Tubb2b (tubulin, beta 2B class IIb) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tubb2b (tubulin, beta 2B class IIb) Rattus norvegicus
Analyze
Symbol: Tubb2b
Name: tubulin, beta 2B class IIb
RGD ID: 1309427
Description: Predicted to enable GTP binding activity and protein heterodimerization activity. Predicted to be a structural constituent of cytoskeleton. Involved in neuron migration. Predicted to be located in intercellular bridge and mitotic spindle. Predicted to be active in Schaffer collateral - CA1 synapse; cytoplasm; and microtubule. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 7. Orthologous to human TUBB2B (tubulin beta 2B class IIb); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-tubulin T beta15 (aa 1-445); LOC291081; MGC124866; RGD1309427; similar to tubulin, beta; t beta-15; Tubb2; tubulin beta-2B chain; tubulin, beta 2; tubulin, beta 2B; tubulin, beta-like
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81730,953,086 - 30,956,133 (+)NCBIGRCr8
mRatBN7.21730,747,734 - 30,750,781 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,747,734 - 30,750,638 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1730,560,900 - 30,563,955 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,164,652 - 32,167,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,556,638 - 30,559,693 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01731,441,640 - 31,444,687 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1731,441,630 - 31,482,759 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01733,336,065 - 33,339,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,087,922 - 37,090,969 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,142,086 - 37,145,700 (+)NCBI
Celera1730,312,117 - 30,315,164 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tubb2bRatbilateral perisylvian polymicrogyria  ISORGD:16024078554872ClinVar Annotator: match by term: Congenital bilateral perisylvian syndromeClinVarPMID:25741868
Tubb2bRatcomplex cortical dysplasia with other brain malformations 1  ISORGD:16024078554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 1ClinVarPMID:25741868
Tubb2bRatcomplex cortical dysplasia with other brain malformations 7  ISORGD:16024078554872ClinVar Annotator: match by term: Complex cortical dysplasia with other brain malformations 7 | ClinVar more ...ClinVarPMID:11425694|PMID:18414213|PMID:19465910|PMID:22333901|PMID:22591407|PMID:23001566|PMID:23361065|PMID:24860126|PMID:25059107|PMID:25140959|PMID:25741868|PMID:26467025|PMID:26732629|PMID:28492532|PMID:29671837|PMID:31481326|PMID:39825153|PMID:9628483
Tubb2bRatgenetic disease  ISORGD:16024078554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:18414213|PMID:22591407|PMID:23001566|PMID:25741868|PMID:26467025|PMID:26732629|PMID:28013290|PMID:28492532|PMID:28835377|PMID:9628483
Tubb2bRatlissencephaly  ISORGD:16024078554872ClinVar Annotator: match by term: LissencephalyClinVarPMID:11425694|PMID:23001566|PMID:25741868|PMID:29671837
Tubb2bRattubulinopathy  ISORGD:16024078554872ClinVar Annotator: match by term: TubulinopathyClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tubb2bRatAnimal Mammary Neoplasms  ISORGD:160240711554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462
Tubb2bRatcarcinoma  ISORGD:160240711554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462
Tubb2bRatcomplex cortical dysplasia with other brain malformations  ISORGD:160240711554173CTD Direct Evidence: marker/mechanismCTDPMID:19465910
Tubb2bRatExperimental Mammary Neoplasms  ISORGD:160240711554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tubb2bRatcomplex cortical dysplasia with other brain malformations 7  ISSRGD:131976513592920OMIM:610031MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tubb2bRatcomplex cortical dysplasia with other brain malformations 7  ISORGD:16024077240710 OMIM 

