Dsg1 (desmoglein 1) - Rat Genome Database

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Gene: Dsg1 (desmoglein 1) Rattus norvegicus
Analyze
Symbol: Dsg1
Name: desmoglein 1
RGD ID: 1309925
Description: Predicted to enable calcium ion binding activity and gamma-catenin binding activity. Involved in maternal process involved in female pregnancy and response to progesterone. Located in apical plasma membrane and lateral plasma membrane. Human ortholog(s) of this gene implicated in keratosis palmoplantaris striata 1. Orthologous to human DSG1 (desmoglein 1); PARTICIPATES IN Staphylococcus aureus infection pathway; INTERACTS WITH 1-naphthyl isothiocyanate; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: desmoglein 1 beta; desmoglein 1 gamma; desmoglein-1; Dsg1b; Dsg1c; LOC291755
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81811,948,098 - 11,980,455 (+)NCBIGRCr8
mRatBN7.21811,674,687 - 11,705,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,674,402 - 11,703,443 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01812,008,301 - 12,040,337 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,008,759 - 12,038,053 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01811,807,285 - 11,838,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,127,180 - 12,156,469 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11812,096,380 - 12,182,381 (+)NCBI
Celera1811,690,076 - 11,721,312 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dsg1RatChronic Periodontitis  ISODSG1 (Homo sapiens)6480655mRNA:decreased expression:gingival tissues (human)RGD 
Dsg1Ratkeratosis palmoplantaris striata 1  ISODSG1 (Homo sapiens)1598781DNA:snp:intron:IVS2-1G>A (human)RGD 
Dsg1RatReperfusion Injury  IEP 2316254protein:decreased expression:lungRGD 
1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Dsg1Ratarrhythmogenic right ventricular dysplasia 11  ISODSG1 (Homo sapiens)8554872ClinVar Annotator: match by term: Arrhythmogenic right ventricular dysplasia 11ClinVarPMID:23911551 more ...
Dsg1Ratcardiac amyloidosis  ISODSG1 (Homo sapiens)8554872ClinVar Annotator: match by term: AMYLOID CARDIOMYOPATHYClinVarPMID:28492532
Dsg1Ratchromosome 18q deletion syndrome  ISODSG1 (Homo sapiens)8554872ClinVar Annotator: match by term: Monosomy 18q and deletion 18qClinVarPMID:31690835
Dsg1RatCongenital Erythroderma with Palmoplantar Keratoderma, Hypotrichosis, and Hyper-IgE  ISODSG1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23974871 more ...
Dsg1RatFamilial Amyloid Polyneuropathies  ISODSG1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial amyloid polyneuropathyClinVarPMID:28492532
Dsg1Ratgenetic disease  ISODSG1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:23974871 more ...
Dsg1Ratintellectual disability  ISODSG1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Dsg1Ratkeratosis palmoplantaris striata 1  ISODSG1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10332028 more ...
Dsg1Ratpalmoplantar keratoderma-deafness syndrome  ISODSG1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary palmoplantar keratodermaClinVarPMID:25741868
Dsg1Rattransthyretin amyloidosis  ISODSG1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial Transthyretin AmyloidosisClinVarPMID:28492532
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Object Symbol
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Original Reference(s)
Dsg1Ratallergic disease  ISODSG1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23974871
Dsg1Ratdermatitis  ISODSG1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23974871
Dsg1Ratdisease of metabolism  ISODSG1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23974871
Dsg1Ratkeratosis palmoplantaris striata 1  ISODSG1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 

