En1 (engrailed 1) - Rat Genome Database

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Gene: En1 (engrailed 1) Mus musculus
Analyze
Symbol: En1
Name: engrailed 1
RGD ID: 1618434
MGI Page MGI
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including drinking behavior; embryonic brain development; and motor learning. Acts upstream of or within several processes, including embryonic forelimb morphogenesis; nervous system development; and regionalization. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1); INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: En-; En-1; engrai; engrailed-1; homeobox protein en-1; homeobox protein engrailed-1; Mo-en; mo-En-1; Mo-en.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,530,216 - 120,535,720 (+)NCBIGRCm39mm39
GRCm39 Ensembl1120,530,147 - 120,535,721 (+)Ensembl
GRCm381120,602,487 - 120,607,991 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,602,418 - 120,607,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,499,064 - 122,504,568 (+)NCBIGRCm37mm9NCBIm37
MGSCv361122,430,227 - 122,435,517 (+)NCBImm8
Celera1123,260,515 - 123,266,033 (+)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (ISO)
nucleus  (IBA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal autophagy  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal axon extension  (IAGP)
abnormal axon guidance  (IAGP)
abnormal axon morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal brain commissure morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal brain interneuron morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell migration  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellar granule cell precursor proliferation  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellar lobule formation  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal cerebellum anterior vermis morphology  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum fissure morphology  (IAGP)
abnormal cerebellum hemisphere lobule morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebellum posterior vermis morphology  (IAGP)
abnormal cerebellum vermis lobule morphology  (IAGP)
abnormal cerebellum vermis morphology  (IAGP)
abnormal cerebral aqueduct morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal corpora quadrigemina morphology  (IAGP)
abnormal cranial nerve morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal digit pigmentation  (IAGP)
abnormal dopamine level  (IAGP)
abnormal dopaminergic neuron morphology  (IAGP)
abnormal eccrine sweat gland morphology  (IAGP)
abnormal facial nerve morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal foot pad morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal GABAergic neuron morphology  (IAGP)
abnormal gait  (IAGP)
abnormal hair follicle dermal papilla morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal inferior colliculus morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal limb morphology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal locomotor coordination  (IAGP)
abnormal locus ceruleus morphology  (IAGP)
abnormal midbrain development  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal midbrain-hindbrain boundary development  (IAGP)
abnormal midbrain-hindbrain boundary morphology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal nail morphology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal posture  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal Raphe nucleus morphology  (IAGP)
abnormal red nucleus morphology  (IAGP)
abnormal rhombomere morphology  (IAGP)
abnormal serotonergic neuron morphology  (IAGP)
abnormal spinal cord interneuron morphology  (IAGP)
abnormal sternebra morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal substantia nigra morphology  (IAGP)
abnormal substantia nigra pars compacta morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal synaptic dopamine release  (IAGP)
abnormal tectum morphology  (IAGP)
abnormal trochlear nerve morphology  (IAGP)