1 to 20 of 150 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tubb2bRat(+)-catechin multiple interactionsISORGD:16024076480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TUBB2B mRNACTDPMID:24763279
Tubb2bRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISORGD:13197656480464o,p'-DDT results in increased expression of TUBB2B mRNACTDPMID:24096037
Tubb2bRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionEXP 6480464o,p'-DDT results in increased expression of TUBB2B mRNACTDPMID:24096037
Tubb2bRat1,2-dimethylhydrazine multiple interactionsISORGD:13197656480464Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of TUBB2B mRNA]CTDPMID:22206623
Tubb2bRat1,2-dimethylhydrazine decreases expressionISORGD:131976564804641,2-Dimethylhydrazine results in decreased expression of TUBB2B mRNACTDPMID:22206623
Tubb2bRat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of TUBB2B mRNACTDPMID:12832660
Tubb2bRat17alpha-ethynylestradiol increases expressionISORGD:13197656480464Ethinyl Estradiol results in increased expression of TUBB2B mRNACTDPMID:24096037
Tubb2bRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of TUBB2B mRNACTDPMID:24096037
Tubb2bRat17beta-estradiol multiple interactionsISORGD:16024076480464[Estradiol co-treated with Progesterone] results in decreased expression of TUBB2B mRNACTDPMID:20660070
Tubb2bRat17beta-estradiol increases expressionISORGD:16024076480464Estradiol results in increased expression of TUBB2B mRNACTDPMID:31614463
Tubb2bRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of TUBB2B mRNACTDPMID:32145629
Tubb2bRat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TUBB2B mRNACTDPMID:32741896
Tubb2bRat17beta-estradiol 3-benzoate decreases methylationEXP 6480464estradiol 3-benzoate results in decreased methylation of TUBB2B promoterCTDPMID:27415467
Tubb2bRat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TUBB2B mRNACTDPMID:32741896
Tubb2bRat2,3',4,4',5-Pentachlorobiphenyl affects expressionISORGD:131976564804642,3',4,4',5-pentachlorobiphenyl affects the expression of TUBB2B mRNACTDPMID:31388691
Tubb2bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:13197656480464Tetrachlorodibenzodioxin results in increased expression of TUBB2B mRNACTDPMID:19770486|PMID:33956508
Tubb2bRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TUBB2B mRNACTDPMID:32109520
Tubb2bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13197656480464Tetrachlorodibenzodioxin affects the expression of TUBB2B mRNACTDPMID:21570461
Tubb2bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:16024076480464Tetrachlorodibenzodioxin results in increased expression of TUBB2B mRNACTDPMID:21632981
Tubb2bRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:13197656480464Tetrachlorodibenzodioxin results in decreased expression of TUBB2B mRNACTDPMID:21041162

1 to 20 of 150 rows

Biological Process
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tubb2bRatbiological_process  ND 159840704/2015: no relevant rat dataRGD 
Tubb2bRatcerebral cortex development involved_inIEAUniProtKB:Q7TMM9|ensembl:ENSMUSP000000602461600115GO_REF:0000107EnsemblGO_REF:0000107
Tubb2bRatcerebral cortex development involved_inISORGD:13197651624291MGI:6506266 PMID:31386652RGDPMID:31386652
Tubb2bRatcytoskeleton organization involved_inIEAGO:00052001600115GO_REF:0000108GOCGO_REF:0000108
Tubb2bRatembryonic brain development acts_upstream_of_or_withinISORGD:13197651624291MGI:5056364 PMID:21515572RGDPMID:21515572
Tubb2bRatmicrotubule cytoskeleton organization involved_inIBAFB:FBgn0003885|FB:FBgn0010097|FB:FBgn0052396|FB:FBgn0087040|FB:FBgn0260639|MGI:101834|MGI:107812|MGI:107814|MGI:98869|PANTHER:PTN000172598|PomBase:SPBC16A3.15c|PomBase:SPBC26H8.07c|PomBase:SPBC32F12.04|PomBase:SPBC800.05c|SGD:S000001857|SGD:S000004202|TAIR:locus:2076750|TAIR:locus:2166469|TAIR:locus:3439219|UniProtKB:A0A644F0Y1|UniProtKB:D6XD01|UniProtKB:P10653|UniProtKB:P18695|UniProtKB:P24633|UniProtKB:P54401|UniProtKB:P68363|UniProtKB:Q13509|UniProtKB:Q3ZCM7|UniProtKB:Q4QQZ8|WB:WBGene00003171|WB:WBGene00006528|WB:WBGene00006529|WB:WBGene00006537|WB:WBGene000065401600115GO_REF:0000033GO_CentralGO_REF:0000033
Tubb2bRatmicrotubule-based process involved_inIEAInterPro:IPR000217|InterPro:IPR002453|InterPro:IPR0179751600115GO_REF:0000002InterProGO_REF:0000002
Tubb2bRatmicrotubule-based process involved_inISORGD:16024071624291 PMID:26732629RGDPMID:26732629
Tubb2bRatmicrotubule-based process involved_inISSUniProtKB:Q9BVA11600115GO_REF:0000024UniProtGO_REF:0000024
Tubb2bRatmitotic cell cycle involved_inIBAFB:FBgn0087040|FB:FBgn0260639|PANTHER:PTN000172598|PomBase:SPBC26H8.07c|PomBase:SPBC32F12.04|PomBase:SPBC800.05c|SGD:S000001857|SGD:S000004202|SGD:S000004550|TAIR:locus:2076750|TAIR:locus:2166469|UniProtKB:A0A644F0Y1|UniProtKB:P10653|UniProtKB:P18695|WB:WBGene00006528|WB:WBGene00006529|WB:WBGene000065401600115GO_REF:0000033GO_CentralGO_REF:0000033
Tubb2bRatmodulation of chemical synaptic transmission involved_inISORGD:13197651624291 PMID:27594048RGDPMID:27594048
Tubb2bRatnervous system development involved_inIEAUniProtKB-KW:KW-05241600115GO_REF:0000043UniProtGO_REF:0000043
Tubb2bRatneuron migration involved_inIMP 8554405PMID:19465910UniProt 
Tubb2bRatneuron migration involved_inIBAPANTHER:PTN001358285|RGD:1309427|UniProtKB:Q9BVA11600115GO_REF:0000033GO_CentralGO_REF:0000033
Tubb2bRatneuron migration involved_inISORGD:16024071624291 PMID:19465910RGDPMID:19465910
Tubb2bRatpositive regulation of axon guidance involved_inISSUniProtKB:Q9BVA11600115GO_REF:0000024UniProtGO_REF:0000024
Tubb2bRatpositive regulation of axon guidance involved_inISORGD:16024071624291 PMID:23001566RGDPMID:23001566
1 to 17 of 17 rows