1 to 20 of 48 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dsg1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of DSG1 mRNACTDPMID:30723492
Dsg1Rat17beta-estradiol decreases expressionISODSG1 (Homo sapiens)6480464Estradiol results in decreased expression of DSG1 mRNACTDPMID:31614463
Dsg1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISODsg1a (Mus musculus)6480464[Tetrachlorodibenzodioxin analog co-treated with FGF2 protein] results in increased expression of DSG1A mRNA more ...CTDPMID:23212921
Dsg1Rat2,6-dimethoxyphenol multiple interactionsISODSG1 (Homo sapiens)6480464[pyrogallol 1 more ...CTDPMID:38598786
Dsg1Rat2-bromohexadecanoic acid multiple interactionsISODSG1 (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of DSG1 protein]CTDPMID:38195004
Dsg1Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of DSG1 mRNACTDPMID:35163327
Dsg1Ratalpha-Zearalanol decreases expressionEXP 6480464Zeranol results in decreased expression of DSG1 mRNACTDPMID:35163327
Dsg1Ratantimonite multiple interactionsISODSG1 (Homo sapiens)64804642-tert-butyl-9-fluoro-3 more ...CTDPMID:32076005
Dsg1Ratantirheumatic drug decreases expressionISODSG1 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of DSG1 mRNACTDPMID:24449571
Dsg1Ratarsane affects methylationISODSG1 (Homo sapiens)6480464Arsenic affects the methylation of DSG1 geneCTDPMID:25304211
Dsg1Ratarsane multiple interactionsISODSG1 (Homo sapiens)6480464[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of DSG1 mRNACTDPMID:32525701
Dsg1Ratarsenic atom affects methylationISODSG1 (Homo sapiens)6480464Arsenic affects the methylation of DSG1 geneCTDPMID:25304211
Dsg1Ratarsenic atom multiple interactionsISODSG1 (Homo sapiens)6480464[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of DSG1 mRNACTDPMID:32525701
Dsg1Ratarsenite(3-) multiple interactionsISODSG1 (Homo sapiens)64804642-tert-butyl-9-fluoro-3 more ...CTDPMID:32076005
Dsg1Ratatrazine multiple interactionsISODSG1 (Homo sapiens)6480464[Atrazine co-treated with Arsenates] results in increased expression of DSG1A mRNACTDPMID:18585445
Dsg1Ratavobenzone decreases expressionISODSG1 (Homo sapiens)6480464avobenzone results in decreased expression of DSG1 mRNACTDPMID:31016361
Dsg1Ratbenzo[a]pyrene increases expressionISODsg1a (Mus musculus)6480464Benzo(a)pyrene results in increased expression of DSG1A mRNACTDPMID:23735875
Dsg1Ratbenzo[a]pyrene affects methylationISODSG1 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of DSG1 promoterCTDPMID:27901495
Dsg1Ratbis(2-ethylhexyl) phthalate increases expressionISODSG1 (Homo sapiens)6480464Diethylhexyl Phthalate results in increased expression of DSG1 proteinCTDPMID:31163220
Dsg1Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of DSG1 mRNACTDPMID:25181051

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Biological Process

  
Object Symbol
Species
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Reference
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Source
Original Reference(s)
Dsg1Ratcell adhesion involved_inIEAUniProtKB-KW:KW-01301600115GO_REF:0000043UniProtGO_REF:0000043
Dsg1Ratcell adhesion involved_inIEAInterPro:IPR0208941600115GO_REF:0000002InterProGO_REF:0000002
Dsg1Ratcell-cell adhesion involved_inIBAFB:FBgn0015609 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dsg1Rathomophilic cell adhesion via plasma membrane adhesion molecules involved_inIEAInterPro:IPR000233 and InterPro:IPR0021261600115GO_REF:0000002InterProGO_REF:0000002
Dsg1Ratmaternal process involved in female pregnancy  IEP 1581662 RGD 
Dsg1Ratprotein stabilization involved_inISODSG1 (Homo sapiens)1624291 PMID:7983064RGDPMID:7983064
Dsg1Ratprotein stabilization involved_inIEAUniProtKB:Q02413 and ensembl:ENSP000002571921600115GO_REF:0000107EnsemblGO_REF:0000107
Dsg1Ratresponse to progesterone  IEP 1581662 RGD 