absent cerebellar lobules  (IAGP)
absent cerebellum  (IAGP)
absent cerebellum vermis  (IAGP)
absent colliculi  (IAGP)
absent gastric milk in neonates  (IAGP)
absent inferior colliculus  (IAGP)
absent midbrain  (IAGP)
absent midbrain-hindbrain boundary  (IAGP)
absent oculomotor nerve  (IAGP)
absent Purkinje cell layer  (IAGP)
absent rhombomere 1  (IAGP)
absent superior colliculus  (IAGP)
absent tectum  (IAGP)
absent trochlear nerve  (IAGP)
aphagia  (IAGP)
astrocytosis  (IAGP)
asymmetric sternocostal joints  (IAGP)
ataxia  (IAGP)
axon degeneration  (IAGP)
axonal dystrophy  (IAGP)
axonal spheroids  (IAGP)
cerebellum hypoplasia  (IAGP)
cerebellum vermis hypoplasia  (IAGP)
decreased anterior vermis size  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased dopamine level  (IAGP)
decreased dopaminergic neuron number  (IAGP)
decreased embryonic neuroepithelial cell proliferation  (IAGP)
decreased embryonic neuroepithelium thickness  (IAGP)
decreased food intake  (IAGP)
decreased grip strength  (IAGP)
decreased inferior colliculus size  (IAGP)
decreased midbrain size  (IAGP)
decreased neuron number  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased neurotransmitter release  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased rhombomere 1 size  (IAGP)
decreased rib number  (IAGP)
decreased serotonin level  (IAGP)
decreased superior colliculus size  (IAGP)
decreased survivor rate  (IAGP)
deformed nails  (IAGP)
delayed bone ossification  (IAGP)
dystonia  (IAGP)
ectopic digits  (IAGP)
ectopic dopaminergic neuron  (IAGP)
enhanced behavioral response to anesthetic  (IAGP)
enhanced behavioral response to cocaine  (IAGP)
enhanced behavioral response to xenobiotic  (IAGP)
enlarged tectum  (IAGP)
fused phalanges  (IAGP)
gliosis  (IAGP)
hyperactivity  (IAGP)
hypoactivity  (IAGP)
impaired balance  (IAGP)
impaired coordination  (IAGP)
impaired limb coordination  (IAGP)
impaired righting response  (IAGP)
increased cell proliferation  (IAGP)
increased dopamine level  (IAGP)
increased inferior colliculus size  (IAGP)
increased monocyte cell number  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuronal precursor proliferation  (IAGP)
increased superior colliculus size  (IAGP)
increased vertical activity  (IAGP)
induced hyperactivity  (IAGP)
limb grasping  (IAGP)
loss of dopaminergic neurons  (IAGP)
loss of GABAergic neurons  (IAGP)
male infertility  (IAGP)
microgliosis  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
oligodactyly  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polydactyly  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
Purkinje cell degeneration  (IAGP)
reduced cerebellar foliation  (IAGP)
short sternum  (IAGP)
slow postnatal weight gain  (IAGP)
small cerebellum  (IAGP)
small tectum  (IAGP)
syndactyly  (IAGP)
thin apical ectodermal ridge  (IAGP)
thin external granule cell layer  (IAGP)
tremors  (IAGP)
truncation of digits  (IAGP)
weight loss  (IAGP)
wrinkled skin  (IAGP)
References

Additional References at PubMed
PMID:1295725   PMID:1350294   PMID:1359870   PMID:1360439   PMID:1363401   PMID:1534034   PMID:1672292   PMID:1673105   PMID:1680044   PMID:1720547   PMID:1980115   PMID:2307472  
PMID:2416459   PMID:2878091   PMID:2882954   PMID:2892757   PMID:2907320   PMID:2908202   PMID:7482350   PMID:7482351   PMID:7545711   PMID:7577673   PMID:7624797   PMID:7677729  
PMID:7700351   PMID:7729687   PMID:7903253   PMID:7925010   PMID:8069909   PMID:8096059   PMID:8358176   PMID:8375331   PMID:8441607   PMID:8565076   PMID:8575294   PMID:8626038  
PMID:8684466   PMID:8741855   PMID:8751373   PMID:8805331   PMID:8805699   PMID:8812055   PMID:8848044   PMID:8951055   PMID:9027508   PMID:9056772   PMID:9056778   PMID:9102311  
PMID:9152013   PMID:9159136   PMID:9230312   PMID:9247260   PMID:9309186   PMID:9315901   PMID:9342056   PMID:9362461   PMID:9362463   PMID:9405645   PMID:9409667   PMID:9435295  
PMID:9449667   PMID:9463360   PMID:9486536   PMID:9585504   PMID:9598342   PMID:9651475   PMID:9655799   PMID:9724755   PMID:9767163   PMID:9778510   PMID:9790191   PMID:9811581  
