 mRNACTDPMID:28628672
En1Rat4,4'-sulfonyldiphenol increases expressionISOEn1 (Mus musculus)6480464bisphenol S results in increased expression of EN1 mRNACTDPMID:30951980
En1Rat5-aza-2'-deoxycytidine increases expressionISOEN1 (Homo sapiens)6480464Decitabine results in increased expression of EN1 mRNACTDPMID:27901495
En1Ratall-trans-retinoic acid decreases expressionISOEn1 (Mus musculus)6480464Tretinoin results in decreased expression of EN1 mRNACTDPMID:16604517
En1Ratall-trans-retinoic acid multiple interactionsISOEn1 (Mus musculus)6480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of EN1 mRNACTDPMID:36189433
En1Ratall-trans-retinoic acid increases expressionISOEN1 (Homo sapiens)6480464Tretinoin results in increased expression of EN1 mRNACTDPMID:34742744
En1Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of EN1 mRNACTDPMID:35163327
En1Ratarsenite(3-) increases methylationISOEN1 (Homo sapiens)6480464arsenite results in increased methylation of EN1 promoterCTDPMID:23974009
En1Ratatrazine increases expressionISOEN1 (Homo sapiens)6480464Atrazine results in increased expression of EN1 mRNACTDPMID:22378314
En1Ratbenzo[a]pyrene affects methylationISOEN1 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of EN1 exonCTDPMID:27901495
En1Ratbenzo[a]pyrene decreases expressionISOEN1 (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of EN1 mRNACTDPMID:27901495
En1Ratbenzo[a]pyrene multiple interactionsISOEN1 (Homo sapiens)6480464Ascorbic Acid inhibits the reaction [Benzo(a)pyrene results in decreased expression of EN1 mRNA] more ...CTDPMID:27901495
En1Ratbenzo[a]pyrene increases methylationISOEN1 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of EN1 promoterCTDPMID:27901495
En1Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of EN1 mRNACTDPMID:25181051
En1Ratbisphenol A increases expressionISOEn1 (Mus musculus)6480464bisphenol A results in increased expression of EN1 mRNACTDPMID:30951980
En1Ratbisphenol A affects methylationISOEn1 (Mus musculus)6480464bisphenol A affects the methylation of EN1 promoterCTDPMID:27334623
En1Ratbisphenol A increases methylationISOEn1 (Mus musculus)6480464bisphenol A results in increased methylation of EN1 promoterCTDPMID:27312807

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Biological Process
1 to 20 of 53 rows

  
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Original Reference(s)
En1Ratadult locomotory behavior involved_inISOEn1 (Mus musculus)1624291 PMID:17267560RGDPMID:17267560
En1Ratadult locomotory behavior involved_inIEAUniProtKB:P09065 and ensembl:ENSMUSP000000786591600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratcentral nervous system neuron differentiation acts_upstream_of_or_withinISOEn1 (Mus musculus)1624291MGI:95390 PMID:15340832RGDPMID:15340832
En1Ratcentral nervous system neuron differentiation acts_upstream_of_or_withinIEAUniProtKB:P09065 and ensembl:ENSMUSP000000786591600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratcerebellum development involved_inISOEn1 (Mus musculus)1624291UniProtKB:P04426 and PMID:8848044RGDPMID:8848044
En1Ratcerebellum development involved_inIEAUniProtKB:P09065 and ensembl:ENSMUSP000000786591600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratdopaminergic neuron differentiation acts_upstream_of_or_withinIEAUniProtKB:P09065 and ensembl:ENSMUSP000000786591600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratdopaminergic neuron differentiation acts_upstream_of_or_withinISOEn1 (Mus musculus)1624291MGI:95390 PMID:15175251 and PMID:15340832RGDPMID:15175251 and PMID:15340832
En1Ratdorsal/ventral pattern formation acts_upstream_of_or_withinISOEn1 (Mus musculus)1624291MGI:1857163 PMID:8684466 and PMID:9362463RGDPMID:8684466 and PMID:9362463
En1Ratdorsal/ventral pattern formation acts_upstream_of_or_withinIEAUniProtKB:P09065 and ensembl:ENSMUSP000000786591600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratdrinking behavior involved_inISOEn1 (Mus musculus)1624291 PMID:17267560RGDPMID:17267560
En1Ratdrinking behavior involved_inIEAUniProtKB:P09065 and ensembl:ENSMUSP000000786591600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratembryonic brain development involved_inIEAUniProtKB:P09065 and ensembl:ENSMUSP000000786591600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratembryonic brain development involved_inISOEn1 (Mus musculus)1624291 PMID:7624797RGDPMID:7624797
En1Ratembryonic forelimb morphogenesis acts_upstream_of_or_withinISOEn1 (Mus musculus)1624291MGI:98961 PMID:9362463RGDPMID:9362463
En1Ratembryonic forelimb morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P09065 and ensembl:ENSMUSP000000786591600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratembryonic limb morphogenesis involved_inISOEn1 (Mus musculus)1624291 PMID:7624797RGDPMID:7624797
En1Ratembryonic limb morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P09065 and ensembl:ENSMUSP000000786591600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratembryonic limb morphogenesis acts_upstream_of_or_withinISOEn1 (Mus musculus)1624291MGI:1329040 more ...RGDPMID:15242796 and PMID:8684466
En1Rathindbrain development acts_upstream_of_or_withinISOEn1 (Mus musculus)1624291MGI:95390 PMID:15607945RGDPMID:15607945
1 to 20 of 53 rows

