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Gene: Gsdmd (gasdermin D) Rattus norvegicus

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Symbol:

Gsdmd

Name:

gasdermin D

RGD ID:

1307261

Description:

Predicted to enable phospholipid binding activity; transcription coactivator activity; and wide pore channel activity. Predicted to be involved in several processes, including defense response to bacterium; positive regulation of cytokine production; and protein-containing complex assembly. Predicted to be located in several cellular components, including extracellular space; mitochondrial membrane; and nucleoplasm. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in plasma membrane. Orthologous to human GSDMD (gasdermin D); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

gasdermin domain containing 1; gasdermin-D; Gsdmdc1; LOC315084

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GSDMD (gasdermin D)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Gsdmd (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gsdmd (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GSDMD (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GSDMD (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gsdmd (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GSDMD (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GSDMD (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gsdmd (gasdermin D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GSDMD (gasdermin D)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gsdmd (gasdermin D)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	109,423,209 - 109,427,771 (+)	NCBI		GRCr8
mRatBN7.2	7	107,542,489 - 107,547,051 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	107,542,083 - 107,547,055 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	109,281,502 - 109,286,064 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	111,505,178 - 111,509,740 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	111,451,127 - 111,455,689 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	116,889,147 - 116,894,134 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	116,889,572 - 116,894,134 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	116,781,947 - 116,786,875 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	113,832,420 - 113,837,007 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	113,847,420 - 113,871,239 (+)	NCBI
Celera	7	103,902,119 - 103,906,706 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsdmd	Rat	Brown-Vialetto-Van Laere syndrome 2		ISO	GSDMD (Homo sapiens)	8554872	ClinVar Annotator: match by term: Brown-Vialetto-van Laere syndrome 2	ClinVar	PMID:20301336 more ...
Gsdmd	Rat	epidermolysis bullosa simplex with muscular dystrophy		ISO	GSDMD (Homo sapiens)	8554872	ClinVar Annotator: match by term: Epidermolysis bullosa simplex 5B and with muscular dystrophy	ClinVar	PMID:20301336 more ...
Gsdmd	Rat	holoprosencephaly		ISO	GSDMD (Homo sapiens)	8554872	ClinVar Annotator: match by term: Holoprosencephaly sequence	ClinVar	PMID:28492532
Gsdmd	Rat	Recombinant Chromosome 8 Syndrome		ISO	GSDMD (Homo sapiens)	8554872	ClinVar Annotator: match by term: Recombinant 8 syndrome	ClinVar	PMID:31690835