PMID:9811592   PMID:9858722   PMID:9895322   PMID:10026229   PMID:10075844   PMID:10090727   PMID:10191046   PMID:10349636   PMID:10354469   PMID:10399918   PMID:10431240   PMID:10464179  
PMID:10477289   PMID:10482235   PMID:10490025   PMID:10518499   PMID:10575213   PMID:10585298   PMID:10625539   PMID:10662781   PMID:10677261   PMID:10688202   PMID:10837030   PMID:10934027  
PMID:10952903   PMID:11042159   PMID:11076861   PMID:11118883   PMID:11124114   PMID:11180961   PMID:11217851   PMID:11239429   PMID:11239430   PMID:11290295   PMID:11299042   PMID:11312297  
PMID:11330864   PMID:11336496   PMID:11412024   PMID:11455436   PMID:11456454   PMID:11476582   PMID:11493561   PMID:11500373   PMID:11502253   PMID:11509733   PMID:11543625   PMID:11551904  
PMID:11567614   PMID:11704761   PMID:11714671   PMID:11731459   PMID:11748135   PMID:11781239   PMID:11782416   PMID:11804784   PMID:11900971   PMID:12015293   PMID:12062038   PMID:12086465  
PMID:12112475   PMID:12117807   PMID:12118102   PMID:12167404   PMID:12175515   PMID:12358782   PMID:12361972   PMID:12367504   PMID:12404118   PMID:12412013   PMID:12414734   PMID:12421714  
PMID:12435628   PMID:12435629   PMID:12466851   PMID:12569130   PMID:12588849   PMID:12588852   PMID:12648495   PMID:12668638   PMID:12682014   PMID:12736208   PMID:12764108   PMID:12782276  
PMID:12832534   PMID:12915123   PMID:12915301   PMID:12923052   PMID:14507778   PMID:14507786   PMID:14526104   PMID:14534138   PMID:14597661   PMID:14605369   PMID:14643684   PMID:14645517  
PMID:14668413   PMID:14671317   PMID:14681479   PMID:14723851   PMID:14762144   PMID:14973278   PMID:15030763   PMID:15033168   PMID:15075292   PMID:15081361   PMID:15105370   PMID:15121182  
PMID:15124223   PMID:15134635   PMID:15162501   PMID:15170224   PMID:15175251   PMID:15207855   PMID:15215207   PMID:15236237   PMID:15242796   PMID:15294143   PMID:15340832   PMID:15361870  
PMID:15469980   PMID:15576403   PMID:15581864   PMID:15584907   PMID:15607945   PMID:15618518   PMID:15629700   PMID:15680361   PMID:15761950   PMID:15830353   PMID:15930098   PMID:15930102  
PMID:16020526   PMID:16141072   PMID:16141073   PMID:16202705   PMID:16243425   PMID:16256364   PMID:16291788   PMID:16319118   PMID:16339193   PMID:16438966   PMID:16495310   PMID:16525473  
PMID:16530751   PMID:16556916   PMID:16571625   PMID:16571630   PMID:16571633   PMID:16602821   PMID:16651541   PMID:16678814   PMID:16728479   PMID:16730693   PMID:16782087   PMID:16884697  
PMID:17055592   PMID:17067568   PMID:17119023   PMID:17123502   PMID:17141511   PMID:17150206   PMID:17166916   PMID:17219401   PMID:17222543   PMID:17241623   PMID:17267560   PMID:17319963  
PMID:17321515   PMID:17325035   PMID:17359917   PMID:17360769   PMID:17442818   PMID:17488627   PMID:17492640   PMID:17507393   PMID:17507410   PMID:17537797   PMID:17596284   PMID:17664423  
PMID:17670789   PMID:17687036   PMID:17693261   PMID:17699604   PMID:18067586   PMID:18094027   PMID:18196597   PMID:18216176   PMID:18287559   PMID:18330926   PMID:18344997   PMID:18391535  
PMID:18403408   PMID:18463247   PMID:18480159   PMID:18513381   PMID:18522499   PMID:18538759   PMID:18539921   PMID:18539925   PMID:18585948   PMID:18585951   PMID:18594950   PMID:18784307  
PMID:18820178   PMID:18953410   PMID:19004860   PMID:19020009   PMID:19029045   PMID:19088086   PMID:19144721   PMID:19210962   PMID:19291307   PMID:19298856   PMID:19389377   PMID:19463901  
PMID:19479951   PMID:19515692   PMID:19527706   PMID:19592574   PMID:19603509   PMID:19607821   PMID:19616131   PMID:19635527   PMID:19666503   PMID:19666821   PMID:19679071   PMID:19752021  
PMID:19780901   PMID:19795519   PMID:19797899   PMID:19804761   PMID:19914184   PMID:19940436   PMID:19968985   PMID:20035737   PMID:20042997   PMID:20059953   PMID:20081190   PMID:20081196  
PMID:20089898   PMID:20181585   PMID:20357111   PMID:20460368   PMID:20493948   PMID:20532162   PMID:20606007   PMID:20668186   PMID:20806357   PMID:20816794   PMID:20873986   PMID:20941375  