Cellular Component

  
Object Symbol
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Term
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Reference
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Original Reference(s)
En1Ratnucleus located_inISOEN1 (Homo sapiens)1624291 PMID:24399192RGDPMID:24399192
En1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
En1Ratnucleus located_inIEAUniProtKB:Q05925 and ensembl:ENSP000002952061600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratnucleus located_inIEAUniRule:UR000048440 and UniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
En1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
En1Ratnucleus located_inIEAInterPro:IPR0007471600115GO_REF:0000002InterProGO_REF:0000002
En1Ratnucleus is_active_inIBACGD:CAL0000190097 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 13 of 13 rows

  
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Original Reference(s)
En1RatDNA binding enablesIEAUniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
En1RatDNA binding enablesIEAUniProtKB-KW:KW-0238 and UniProtKB-KW:KW-03711600115GO_REF:0000043UniProtGO_REF:0000043
En1RatDNA binding enablesIEAInterPro:IPR000747 more ...1600115GO_REF:0000002InterProGO_REF:0000002
En1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAInterPro:IPR0179701600115GO_REF:0000002InterProGO_REF:0000002
En1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0000577 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
En1RatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISOEN1 (Homo sapiens)1624291 PMID:21672318RGDPMID:21672318
En1RatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q05925 and ensembl:ENSP000002952061600115GO_REF:0000107EnsemblGO_REF:0000107
En1Ratprotein binding enablesISOEn1 (Mus musculus)1624291PR:Q8VIJ6 PMID:23863478RGDPMID:23863478
En1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOEN1 (Homo sapiens)1624291 PMID:21672318RGDPMID:21672318
En1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:Q05925 and ensembl:ENSP000002952061600115GO_REF:0000107EnsemblGO_REF:0000107
En1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAFB:FBgn0000577 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
En1Ratsequence-specific double-stranded DNA binding enablesISOEN1 (Homo sapiens)1624291 PMID:28473536RGDPMID:28473536
En1Ratsequence-specific double-stranded DNA binding enablesIEAUniProtKB:Q05925 and ensembl:ENSP000002952061600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 13 of 13 rows


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease. Haubenberger D, etal., Neurobiol Aging. 2011 Feb;32(2):302-7. Epub 2009 Apr 3.
3. Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties. Joliot A, etal., Development. 1997 May;124(10):1865-75.
4. Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function. Leo D, etal., Exp Neurol. 2007 Feb;203(2):472-80. Epub 2006 Oct 27.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Sgado P, etal., Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15242-7. Epub 2006 Oct 2.
PMID:7624797   PMID:8684466   PMID:8848044   PMID:9102311   PMID:9362463   PMID:11312297   PMID:15175251   PMID:15242796   PMID:15340832   PMID:15607945   PMID:17267560   PMID:20042388  
PMID:21672318   PMID:23863478   PMID:24399192  



En1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81334,303,684 - 34,309,269 (+)NCBIGRCr8
mRatBN7.21331,750,892 - 31,756,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,751,545 - 31,755,943 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1334,309,142 - 34,314,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,596,963 - 35,602,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,871,391 - 32,876,977 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,532,758 - 36,537,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,532,758 - 36,537,093 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,634,070 - 41,638,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,623,592 - 31,629,063 (+)NCBICelera
Cytogenetic Map13q11NCBI
EN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382118,842,171 - 118,847,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2118,842,171 - 118,847,648 (-)EnsemblGRCh38hg38GRCh38
GRCh372119,599,747 - 119,605,224 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,316,217 - 119,322,229 (-)NCBINCBI36Build 36hg18NCBI36
Build 342119,315,995 - 119,321,989NCBI
Celera2112,924,401 - 112,930,414 (-)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2111,924,919 - 111,930,585 (-)NCBIHuRef
CHM1_12119,603,429 - 119,609,441 (-)NCBICHM1_1
T2T-CHM13v2.02119,275,530 - 119,281,008 (-)NCBIT2T-CHM13v2.0
En1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,530,246 - 120,535,719 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,530,147 - 120,535,721 (+)EnsemblGRCm39 Ensembl
GRCm381120,602,487 - 120,607,991 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,602,418 - 120,607,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,499,064 - 122,504,568 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,430,227 - 122,435,517 (+)NCBIMGSCv36mm8
Celera1123,260,515 - 123,266,033 (+)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.74NCBI
En1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545910,839,581 - 10,844,198 (+)NCBIChiLan1.0ChiLan1.0
EN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21320,867,576 - 20,875,017 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B20,882,547 - 20,888,391 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B5,798,557 - 5,804,368 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11931,124,325 - 31,129,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1931,388,610 - 31,392,987 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01932,511,803 - 32,516,772 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1932,511,803 - 32,516,949 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11931,195,351 - 31,200,286 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01931,362,291 - 31,366,665 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01932,548,697 - 32,553,632 (+)NCBIUU_Cfam_GSD_1.0
En1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,166,409 - 90,170,431 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493646951,439,944 - 51,451,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1524,402,370 - 24,407,692 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11524,402,605 - 24,408,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,041,846 - 28,047,020 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216935
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11011,470,295 - 11,558,688 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1011,475,221 - 11,479,475 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606111,121,703 - 11,124,623 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
En1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473226,333,653 - 26,337,904 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473226,333,642 - 26,338,450 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in En1
27 total Variants