Cellular Component
1 to 20 of 26 rows

  
Object Symbol
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Reference
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Source
Original Reference(s)
Dsg1Ratanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Dsg1Ratapical plasma membrane  IDA 2316256 RGD 
Dsg1Ratcell-cell junction located_inISODSG1 (Homo sapiens)1624291 PMID:7983064RGDPMID:7983064
Dsg1Ratcell-cell junction located_inIEAUniProtKB:Q02413 and ensembl:ENSP000002571921600115GO_REF:0000107EnsemblGO_REF:0000107
Dsg1Ratcytoplasm located_inIEAUniProtKB:Q02413 and ensembl:ENSP000002571921600115GO_REF:0000107EnsemblGO_REF:0000107
Dsg1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Dsg1Ratcytoplasm located_inISODSG1 (Homo sapiens)1624291 PMID:34368962RGDPMID:34368962
Dsg1Ratcytoplasmic side of plasma membrane located_inISODSG1 (Homo sapiens)1624291 PMID:7983064RGDPMID:7983064
Dsg1Ratcytoplasmic side of plasma membrane located_inIEAUniProtKB:Q02413 and ensembl:ENSP000002571921600115GO_REF:0000107EnsemblGO_REF:0000107
Dsg1Ratdesmosome located_inISODSG1 (Homo sapiens)1624291 PMID:34368962RGDPMID:34368962
Dsg1Ratdesmosome located_inIEAUniProtKB:Q02413 and ensembl:ENSP000002571921600115GO_REF:0000107EnsemblGO_REF:0000107
Dsg1Ratdesmosome is_active_inIBAMGI:1196466 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dsg1Ratdesmosome located_inIEAARBA:ARBA000283371600115GO_REF:0000117UniProtGO_REF:0000117
Dsg1Ratdesmosome located_inISODsg1a (Mus musculus)1624291 PMID:12631242 more ...RGDPMID:12631242 more ...
Dsg1Ratdesmosome located_inIEAUniProtKB-SubCell:SL-00921600115GO_REF:0000044UniProtGO_REF:0000044
Dsg1Ratlateral plasma membrane  IDA 1581662 RGD 
Dsg1Ratmembrane located_inIEAInterPro:IPR002126 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Dsg1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Dsg1Ratnucleus located_inIEAUniProtKB:Q02413 and ensembl:ENSP000002571921600115GO_REF:0000107EnsemblGO_REF:0000107
Dsg1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
1 to 20 of 26 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Dsg1Ratcalcium ion binding enablesIEAUniRule:UR0004134501600115GO_REF:0000104UniProtGO_REF:0000104
Dsg1Ratcalcium ion binding enablesIEAInterPro:IPR000233 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Dsg1Ratcalcium ion binding enablesIBAFB:FBgn0015609 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dsg1Ratgamma-catenin binding enablesISODSG1 (Homo sapiens)1624291UniProtKB:P14923 and PMID:7983064RGDPMID:7983064
Dsg1Ratgamma-catenin binding enablesIBAPANTHER:PTN000615955 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dsg1Ratgamma-catenin binding enablesIEAUniProtKB:Q02413 and ensembl:ENSP000002571921600115GO_REF:0000107EnsemblGO_REF:0000107
Dsg1Ratprotein binding enablesISODSG1 (Homo sapiens)1624291UniProtKB:P14923 more ...RGDPMID:11790773 more ...
Dsg1Ratprotein binding enablesISODsg1a (Mus musculus)1624291PR:Q02257 PMID:12847106RGDPMID:12847106

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dsg1RatStaphylococcus aureus infection pathway  IEA 6907045 KEGGrno:05150

