En1 (engrailed 1) - Rat Genome Database

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Gene: En1 (engrailed 1) Mus musculus
Analyze
Symbol: En1
Name: engrailed 1
RGD ID: 1618434
MGI Page MGI
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including brain development; embryonic brain development; and motor learning. Acts upstream of or within several processes, including embryonic forelimb morphogenesis; nervous system development; and regionalization. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; integumental system; and limb ectoderm. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: En-; En-1; engrai; engrailed-1; homeobox protein en-1; homeobox protein engrailed-1; Mo-en; mo-En-1; Mo-en.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,530,246 - 120,535,719 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,530,147 - 120,535,721 (+)EnsemblGRCm39 Ensembl
GRCm381120,602,487 - 120,607,991 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,602,418 - 120,607,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,499,064 - 122,504,568 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,430,227 - 122,435,517 (+)NCBIMGSCv36mm8
Celera1123,260,515 - 123,266,033 (+)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal autophagy  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal axon extension  (IAGP)
abnormal axon guidance  (IAGP)
abnormal axon morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal brain commissure morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal brain interneuron morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell migration  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellar granule cell precursor proliferation  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellar lobule formation  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal cerebellum anterior vermis morphology  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum fissure morphology  (IAGP)
abnormal cerebellum hemisphere lobule morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebellum posterior vermis morphology  (IAGP)
abnormal cerebellum vermis lobule morphology  (IAGP)
abnormal cerebellum vermis morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal corpora quadrigemina morphology  (IAGP)
abnormal cranial nerve morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal digit pigmentation  (IAGP)
abnormal dopamine level  (IAGP)
abnormal dopaminergic neuron morphology  (IAGP)
abnormal eccrine sweat gland morphology  (IAGP)
abnormal facial nerve morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal foot pad morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal GABAergic neuron morphology  (IAGP)
abnormal gait  (IAGP)
abnormal hair follicle dermal papilla morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal inferior colliculus morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal limb morphology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal locomotor coordination  (IAGP)
abnormal locus ceruleus morphology  (IAGP)
abnormal midbrain development  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal midbrain-hindbrain boundary development  (IAGP)
abnormal midbrain-hindbrain boundary morphology  (IAGP)
abnormal nail morphology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron mitochondrial morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal posture  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal Purkinje cell mitochondrial morphology  (IAGP)
abnormal Raphe nucleus morphology  (IAGP)
abnormal red nucleus morphology  (IAGP)
abnormal rhombomere morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal serotonergic neuron morphology  (IAGP)
abnormal sternebra morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal substantia nigra morphology  (IAGP)
abnormal substantia nigra pars compacta morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal synaptic dopamine release  (IAGP)
abnormal tectum morphology  (IAGP)
abnormal trochlear nerve morphology  (IAGP)
abnormal ventral interneuron 1 morphology  (IAGP)
absent cerebellar lobules  (IAGP)
absent cerebellum  (IAGP)
absent cerebellum vermis  (IAGP)
absent colliculi  (IAGP)
absent gastric milk in neonates  (IAGP)
absent inferior colliculus  (IAGP)
absent midbrain  (IAGP)
absent midbrain-hindbrain boundary  (IAGP)
absent oculomotor nerve  (IAGP)
absent Purkinje cell layer  (IAGP)
absent rhombomere 1  (IAGP)
absent superior colliculus  (IAGP)
absent tectum  (IAGP)
absent trochlear nerve  (IAGP)
aphagia  (IAGP)
astrocytosis  (IAGP)
asymmetric sternocostal joints  (IAGP)
ataxia  (IAGP)
axon degeneration  (IAGP)
axonal dystrophy  (IAGP)
axonal spheroids  (IAGP)
cerebellum hypoplasia  (IAGP)
cerebellum vermis hypoplasia  (IAGP)
decreased anterior vermis size  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased dopamine level  (IAGP)
decreased dopaminergic neuron number  (IAGP)
decreased embryonic neuroepithelial cell proliferation  (IAGP)
decreased embryonic neuroepithelium thickness  (IAGP)
decreased food intake  (IAGP)
decreased grip strength  (IAGP)
decreased inferior colliculus size  (IAGP)
decreased locomotor activity  (IAGP)
decreased midbrain size  (IAGP)
decreased neuron number  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased neurotransmitter release  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased rhombomere 1 size  (IAGP)
decreased rib number  (IAGP)
decreased serotonin level  (IAGP)
decreased sternebra size  (IAGP)
decreased superior colliculus size  (IAGP)
decreased survivor rate  (IAGP)
deformed nails  (IAGP)
delayed bone ossification  (IAGP)
dystonia  (IAGP)
ectopic digits  (IAGP)
ectopic dopaminergic neuron  (IAGP)
enhanced behavioral response to anesthetic  (IAGP)
enhanced behavioral response to cocaine  (IAGP)
enhanced behavioral response to xenobiotic  (IAGP)
enlarged cerebral aqueduct  (IAGP)
enlarged tectum  (IAGP)
fused phalanges  (IAGP)
gliosis  (IAGP)
hyperactivity  (IAGP)
impaired balance  (IAGP)
impaired coordination  (IAGP)
impaired limb coordination  (IAGP)
impaired righting response  (IAGP)
increased cell proliferation  (IAGP)
increased dopamine level  (IAGP)
increased inferior colliculus size  (IAGP)
increased locomotor activity  (IAGP)
increased monocyte cell number  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuronal precursor proliferation  (IAGP)
increased superior colliculus size  (IAGP)
increased vertical activity  (IAGP)
induced hyperactivity  (IAGP)
limb grasping  (IAGP)
loss of dopaminergic neurons  (IAGP)
loss of GABAergic neurons  (IAGP)
male infertility  (IAGP)
microgliosis  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
oligodactyly  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polydactyly  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
Purkinje cell degeneration  (IAGP)
reduced cerebellar foliation  (IAGP)
short sternum  (IAGP)
slow postnatal weight gain  (IAGP)
small cerebellum  (IAGP)
small tectum  (IAGP)
syndactyly  (IAGP)
thin apical ectodermal ridge  (IAGP)
thin external granule cell layer  (IAGP)
tremors  (IAGP)
truncated digits  (IAGP)
weight loss  (IAGP)
wrinkled skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease. Haubenberger D, etal., Neurobiol Aging. 2011 Feb;32(2):302-7. Epub 2009 Apr 3.
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Sgado P, etal., Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15242-7. Epub 2006 Oct 2.
Additional References at PubMed
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PMID:31776510   PMID:32027825   PMID:32187534   PMID:32326436   PMID:32366677   PMID:32561725   PMID:32562661   PMID:32568072   PMID:32703236   PMID:32741376   PMID:32858144   PMID:33046550  
PMID:33053343   PMID:33176144   PMID:33195246   PMID:33230114   PMID:33305180   PMID:33469032   PMID:33494858   PMID:33522480   PMID:33568816   PMID:33850016   PMID:33888614   PMID:33899734  
PMID:34100719   PMID:34199092   PMID:34259830   PMID:34321664   PMID:34518367   PMID:34542409   PMID:34615947   PMID:34808238   PMID:34884468   PMID:35044072   PMID:35077667   PMID:35163043  
PMID:35165395   PMID:35354953   PMID:35399523   PMID:35672398   PMID:35700056   PMID:35753346   PMID:35815619   PMID:35981041   PMID:36007540   PMID:36417876   PMID:36564387   PMID:36745673  
PMID:37298722   PMID:37415561   PMID:37534581   PMID:37983249   PMID:38025786   PMID:38509075  