PMID:20960561   PMID:20980404   PMID:21057506   PMID:21068056   PMID:21074523   PMID:21093436   PMID:21093585   PMID:21104462   PMID:21124801   PMID:21172336   PMID:21215373   PMID:21267068  
PMID:21307092   PMID:21307096   PMID:21337666   PMID:21338882   PMID:21431469   PMID:21693512   PMID:21709239   PMID:21736876   PMID:21795554   PMID:21858141   PMID:21866153   PMID:21873635  
PMID:21892157   PMID:21925158   PMID:21925604   PMID:22036570   PMID:22069189   PMID:22102330   PMID:22102609   PMID:22115757   PMID:22147955   PMID:22151329   PMID:22240098   PMID:22278924  
PMID:22279202   PMID:22370000   PMID:22377357   PMID:22395741   PMID:22434869   PMID:22537018   PMID:22564796   PMID:22627282   PMID:22674259   PMID:22696295   PMID:22718343   PMID:22745501  
PMID:22748019   PMID:22792203   PMID:22819676   PMID:22889265   PMID:22987640   PMID:22993445   PMID:23007396   PMID:23041116   PMID:23095887   PMID:23117062   PMID:23132022   PMID:23136394  
PMID:23152632   PMID:23213437   PMID:23213462   PMID:23223237   PMID:23264561   PMID:23329048   PMID:23400959   PMID:23418536   PMID:23444360   PMID:23459943   PMID:23684768   PMID:23810416  
PMID:23843306   PMID:23852112   PMID:23863478   PMID:23900540   PMID:23988635   PMID:24009395   PMID:24048834   PMID:24066094   PMID:24146773   PMID:24167708   PMID:24348261   PMID:24384227  
PMID:24431450   PMID:24485459   PMID:24572428   PMID:24586192   PMID:24698273   PMID:24733890   PMID:24937429   PMID:24946904   PMID:24948600   PMID:24952961   PMID:24963847   PMID:25033181  
PMID:25166858   PMID:25179941   PMID:25241801   PMID:25281317   PMID:25451192   PMID:25466916   PMID:25497093   PMID:25543457   PMID:25710467   PMID:25834018   PMID:25857446   PMID:25883361  
PMID:25888505   PMID:25915474   PMID:25977363   PMID:26049140   PMID:26109658   PMID:26187199   PMID:26195765   PMID:26340333   PMID:26367794   PMID:26370418   PMID:26411690   PMID:26444681  
PMID:26459030   PMID:26465208   PMID:26494173   PMID:26542008   PMID:26586220   PMID:26677825   PMID:26680198   PMID:26718003   PMID:26758845   PMID:26762209   PMID:26839365   PMID:26879466  
PMID:26914477   PMID:26940020   PMID:26949184   PMID:27171818   PMID:27264177   PMID:27313055   PMID:27414798   PMID:27550741   PMID:27568519   PMID:27578777   PMID:27609139   PMID:27671625  
PMID:27789623   PMID:27858314   PMID:27866798   PMID:27889925   PMID:27928028   PMID:27929058   PMID:28007900   PMID:28174244   PMID:28195039   PMID:28392070   PMID:28422959   PMID:28489004  
PMID:28775681   PMID:28800615   PMID:28807781   PMID:28809922   PMID:28875587   PMID:28916788   PMID:29028795   PMID:29209359   PMID:29307712   PMID:29321139   PMID:29526553   PMID:29576387  
PMID:29593327   PMID:29689292   PMID:29722912   PMID:29769718   PMID:29789381   PMID:29852132   PMID:29941661   PMID:29972353   PMID:29972793   PMID:29992973   PMID:30177510   PMID:30308166  
PMID:30311906   PMID:30587537   PMID:30593496   PMID:30615824   PMID:30718509   PMID:30917309   PMID:30932894   PMID:31291587   PMID:31332038   PMID:31336385   PMID:31351040   PMID:31561919  
PMID:31742552   PMID:31776510   PMID:32027825   PMID:32187534   PMID:32326436   PMID:32366677   PMID:32561725   PMID:32562661   PMID:32568072   PMID:32741376   PMID:32858144   PMID:33046550  
PMID:33053343   PMID:33230114   PMID:33305180   PMID:33469032   PMID:33494858   PMID:33522480   PMID:33568816   PMID:33850016   PMID:33888614   PMID:33899734  


Genomics

Comparative Map Data
En1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,530,216 - 120,535,720 (+)NCBIGRCm39mm39
GRCm39 Ensembl1120,530,147 - 120,535,721 (+)Ensembl
GRCm381120,602,487 - 120,607,991 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,602,418 - 120,607,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,499,064 - 122,504,568 (+)NCBIGRCm37mm9NCBIm37
MGSCv361122,430,227 - 122,435,517 (+)NCBImm8
Celera1123,260,515 - 123,266,033 (+)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.74NCBI
