Flnc (filamin C) - Rat Genome Database

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Gene: Flnc (filamin C) Rattus norvegicus
Analyze
Symbol: Flnc
Name: filamin C
RGD ID: 1308807
Description: Enables ankyrin binding activity. Predicted to be involved in sarcomere organization. Located in sarcolemma and sarcoplasm. Human ortholog(s) of this gene implicated in distal myopathy 4; hypertrophic cardiomyopathy 26; and myofibrillar myopathy 5. Orthologous to human FLNC (filamin C); PARTICIPATES IN integrin mediated signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ABP-L; filamin C, gamma; filamin C, gamma (actin binding protein 280); filamin-2; filamin-C; FLN-C; gamma-filamin; LOC362332
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,999,445 - 59,027,240 (+)NCBIGRCr8
mRatBN7.2458,034,088 - 58,061,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,034,189 - 58,061,844 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx463,017,203 - 63,044,933 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,933,350 - 58,961,083 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,335,244 - 57,362,974 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,710,934 - 56,738,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,711,049 - 56,738,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,478,171 - 56,505,940 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,313,707 - 56,341,400 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1456,572,156 - 56,598,993 (+)NCBI
Celera453,142,130 - 53,169,823 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP,ISO)
cyclophosphamide  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
Didecyldimethylammonium  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylselenide  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
ethylparaben  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methylarsonic acid  (ISO)
methylseleninic acid  (ISO)
Monobutylphthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
trametinib  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Integrin inactivators: balancing cellular functions in vitro and in vivo. Bouvard D, etal., Nat Rev Mol Cell Biol. 2013 Jul;14(7):430-42. doi: 10.1038/nrm3599. Epub 2013 May 30.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C. Maiweilidan Y, etal., Exp Cell Res. 2011 Apr 1;317(6):724-36. doi: 10.1016/j.yexcr.2011.01.002. Epub 2011 Jan 9.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12393796   PMID:15642266   PMID:15886195   PMID:16914736   PMID:17987659   PMID:21423176   PMID:22082260   PMID:23106098   PMID:25351925   PMID:35352799  