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsdmd	Rat	(-)-epigallocatechin 3-gallate	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	epigallocatechin gallate inhibits the reaction [bisphenol A results in increased expression of GSDMD mRNA] and epigallocatechin gallate inhibits the reaction [bisphenol A results in increased expression of GSDMD protein]	CTD	PMID:35439536
Gsdmd	Rat	(1->4)-beta-D-glucan	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of GSDMD mRNA	CTD	PMID:36331819
Gsdmd	Rat	(S)-ropivacaine	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein] more ...	CTD	PMID:36858639
Gsdmd	Rat	(S)-ropivacaine	increases cleavage	ISO	GSDMD (Homo sapiens)	6480464	Ropivacaine results in increased cleavage of GSDMD protein	CTD	PMID:36858639
Gsdmd	Rat	1,1-dichloroethene	increases expression	ISO	Gsdmd (Mus musculus)	6480464	vinylidene chloride results in increased expression of GSDMD mRNA	CTD	PMID:26682919
Gsdmd	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GSDMD mRNA	CTD	PMID:22206623
Gsdmd	Rat	17beta-estradiol	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Estradiol results in increased expression of GSDMD mRNA	CTD	PMID:39298647
Gsdmd	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of GSDMD mRNA	CTD	PMID:21215274
Gsdmd	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of GSDMD mRNA	CTD	PMID:34747641
Gsdmd	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Tetrachlorodibenzodioxin results in increased expression of GSDMD mRNA	CTD	PMID:19933214 and PMID:23994337
Gsdmd	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Gsdmd (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of GSDMD mRNA	CTD	PMID:21570461
Gsdmd	Rat	2,5-hexanedione	multiple interactions	EXP		6480464	Glyburide inhibits the reaction [2 and 5-hexanedione results in increased cleavage of GSDMD protein]	CTD	PMID:32522579 and PMID:32860822
Gsdmd	Rat	2,5-hexanedione	increases cleavage	EXP		6480464	2 and 5-hexanedione results in increased cleavage of GSDMD protein	CTD	PMID:32522579 and PMID:32860822
Gsdmd	Rat	2-palmitoylglycerol	increases expression	ISO	GSDMD (Homo sapiens)	6480464	2-palmitoylglycerol results in increased expression of GSDMD mRNA	CTD	PMID:37199045
Gsdmd	Rat	3,3',4,4',5-pentachlorobiphenyl	increases expression	ISO	Gsdmd (Mus musculus)	6480464	3 more ...	CTD	PMID:23994337
Gsdmd	Rat	3-chloropropane-1,2-diol	increases cleavage	EXP		6480464	alpha-Chlorohydrin results in increased cleavage of GSDMD protein	CTD	PMID:33187795 and PMID:38373586
Gsdmd	Rat	3-chloropropane-1,2-diol	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]	CTD	PMID:38373586
Gsdmd	Rat	3-chloropropane-1,2-diol	multiple interactions	EXP		6480464	Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]] and ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]	CTD	PMID:38373586
Gsdmd	Rat	3-chloropropane-1,2-diol	increases cleavage	ISO	Gsdmd (Mus musculus)	6480464	alpha-Chlorohydrin results in increased cleavage of GSDMD protein	CTD	PMID:38373586
Gsdmd	Rat	3-methyladenine	multiple interactions	EXP		6480464	3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of GSDMD protein]	CTD	PMID:37654027
Gsdmd	Rat	3-methylcholanthrene	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Methylcholanthrene results in increased expression of GSDMD mRNA	CTD	PMID:20713471
Gsdmd	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	Gsdmd (Mus musculus)	6480464	bisphenol S results in increased expression of GSDMD mRNA	CTD	PMID:39298647
Gsdmd	Rat	4-hydroxybenzoic acid	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	4-hydroxybenzoic acid affects the reaction [lipopolysaccharide more ...	CTD	PMID:39389441
Gsdmd	Rat	4-phenylbutyric acid	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of GSDMD mRNA]	CTD	PMID:30796460
Gsdmd	Rat	4-phenylbutyric acid	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	4-phenylbutyric acid inhibits the reaction [7 more ...	CTD	PMID:35297523 and PMID:36646296
Gsdmd	Rat	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	6-chloro-2 more ...	CTD	PMID:38471628
Gsdmd	Rat	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	6-chloro-2 more ...	CTD	PMID:38471628
Gsdmd	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of GSDMD mRNA and Propylthiouracil results in increased expression of GSDMD protein	CTD	PMID:37047793
Gsdmd	Rat	7,9-dihydro-1H-purine-2,6,8(3H)-trione	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[lipopolysaccharide more ...	CTD	PMID:36577999
Gsdmd	Rat	aflatoxin B1	decreases expression	ISO	GSDMD (Homo sapiens)	6480464	Aflatoxin B1 results in decreased expression of GSDMD mRNA	CTD	PMID:27153756
Gsdmd	Rat	aflatoxin B1	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Aflatoxin B1 results in increased expression of GSDMD mRNA and Aflatoxin B1 results in increased expression of GSDMD protein	CTD	PMID:35063475
Gsdmd	Rat	aflatoxin B1	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD mRNA] and Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD protein]	CTD	PMID:35063475
Gsdmd	Rat	Aflatoxin B2 alpha	decreases methylation	ISO	GSDMD (Homo sapiens)	6480464	aflatoxin B2 results in decreased methylation of GSDMD intron	CTD	PMID:30157460
Gsdmd	Rat	aldehydo-D-glucose	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Glucose results in increased expression of GSDMD mRNA	CTD	PMID:34212273
Gsdmd	Rat	aldehydo-D-glucose	increases cleavage	ISO	GSDMD (Homo sapiens)	6480464	Glucose results in increased cleavage of GSDMD protein	CTD	PMID:35607288
Gsdmd	Rat	aldehydo-D-glucose	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of GSDMD protein alternative form more ...	CTD	PMID:35607288 more ...
Gsdmd	Rat	aldehydo-D-glucose	increases expression	ISO	GSDMD (Homo sapiens)	6480464	Glucose results in increased expression of GSDMD mRNA and Glucose results in increased expression of GSDMD protein	CTD	PMID:37473909 and PMID:38088496
Gsdmd	Rat	aldehydo-D-glucose	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Glucose results in increased expression of and results in increased cleavage of GSDMD protein more ...	CTD	PMID:34212273
Gsdmd	Rat	all-trans-retinoic acid	decreases expression	EXP		6480464	Tretinoin results in decreased expression of GSDMD mRNA	CTD	PMID:20488242
Gsdmd	Rat	aluminium hydroxide	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of GSDMD protein more ...	CTD	PMID:38176579
Gsdmd	Rat	andrographolide	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	andrographolide inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased cleavage of GSDMD protein]	CTD	PMID:37987454
Gsdmd	Rat	antirheumatic drug	decreases expression	ISO	GSDMD (Homo sapiens)	6480464	Antirheumatic Agents results in decreased expression of GSDMD mRNA	CTD	PMID:24449571
Gsdmd	Rat	apocynin	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of GSDMD protein]	CTD	PMID:30378427
Gsdmd	Rat	aristolochic acid A	increases cleavage	EXP		6480464	aristolochic acid I results in increased cleavage of GSDMD protein	CTD	PMID:36863539
Gsdmd	Rat	ATP	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	[Adenosine Triphosphate co-treated with lipopolysaccharide more ...	CTD	PMID:33851234 more ...
Gsdmd	Rat	ATP	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[lipopolysaccharide more ...	CTD	PMID:34212273 and PMID:36577999
Gsdmd	Rat	ATP	multiple interactions	EXP		6480464	[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein more ...	CTD	PMID:35962723
Gsdmd	Rat	atrazine	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Atrazine results in increased expression of GSDMD mRNA and Atrazine results in increased expression of GSDMD protein	CTD	PMID:38301994
Gsdmd	Rat	atrazine	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Acetylcysteine inhibits the reaction [Atrazine results in increased expression of GSDMD protein] more ...	CTD	PMID:38301994
Gsdmd	Rat	Bavachinin	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[Lipopolysaccharides co-treated with bavachinin] results in increased cleavage of GSDMD protein more ...	CTD	PMID:38969277
Gsdmd	Rat	Bavachinin	increases cleavage	ISO	Gsdmd (Mus musculus)	6480464	bavachinin results in increased cleavage of GSDMD protein	CTD	PMID:38969277
Gsdmd	Rat	bellidifolin	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of GSDMD protein alternative form] and bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSDMD protein]	CTD	PMID:37127800
Gsdmd	Rat	Belnacasan	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	belnacasan affects the reaction [diallyl trisulfide results in increased expression of and results in increased cleavage of GSDMD protein]	CTD	PMID:38821455
Gsdmd	Rat	benzo[a]pyrene	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Benzo(a)pyrene results in increased expression of GSDMD mRNA	CTD	PMID:20713471 more ...
Gsdmd	Rat	benzo[a]pyrene	multiple interactions	EXP		6480464	[Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased expression of GSDMD mRNA and [Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased expression of GSDMD protein	CTD	PMID:36592837
Gsdmd	Rat	benzo[a]pyrene	decreases methylation	ISO	GSDMD (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of GSDMD exon and Benzo(a)pyrene results in decreased methylation of GSDMD promoter	CTD	PMID:27901495
Gsdmd	Rat	benzo[a]pyrene	affects methylation	ISO	GSDMD (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of GSDMD 5' UTR and Benzo(a)pyrene affects the methylation of GSDMD intron	CTD	PMID:27901495 and PMID:30157460
Gsdmd	Rat	benzo[a]pyrene diol epoxide I	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	4-phenylbutyric acid inhibits the reaction [7 more ...	CTD	PMID:35297523
Gsdmd	Rat	benzo[b]fluoranthene	increases expression	ISO	Gsdmd (Mus musculus)	6480464	benzo(b)fluoranthene results in increased expression of GSDMD mRNA	CTD	PMID:26377693
Gsdmd	Rat	benzo[e]pyrene	decreases methylation	ISO	GSDMD (Homo sapiens)	6480464	benzo(e)pyrene results in decreased methylation of GSDMD intron	CTD	PMID:30157460
Gsdmd	Rat	beta-cyclodextrin	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of GSDMD protein and lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of GSDMD protein]	CTD	PMID:36577999
Gsdmd	Rat	beta-naphthoflavone	increases expression	ISO	Gsdmd (Mus musculus)	6480464	beta-Naphthoflavone results in increased expression of GSDMD mRNA	CTD	PMID:23994337
Gsdmd	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Diethylhexyl Phthalate results in increased expression of GSDMD protein	CTD	PMID:36610486
Gsdmd	Rat	bis(2-ethylhexyl) phthalate	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	4-methyl-N1-(3-phenylpropyl)benzene-1 more ...	CTD	PMID:36610486 and PMID:36774801
Gsdmd	Rat	bis(2-ethylhexyl) phthalate	increases cleavage	ISO	GSDMD (Homo sapiens)	6480464	Diethylhexyl Phthalate results in increased cleavage of GSDMD protein	CTD	PMID:36774801
Gsdmd	Rat	bis(2-ethylhexyl) phthalate	increases cleavage	ISO	Gsdmd (Mus musculus)	6480464	Diethylhexyl Phthalate results in increased cleavage of GSDMD protein	CTD	PMID:36774801
Gsdmd	Rat	bis(2-ethylhexyl) phthalate	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	4-methyl-N1-(3-phenylpropyl)benzene-1 more ...	CTD	PMID:36774801
Gsdmd	Rat	bisphenol A	decreases expression	ISO	GSDMD (Homo sapiens)	6480464	bisphenol A results in decreased expression of GSDMD mRNA	CTD	PMID:19371625
Gsdmd	Rat	bisphenol A	increases expression	ISO	GSDMD (Homo sapiens)	6480464	bisphenol A results in increased expression of GSDMD mRNA and bisphenol A results in increased expression of GSDMD protein	CTD	PMID:35439536
Gsdmd	Rat	bisphenol A	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [bisphenol A results in increased expression of GSDMD mRNA] more ...	CTD	PMID:35439536
Gsdmd	Rat	bisphenol A	decreases methylation	ISO	GSDMD (Homo sapiens)	6480464	bisphenol A results in decreased methylation of GSDMD gene	CTD	PMID:31601247
Gsdmd	Rat	bisphenol A	increases expression	ISO	Gsdmd (Mus musculus)	6480464	bisphenol A results in increased expression of GSDMD mRNA	CTD	PMID:33221593
Gsdmd	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of GSDMD gene	CTD	PMID:28505145
Gsdmd	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of GSDMD mRNA	CTD	PMID:25181051
Gsdmd	Rat	cadmium acetate	multiple interactions	EXP		6480464	Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of GSDMD protein]	CTD	PMID:36347317
Gsdmd	Rat	cadmium acetate	increases expression	EXP		6480464	cadmium acetate results in increased expression of GSDMD protein	CTD	PMID:36347317
Gsdmd	Rat	cadmium atom	multiple interactions	EXP		6480464	icariin inhibits the reaction [Cadmium results in increased expression of GSDMD mRNA]	CTD	PMID:39197519
Gsdmd	Rat	cadmium atom	increases cleavage	ISO	Gsdmd (Mus musculus)	6480464	Cadmium results in increased cleavage of GSDMD protein	CTD	PMID:38944328
Gsdmd	Rat	cadmium atom	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	AIM2 protein affects the reaction [Cadmium results in increased cleavage of GSDMD protein] and Melatonin inhibits the reaction [Cadmium results in increased cleavage of GSDMD protein]	CTD	PMID:38944328
Gsdmd	Rat	cadmium atom	increases expression	EXP		6480464	Cadmium results in increased expression of GSDMD mRNA	CTD	PMID:39197519
Gsdmd	Rat	cadmium dichloride	affects expression	EXP		6480464	Cadmium Chloride affects the expression of GSDMD mRNA	CTD	PMID:22110744
Gsdmd	Rat	cadmium dichloride	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of GSDMD mRNA]	CTD	PMID:30796460
Gsdmd	Rat	cadmium dichloride	increases expression	ISO	GSDMD (Homo sapiens)	6480464	Cadmium Chloride results in increased expression of GSDMD mRNA	CTD	PMID:30796460
Gsdmd	Rat	cadmium dichloride	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased expression of GSDMD mRNA] more ...	CTD	PMID:30796460