EN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2118,842,171 - 118,847,648 (-)EnsemblGRCh38hg38GRCh38
GRCh382118,842,171 - 118,847,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372119,599,747 - 119,605,224 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,316,217 - 119,322,229 (-)NCBINCBI36hg18NCBI36
Build 342119,315,995 - 119,321,989NCBI
Celera2112,924,401 - 112,930,414 (-)NCBI
Cytogenetic Map2q14.2NCBI
HuRef2111,924,919 - 111,930,585 (-)NCBIHuRef
CHM1_12119,603,429 - 119,609,441 (-)NCBICHM1_1
En1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21331,750,892 - 31,756,477 (+)NCBI
Rnor_6.0 Ensembl1336,532,758 - 36,537,093 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01336,532,758 - 36,537,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01341,634,070 - 41,638,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,623,592 - 31,629,063 (+)NCBICelera
Cytogenetic Map13q11NCBI
En1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545910,839,581 - 10,844,198 (+)NCBIChiLan1.0ChiLan1.0
EN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v02B5,798,557 - 5,804,368 (-)NCBIMhudiblu_PPA_v0panPan3
EN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11931,124,325 - 31,129,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1931,388,610 - 31,392,987 (+)NCBI
ROS_Cfam_1.01932,511,803 - 32,516,772 (+)NCBI
UMICH_Zoey_3.11931,195,351 - 31,200,286 (+)NCBI
UNSW_CanFamBas_1.01931,362,291 - 31,366,665 (+)NCBI
UU_Cfam_GSD_1.01932,548,697 - 32,553,632 (+)NCBI
En1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,166,409 - 90,170,431 (-)NCBI
SpeTri2.0NW_00493646951,439,944 - 51,451,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1524,402,605 - 24,407,798 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11524,402,605 - 24,408,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,041,846 - 28,047,020 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216935
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11011,470,295 - 11,558,688 (+)NCBI
ChlSab1.1 Ensembl1011,475,221 - 11,479,475 (+)Ensembl
Vero_WHO_p1.0NW_02366606111,121,703 - 11,124,623 (-)NCBI
En1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473226,333,642 - 26,338,450 (+)NCBI

Position Markers
En1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371122,504,351 - 122,504,454UniSTSGRCm37
Celera1123,265,816 - 123,265,919UniSTS
Cytogenetic Map1C2-qterUniSTS
cM Map164.1UniSTS
D1Mit217  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,601,778 - 120,601,949UniSTSGRCm38
MGSCv371122,498,355 - 122,498,526UniSTSGRCm37
Celera1123,259,791 - 123,259,976UniSTS
Cytogenetic Map1C2-qterUniSTS
cM Map163.1UniSTS
Whitehead Genetic166.7UniSTS
Whitehead_YAC1 UniSTS
PMC314463P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,606,877 - 120,607,679UniSTSGRCm38
MGSCv371122,503,454 - 122,504,256UniSTSGRCm37
Celera1123,264,919 - 123,265,721UniSTS
Cytogenetic Map1C2-qterUniSTS
RH104030  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,607,746 - 120,607,906UniSTSGRCm38
MGSCv371122,504,323 - 122,504,483UniSTSGRCm37
Celera1123,265,788 - 123,265,948UniSTS
Cytogenetic Map1C2-qterUniSTS
En1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381120,607,774 - 120,607,877UniSTSGRCm38
MGSCv371122,504,351 - 122,504,454UniSTSGRCm37
Celera1123,265,816 - 123,265,919UniSTS
Cytogenetic Map1C2-qterUniSTS
cM Map164.1UniSTS
En1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C2-qterUniSTS
En1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C2-qterUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167300000129800000Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173716016147249632Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74477076148839837Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174952818133363199Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)176000000128600000Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)176000000148900000Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180267876126458780Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782314261147249632Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182665468135687641Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89858782123858782Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189858782123858782Mouse
