RGD Reference Report - Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function. - Rat Genome Database

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Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function.

Authors: Leo, D  Di Porzio, U  Racagni, G  Riva, MA  Fumagalli, F  Perrone-Capano, C 
Citation: Leo D, etal., Exp Neurol. 2007 Feb;203(2):472-80. Epub 2006 Oct 27.
RGD ID: 5687200
Pubmed: PMID:17070804   (View Abstract at PubMed)
DOI: DOI:10.1016/j.expneurol.2006.08.024   (Journal Full-text)

Chronic cocaine use leads to pronounced alterations in neuronal functions in brain circuits associated with reward. In the present study, we examined in the rat midbrain the effects of acute, subchronic (5 days) and chronic cocaine treatments (14 days) on the gene expression of transcription factors involved in the development and maintenance of dopaminergic neurons. We show that chronic, but not acute or subchronic, cocaine administration downregulates Nurr1 and Pitx3 transcripts whereas En1 transcripts are upregulated. Conversely, Lmx1b and En2 transcripts are not affected by the drug treatment, indicating that the modulation of the midbrain transcription factors analyzed is highly selective. Interestingly, modification of the gene expression for these transcription factors persists in midbrain as long as two weeks after the last drug administration, suggesting that it may account for some of the enduring alterations in midbrain dopaminergic circuits associated with chronic cocaine use.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
En1Ratresponse to cocaine  IEP  RGD 
Pitx3Ratresponse to cocaine  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
En1  (engrailed homeobox 1)
Pitx3  (paired-like homeodomain 3)


Additional Information