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Gene: En1 (engrailed 1) Mus musculus
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Symbol: En1
Name: engrailed 1
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including embryonic brain development; nervous system development; and regionalization. Predicted to localize to the RSC-type complex and membrane. Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human EN1 (engrailed homeobox 1); INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: En-1; engrailed-1; homeobox protein en-1; homeobox protein engrailed-1; mo-En-1; Mo-en.1
Orthologs:
Homo sapiens (human) : EN1 (engrailed homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : En1 (engrailed homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : En1 (engrailed homeobox 1)
Canis lupus familiaris (dog) : EN1 (engrailed homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : En1 (engrailed homeobox 1)
Sus scrofa (pig) : EN1 (engrailed homeobox 1)
Chlorocebus sabaeus (green monkey) : EN1 (engrailed homeobox 1)
Heterocephalus glaber (naked mole-rat) : En1 (engrailed homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1120,602,418 - 120,607,992 (+)Ensembl
GRCm381120,602,487 - 120,607,991 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371122,499,064 - 122,504,568 (+)NCBIGRCm37mm9NCBIm37
MGSCv361122,430,227 - 122,435,517 (+)NCBImm8
Celera1123,260,515 - 123,266,033 (+)NCBICelera
Cytogenetic Map1 E2.3NCBI
cM Map152.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on En1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1618434
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.