Cellular Component
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tubb2bRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Tubb2bRatcytoplasm is_active_inIBAFB:FBgn0003884|FB:FBgn0003885|FB:FBgn0003886|FB:FBgn0010097|FB:FBgn0087040|FB:FBgn0260639|MGI:101834|MGI:107804|MGI:107813|MGI:107848|MGI:1095409|MGI:1858225|MGI:1891826|MGI:2144208|MGI:98869|PANTHER:PTN000172598|PomBase:SPBC26H8.07c|PomBase:SPBC32F12.04|TAIR:locus:2076750|UniProtKB:A0A644F0Y1|UniProtKB:D6XD01|UniProtKB:P04350|UniProtKB:P07437|UniProtKB:P10653|UniProtKB:P23258|UniProtKB:P24633|UniProtKB:P68371|UniProtKB:Q71U36|UniProtKB:Q9H4B7|UniProtKB:Q9UJT1|WB:WBGene00006531|WB:WBGene00006538|WB:WBGene00006540|dictyBase:DDB_G02717381600115GO_REF:0000033GO_CentralGO_REF:0000033
Tubb2bRatcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Tubb2bRatcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Tubb2bRatintercellular bridge located_inIEAUniProtKB:Q13885|ensembl:ENSP000003697031600115GO_REF:0000107EnsemblGO_REF:0000107
Tubb2bRatintercellular bridge located_inISORGD:16024071624291 RGDGO_REF:0000052
Tubb2bRatmicrotubule located_inISORGD:16024071624291 PMID:21525035RGDPMID:21525035
Tubb2bRatmicrotubule is_active_inIBACGD:CAL0000176403|FB:FBgn0003884|FB:FBgn0003886|FB:FBgn0003888|FB:FBgn0052396|FB:FBgn0087040|FB:FBgn0260639|FB:FBgn0284243|MGI:101834|MGI:107804|MGI:107812|MGI:107814|MGI:1095406|MGI:1095409|MGI:2144208|MGI:98869|PANTHER:PTN000172598|PomBase:SPBC26H8.07c|PomBase:SPBC800.05c|TAIR:locus:2076750|TAIR:locus:2166469|TAIR:locus:3439219|UniProtKB:A0A1D8PTV4|UniProtKB:P04350|UniProtKB:P07437|UniProtKB:P10653|UniProtKB:P23258|UniProtKB:P24633|UniProtKB:P68363|UniProtKB:P68366|UniProtKB:P68371|UniProtKB:Q13509|UniProtKB:Q13885|UniProtKB:Q71U36|UniProtKB:Q9BUF5|UniProtKB:Q9BVA1|UniProtKB:Q9NRH3|WB:WBGene00003175|WB:WBGene00006531|WB:WBGene00006536|WB:WBGene00006537|WB:WBGene00006538|dictyBase:DDB_G0269196|dictyBase:DDB_G02876891600115GO_REF:0000033GO_CentralGO_REF:0000033
Tubb2bRatmicrotubule located_inIEAInterPro:IPR000217|InterPro:IPR002453|InterPro:IPR0179751600115GO_REF:0000002InterProGO_REF:0000002
Tubb2bRatmicrotubule located_inIEAUniProtKB-KW:KW-04931600115GO_REF:0000043UniProtGO_REF:0000043
Tubb2bRatmicrotubule located_inIEAUniProtKB:Q13885|ensembl:ENSP000003697031600115GO_REF:0000107EnsemblGO_REF:0000107
Tubb2bRatmicrotubule cytoskeleton located_inISSUniProtKB:Q9BVA11600115GO_REF:0000024UniProtGO_REF:0000024
Tubb2bRatmicrotubule cytoskeleton located_inIEAUniProtKB:Q13885|ensembl:ENSP000003697031600115GO_REF:0000107EnsemblGO_REF:0000107
Tubb2bRatmicrotubule cytoskeleton located_inISORGD:16024071624291 PMID:23001566, PMID:28013290RGDGO_REF:0000052|PMID:23001566|PMID:28013290
Tubb2bRatmitotic spindle located_inIEAUniProtKB:Q13885|ensembl:ENSP000003697031600115GO_REF:0000107EnsemblGO_REF:0000107
Tubb2bRatmitotic spindle located_inISORGD:16024071624291 RGDGO_REF:0000052
Tubb2bRatSchaffer collateral - CA1 synapse is_active_inISORGD:13197651624291 PMID:27594048RGDPMID:27594048
1 to 17 of 17 rows