Gsdmd	Rat	cannabidiol	decreases expression	ISO	GSDMD (Homo sapiens)	6480464	Cannabidiol results in decreased expression of GSDMD protein	CTD	PMID:34269108
Gsdmd	Rat	cannabidiol	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	2-chloro-5-nitrobenzanilide inhibits the reaction [Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]] and Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]	CTD	PMID:34269108
Gsdmd	Rat	carbon nanotube	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Nanotubes and Carbon analog results in increased expression of GSDMD mRNA	CTD	PMID:25554681
Gsdmd	Rat	carbon nanotube	decreases expression	ISO	Gsdmd (Mus musculus)	6480464	Nanotubes more ...	CTD	PMID:25620056
Gsdmd	Rat	chitosan	multiple interactions	EXP		6480464	Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in decreased expression of GSDMD mRNA]]	CTD	PMID:38369055
Gsdmd	Rat	chloroquine	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	Chloroquine promotes the reaction [[lipopolysaccharide and Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of and results in increased cleavage of GSDMD protein]	CTD	PMID:34920032
Gsdmd	Rat	chlorquinaldol	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of GSDMD protein]	CTD	PMID:36002070
Gsdmd	Rat	cisplatin	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	[Cisplatin co-treated with jinfukang] results in increased expression of GSDMD mRNA	CTD	PMID:27392435
Gsdmd	Rat	copper atom	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	[NSC 689534 binds to Copper] which results in decreased expression of GSDMD mRNA	CTD	PMID:20971185
Gsdmd	Rat	copper(0)	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	[NSC 689534 binds to Copper] which results in decreased expression of GSDMD mRNA	CTD	PMID:20971185
Gsdmd	Rat	copper(II) sulfate	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Copper Sulfate results in increased expression of GSDMD mRNA and Copper Sulfate results in increased expression of GSDMD protein	CTD	PMID:37353053
Gsdmd	Rat	copper(II) sulfate	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Copper Sulfate results in increased expression of GSDMD mRNA] more ...	CTD	PMID:37353053
Gsdmd	Rat	curcumin	multiple interactions	EXP		6480464	Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in decreased expression of GSDMD mRNA]] and Curcumin inhibits the reaction [fenpropathrin results in decreased expression of GSDMD mRNA]	CTD	PMID:38369055
Gsdmd	Rat	curcumin	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide more ...	CTD	PMID:34998855 more ...
Gsdmd	Rat	cyclosporin A	decreases expression	ISO	Gsdmd (Mus musculus)	6480464	Cyclosporine results in decreased expression of GSDMD mRNA	CTD	PMID:19770486
Gsdmd	Rat	cyclosporin A	multiple interactions	EXP		6480464	Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]]	CTD	PMID:38373586
Gsdmd	Rat	D-glucose	increases expression	ISO	GSDMD (Homo sapiens)	6480464	Glucose results in increased expression of GSDMD mRNA and Glucose results in increased expression of GSDMD protein	CTD	PMID:37473909 and PMID:38088496
Gsdmd	Rat	D-glucose	increases cleavage	ISO	GSDMD (Homo sapiens)	6480464	Glucose results in increased cleavage of GSDMD protein	CTD	PMID:35607288
Gsdmd	Rat	D-glucose	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of GSDMD protein alternative form more ...	CTD	PMID:35607288 more ...
Gsdmd	Rat	D-glucose	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Glucose results in increased expression of and results in increased cleavage of GSDMD protein more ...	CTD	PMID:34212273
Gsdmd	Rat	D-glucose	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Glucose results in increased expression of GSDMD mRNA	CTD	PMID:34212273
Gsdmd	Rat	D-penicillamine	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Penicillamine inhibits the reaction [NLRP3 mutant form results in increased cleavage of GSDMD protein]	CTD	PMID:38761876
Gsdmd	Rat	DDE	increases expression	ISO	GSDMD (Homo sapiens)	6480464	Dichlorodiphenyl Dichloroethylene results in increased expression of GSDMD mRNA	CTD	PMID:38568856
Gsdmd	Rat	deoxynivalenol	increases expression	ISO	Gsdmd (Mus musculus)	6480464	deoxynivalenol results in increased expression of GSDMD mRNA and deoxynivalenol results in increased expression of GSDMD protein	CTD	PMID:36309173
Gsdmd	Rat	deoxynivalenol	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	deoxynivalenol promotes the reaction [fumonisin B1 results in increased expression of GSDMD mRNA] more ...	CTD	PMID:35925383 and PMID:36309173
Gsdmd	Rat	dexamethasone	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide and Escherichia coli O111 B4] results in increased expression of GSDMD protein]	CTD	PMID:34998855
Gsdmd	Rat	dexamethasone	multiple interactions	EXP		6480464	PPARG protein inhibits the reaction [Dexamethasone results in increased expression of GSDMD protein]	CTD	PMID:38286393
Gsdmd	Rat	dexamethasone	increases expression	EXP		6480464	Dexamethasone results in increased expression of GSDMD protein	CTD	PMID:38286393
Gsdmd	Rat	dexmedetomidine	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein] more ...	CTD	PMID:36858639
Gsdmd	Rat	dextran sulfate	increases cleavage	ISO	Gsdmd (Mus musculus)	6480464	Dextran Sulfate results in increased cleavage of GSDMD protein	CTD	PMID:37001609
Gsdmd	Rat	dextran sulfate	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased cleavage of GSDMD protein] and Mesalamine inhibits the reaction [Dextran Sulfate results in increased cleavage of GSDMD protein]	CTD	PMID:37001609
Gsdmd	Rat	diallyl trisulfide	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	Acetylcysteine affects the reaction [diallyl trisulfide results in increased expression of and results in increased cleavage of GSDMD protein] more ...	CTD	PMID:38821455
Gsdmd	Rat	diallyl trisulfide	increases expression	ISO	GSDMD (Homo sapiens)	6480464	diallyl trisulfide results in increased expression of GSDMD protein	CTD	PMID:38821455
Gsdmd	Rat	Dibutyl phosphate	affects expression	ISO	GSDMD (Homo sapiens)	6480464	di-n-butylphosphoric acid affects the expression of GSDMD mRNA	CTD	PMID:37042841
Gsdmd	Rat	dibutyl phthalate	multiple interactions	EXP		6480464	[Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased expression of GSDMD mRNA and [Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased expression of GSDMD protein	CTD	PMID:36592837
Gsdmd	Rat	diclofenac	increases cleavage	EXP		6480464	Diclofenac results in increased cleavage of GSDMD protein	CTD	PMID:38582345
Gsdmd	Rat	diclofenac	multiple interactions	EXP		6480464	diacerein inhibits the reaction [Diclofenac results in increased cleavage of GSDMD protein]	CTD	PMID:38582345
Gsdmd	Rat	dimethyl fumarate	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	Dimethyl Fumarate inhibits the reaction [piperlongumine results in increased expression of GSDMD protein]	CTD	PMID:38242274
Gsdmd	Rat	dioxygen	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of GSDMD protein alternative form more ...	CTD	PMID:37127800
Gsdmd	Rat	dioxygen	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Oxygen deficiency results in increased expression of GSDMD mRNA	CTD	PMID:39038764
Gsdmd	Rat	dioxygen	increases cleavage	ISO	Gsdmd (Mus musculus)	6480464	Oxygen deficiency results in increased cleavage of GSDMD protein	CTD	PMID:39038764
Gsdmd	Rat	diquat	decreases expression	ISO	Gsdmd (Mus musculus)	6480464	Diquat results in decreased expression of GSDMD protein	CTD	PMID:36851058
Gsdmd	Rat	disulfiram	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	Disulfiram binds to and results in decreased activity of GSDMD protein and Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]	CTD	PMID:32367036 and PMID:33851234
Gsdmd	Rat	disulfiram	decreases cleavage	ISO	GSDMD (Homo sapiens)	6480464	Disulfiram results in decreased cleavage of GSDMD protein	CTD	PMID:33851234
Gsdmd	Rat	eritoran	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of GSDMD protein]	CTD	PMID:38761876
Gsdmd	Rat	fenpropathrin	decreases expression	EXP		6480464	fenpropathrin results in decreased expression of GSDMD mRNA	CTD	PMID:38369055
Gsdmd	Rat	fenpropathrin	multiple interactions	EXP		6480464	Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in decreased expression of GSDMD mRNA]] and Curcumin inhibits the reaction [fenpropathrin results in decreased expression of GSDMD mRNA]	CTD	PMID:38369055
Gsdmd	Rat	folic acid	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GSDMD mRNA	CTD	PMID:22206623
Gsdmd	Rat	fulvestrant	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of GSDMD mRNA] and Fulvestrant inhibits the reaction [bisphenol A results in increased expression of GSDMD protein]	CTD	PMID:35439536
Gsdmd	Rat	fumonisin B1	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	deoxynivalenol promotes the reaction [fumonisin B1 results in increased expression of GSDMD mRNA] more ...	CTD	PMID:36309173
Gsdmd	Rat	fumonisin B1	increases expression	ISO	Gsdmd (Mus musculus)	6480464	fumonisin B1 results in increased expression of GSDMD mRNA and fumonisin B1 results in increased expression of GSDMD protein	CTD	PMID:36309173
Gsdmd	Rat	ginsenoside Rb1	multiple interactions	EXP		6480464	Cyclosporine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]] and ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]	CTD	PMID:38373586
Gsdmd	Rat	ginsenoside Rb1	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of GSDMD protein]	CTD	PMID:38373586
Gsdmd	Rat	glafenine	decreases expression	EXP		6480464	Glafenine results in decreased expression of GSDMD mRNA	CTD	PMID:24136188
Gsdmd	Rat	glucose	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Glucose results in increased expression of and results in increased cleavage of GSDMD protein more ...	CTD	PMID:34212273
Gsdmd	Rat	glucose	increases cleavage	ISO	GSDMD (Homo sapiens)	6480464	Glucose results in increased cleavage of GSDMD protein	CTD	PMID:35607288
Gsdmd	Rat	glucose	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of GSDMD protein alternative form more ...	CTD	PMID:35607288 more ...
Gsdmd	Rat	glucose	increases expression	ISO	GSDMD (Homo sapiens)	6480464	Glucose results in increased expression of GSDMD mRNA and Glucose results in increased expression of GSDMD protein	CTD	PMID:37473909 and PMID:38088496
Gsdmd	Rat	glucose	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Glucose results in increased expression of GSDMD mRNA	CTD	PMID:34212273
Gsdmd	Rat	glyburide	multiple interactions	EXP		6480464	Glyburide inhibits the reaction [2 and 5-hexanedione results in increased cleavage of GSDMD protein]	CTD	PMID:32522579 and PMID:32860822
Gsdmd	Rat	glycerol	multiple interactions	EXP		6480464	Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of GSDMD protein] and Thiamine inhibits the reaction [Glycerol results in increased cleavage of GSDMD protein]	CTD	PMID:36690085
Gsdmd	Rat	glycerol	increases cleavage	EXP		6480464	Glycerol results in increased cleavage of GSDMD protein	CTD	PMID:36690085
Gsdmd	Rat	glycidol	increases cleavage	EXP		6480464	glycidol results in increased cleavage of GSDMD protein	CTD	PMID:33187795
Gsdmd	Rat	graphene oxide	increases expression	ISO	GSDMD (Homo sapiens)	6480464	graphene oxide results in increased expression of GSDMD mRNA	CTD	PMID:33973267
Gsdmd	Rat	GW 4064	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased cleavage of GSDMD protein]	CTD	PMID:36328986
Gsdmd	Rat	hyaluronic acid	increases cleavage	EXP		6480464	Hyaluronic Acid results in increased cleavage of GSDMD protein	CTD	PMID:33383130
Gsdmd	Rat	hyaluronic acid	increases expression	EXP		6480464	Hyaluronic Acid results in increased expression of GSDMD mRNA	CTD	PMID:33383130
Gsdmd	Rat	hydroquinone	increases expression	ISO	GSDMD (Homo sapiens)	6480464	hydroquinone results in increased expression of GSDMD protein	CTD	PMID:36646296
Gsdmd	Rat	hydroquinone	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [hydroquinone results in increased expression of GSDMD protein] more ...	CTD	PMID:36646296
Gsdmd	Rat	hydroxysafflor yellow A	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	HK1 protein affects the reaction [hydroxysafflor yellow A inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide more ...	CTD	PMID:37001609
Gsdmd	Rat	hydroxysafflor yellow A	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased cleavage of GSDMD protein]	CTD	PMID:37001609
Gsdmd	Rat	icariin	multiple interactions	EXP		6480464	icariin inhibits the reaction [Cadmium results in increased expression of GSDMD mRNA]	CTD	PMID:39197519
Gsdmd	Rat	imiquimod	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[lipopolysaccharide more ...	CTD	PMID:36577999
Gsdmd	Rat	isoflurane	increases cleavage	ISO	Gsdmd (Mus musculus)	6480464	Isoflurane results in increased cleavage of GSDMD protein	CTD	PMID:35187972
Gsdmd	Rat	isoflurane	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	SETD7 protein affects the reaction [Isoflurane results in increased cleavage of GSDMD protein]	CTD	PMID:35187972
Gsdmd	Rat	ivermectin	decreases expression	ISO	GSDMD (Homo sapiens)	6480464	Ivermectin results in decreased expression of GSDMD protein	CTD	PMID:32959892
Gsdmd	Rat	lipopolysaccharide	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	2-chloro-5-nitrobenzanilide inhibits the reaction [Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]] more ...	CTD	PMID:33851234 more ...
Gsdmd	Rat	lipopolysaccharide	increases cleavage	ISO	Gsdmd (Mus musculus)	6480464	Lipopolysaccharides results in increased cleavage of GSDMD protein	CTD	PMID:38969277
Gsdmd	Rat	lipopolysaccharide	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Lipopolysaccharides results in increased expression of GSDMD mRNA and Lipopolysaccharides results in increased expression of GSDMD protein	CTD	PMID:37379125 more ...