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#
Reference Title
Reference Citation
1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Progesterone treatment and the progress of early pregnancy reduce desmoglein 1&2 staining along the lateral plasma membrane in rat uterine epithelial cells. Preston AM, etal., Acta Histochem. 2004;106(5):345-51.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma. Rickman L, etal., Hum Mol Genet. 1999 Jun;8(6):971-6.
12. Coordinated reassembly of the basement membrane and junctional proteins during corneal epithelial wound healing. Suzuki K, etal., Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2495-500.
13. Cell-cell junctions and vascular endothelial growth factor in rat lung as affected by ischemia/reperfusion and preconditioning with inhaled nitric oxide. Waldow T, etal., J Surg Res. 2009 Nov;157(1):30-42. Epub 2008 Sep 4.
1 to 13 of 13 rows
PMID:7983064   PMID:12093888   PMID:12631242   PMID:14673151   PMID:15775979   PMID:23376485   PMID:23979707   PMID:25931508  



Dsg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81811,948,098 - 11,980,455 (+)NCBIGRCr8
mRatBN7.21811,674,687 - 11,705,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,674,402 - 11,703,443 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01812,008,301 - 12,040,337 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,008,759 - 12,038,053 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01811,807,285 - 11,838,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,127,180 - 12,156,469 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11812,096,380 - 12,182,381 (+)NCBI
Celera1811,690,076 - 11,721,312 (+)NCBICelera
Cytogenetic Map18p12NCBI
DSG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381831,318,160 - 31,359,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1831,318,160 - 31,359,246 (+)EnsemblGRCh38hg38GRCh38
GRCh371828,898,123 - 28,939,209 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361827,152,050 - 27,191,392 (+)NCBINCBI36Build 36hg18NCBI36
Build 341827,152,049 - 27,190,453NCBI
Celera1825,705,178 - 25,744,520 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1825,754,044 - 25,793,387 (+)NCBIHuRef
CHM1_11828,825,336 - 28,864,663 (+)NCBICHM1_1
T2T-CHM13v2.01831,508,717 - 31,549,794 (+)NCBIT2T-CHM13v2.0
Dsg1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391820,443,982 - 20,476,407 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1820,443,868 - 20,476,407 (+)EnsemblGRCm39 Ensembl
GRCm381820,310,873 - 20,343,353 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1820,310,811 - 20,343,350 (+)EnsemblGRCm38mm10GRCm38
MGSCv371820,469,374 - 20,501,854 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361820,453,821 - 20,486,363 (+)NCBIMGSCv36mm8
Celera1820,815,287 - 20,847,880 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.29NCBI
Dsg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540218,668,196 - 18,700,630 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540218,668,717 - 18,704,329 (+)NCBIChiLan1.0ChiLan1.0
DSG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21748,717,713 - 48,753,739 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11834,410,308 - 34,446,335 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01824,543,061 - 24,579,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11828,140,132 - 28,171,831 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,078,131 - 28,175,803 (+)Ensemblpanpan1.1panPan2
DSG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1758,159,283 - 58,239,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl758,102,113 - 58,193,708 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha757,597,684 - 57,630,602 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0758,144,506 - 58,179,775 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl758,147,900 - 58,178,837 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1757,822,159 - 57,855,070 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0757,848,322 - 57,881,239 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0758,137,415 - 58,170,337 (-)NCBIUU_Cfam_GSD_1.0
Dsg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494453,853,056 - 53,887,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366821,853,594 - 1,889,488 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366821,854,637 - 1,889,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6115,237,677 - 115,276,645 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16115,237,836 - 115,272,944 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26107,865,594 - 107,900,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DSG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11849,372,261 - 49,408,818 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1849,375,262 - 49,406,742 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605024,016,372 - 24,052,276 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dsg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247701,517,027 - 1,542,322 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247701,514,978 - 1,551,437 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Dsg1
270 total Variants

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:143
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000022665, ENSRNOT00000038635, ENSRNOT00000061344
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18679125112205285Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18679125112205285Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18679125112205285Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18679125112205285Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat