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tubb2bRatGTP binding enablesIEAUniRule:UR0000000851600115GO_REF:0000104UniProtGO_REF:0000104
Tubb2bRatGTP binding enablesIEAUniProtKB-KW:KW-03421600115GO_REF:0000043UniProtGO_REF:0000043
Tubb2bRatGTP binding enablesIEAInterPro:IPR002453|InterPro:IPR003008|InterPro:IPR0179751600115GO_REF:0000002InterProGO_REF:0000002
Tubb2bRatGTP binding enablesIBAFB:FBgn0010097|FB:FBgn0260639|MGI:98869|PANTHER:PTN000172598|UniProtKB:P68363|UniProtKB:Q135091600115GO_REF:0000033GO_CentralGO_REF:0000033
Tubb2bRatGTPase activity enablesIEAInterPro:IPR0024531600115GO_REF:0000002InterProGO_REF:0000002
Tubb2bRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Tubb2bRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Tubb2bRatprotein binding enablesISORGD:16024071624291UniProtKB:O00555 PMID:21078624RGDPMID:21078624
Tubb2bRatprotein heterodimerization activity enablesISORGD:16024071624291 PMID:23001566, PMID:26732629, PMID:28013290RGDPMID:23001566|PMID:26732629|PMID:28013290
Tubb2bRatprotein heterodimerization activity enablesISSUniProtKB:Q9BVA11600115GO_REF:0000024UniProtGO_REF:0000024
Tubb2bRatstructural constituent of cytoskeleton enablesIEAInterPro:IPR0024531600115GO_REF:0000002InterProGO_REF:0000002
Tubb2bRatstructural constituent of cytoskeleton enablesIBACGD:CAL0000176403|FB:FBgn0003886|FB:FBgn0003888|FB:FBgn0052396|FB:FBgn0284243|MGI:107812|MGI:107814|PANTHER:PTN000172598|SGD:S000001857|SGD:S000004202|SGD:S000004593|UniProtKB:A0A1D8PTV4|UniProtKB:P18695|UniProtKB:P24633|UniProtKB:P68363|UniProtKB:Q13509|dictyBase:DDB_G0269196|dictyBase:DDB_G02876891600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 12 of 12 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tubb2bRatphagocytosis pathway  IEA 6907045 KEGGrno:04145

1 to 9 of 9 rows
#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin. Ivings L, etal., Biochem J 2002 May 1;363(Pt 3):599-608.
3. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Jaglin XH, etal., Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
1 to 9 of 9 rows
PMID:2868892   PMID:8631991   PMID:12112145   PMID:12477932   PMID:14760703   PMID:15489334   PMID:19666135   PMID:21515572   PMID:21525035   PMID:21630459   PMID:22082260   PMID:23001566  
PMID:26306046   PMID:26732629   PMID:27594048   PMID:28013290   PMID:29476059   PMID:32357304  