Gsdmd	Rat	lipopolysaccharide	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased cleavage of GSDMD protein more ...	CTD	PMID:34212273 more ...
Gsdmd	Rat	lipopolysaccharide	multiple interactions	EXP		6480464	3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of GSDMD protein] more ...	CTD	PMID:35962723 and PMID:37654027
Gsdmd	Rat	lipopolysaccharide	increases cleavage	ISO	GSDMD (Homo sapiens)	6480464	Lipopolysaccharides results in increased cleavage of GSDMD protein	CTD	PMID:34791735
Gsdmd	Rat	lipopolysaccharide	increases expression	EXP		6480464	Lipopolysaccharides results in increased expression of GSDMD protein	CTD	PMID:37654027
Gsdmd	Rat	loganin	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	loganin inhibits the reaction [Glucose results in increased expression of GSDMD mRNA] and loganin inhibits the reaction [Glucose results in increased expression of GSDMD protein]	CTD	PMID:37473909
Gsdmd	Rat	loganin	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	loganin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GSDMD mRNA] and loganin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GSDMD protein]	CTD	PMID:37473909
Gsdmd	Rat	lonidamine	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	lonidamine inhibits the reaction [[lipopolysaccharide more ...	CTD	PMID:36577999
Gsdmd	Rat	luteolin	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein]	CTD	PMID:34217685
Gsdmd	Rat	luteolin	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of GSDMD protein]	CTD	PMID:37379125
Gsdmd	Rat	LY294002	multiple interactions	EXP		6480464	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased cleavage of GSDMD protein]] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased expression of GSDMD mRNA]]	CTD	PMID:36094782 and PMID:36898572
Gsdmd	Rat	lycopene	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of GSDMD protein]	CTD	PMID:36610486
Gsdmd	Rat	melatonin	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Melatonin inhibits the reaction [Cadmium results in increased cleavage of GSDMD protein]	CTD	PMID:38944328
Gsdmd	Rat	mesalamine	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Mesalamine inhibits the reaction [Dextran Sulfate results in increased cleavage of GSDMD protein]	CTD	PMID:37001609
Gsdmd	Rat	methapyrilene	decreases methylation	ISO	GSDMD (Homo sapiens)	6480464	Methapyrilene results in decreased methylation of GSDMD intron	CTD	PMID:30157460
Gsdmd	Rat	N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Copper Sulfate results in increased expression of GSDMD mRNA] and N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Copper Sulfate results in increased expression of GSDMD protein]	CTD	PMID:37353053
Gsdmd	Rat	N-acetyl-L-cysteine	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	Acetylcysteine affects the reaction [diallyl trisulfide results in increased expression of and results in increased cleavage of GSDMD protein] more ...	CTD	PMID:30378427 more ...
Gsdmd	Rat	N-acetyl-L-cysteine	increases expression	ISO	GSDMD (Homo sapiens)	6480464	Acetylcysteine results in increased expression of GSDMD protein	CTD	PMID:36646296
Gsdmd	Rat	N-acetyl-L-cysteine	multiple interactions	EXP		6480464	Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of GSDMD protein]	CTD	PMID:36347317
Gsdmd	Rat	N-acetyl-L-cysteine	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of GSDMD mRNA] more ...	CTD	PMID:36354081 and PMID:38301994
Gsdmd	Rat	N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	[lipopolysaccharide more ...	CTD	PMID:34920032
Gsdmd	Rat	nickel atom	increases expression	ISO	GSDMD (Homo sapiens)	6480464	Nickel results in increased expression of GSDMD mRNA	CTD	PMID:25583101
Gsdmd	Rat	nigericin	multiple interactions	EXP		6480464	Nigericin inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased cleavage of GSDMD protein]]	CTD	PMID:36898572
Gsdmd	Rat	nigericin	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	4-hydroxybenzoic acid inhibits the reaction [[Nigericin co-treated with lipopolysaccharide more ...	CTD	PMID:36002070 more ...
Gsdmd	Rat	Nonylphenol	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of GSDMD mRNA] and nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of GSDMD protein]	CTD	PMID:38176579
Gsdmd	Rat	obeticholic acid	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein]	CTD	PMID:36328986
Gsdmd	Rat	ochratoxin A	increases expression	ISO	Gsdmd (Mus musculus)	6480464	ochratoxin A results in increased expression of GSDMD mRNA and ochratoxin A results in increased expression of GSDMD protein	CTD	PMID:33543323
Gsdmd	Rat	ozone	multiple interactions	EXP		6480464	Ozone results in increased expression of and results in increased cleavage of GSDMD protein	CTD	PMID:33383130
Gsdmd	Rat	paclitaxel	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased expression of and results in increased cleavage of GSDMD protein] and Paclitaxel results in increased expression of and results in increased cleavage of GSDMD protein	CTD	PMID:31993881
Gsdmd	Rat	paclitaxel	affects response to substance	ISO	GSDMD (Homo sapiens)	6480464	GSDMD protein affects the susceptibility to Paclitaxel	CTD	PMID:31993881
Gsdmd	Rat	paeoniflorin	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	2-(1 more ...	CTD	PMID:38705442
Gsdmd	Rat	paeoniflorin	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	peoniflorin inhibits the reaction [Particulate Matter results in increased cleavage of GSDMD protein]	CTD	PMID:38705442
Gsdmd	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of GSDMD mRNA	CTD	PMID:33387578
Gsdmd	Rat	paraquat	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	mitoquinone inhibits the reaction [Paraquat results in increased cleavage of GSDMD protein]	CTD	PMID:38237652
Gsdmd	Rat	paraquat	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	mitoquinone inhibits the reaction [Paraquat results in increased cleavage of GSDMD protein] and SB 203580 inhibits the reaction [Paraquat results in increased cleavage of GSDMD protein]	CTD	PMID:38237652
Gsdmd	Rat	paraquat	increases cleavage	ISO	Gsdmd (Mus musculus)	6480464	Paraquat results in increased cleavage of GSDMD protein	CTD	PMID:38237652
Gsdmd	Rat	paraquat	increases cleavage	ISO	GSDMD (Homo sapiens)	6480464	Paraquat results in increased cleavage of GSDMD protein	CTD	PMID:38237652
Gsdmd	Rat	patulin	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	ATG5 protein affects the reaction [Patulin results in increased expression of and results in increased cleavage of GSDMD protein] more ...	CTD	PMID:33217525
Gsdmd	Rat	Pentoxifylline	multiple interactions	EXP		6480464	Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of GSDMD protein]	CTD	PMID:36690085
Gsdmd	Rat	perfluorohexanesulfonic acid	increases expression	ISO	Gsdmd (Mus musculus)	6480464	perfluorohexanesulfonic acid results in increased expression of GSDMD mRNA	CTD	PMID:37995155
Gsdmd	Rat	perfluorooctane-1-sulfonic acid	increases cleavage	ISO	Gsdmd (Mus musculus)	6480464	perfluorooctane sulfonic acid results in increased cleavage of GSDMD protein	CTD	PMID:34006824
Gsdmd	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of GSDMD mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of GSDMD mRNA	CTD	PMID:36331819
Gsdmd	Rat	pirinixic acid	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GSDMD mRNA	CTD	PMID:19710929
Gsdmd	Rat	pirinixic acid	decreases expression	ISO	Gsdmd (Mus musculus)	6480464	pirinixic acid results in decreased expression of GSDMD mRNA	CTD	PMID:23811191
Gsdmd	Rat	quartz	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	GSDMD promotes the reaction [Quartz results in increased secretion of IL1A protein]	CTD	PMID:36840754
Gsdmd	Rat	quercetin	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	Quercetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein] and Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]]	CTD	PMID:34791735
Gsdmd	Rat	resveratrol	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	Resveratrol inhibits the reaction [Aluminum Chloride results in increased expression of GSDMD mRNA] and Resveratrol inhibits the reaction [Aluminum Chloride results in increased expression of GSDMD protein]	CTD	PMID:34614429
Gsdmd	Rat	Ruscogenin	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	ruscogenin inhibits the reaction [piperlongumine results in increased expression of GSDMD protein]	CTD	PMID:38242274
Gsdmd	Rat	SB 203580	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	SB 203580 inhibits the reaction [Paraquat results in increased cleavage of GSDMD protein]	CTD	PMID:38237652
Gsdmd	Rat	scutellarin	multiple interactions	EXP		6480464	scutellarin inhibits the reaction [Streptozocin results in increased expression of GSDMD protein]	CTD	PMID:37081038
Gsdmd	Rat	sevoflurane	increases expression	EXP		6480464	Sevoflurane results in increased expression of GSDMD protein modified form	CTD	PMID:36155068
Gsdmd	Rat	sevoflurane	multiple interactions	EXP		6480464	PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of GSDMD protein modified form]	CTD	PMID:36155068
Gsdmd	Rat	silicon dioxide	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Silicon Dioxide results in increased expression of GSDMD mRNA and Silicon Dioxide results in increased expression of GSDMD protein	CTD	PMID:39362619
Gsdmd	Rat	sirolimus	multiple interactions	EXP		6480464	Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of GSDMD protein]	CTD	PMID:37654027
Gsdmd	Rat	sodium arsenite	multiple interactions	EXP		6480464	sodium arsenite results in increased expression of and results in decreased ubiquitination of GSDMD protein and sodium arsenite results in increased expression of and results in increased cleavage of GSDMD protein	CTD	PMID:34920032
Gsdmd	Rat	sodium arsenite	increases expression	ISO	GSDMD (Homo sapiens)	6480464	sodium arsenite results in increased expression of GSDMD mRNA	CTD	PMID:34032870
Gsdmd	Rat	sodium arsenite	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	[lipopolysaccharide more ...	CTD	PMID:34920032
Gsdmd	Rat	sodium arsenite	decreases expression	ISO	GSDMD (Homo sapiens)	6480464	sodium arsenite results in decreased expression of GSDMD mRNA	CTD	PMID:38568856
Gsdmd	Rat	sorafenib	increases expression	ISO	GSDMD (Homo sapiens)	6480464	Sorafenib results in increased expression of GSDMD protein	CTD	PMID:33271325
Gsdmd	Rat	streptozocin	increases expression	ISO	Gsdmd (Mus musculus)	6480464	Streptozocin results in increased expression of GSDMD mRNA	CTD	PMID:34212273
Gsdmd	Rat	streptozocin	multiple interactions	EXP		6480464	scutellarin inhibits the reaction [Streptozocin results in increased expression of GSDMD protein]	CTD	PMID:37081038
Gsdmd	Rat	streptozocin	increases expression	EXP		6480464	Streptozocin results in increased expression of GSDMD protein	CTD	PMID:37081038
Gsdmd	Rat	streptozocin	affects response to substance	ISO	Gsdmd (Mus musculus)	6480464	GSDMD protein affects the susceptibility to Streptozocin	CTD	PMID:34212273
Gsdmd	Rat	streptozocin	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[Dietary Fats co-treated with Streptozocin] results in increased expression of GSDMD mRNA more ...	CTD	PMID:34212273 and PMID:37473909
Gsdmd	Rat	temozolomide	increases expression	ISO	GSDMD (Homo sapiens)	6480464	Temozolomide results in increased expression of GSDMD mRNA	CTD	PMID:31758290
Gsdmd	Rat	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of GSDMD mRNA	CTD	PMID:31150632
Gsdmd	Rat	thapsigargin	increases expression	ISO	GSDMD (Homo sapiens)	6480464	Thapsigargin results in increased expression of GSDMD mRNA	CTD	PMID:30796460
Gsdmd	Rat	thiamine(1+) chloride	multiple interactions	EXP		6480464	Thiamine inhibits the reaction [Glycerol results in increased cleavage of GSDMD protein]	CTD	PMID:36690085
Gsdmd	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of GSDMD mRNA	CTD	PMID:23411599
Gsdmd	Rat	thiram	decreases expression	ISO	GSDMD (Homo sapiens)	6480464	Thiram results in decreased expression of GSDMD mRNA	CTD	PMID:38568856
Gsdmd	Rat	titanium dioxide	decreases methylation	ISO	Gsdmd (Mus musculus)	6480464	titanium dioxide results in decreased methylation of GSDMD gene	CTD	PMID:35295148
Gsdmd	Rat	triphenyl phosphate	affects expression	ISO	GSDMD (Homo sapiens)	6480464	triphenyl phosphate affects the expression of GSDMD mRNA	CTD	PMID:37042841
Gsdmd	Rat	Triptolide	increases expression	EXP		6480464	triptolide results in increased expression of GSDMD protein	CTD	PMID:32519852
Gsdmd	Rat	Triptolide	multiple interactions	ISO	Gsdmd (Mus musculus)	6480464	[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein more ...	CTD	PMID:36328986
Gsdmd	Rat	valproic acid	decreases expression	ISO	GSDMD (Homo sapiens)	6480464	Valproic Acid results in decreased expression of GSDMD mRNA	CTD	PMID:29154799 and PMID:29501571
Gsdmd	Rat	valproic acid	increases methylation	ISO	GSDMD (Homo sapiens)	6480464	Valproic Acid results in increased methylation of GSDMD gene	CTD	PMID:29154799 and PMID:29501571
Gsdmd	Rat	valproic acid	affects expression	ISO	GSDMD (Homo sapiens)	6480464	Valproic Acid affects the expression of GSDMD mRNA	CTD	PMID:25979313
Gsdmd	Rat	valproic acid	affects expression	ISO	Gsdmd (Mus musculus)	6480464	Valproic Acid affects the expression of GSDMD mRNA	CTD	PMID:17963808
Gsdmd	Rat	vinclozolin	decreases expression	EXP		6480464	vinclozolin results in decreased expression of GSDMD mRNA	CTD	PMID:23034163
Gsdmd	Rat	zearalenone	decreases expression	ISO	GSDMD (Homo sapiens)	6480464	Zearalenone results in decreased expression of GSDMD mRNA	CTD	PMID:19371625
Gsdmd	Rat	zinc protoporphyrin	multiple interactions	ISO	GSDMD (Homo sapiens)	6480464	zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]]	CTD	PMID:36858639