Genomics

Comparative Map Data
En1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,530,246 - 120,535,719 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,530,147 - 120,535,721 (+)EnsemblGRCm39 Ensembl
GRCm381120,602,487 - 120,607,991 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,602,418 - 120,607,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,499,064 - 122,504,568 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,430,227 - 122,435,517 (+)NCBIMGSCv36mm8
Celera1123,260,515 - 123,266,033 (+)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.74NCBI
EN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382118,842,171 - 118,847,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2118,842,171 - 118,847,648 (-)EnsemblGRCh38hg38GRCh38
GRCh372119,599,747 - 119,605,224 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,316,217 - 119,322,229 (-)NCBINCBI36Build 36hg18NCBI36
Build 342119,315,995 - 119,321,989NCBI
Celera2112,924,401 - 112,930,414 (-)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2111,924,919 - 111,930,585 (-)NCBIHuRef
CHM1_12119,603,429 - 119,609,441 (-)NCBICHM1_1
T2T-CHM13v2.02119,275,530 - 119,281,008 (-)NCBIT2T-CHM13v2.0
En1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81334,303,684 - 34,309,269 (+)NCBIGRCr8
mRatBN7.21331,750,892 - 31,756,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,751,545 - 31,755,943 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1334,309,142 - 34,314,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,596,963 - 35,602,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,871,391 - 32,876,977 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,532,758 - 36,537,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,532,758 - 36,537,093 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,634,070 - 41,638,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,623,592 - 31,629,063 (+)NCBICelera
Cytogenetic Map13q11NCBI
En1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545910,839,581 - 10,844,198 (+)NCBIChiLan1.0ChiLan1.0
EN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21320,867,576 - 20,875,017 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B20,882,547 - 20,888,391 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B5,798,557 - 5,804,368 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11931,124,325 - 31,129,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1931,388,610 - 31,392,987 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01932,511,803 - 32,516,772 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1932,511,803 - 32,516,949 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11931,195,351 - 31,200,286 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01931,362,291 - 31,366,665 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01932,548,697 - 32,553,632 (+)NCBIUU_Cfam_GSD_1.0
En1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,166,409 - 90,170,431 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493646951,439,944 - 51,451,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1524,402,370 - 24,407,692 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11524,402,605 - 24,408,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,041,846 - 28,047,020 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216935
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11011,470,295 - 11,558,688 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1011,475,221 - 11,479,475 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606111,121,703 - 11,124,623 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
En1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473226,333,653 - 26,337,904 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473226,333,642 - 26,338,450 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in En1
190 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:843
Count of miRNA genes:493
Interacting mature miRNAs:588
Transcripts:ENSMUST00000079721
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
1357760Synch3_msynechia 3 (mouse)Not determined192901442126901550Mouse
4141627Bwq7_mbody weight, QTL 7 (mouse)Not determined192940909124497796Mouse
12879491Hfnq1_mhair follicle number QTL 1 (mouse)193310310123636759Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
1301123Cd8mts2_mCD8 memory T cell subset 2 (mouse)Not determined196618386130618557Mouse
1301753Tir3a_mtrypansomiasis infection response 3a (mouse)Not determined197053986131054190Mouse
13452398Leusq5_mleucocytosis susceptibility QTL 5 (mouse)198474785126386517Mouse
1301536Pbbcp1_mperipheral blood B cell percentage 1 (mouse)Not determined199507660133507845Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
12879492Ecgnq1_meccrine gland number QTL 1 (mouse)1103278062120535225Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse

Markers in Region
En1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371122,504,351 - 122,504,454UniSTSGRCm37
Celera1123,265,816 - 123,265,919UniSTS
Cytogenetic Map1C2-qterUniSTS
cM Map164.1UniSTS
D1Mit217  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,601,778 - 120,601,949UniSTSGRCm38
MGSCv371122,498,355 - 122,498,526UniSTSGRCm37
Celera1123,259,791 - 123,259,976UniSTS
Cytogenetic Map1C2-qterUniSTS
cM Map163.1UniSTS
Whitehead Genetic166.7UniSTS
Whitehead_YAC1 UniSTS
PMC314463P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,606,877 - 120,607,679UniSTSGRCm38
MGSCv371122,503,454 - 122,504,256UniSTSGRCm37
Celera1123,264,919 - 123,265,721UniSTS
Cytogenetic Map1C2-qterUniSTS
RH104030  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,607,746 - 120,607,906UniSTSGRCm38
MGSCv371122,504,323 - 122,504,483UniSTSGRCm37
Celera1123,265,788 - 123,265,948UniSTS
Cytogenetic Map1C2-qterUniSTS
En1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,607,774 - 120,607,877UniSTSGRCm38
MGSCv371122,504,351 - 122,504,454UniSTSGRCm37
Celera1123,265,816 - 123,265,919UniSTS
Cytogenetic Map1C2-qterUniSTS
cM Map164.1UniSTS
En1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C2-qterUniSTS
En1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C2-qterUniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079721   ⟹   ENSMUSP00000078659
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1120,530,147 - 120,535,721 (+)Ensembl
GRCm38.p6 Ensembl1120,602,418 - 120,607,992 (+)Ensembl
RefSeq Acc Id: NM_010133   ⟹   NP_034263
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391120,530,246 - 120,535,719 (+)NCBI
GRCm381120,602,487 - 120,607,991 (+)NCBI
MGSCv371122,499,064 - 122,504,568 (+)RGD
Celera1123,260,515 - 123,266,033 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034263   ⟸   NM_010133
- UniProtKB: Q3USF7 (UniProtKB/Swiss-Prot),   P09065 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000078659   ⟸   ENSMUST00000079721

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09065-F1-model_v2 AlphaFold P09065 1-401 view protein structure

Promoters
RGD ID:6817641
Promoter ID:MM_KWN:1904
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4
Transcripts:NM_010133
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361122,498,671 - 122,499,592 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95389 AgrOrtholog
Ensembl Genes ENSMUSG00000058665 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000079721 ENTREZGENE
  ENSMUST00000079721.9 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
InterPro Homeobox-engrailed_C-terminal UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_engrailed UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
  Homoebox-engrailed_CS UniProtKB/Swiss-Prot
KEGG Report mmu:13798 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95389 ENTREZGENE
NCBI Gene 13798 ENTREZGENE
PANTHER HOMEOBOX PROTEIN ENGRAILED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX PROTEIN ENGRAILED-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Engrail_1_C_sig UniProtKB/Swiss-Prot
  Homeodomain UniProtKB/Swiss-Prot
PhenoGen En1 PhenoGen
PRINTS ENGRAILED UniProtKB/Swiss-Prot
  HOMEOBOX UniProtKB/Swiss-Prot
PROSITE ENGRAILED UniProtKB/Swiss-Prot
  HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP Formin homology 2 domain (FH2 domain) UniProtKB/Swiss-Prot
  SSF46689 UniProtKB/Swiss-Prot
UniProt HME1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3USA2_MOUSE UniProtKB/TrEMBL
  Q3USF7 ENTREZGENE
UniProt Secondary Q3USF7 UniProtKB/Swiss-Prot