Tubb2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81730,953,086 - 30,956,133 (+)NCBIGRCr8
mRatBN7.21730,747,734 - 30,750,781 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1730,747,734 - 30,750,638 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1730,560,900 - 30,563,955 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,164,652 - 32,167,707 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01730,556,638 - 30,559,693 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01731,441,640 - 31,444,687 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1731,441,630 - 31,482,759 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01733,336,065 - 33,339,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,087,922 - 37,090,969 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11737,142,086 - 37,145,700 (+)NCBI
Celera1730,312,117 - 30,315,164 (+)NCBICelera
Cytogenetic Map17p12NCBI
TUBB2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3863,224,277 - 3,227,653 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl63,223,324 - 3,231,730 (-)EnsemblGRCh38hg38GRCh38
GRCh3763,224,511 - 3,227,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3663,169,510 - 3,172,870 (-)NCBINCBI36Build 36hg18NCBI36
Celera64,453,394 - 4,456,867 (-)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef63,102,307 - 3,105,779 (-)NCBIHuRef
CHM1_163,226,964 - 3,230,437 (-)NCBICHM1_1
T2T-CHM13v2.063,092,680 - 3,096,055 (-)NCBIT2T-CHM13v2.0
Tubb2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391334,310,991 - 34,314,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1334,310,731 - 34,314,449 (-)EnsemblGRCm39 Ensembl
GRCm381334,127,008 - 34,130,354 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1334,126,748 - 34,130,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv371334,218,877 - 34,222,223 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361334,134,473 - 34,137,819 (-)NCBIMGSCv36mm8
Celera1335,261,212 - 35,264,555 (-)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.04NCBI
LOC478702
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,494,982 - 3,498,274 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,495,277 - 3,498,248 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha353,505,910 - 3,509,204 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,555,009 - 3,558,303 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,505,153 - 3,558,836 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,431,487 - 3,434,784 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,453,807 - 3,457,098 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,786,156 - 4,789,450 (-)NCBIUU_Cfam_GSD_1.0
LOC100624785
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl71,910,269 - 1,914,761 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.171,910,585 - 1,914,668 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,975,079 - 1,987,569 (-)NCBISscrofa10.2Sscrofa10.2susScr3

.

.
Variants in Tubb2b
7 total Variants

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:95
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000023582
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 41 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat

1 to 10 of 41 rows
AU047860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,748,394 - 30,748,534 (+)MAPPERmRatBN7.2
Rnor_6.01731,442,301 - 31,442,440NCBIRnor6.0
Rnor_5.01733,336,726 - 33,336,865UniSTSRnor5.0
RGSC_v3.41737,088,583 - 37,088,722UniSTSRGSC3.4
Celera1730,312,778 - 30,312,917UniSTS
Cytogenetic Map17p12UniSTS
RH141109  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,800,069 - 30,800,523 (+)MAPPERmRatBN7.2
mRatBN7.21730,750,076 - 30,750,574 (+)MAPPERmRatBN7.2
Rnor_6.01731,443,983 - 31,444,480NCBIRnor6.0
Rnor_5.01733,338,408 - 33,338,905UniSTSRnor5.0
RGSC_v3.41737,090,265 - 37,090,762UniSTSRGSC3.4
Celera1730,314,460 - 30,314,957UniSTS
RH 3.4 Map5977.8UniSTS
Cytogenetic Map17p12UniSTS
MARC_26445-26446:1030655521:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,749,123 - 30,749,576 (+)MAPPERmRatBN7.2
mRatBN7.21730,798,685 - 30,799,569 (+)MAPPERmRatBN7.2
Rnor_6.01731,494,989 - 31,495,872NCBIRnor6.0
Rnor_6.01731,443,030 - 31,443,482NCBIRnor6.0
Rnor_5.01733,388,175 - 33,389,058UniSTSRnor5.0
Rnor_5.01733,337,455 - 33,337,907UniSTSRnor5.0
RGSC_v3.41737,089,312 - 37,089,764UniSTSRGSC3.4
RGSC_v3.41737,141,022 - 37,141,905UniSTSRGSC3.4
Celera1730,362,961 - 30,363,844UniSTS
Celera1730,313,507 - 30,313,959UniSTS
Cytogenetic Map17p12UniSTS
Tubb2b  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81730,953,132 - 30,954,128 (+)Marker Load Pipeline
mRatBN7.21730,747,780 - 30,748,776 (+)MAPPERmRatBN7.2
Rnor_6.01731,441,687 - 31,442,682NCBIRnor6.0
Rnor_5.01733,336,112 - 33,337,107UniSTSRnor5.0
Celera1730,312,164 - 30,313,159UniSTS
Cytogenetic Map17p12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000023582   ⟹   ENSRNOP00000023582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1731,441,640 - 31,444,685 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083705   ⟹   ENSRNOP00000073323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1730,747,734 - 30,750,638 (+)Ensembl
Rnor_6.0 Ensembl1731,441,630 - 31,482,759 (+)Ensembl
RefSeq Acc Id: NM_001013886   ⟹   NP_001013908
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81730,953,086 - 30,956,133 (+)NCBI
mRatBN7.21730,747,734 - 30,750,781 (+)NCBI
Rnor_6.01731,441,640 - 31,444,687 (+)NCBI
Rnor_5.01733,336,065 - 33,339,112 (+)NCBI
RGSC_v3.41737,087,922 - 37,090,969 (+)RGD
Celera1730,312,117 - 30,315,164 (+)RGD
Sequence:
Protein RefSeqs NP_001013908 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI05755 (Get FASTA)   NCBI Sequence Viewer  
  EDL98315 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023582
GenBank Protein Q3KRE8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013908   ⟸   NM_001013886
- UniProtKB: A3KMR7 (UniProtKB/Swiss-Prot),   P04691 (UniProtKB/Swiss-Prot),   Q3KRE8 (UniProtKB/Swiss-Prot),   A6J7G5 (UniProtKB/TrEMBL),   A0A8L2R4U4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023582   ⟸   ENSRNOT00000023582
Ensembl Acc Id: ENSRNOP00000073323   ⟸   ENSRNOT00000083705
Name Modeler Protein Id AA Range Protein Structure
AF-Q3KRE8-F1-model_v2 AlphaFold Q3KRE8 1-445 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700419
Promoter ID:EPDNEW_R10935
Type:initiation region
Name:Tubb2b_1
Description:tubulin, beta 2B class IIb
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01731,441,600 - 31,441,660EPDNEW


