Predicted to enable several functions, including beta-catenin binding activity; histone binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of canonical Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blastocyst hatching; fat pad development; and white fat cell differentiation. Predicted to be located in mitotic spindle and nucleus. Predicted to be part of histone deacetylase complex and transcription repressor complex. Human ortholog(s) of this gene implicated in Pierpont syndrome and autosomal dominant intellectual developmental disorder 41. Orthologous to human TBL1XR1 (TBL1X/Y related 1); PARTICIPATES IN Wnt signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TBL1XR1 mRNA and [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TBL1XR1 mRNA
(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of TBL1XR1 mRNA] and panobinostat promotes the reaction [(+)-JQ1 compound affects the expression of TBL1XR1 mRNA]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA
[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA