Cped1 (cadherin-like and PC-esterase domain containing 1) - Rat Genome Database

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Gene: Cped1 (cadherin-like and PC-esterase domain containing 1) Rattus norvegicus
Analyze
Symbol: Cped1
Name: cadherin-like and PC-esterase domain containing 1
RGD ID: 1563491
Description: Predicted to be located in endoplasmic reticulum. Orthologous to human CPED1 (cadherin like and PC-esterase domain containing 1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cadherin-like and PC-esterase domain-containing protein 1; hypothetical protein LOC500046; LOC500046; MGC112827; similar to hypothetical protein FLJ21986; uncharacterized protein LOC500046
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8451,482,497 - 51,755,440 (+)NCBIGRCr8
mRatBN7.2450,516,712 - 50,789,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl450,516,819 - 50,788,674 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0449,055,988 - 49,333,729 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl449,056,010 - 49,333,304 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0448,850,970 - 49,127,847 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4448,295,056 - 48,568,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera445,723,759 - 45,996,332 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Cped1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8451,482,497 - 51,755,440 (+)NCBIGRCr8
mRatBN7.2450,516,712 - 50,789,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl450,516,819 - 50,788,674 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0449,055,988 - 49,333,729 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl449,056,010 - 49,333,304 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0448,850,970 - 49,127,847 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4448,295,056 - 48,568,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera445,723,759 - 45,996,332 (+)NCBICelera
Cytogenetic Map4q22NCBI
CPED1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387120,988,711 - 121,297,442 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7120,988,697 - 121,297,442 (+)EnsemblGRCh38hg38GRCh38
GRCh377120,628,765 - 120,937,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367120,415,987 - 120,724,734 (+)NCBINCBI36Build 36hg18NCBI36
Celera7115,438,272 - 115,746,685 (+)NCBICelera
Cytogenetic Map7q31.31NCBI
HuRef7114,991,976 - 115,300,687 (+)NCBIHuRef
CHM1_17120,562,065 - 120,870,800 (+)NCBICHM1_1
T2T-CHM13v2.07122,304,057 - 122,612,831 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27120,023,845 - 120,332,239 (+)NCBI
Cped1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39621,985,875 - 22,256,406 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl621,985,915 - 22,256,403 (+)EnsemblGRCm39 Ensembl
GRCm38621,985,710 - 22,256,407 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl621,985,916 - 22,256,404 (+)EnsemblGRCm38mm10GRCm38
MGSCv37621,935,910 - 22,205,606 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36621,935,911 - 22,205,607 (+)NCBIMGSCv36mm8
Celera622,039,934 - 22,310,126 (+)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map68.86NCBI
Cped1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554792,782,059 - 3,039,030 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554792,782,057 - 3,039,440 (+)NCBIChiLan1.0ChiLan1.0
CPED1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26157,858,549 - 158,171,351 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan179,868,929 - 10,184,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07112,997,867 - 113,240,213 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17125,684,738 - 125,997,449 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7125,685,423 - 125,996,060 (+)Ensemblpanpan1.1panPan2
CPED1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11459,104,501 - 59,364,820 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1459,104,496 - 59,364,695 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1458,521,215 - 58,782,351 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01459,140,853 - 59,401,889 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1459,140,818 - 59,400,275 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11459,234,426 - 59,495,308 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01458,857,948 - 59,120,135 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01459,236,763 - 59,498,137 (+)NCBIUU_Cfam_GSD_1.0
Cped1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511848,061,285 - 48,311,206 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366053,892,718 - 4,141,659 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366053,892,728 - 4,142,538 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPED1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1825,655,735 - 25,937,232 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11825,655,730 - 25,937,923 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21827,260,306 - 27,541,802 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CPED1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12189,813,375 - 90,121,527 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2189,814,332 - 90,123,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604213,440,952 - 13,757,412 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cped1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478314,790,540 - 15,085,263 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478314,791,083 - 15,085,241 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cped1
1917 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:28
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000038566
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)44917811657114705Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat

Markers in Region
D4Got28  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera445,777,835 - 45,778,013UniSTS
RH 3.4 Map4285.5UniSTS
RH 3.4 Map4285.5RGD
RH 2.0 Map4346.6RGD
Cytogenetic Map4q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 13 32 22 11 22 8 8 4 27 30 11 8
Low 3 30 25 19 8 19 3 70 8 11
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000038566   ⟹   ENSRNOP00000030602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl450,516,819 - 50,788,674 (+)Ensembl
Rnor_6.0 Ensembl449,056,010 - 49,333,304 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105639   ⟹   ENSRNOP00000092551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl450,516,819 - 50,788,666 (+)Ensembl
RefSeq Acc Id: XM_002729287   ⟹   XP_002729333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8451,482,498 - 51,755,440 (+)NCBI
mRatBN7.2450,516,712 - 50,789,651 (+)NCBI
Rnor_6.0449,055,988 - 49,333,729 (+)NCBI
Rnor_5.0448,850,970 - 49,127,847 (+)NCBI
RGSC_v3.4448,295,056 - 48,568,314 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108607   ⟹   XP_038964535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8451,482,498 - 51,755,440 (+)NCBI
mRatBN7.2450,516,712 - 50,789,651 (+)NCBI
RefSeq Acc Id: XM_039108608   ⟹   XP_038964536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8451,482,497 - 51,667,473 (+)NCBI
mRatBN7.2450,516,712 - 50,691,033 (+)NCBI
Protein Sequences
Protein RefSeqs XP_002729333 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964535 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964536 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI00098 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030602.6
  ENSRNOP00000092551
  ENSRNOP00000092551.1
RefSeq Acc Id: XP_002729333   ⟸   XM_002729287
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AHU9 (UniProtKB/TrEMBL),   A0A0G2QC10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030602   ⟸   ENSRNOT00000038566
RefSeq Acc Id: XP_038964535   ⟸   XM_039108607
- Peptide Label: isoform X2
- UniProtKB: A0A0G2QC10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964536   ⟸   XM_039108608
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000092551   ⟸   ENSRNOT00000105639
Protein Domains
Cadherin-like beta sandwich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2QC10-F1-model_v2 AlphaFold A0A0G2QC10 1-1018 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692908
Promoter ID:EPDNEW_R3423
Type:initiation region
Name:Cped1_1
Description:cadherin-like and PC-esterase domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0449,056,050 - 49,056,110EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563491 AgrOrtholog
BioCyc Gene G2FUF-45509 BioCyc
Ensembl Genes ENSRNOG00000021840 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038566.7 UniProtKB/TrEMBL
  ENSRNOT00000105639.1 UniProtKB/TrEMBL
InterPro Cadherin-like_b_sandwich UniProtKB/TrEMBL
KEGG Report rno:500046 UniProtKB/TrEMBL
NCBI Gene 500046 ENTREZGENE
PANTHER CADHERIN-LIKE AND PC-ESTERASE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  CADHERIN-LIKE AND PC-ESTERASE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam Cadherin-like UniProtKB/TrEMBL
PhenoGen Cped1 PhenoGen
RatGTEx ENSRNOG00000021840 RatGTEx
UniProt A0A0G2QC10 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHU9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-18 Cped1  cadherin-like and PC-esterase domain containing 1  LOC500046  similar to hypothetical protein FLJ21986  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500046  similar to hypothetical protein FLJ21986      Symbol and Name status set to provisional 70820 PROVISIONAL