1357760Synch3_msynechia 3 (mouse)Not determined192973712126973820Mouse
4141627Bwq7_mbody weight, QTL 7 (mouse)Not determined193013187124570059Mouse
12879491Hfnq1_mhair follicle number QTL 1 (mouse)193382588123709030Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194200000148900000Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194200000172200000Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195600000162200000Mouse
1301123Cd8mts2_mCD8 memory T cell subset 2 (mouse)Not determined196690656130690827Mouse
1301753Tir3a_mtrypansomiasis infection response 3a (mouse)Not determined197126256131126460Mouse
13452398Leusq5_mleucocytosis susceptibility QTL 5 (mouse)198547060126458780Mouse
1301536Pbbcp1_mperipheral blood B cell percentage 1 (mouse)Not determined199579930133580115Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1103040804137040937Mouse
12879492Ecgnq1_meccrine gland number QTL 1 (mouse)1103350337120607496Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1104005680191493284Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109568206143568206Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109710525143710742Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110625442144625561Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110625442144625561Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112081092168358833Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112081092175641372Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112203268146203348Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116363098150363199Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117600000180000000Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118171982152172078Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:843
Count of miRNA genes:493
Interacting mature miRNAs:588
Transcripts:ENSMUST00000079721
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079721   ⟹   ENSMUSP00000078659
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1120,602,418 - 120,607,992 (+)Ensembl
RefSeq Acc Id: NM_010133   ⟹   NP_034263
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391120,530,216 - 120,535,720 (+)NCBI
GRCm381120,602,487 - 120,607,991 (+)NCBI
MGSCv371122,499,064 - 122,504,568 (+)RGD
Celera1123,260,515 - 123,266,033 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034263   ⟸   NM_010133
- UniProtKB: P09065 (UniProtKB/Swiss-Prot),   Q3USA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000078659   ⟸   ENSMUST00000079721

Promoters
RGD ID:6817641
Promoter ID:MM_KWN:1904
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4
Transcripts:NM_010133
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361122,498,671 - 122,499,592 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95389 AgrOrtholog
Ensembl Genes ENSMUSG00000058665 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000078659 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000079721 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Homeobox-engrailed_C-terminal UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_engrailed UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
  Homoebox-engrailed_CS UniProtKB/Swiss-Prot
KEGG Report mmu:13798 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95389 ENTREZGENE
NCBI Gene 13798 ENTREZGENE
Pfam Engrail_1_C_sig UniProtKB/Swiss-Prot
  Homeodomain UniProtKB/Swiss-Prot
PhenoGen En1 PhenoGen
PRINTS ENGRAILED UniProtKB/Swiss-Prot
  HOMEOBOX UniProtKB/Swiss-Prot
PROSITE ENGRAILED UniProtKB/Swiss-Prot
  HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt HME1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3USA2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3USF7 UniProtKB/Swiss-Prot