DSG1 (desmoglein 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: DSG1 (desmoglein 1) Canis lupus familiaris
Analyze
Symbol: DSG1
Name: desmoglein 1
RGD ID: 12408920
Description: ENCODES a protein that exhibits calcium ion binding (inferred); gamma-catenin binding (inferred); metal ion binding (inferred); INVOLVED IN maternal process involved in female pregnancy (ortholog); response to progesterone (ortholog); ASSOCIATED WITH allergic disease (ortholog); Chronic Periodontitis (ortholog); Congenital Erythroderma with Palmoplantar Keratoderma, Hypotrichosis, and Hyper-IgE (ortholog); FOUND IN apical plasma membrane (ortholog); lateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: desmoglein-1; desmosomal glycoprotein 1; DG1; DGI; DSG-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1758,159,283 - 58,239,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl758,102,113 - 58,193,708 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha757,597,684 - 57,630,602 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0758,144,506 - 58,179,775 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl758,147,900 - 58,178,837 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1757,822,159 - 57,855,070 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0757,848,322 - 57,881,239 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0758,137,415 - 58,170,337 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:10844571   PMID:22301074   PMID:30032202   PMID:32344723  


Genomics

Comparative Map Data
DSG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1758,159,283 - 58,239,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl758,102,113 - 58,193,708 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha757,597,684 - 57,630,602 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0758,144,506 - 58,179,775 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl758,147,900 - 58,178,837 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1757,822,159 - 57,855,070 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0757,848,322 - 57,881,239 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0758,137,415 - 58,170,337 (-)NCBIUU_Cfam_GSD_1.0
DSG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381831,318,160 - 31,359,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1831,318,160 - 31,359,246 (+)EnsemblGRCh38hg38GRCh38
GRCh371828,898,123 - 28,939,209 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361827,152,050 - 27,191,392 (+)NCBINCBI36Build 36hg18NCBI36
Build 341827,152,049 - 27,190,453NCBI
Celera1825,705,178 - 25,744,520 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1825,754,044 - 25,793,387 (+)NCBIHuRef
CHM1_11828,825,336 - 28,864,663 (+)NCBICHM1_1
T2T-CHM13v2.01831,508,717 - 31,549,794 (+)NCBIT2T-CHM13v2.0
Dsg1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391820,443,982 - 20,476,407 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1820,443,868 - 20,476,407 (+)EnsemblGRCm39 Ensembl
GRCm381820,310,873 - 20,343,353 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1820,310,811 - 20,343,350 (+)EnsemblGRCm38mm10GRCm38
MGSCv371820,469,374 - 20,501,854 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361820,453,821 - 20,486,363 (+)NCBIMGSCv36mm8
Celera1820,815,287 - 20,847,880 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.29NCBI
Dsg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81811,948,098 - 11,980,455 (+)NCBIGRCr8
mRatBN7.21811,674,687 - 11,705,383 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,674,402 - 11,703,443 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01812,008,301 - 12,040,337 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,008,759 - 12,038,053 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01811,807,285 - 11,838,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,127,180 - 12,156,469 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11812,096,380 - 12,182,381 (+)NCBI
Celera1811,690,076 - 11,721,312 (+)NCBICelera
Cytogenetic Map18p12NCBI
Dsg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540218,668,196 - 18,700,630 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540218,668,717 - 18,704,329 (+)NCBIChiLan1.0ChiLan1.0
DSG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21748,717,713 - 48,753,739 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11834,410,308 - 34,446,335 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01824,543,061 - 24,579,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11828,140,132 - 28,171,831 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,078,131 - 28,175,803 (+)Ensemblpanpan1.1panPan2
Dsg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494453,853,056 - 53,887,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366821,853,594 - 1,889,488 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366821,854,637 - 1,889,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6115,237,677 - 115,276,645 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16115,237,836 - 115,272,944 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26107,865,594 - 107,900,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DSG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11849,372,261 - 49,408,818 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1849,375,262 - 49,406,742 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605024,016,372 - 24,052,276 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dsg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247701,517,027 - 1,542,322 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247701,514,978 - 1,551,437 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DSG1
959 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6
Low 2 6 6 6
Below cutoff 5 3 16 6 6 11 8 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000028693   ⟹   ENSCAFP00000026689
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl758,102,113 - 58,193,572 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000028696   ⟹   ENSCAFP00000026691
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl758,162,989 - 58,193,708 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000035921   ⟹   ENSCAFP00000031230
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl758,102,113 - 58,193,572 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845019678   ⟹   ENSCAFP00845015394
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl758,147,900 - 58,178,837 (-)Ensembl
RefSeq Acc Id: NM_001002939   ⟹   NP_001002939
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1758,160,669 - 58,193,572 (-)NCBI
Dog10K_Boxer_Tasha757,597,684 - 57,630,602 (-)NCBI
ROS_Cfam_1.0758,145,892 - 58,178,837 (-)NCBI
UMICH_Zoey_3.1757,822,159 - 57,855,070 (-)NCBI
UNSW_CanFamBas_1.0757,848,322 - 57,881,239 (-)NCBI
UU_Cfam_GSD_1.0758,137,415 - 58,170,337 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038670464   ⟹   XP_038526392
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0758,148,212 - 58,179,775 (-)NCBI
RefSeq Acc Id: XM_038670465   ⟹   XP_038526393
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0758,144,506 - 58,179,774 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001002939   ⟸   NM_001002939
- Peptide Label: precursor
- UniProtKB: Q9GKQ8 (UniProtKB/Swiss-Prot),   A0A8C0SHV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000031230   ⟸   ENSCAFT00000035921
RefSeq Acc Id: ENSCAFP00000026689   ⟸   ENSCAFT00000028693
RefSeq Acc Id: ENSCAFP00000026691   ⟸   ENSCAFT00000028696
RefSeq Acc Id: XP_038526393   ⟸   XM_038670465
- Peptide Label: isoform X1
- UniProtKB: A0A8P0SMG9 (UniProtKB/TrEMBL),   A0A8I3NIB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038526392   ⟸   XM_038670464
- Peptide Label: isoform X1
- UniProtKB: A0A8P0SMG9 (UniProtKB/TrEMBL),   A0A8I3NIB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845015394   ⟸   ENSCAFT00845019678
Protein Domains
Cadherin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018064 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001077 UniProtKB/TrEMBL
  ENSCAFG00040013087 UniProtKB/TrEMBL
  ENSCAFG00845011100 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028696.6 UniProtKB/TrEMBL
  ENSCAFT00030001956.1 UniProtKB/TrEMBL
  ENSCAFT00040024554.1 UniProtKB/TrEMBL
  ENSCAFT00845019678 ENTREZGENE
  ENSCAFT00845019678.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cadherin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catenin-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Desmosomal_cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403401 UniProtKB/Swiss-Prot
NCBI Gene DSG1 ENTREZGENE
PANTHER DESMOGLEIN FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DESMOGLEIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CADHERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DESMOCADHERN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DESMOGLEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0SHV9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NIB1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SMG9 ENTREZGENE, UniProtKB/TrEMBL
  DSG1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:40105 ENTREZGENE