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Gene: En1 (engrailed 1) Mus musculus
Symbol: En1
Name: engrailed 1
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including embryonic brain development; nervous system development; and regionalization. Predicted to localize to the RSC-type complex and membrane. Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human EN1 (engrailed homeobox 1); INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: En-1; engrailed-1; homeobox protein en-1; homeobox protein engrailed-1; mo-En-1; Mo-en.1
Homo sapiens (human) : EN1 (engrailed homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : En1 (engrailed homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : En1 (engrailed homeobox 1)
Canis lupus familiaris (dog) : EN1 (engrailed homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : En1 (engrailed homeobox 1)
Sus scrofa (pig) : EN1 (engrailed homeobox 1)
Chlorocebus sabaeus (green monkey) : EN1 (engrailed homeobox 1)
Heterocephalus glaber (naked mole-rat) : En1 (engrailed homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1120,602,418 - 120,607,992 (+)Ensembl
GRCm381120,602,487 - 120,607,991 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371122,499,064 - 122,504,568 (+)NCBIGRCm37mm9NCBIm37
MGSCv361122,430,227 - 122,435,517 (+)NCBImm8
Celera1123,260,515 - 123,266,033 (+)NCBICelera
Cytogenetic Map1 E2.3NCBI
cM Map152.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on En1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1618434
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.