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:82
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000074125
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 28 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat

1 to 10 of 28 rows
RH104030  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,756,240 - 31,756,393 (+)MAPPERmRatBN7.2
Rnor_6.01336,537,655 - 36,537,807NCBIRnor6.0
Rnor_5.01341,638,663 - 41,638,815UniSTSRnor5.0
Celera1331,628,830 - 31,628,982UniSTS
PMC314463P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,755,369 - 31,756,174 (+)MAPPERmRatBN7.2
Rnor_6.01336,536,784 - 36,537,588NCBIRnor6.0
Rnor_5.01341,637,792 - 41,638,596UniSTSRnor5.0
Celera1331,627,959 - 31,628,763UniSTS
AU047989  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,750,275 - 31,750,426 (+)MAPPERmRatBN7.2
Rnor_6.01336,531,487 - 36,531,639NCBIRnor6.0
Rnor_5.01341,632,776 - 41,632,928UniSTSRnor5.0
Celera1331,622,875 - 31,623,027UniSTS
En1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,755,823 - 31,756,407 (+)MAPPERmRatBN7.2
Rnor_6.01336,537,238 - 36,537,821NCBIRnor6.0
Rnor_5.01341,638,246 - 41,638,829UniSTSRnor5.0
Celera1331,628,413 - 31,628,996UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 11 1 97 36 28 11 14 11 6 71 38 77 8 53 17


RefSeq Transcripts NM_001398705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000083007   ⟹   ENSRNOP00000068605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1331,751,545 - 31,755,943 (+)Ensembl
Rnor_6.0 Ensembl1336,532,758 - 36,537,093 (+)Ensembl
RefSeq Acc Id: NM_001398705   ⟹   NP_001385634
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81334,303,684 - 34,309,269 (+)NCBI
mRatBN7.21331,750,892 - 31,756,477 (+)NCBI
Protein RefSeqs NP_001385634 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068605
  ENSRNOP00000068605.2
Ensembl Acc Id: ENSRNOP00000068605   ⟸   ENSRNOT00000083007
RefSeq Acc Id: NP_001385634   ⟸   NM_001398705
- UniProtKB: A0A0G2JT82 (UniProtKB/TrEMBL)
Homeobox

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JT82-F1-model_v2 AlphaFold A0A0G2JT82 1-399 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-18503 BioCyc
Ensembl Genes ENSRNOG00000056580 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083007 ENTREZGENE
  ENSRNOT00000083007.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Engrailed_Homeobox_TFs UniProtKB/TrEMBL
  Homeobox-engrailed_C-terminal UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_engrailed UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
  Homoebox-engrailed_CS UniProtKB/TrEMBL
NCBI Gene 685360 ENTREZGENE
PANTHER HOMEOBOX PROTEIN ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX PROTEIN ENGRAILED-1 UniProtKB/TrEMBL
Pfam Engrail_1_C_sig UniProtKB/TrEMBL
  Homeodomain UniProtKB/TrEMBL
PhenoGen En1 PhenoGen
PRINTS ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX UniProtKB/TrEMBL
PROSITE ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056580 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Formin homology 2 domain (FH2 domain) UniProtKB/TrEMBL
  SSF46689 UniProtKB/TrEMBL
UniProt A0A0G2JT82 ENTREZGENE, UniProtKB/TrEMBL
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 En1  engrailed homeobox 1  LOC679094  similar to Homeobox protein engrailed-1 (Mo-En-1)  Data merged from RGD:1593033 1643240 APPROVED
2008-10-28 En1  engrailed homeobox 1  En1  engrailed 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 En1  engrailed 1  LOC685360  similar to Homeobox protein engrailed-1 (Mo-En-1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685360  similar to Homeobox protein engrailed-1 (Mo-En-1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC679094  similar to Homeobox protein engrailed-1 (Mo-En-1)      Symbol and Name status set to provisional 70820 PROVISIONAL