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsdmd	Rat	ceramide biosynthetic process	acts_upstream_of_or_within	ISO	Gsdmd (Mus musculus)	1624291	PMID:35705808	RGD	PMID:35705808
Gsdmd	Rat	defense response to bacterium	involved_in	IBA	MGI:1916396 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gsdmd	Rat	defense response to Gram-negative bacterium	involved_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986 and PMID:37988464	RGD	PMID:27383986 and PMID:37988464
Gsdmd	Rat	defense response to Gram-positive bacterium	involved_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	plasma membrane repair	acts_upstream_of_or_within	ISO	Gsdmd (Mus musculus)	1624291	PMID:35705808	RGD	PMID:35705808
Gsdmd	Rat	pore complex assembly	involved_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	positive regulation of inflammatory response	involved_in	ISO	GSDMD (Homo sapiens)	1624291	PMID:32109412 and PMID:33883744	RGD	PMID:32109412 and PMID:33883744
Gsdmd	Rat	positive regulation of inflammatory response	involved_in	IEA	UniProtKB:P57764 and ensembl:ENSP00000262580	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gsdmd	Rat	positive regulation of inflammatory response	involved_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	positive regulation of inflammatory response	acts_upstream_of_or_within	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	positive regulation of interleukin-1 beta production	involved_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:26611636 more ...	RGD	PMID:26611636 more ...
Gsdmd	Rat	positive regulation of interleukin-1 production	involved_in	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:33883744	RGD	PMID:33883744
Gsdmd	Rat	positive regulation of interleukin-18 production	involved_in	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:33883744	RGD	PMID:33883744
Gsdmd	Rat	programmed cell death	involved_in	IEA	UniProtKB-KW:KW-1210	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gsdmd	Rat	protein homooligomerization	involved_in	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:33883744 and PMID:38040708	RGD	PMID:33883744 and PMID:38040708
Gsdmd	Rat	protein homooligomerization	involved_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	protein maturation	acts_upstream_of_or_within	ISO	Gsdmd (Mus musculus)	1624291	PMID:35705808	RGD	PMID:35705808
Gsdmd	Rat	protein secretion	involved_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:35705808	RGD	PMID:35705808
Gsdmd	Rat	protein secretion	involved_in	IEA	UniProtKB:P57764 and ensembl:ENSP00000262580	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gsdmd	Rat	protein secretion	involved_in	ISO	GSDMD (Homo sapiens)	1624291	PMID:33883744 more ...	RGD	PMID:33883744 more ...
Gsdmd	Rat	pyroptotic cell death	involved_in	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:32820063 more ...	RGD	PMID:32820063 more ...
Gsdmd	Rat	pyroptotic cell death	involved_in	IEA	UniProtKB:P57764 and ensembl:ENSP00000262580	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gsdmd	Rat	pyroptotic cell death	involved_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:27339137 and PMID:27383986	RGD	PMID:27339137 and PMID:27383986
Gsdmd	Rat	pyroptotic cell death	involved_in	ISO	Gsdmd (Mus musculus) and UniProtKB:Q9D8T2-PRO_0000437528	1624291	PMID:32820063 and PMID:38538834	RGD	PMID:32820063 and PMID:38538834
Gsdmd	Rat	pyroptotic cell death	involved_in	ISO	Gsdmd (Mus musculus) and UniProtKB:Q9D8T2-PRO_0000437528	1624291	PMID:38632402	RGD	PMID:38632402
Gsdmd	Rat	pyroptotic cell death	involved_in	ISO	GSDMD (Homo sapiens)	1624291	PMID:32109412 more ...	RGD	PMID:32109412 more ...
Gsdmd	Rat	pyroptotic cell death	involved_in	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:36227980	RGD	PMID:36227980
Gsdmd	Rat	pyroptotic inflammatory response	involved_in	ISO	GSDMD (Homo sapiens)	1624291	PMID:36227980	RGD	PMID:36227980
Gsdmd	Rat	pyroptotic inflammatory response	involved_in	IEA	UniProtKB:P57764 and ensembl:ENSP00000262580	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gsdmd	Rat	pyroptotic inflammatory response	involved_in	ISO	Gsdmd (Mus musculus) and UniProtKB:Q9D8T2-PRO_0000437528	1624291	PMID:27339137 more ...	RGD	PMID:27339137 more ...
Gsdmd	Rat	pyroptotic inflammatory response	involved_in	IBA	MGI:1916396 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gsdmd	Rat	pyroptotic inflammatory response	involved_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:26611636 more ...	RGD	PMID:26611636 more ...
Gsdmd	Rat	pyroptotic inflammatory response	acts_upstream_of_or_within	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	pyroptotic inflammatory response	involved_in	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:32109412 and PMID:33883744	RGD	PMID:32109412 and PMID:33883744
Gsdmd	Rat	pyroptotic inflammatory response	involved_in	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:28392147 and PMID:30361383	RGD	PMID:28392147 and PMID:30361383
Gsdmd	Rat	transmembrane transport	involved_in	IEA	GO:0022829	1600115	GO_REF:0000108	GOC	GO_REF:0000108

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsdmd	Rat	cytosol	located_in	IEA	UniProtKB-SubCell:SL-0091	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Gsdmd	Rat	cytosol	located_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	extracellular space	located_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	membrane	is_active_in	ISO	GSDMD (Homo sapiens)	1624291	PMID:32109412 and PMID:33883744	RGD	PMID:32109412 and PMID:33883744
Gsdmd	Rat	membrane	is_active_in	IEA	UniProtKB:P57764 and ensembl:ENSP00000262580	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gsdmd	Rat	mitochondrial membrane	located_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:37001519	RGD	PMID:37001519
Gsdmd	Rat	NLRP3 inflammasome complex	part_of	ISO	Gsdmd (Mus musculus)	1624291	PMID:26611636	RGD	PMID:26611636
Gsdmd	Rat	NLRP3 inflammasome complex	part_of	IBA	MGI:1916396 and PANTHER:PTN000419163	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gsdmd	Rat	nucleoplasm	located_in	ISO	GSDMD (Homo sapiens)	1624291		RGD	GO_REF:0000052
Gsdmd	Rat	nucleoplasm	located_in	IEA	UniProtKB:P57764 and ensembl:ENSP00000262580	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gsdmd	Rat	plasma membrane	located_in	ISO	Gsdmd (Mus musculus) and UniProtKB:Q9D8T2-PRO_0000437528	1624291	PMID:27339137	RGD	PMID:27339137
Gsdmd	Rat	plasma membrane	is_active_in	IEA	UniProtKB:P57764 and ensembl:ENSP00000262580	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gsdmd	Rat	plasma membrane	is_active_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:27339137 more ...	RGD	PMID:27339137 more ...
Gsdmd	Rat	plasma membrane	located_in	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Gsdmd	Rat	plasma membrane	is_active_in	ISO	GSDMD (Homo sapiens)	1624291	PMID:32109412 and PMID:33883744	RGD	PMID:32109412 and PMID:33883744
Gsdmd	Rat	plasma membrane	is_active_in	ISO	Gsdmd (Mus musculus) and UniProtKB:Q9D8T2-PRO_0000437528	1624291	PMID:38538834	RGD	PMID:38538834
Gsdmd	Rat	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gsdmd	Rat	plasma membrane	is_active_in	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:36227980	RGD	PMID:36227980
Gsdmd	Rat	plasma membrane	located_in	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:33883744	RGD	PMID:33883744
Gsdmd	Rat	plasma membrane	is_active_in	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:38530158 and PMID:38599239	RGD	PMID:38530158 and PMID:38599239

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsdmd	Rat	cardiolipin binding	enables	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	phosphatidic acid binding	enables	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	phosphatidylinositol-4,5-bisphosphate binding	enables	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:27281216 and PMID:36227980	RGD	PMID:27281216 and PMID:36227980
Gsdmd	Rat	phosphatidylinositol-4,5-bisphosphate binding	enables	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	phosphatidylinositol-4,5-bisphosphate binding	enables	IBA	MGI:1916396 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gsdmd	Rat	phosphatidylinositol-4,5-bisphosphate binding	enables	IEA	UniProtKB:P57764 and ensembl:ENSP00000262580	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gsdmd	Rat	phosphatidylinositol-4-phosphate binding	enables	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:36227980	RGD	PMID:36227980
Gsdmd	Rat	phosphatidylinositol-4-phosphate binding	enables	IEA	UniProtKB:P57764 and ensembl:ENSP00000262580	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gsdmd	Rat	phosphatidylinositol-4-phosphate binding	enables	IBA	MGI:1916396 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gsdmd	Rat	phosphatidylinositol-4-phosphate binding	enables	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	phosphatidylserine binding	enables	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986	RGD	PMID:27383986
Gsdmd	Rat	phosphatidylserine binding	enables	IBA	MGI:1916396 and PANTHER:PTN000419132	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gsdmd	Rat	protein binding	enables	ISO	GSDMD (Homo sapiens)	1624291	UniProtKB:P0DTC9 more ...	RGD	PMID:25416956 more ...
Gsdmd	Rat	transcription coactivator activity	enables	ISO	Gsdmd (Mus musculus) and UniProtKB:Q9D8T2-PRO_0000459019	1624291	PMID:37327784	RGD	PMID:37327784
Gsdmd	Rat	wide pore channel activity	enables	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000459018	1624291	PMID:35794369	RGD	PMID:35794369
Gsdmd	Rat	wide pore channel activity	enables	IEA	UniProtKB:P57764 and ensembl:ENSP00000262580	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gsdmd	Rat	wide pore channel activity	enables	ISO	Gsdmd (Mus musculus) and UniProtKB:Q9D8T2-PRO_0000459020	1624291	PMID:35749514 and PMID:35794369	RGD	PMID:35749514 and PMID:35794369
Gsdmd	Rat	wide pore channel activity	enables	ISO	Gsdmd (Mus musculus)	1624291	PMID:27383986 more ...	RGD	PMID:27383986 more ...
Gsdmd	Rat	wide pore channel activity	enables	ISO	Gsdmd (Mus musculus) and UniProtKB:Q9D8T2-PRO_0000437528	1624291	PMID:27339137 and PMID:38632402	RGD	PMID:27339137 and PMID:38632402
Gsdmd	Rat	wide pore channel activity	enables	ISO	GSDMD (Homo sapiens)	1624291	PMID:32109412	RGD	PMID:32109412
Gsdmd	Rat	wide pore channel activity	enables	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:33883744	RGD	PMID:33883744
Gsdmd	Rat	wide pore channel activity	enables	ISO	GSDMD (Homo sapiens) and UniProtKB:P57764-PRO_0000437526	1624291	PMID:32820063 more ...	RGD	PMID:32820063 more ...
Gsdmd	Rat	wide pore channel activity	enables	ISO	Gsdmd (Mus musculus) and UniProtKB:Q9D8T2-PRO_0000437528	1624291	PMID:32820063 and PMID:38538834	RGD	PMID:32820063 and PMID:38538834