Genomics

Comparative Map Data
Flnc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,999,445 - 59,027,240 (+)NCBIGRCr8
mRatBN7.2458,034,088 - 58,061,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,034,189 - 58,061,844 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx463,017,203 - 63,044,933 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,933,350 - 58,961,083 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,335,244 - 57,362,974 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,710,934 - 56,738,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,711,049 - 56,738,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,478,171 - 56,505,940 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,313,707 - 56,341,400 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1456,572,156 - 56,598,993 (+)NCBI
Celera453,142,130 - 53,169,823 (+)NCBICelera
Cytogenetic Map4q22NCBI
FLNC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387128,830,406 - 128,859,272 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7128,830,406 - 128,859,274 (+)EnsemblGRCh38hg38GRCh38
GRCh377128,470,460 - 128,499,326 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,257,719 - 128,286,572 (+)NCBINCBI36Build 36hg18NCBI36
Build 347128,064,593 - 128,093,276NCBI
Celera7123,266,997 - 123,295,842 (+)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7122,832,064 - 122,860,967 (+)NCBIHuRef
CHM1_17128,403,744 - 128,432,589 (+)NCBICHM1_1
T2T-CHM13v2.07130,143,333 - 130,172,198 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27127,854,228 - 127,883,073 (+)NCBI
Flnc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,433,150 - 29,461,888 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,433,255 - 29,461,882 (+)EnsemblGRCm39 Ensembl
GRCm38629,433,153 - 29,461,889 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,433,256 - 29,461,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,383,153 - 29,411,888 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36629,383,163 - 29,411,899 (+)NCBIMGSCv36mm8
Celera629,440,371 - 29,469,772 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
Flnc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554799,633,598 - 9,661,777 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554799,633,817 - 9,661,725 (+)NCBIChiLan1.0ChiLan1.0
FLNC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26165,634,918 - 165,663,848 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1717,645,161 - 17,674,094 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07120,782,584 - 120,811,504 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17133,307,041 - 133,335,896 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7133,307,041 - 133,335,896 (+)Ensemblpanpan1.1panPan2
FLNC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1147,792,708 - 7,819,723 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,793,449 - 7,819,940 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha147,479,565 - 7,506,435 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0147,558,590 - 7,585,437 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,558,591 - 7,585,635 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1147,763,614 - 7,790,446 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,505,626 - 7,532,496 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,651,043 - 7,677,902 (-)NCBIUU_Cfam_GSD_1.0
Flnc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511854,632,610 - 54,660,604 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647915,756,370 - 15,784,359 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647915,756,370 - 15,784,365 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLNC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1819,759,740 - 19,787,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11819,759,734 - 19,787,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,855,080 - 20,882,950 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FLNC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,431,666 - 97,460,178 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,431,648 - 97,461,135 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660425,941,273 - 5,970,541 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flnc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247837,334,312 - 7,361,134 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247837,334,421 - 7,360,795 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flnc
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:127
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000027237
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 6 6 6 8 11 13 18 33 7 8
Low 35 19 17 19 61 11 8 4
Below cutoff 16 16 2 16 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027237   ⟹   ENSRNOP00000027237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl458,034,189 - 58,061,844 (+)Ensembl
Rnor_6.0 Ensembl456,711,049 - 56,738,791 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088149   ⟹   ENSRNOP00000070379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl458,034,189 - 58,061,844 (+)Ensembl
Rnor_6.0 Ensembl456,711,275 - 56,738,100 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098293   ⟹   ENSRNOP00000079220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl458,038,691 - 58,061,844 (+)Ensembl
RefSeq Acc Id: NM_001191862   ⟹   NP_001178791
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,999,547 - 59,027,240 (+)NCBI
mRatBN7.2458,034,189 - 58,061,882 (+)NCBI
Rnor_6.0456,711,086 - 56,738,779 (+)NCBI
Rnor_5.0456,478,171 - 56,505,940 (+)NCBI
Celera453,142,130 - 53,169,823 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236214   ⟹   XP_006236276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,999,447 - 59,027,236 (+)NCBI
mRatBN7.2458,034,090 - 58,061,878 (+)NCBI
Rnor_6.0456,710,934 - 56,738,775 (+)NCBI
Rnor_5.0456,478,171 - 56,505,940 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107774   ⟹   XP_038963702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,999,445 - 59,027,236 (+)NCBI
mRatBN7.2458,034,088 - 58,061,878 (+)NCBI
RefSeq Acc Id: XM_039107775   ⟹   XP_038963703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,999,446 - 59,027,236 (+)NCBI
mRatBN7.2458,034,089 - 58,061,878 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001178791   ⟸   NM_001191862
- UniProtKB: D3ZHA0 (UniProtKB/Swiss-Prot),   A0A8L2R384 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236276   ⟸   XM_006236214
- Peptide Label: isoform X3
- UniProtKB: A0A0H2UHR7 (UniProtKB/TrEMBL),   A0A8L2R384 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027237   ⟸   ENSRNOT00000027237
RefSeq Acc Id: ENSRNOP00000070379   ⟸   ENSRNOT00000088149
RefSeq Acc Id: XP_038963702   ⟸   XM_039107774
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R384 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963703   ⟸   XM_039107775
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R384 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079220   ⟸   ENSRNOT00000098293
Protein Domains
Calponin-homology (CH)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692931
Promoter ID:EPDNEW_R3449
Type:single initiation site
Name:Flnc_1
Description:filamin C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0456,711,073 - 56,711,133EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308807 AgrOrtholog
BioCyc Gene G2FUF-45394 BioCyc
Ensembl Genes ENSRNOG00000007281 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055022203 UniProtKB/Swiss-Prot
  ENSRNOG00060027001 UniProtKB/Swiss-Prot
  ENSRNOG00065025534 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027237 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000027237.8 UniProtKB/Swiss-Prot
  ENSRNOT00000088149.2 UniProtKB/TrEMBL
  ENSRNOT00000098293.1 UniProtKB/TrEMBL
  ENSRNOT00055038200 UniProtKB/Swiss-Prot
  ENSRNOT00060046965 UniProtKB/Swiss-Prot
  ENSRNOT00065044058 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Filamin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Filamin/ABP280_repeat-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Filamin/ABP280_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362332 UniProtKB/Swiss-Prot
NCBI Gene 362332 ENTREZGENE
PANTHER JITTERBUG, ISOFORM N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR38537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filamin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Flnc PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FILAMIN_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007281 RatGTEx
  ENSRNOG00055022203 RatGTEx
  ENSRNOG00060027001 RatGTEx
  ENSRNOG00065025534 RatGTEx
SMART IG_FLMN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHR7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMA0_RAT UniProtKB/TrEMBL
  A0A8L2R384 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHA0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Flnc  filamin C  Flnc  filamin C, gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Flnc  filamin C, gamma  Flnc  filamin C, gamma (actin binding protein 280)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Flnc  filamin C, gamma (actin binding protein 280)   Flnc_predicted  filamin C, gamma (actin binding protein 280) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Flnc_predicted  filamin C, gamma (actin binding protein 280) (predicted)      Symbol and Name status set to approved 70820 APPROVED