1 to 10 of 15 rows
RH137413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,703,221 - 11,703,416 (+)MAPPERmRatBN7.2
Rnor_6.01812,038,177 - 12,038,371NCBIRnor6.0
Rnor_5.01811,836,044 - 11,836,238UniSTSRnor5.0
RGSC_v3.41812,155,859 - 12,156,053UniSTSRGSC3.4
Celera1811,719,152 - 11,719,346UniSTS
RH 3.4 Map18133.11UniSTS
Cytogenetic Map18p12UniSTS
RH142083  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,703,889 - 11,704,109 (+)MAPPERmRatBN7.2
Rnor_6.01812,038,845 - 12,039,064NCBIRnor6.0
Rnor_5.01811,836,712 - 11,836,931UniSTSRnor5.0
RGSC_v3.41812,156,527 - 12,156,746UniSTSRGSC3.4
Celera1811,719,820 - 11,720,039UniSTS
RH 3.4 Map18133.7UniSTS
Cytogenetic Map18p12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 4 10 76 74 82 53 25 53 6 133 43 66 24 46 29



Ensembl Acc Id: ENSRNOT00000022665   ⟹   ENSRNOP00000022665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1812,008,759 - 12,037,765 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000038635   ⟹   ENSRNOP00000030176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1812,008,759 - 12,038,053 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061344   ⟹   ENSRNOP00000058060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1811,674,402 - 11,703,443 (+)Ensembl
Rnor_6.0 Ensembl1812,008,759 - 12,038,053 (+)Ensembl
RefSeq Acc Id: XM_063277680   ⟹   XP_063133750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81811,948,098 - 11,980,455 (+)NCBI
Protein RefSeqs NP_001419356 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133750 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058060
  ENSRNOP00000058060.2
Ensembl Acc Id: ENSRNOP00000030176   ⟸   ENSRNOT00000038635
Ensembl Acc Id: ENSRNOP00000058060   ⟸   ENSRNOT00000061344
Ensembl Acc Id: ENSRNOP00000022665   ⟸   ENSRNOT00000022665
RefSeq Acc Id: XP_063133750   ⟸   XM_063277680
Cadherin

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZM39-F1-model_v2 AlphaFold D3ZM39 1-1060 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-8234 BioCyc
Ensembl Genes ENSRNOG00000016853 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061344 ENTREZGENE
  ENSRNOT00000061344.5 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/TrEMBL
  Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-domain_protein UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/TrEMBL
  Catenin_binding_dom UniProtKB/TrEMBL
  Desmo_cadherin UniProtKB/TrEMBL
NCBI Gene 291755 ENTREZGENE
PANTHER DESMOGLEIN FAMILY MEMBER UniProtKB/TrEMBL
  DESMOGLEIN-1 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_C UniProtKB/TrEMBL
PharmGKB DSG1 RGD
PhenoGen Dsg1 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
  DESMOCADHERN UniProtKB/TrEMBL
  DESMOGLEIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016853 RatGTEx
SMART SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
UniProt D3ZM39 ENTREZGENE, UniProtKB/TrEMBL
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-14 Dsg1  desmoglein 1  Dsg1b  desmoglein 1 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Dsg1b  desmoglein 1 beta   LOC679010  similar to Desmoglein-1 alpha precursor (Dsg1-alpha) (Desmoglein-1) (Desmosomal glycoprotein I) (DG1) (DGI)  Data merged from RGD:1593114 1643240 APPROVED
2008-04-30 Dsg1b  desmoglein 1 beta   Dsg1b_predicted  desmoglein 1 beta (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC679010  similar to Desmoglein-1 alpha precursor (Dsg1-alpha) (Desmoglein-1) (Desmosomal glycoprotein I) (DG1) (DGI)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Dsg1c_predicted  desmoglein 1 gamma (predicted)      Symbol and Name status set to approved 70820 APPROVED