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:10322635	PMID:26611636	PMID:27383986	PMID:30161099	PMID:30600840	PMID:34920032	PMID:35775127	PMID:36040608	PMID:36224321	PMID:36988259	PMID:37549514	PMID:37578618

Gsdmd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	109,423,209 - 109,427,771 (+)	NCBI		GRCr8
mRatBN7.2	7	107,542,489 - 107,547,051 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	107,542,083 - 107,547,055 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	109,281,502 - 109,286,064 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	111,505,178 - 111,509,740 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	111,451,127 - 111,455,689 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	116,889,147 - 116,894,134 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	116,889,572 - 116,894,134 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	116,781,947 - 116,786,875 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	113,832,420 - 113,837,007 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	113,847,420 - 113,871,239 (+)	NCBI
Celera	7	103,902,119 - 103,906,706 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

GSDMD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	143,553,387 - 143,563,062 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	143,553,207 - 143,563,062 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	144,635,557 - 144,645,232 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	144,711,635 - 144,716,375 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	144,712,102 - 144,716,372	NCBI
Celera	8	140,945,843 - 140,955,486 (+)	NCBI		Celera
Cytogenetic Map	8	q24.3	NCBI
HuRef	8	139,886,817 - 139,896,607 (+)	NCBI		HuRef
CHM1_1	8	144,675,788 - 144,685,442 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	144,702,722 - 144,712,453 (+)	NCBI		T2T-CHM13v2.0

Gsdmd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	75,733,990 - 75,739,257 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	75,734,176 - 75,739,257 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	75,862,144 - 75,867,408 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	75,862,327 - 75,867,408 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	75,692,769 - 75,697,834 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	75,689,594 - 75,694,659 (+)	NCBI		MGSCv36	mm8
Celera	15	77,363,199 - 77,368,383 (+)	NCBI		Celera
Cytogenetic Map	15	D3	NCBI
cM Map	15	35.0	NCBI

Gsdmd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	2,265,753 - 2,271,655 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955454	2,265,759 - 2,270,569 (+)	NCBI	ChiLan1.0	ChiLan1.0

GSDMD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	161,039,881 - 161,046,166 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	136,557,568 - 136,563,849 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	140,311,042 - 140,316,084 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	143,321,800 - 143,331,455 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	143,326,319 - 143,331,455 (+)	Ensembl	panpan1.1		panPan2

GSDMD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	37,221,219 - 37,226,912 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	37,193,022 - 37,228,360 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	37,178,091 - 37,183,803 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	37,693,423 - 37,699,140 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	37,693,447 - 37,700,588 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	37,367,765 - 37,373,478 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	37,484,726 - 37,490,434 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	37,965,884 - 37,971,607 (+)	NCBI		UU_Cfam_GSD_1.0

Gsdmd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	1,141,008 - 1,145,358 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	8,567,091 - 8,571,467 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	8,567,085 - 8,571,448 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GSDMD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	995,763 - 1,000,271 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	995,753 - 1,001,964 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	1,054,277 - 1,057,736 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GSDMD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	137,778,290 - 137,783,542 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666039	2,110,335 - 2,115,465 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gsdmd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	13,187,687 - 13,192,736 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	13,187,810 - 13,192,843 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Gsdmd
12 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	35
Interacting mature miRNAs:	39
Transcripts:	ENSRNOT00000045475
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	69736356	112729554	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	80221299	109401111	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	80221299	112308525	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

RH133888

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	7	781.4	UniSTS
Cytogenetic Map	7	q34	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001400993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001400994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000075917 ⟹ ENSRNOP00000067951

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	107,542,418 - 107,547,051 (+)	Ensembl
Rnor_6.0 Ensembl	7	116,889,572 - 116,894,134 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095149 ⟹ ENSRNOP00000095279

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	107,542,083 - 107,547,055 (+)	Ensembl

RefSeq Acc Id:

NM_001400993 ⟹ NP_001387922

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	109,423,209 - 109,427,771 (+)	NCBI
mRatBN7.2	7	107,542,489 - 107,547,051 (+)	NCBI

RefSeq Acc Id:

NM_001400994 ⟹ NP_001387923

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	109,423,209 - 109,427,771 (+)	NCBI
mRatBN7.2	7	107,542,489 - 107,547,051 (+)	NCBI


Protein RefSeqs	NP_001387922	(Get FASTA)	NCBI Sequence Viewer
	NP_001387923	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM16048	(Get FASTA)	NCBI Sequence Viewer
	EDM16049	(Get FASTA)	NCBI Sequence Viewer
	EDM16050	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000067951
	ENSRNOP00000067951.1
	ENSRNOP00000095279.1

Ensembl Acc Id:

ENSRNOP00000067951 ⟸ ENSRNOT00000075917

Ensembl Acc Id:

ENSRNOP00000095279 ⟸ ENSRNOT00000095149

RefSeq Acc Id:	NP_001387922 ⟸ NM_001400993
- UniProtKB:	A0A096MJ11 (UniProtKB/TrEMBL), A6HS22 (UniProtKB/TrEMBL), A6HS23 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001387923 ⟸ NM_001400994
- UniProtKB:	A0A096MJ11 (UniProtKB/TrEMBL), A6HS22 (UniProtKB/TrEMBL), A6HS23 (UniProtKB/TrEMBL)

Protein Domains

Gasdermin pore forming Gasdermin PUB

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A096MJ11-F1-model_v2	AlphaFold	A0A096MJ11	1-488	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13695391

Promoter ID:

EPDNEW_R5916

Type:

initiation region

Name:

Gsdmd_1

Description:

gasdermin D

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	116,889,589 - 116,889,649	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-32979	BioCyc
Ensembl Genes	ENSRNOG00000007728	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000075917	ENTREZGENE
	ENSRNOT00000075917.2	UniProtKB/TrEMBL
	ENSRNOT00000095149.1	UniProtKB/TrEMBL
InterPro	Gasdermin	UniProtKB/TrEMBL
	Gasdermin_pore	UniProtKB/TrEMBL
	Gasdermin_PUB	UniProtKB/TrEMBL
NCBI Gene	315084	ENTREZGENE
PANTHER	DFNA5	UniProtKB/TrEMBL
	GASDERMIN-D	UniProtKB/TrEMBL
Pfam	Gasdermin	UniProtKB/TrEMBL
	Gasdermin_C	UniProtKB/TrEMBL
PhenoGen	Gsdmd	PhenoGen
RatGTEx	ENSRNOG00000007728	RatGTEx
UniProt	A0A096MJ11	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6B2B6_RAT	UniProtKB/TrEMBL
	A6HS22	ENTREZGENE, UniProtKB/TrEMBL
	A6HS23	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Gsdmd	gasdermin D	Gsdmdc1_predicted	gasdermin domain containing 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Gsdmdc1_predicted	gasdermin domain containing 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Disease Annotations - ClinVar