1 to 40 of 43 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-9602 BioCyc
Ensembl Genes ENSRNOG00000017445 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023582 ENTREZGENE
Gene3D-CATH 1.10.287.600 UniProtKB/Swiss-Prot
  3.30.1330.20 UniProtKB/Swiss-Prot
  3.40.50.1440 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599369 IMAGE-MGC_LOAD
  IMAGE:8362690 IMAGE-MGC_LOAD
InterPro Beta-tubulin_BS UniProtKB/Swiss-Prot
  Beta_tubulin UniProtKB/Swiss-Prot
  Tub_FtsZ_C UniProtKB/Swiss-Prot
  Tubulin UniProtKB/Swiss-Prot
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/Swiss-Prot
  Tubulin/FtsZ_C_sf UniProtKB/Swiss-Prot
  Tubulin/FtsZ_GTPase_sf UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
  Tubulin_CS UniProtKB/Swiss-Prot
  Tubulin_FtsZ_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:291081 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124866 IMAGE-MGC_LOAD
  MGC:156633 IMAGE-MGC_LOAD
NCBI Gene 291081 ENTREZGENE
PANTHER PTHR11588 UniProtKB/Swiss-Prot
Pfam Tubulin UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
PhenoGen Tubb2b PhenoGen
PRINTS BETATUBULIN UniProtKB/Swiss-Prot
  TUBULIN UniProtKB/Swiss-Prot
PROSITE TUBULIN UniProtKB/Swiss-Prot
  TUBULIN_B_AUTOREG UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017445 RatGTEx
SMART Tubulin UniProtKB/Swiss-Prot
  Tubulin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52490 UniProtKB/Swiss-Prot
  SSF55307 UniProtKB/Swiss-Prot
UniProt A0A8L2R4U4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R7U3_RAT UniProtKB/TrEMBL
  A3KMR7 ENTREZGENE
  A6J7G5 ENTREZGENE, UniProtKB/TrEMBL
  P04691 ENTREZGENE
1 to 40 of 43 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-19 Tubb2b  tubulin, beta 2B class IIb  Tubb2b  tubulin, beta 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-12 Tubb2b  tubulin, beta 2B  Tubb2b  tubulin, beta 2B class IIb  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-10 Tubb2b  tubulin, beta 2B class IIb  Tubb2b  tubulin, beta 2b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tubb2b  tubulin, beta 2b  RGD1309427  similar to tubulin, beta  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1309427  similar to tubulin, beta  RGD1309427_predicted  similar to tubulin, beta (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309427_predicted  similar to tubulin, beta (predicted)  LOC291081_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291081_predicted  similar to tubulin, beta (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL